Dr. Alex Morrow - Global Coordination of Animal Disease Research

Global Coordination of Animal Disease Research

PRRSV/CRWAD - Chicago

Alex Morrow

Focus of Presentation

Background to STAR-IDAZ IRCSTAR-IDAZ

International Research ConsortiumObjectivesGovernance structureSecretariat

PRRSV

CRWAD – PRRSV – Dec ‘16

Animal Health Challenges

•Existing disease challenges/endemic diseases•Re-emerging diseases

•Drug resistance•Threats from Epizootic Diseases•Extension of range of vector-borne diseases•New strains of organisms•“New” disease challenges We can’t all do everything

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Infectious disease emergence events

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West Nile, 1999 PPRV, 2007;

PED, 2010

Nipah, 1998

ASFV, 2007

BTV, 1998

BTV-8, 2006SBV, 2011

SARS, 2002

Hendra, 1994

MERS,2012

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International Research CoordinationSTAR-IDAZ (Global Strategic Alliances for the Coordination of Research on the Major Infectious Diseases of Animals and

Zoonoses)

A global initiative to address the coordination of research programmes at international level in the area of animal health and in particular infectious

animal diseases including zoonoses.

STAR-IDAZ Outputs/Achievements• A database of research publications• A research programmes database (including capacity

and activities)• Research needs at global, regional and industry sector

levels established• Agendas on target priority diseases and issues

developed• Instruments to enable cooperation, clustering and

partnerships identified• Development of a long-term Strategic Research Agenda

• An extensive network of research programme managers developed

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International Research Consortium(IRC)

Higher level of commitment for coordinated research activities through the STAR-IDAZ International Research Consortium for Animal Health (IRC)•Agree minimum level of investment in research on priorities over a five year period (threshold $US 10 million; group funding commitment possible)•Agree delivery targets •Agree to coordinate/align funding to deliver these targets (members' own funding procedures, unless agreed otherwise; governance document & policy guidelines)•Agree to share research results (as much as necessary, without jeopardising IPR)•20 partners from 13 countries plus one international organisation and three from industry have signed Letter of Intent to participate •Total combined research budget of $US 2.5+ billion

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IRC Partners (to date)

DTU/DenmarkINRA/FranceANSES/ FranceMoH/ItalyMinistry of Economic Affairs /The NetherlandsINIA/SpainDefra/UKBBSRC/UKRegional Consortium Belgium (Universiteit Ghent; Universite di

Liege; Federal Public Service, Health Food Chain Safety and the Environment; CODA-CERVA)

Kimron Veterinary Institute/Israel

CRWAD – PRRSV – Dec ‘16

IRC Partners (to date) – continued

ILRITanzania Veterinary Laboratory AgencyNIAH/JapanUSDA-ARS/USINTA/ArgentinaMINCYT/ArgentinaCFIA/CanadaZoetis

HealthforAnimalsEMVD

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G20 Ministry of Agriculture Chief Scientists (MACS) - Beijing, May 2016

We welcome the establishment of the STAR-IDAZ International Research Consortium on animal diseases and high priority vaccines.

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To coordinate research at international level to contribute to new and improved animal health strategies for at least 30 priority diseases/infections/issues

The deliverables include:• Candidate vaccines• Diagnostics• Therapeutics• Other animal health products and procedures• Key scientific information/tools to support risk analysis

and disease control

Objective of STAR-IDAZ IRC

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IRC Governance Structure

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IRC Executive Committee(Representatives of Funders)

Secretariat Scientific Committee

CoronavirusesEmerging Issues One HealthFMD

Diagnostics

ASF

InfluenzaInnovative

anti-infective approaches

Vector-borne diseases Brucellosis Bovine

Tuberculosis

Working GroupsImmunology/ Vaccinology

Mastitis Animal genetics/genomics Foresight Epidemiology

HelminthsPorcine

Respiratory Disease Complex PRRSV ????

STAR-IDAZ

Scientific Committee

Don KnowlesDieter SchillingerGary EntricanMartin BeerEdwin ClaereboutWim van der PoelDenis KolbasovStéphan Zientara

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Bruno Goddeeris Clara María Marín AlcaláGustavo Zielinski Glen GiffordJeremy SaltAnette BøtnerIrit DavidsonSergio Rosati

SIRCAH

“Secretariat for the International Research Consortium on Animal Health”

A €3 million EC- funded initiative.

PartnersDEFRABBSRCOIECABIIFAH-EUROPE

CRWAD – PRRSV – Dec ‘16

SIRCAH Activities• Establish working groups for priority diseases and crosscutting

issues - assisting with the organisation of meetings, including helping to pull together the gap analysis and mapping funding activities against identified research needs.

• Produce and publish gap analysis and roadmap reports from working groups.

• Advise the Scientific Committee (SC) and ExC on how research programmes could be aligned and make funding recommendations based on the gap analysis, roadmap reports and current funding activities.

• Help mobilise resources - bringing together funding bodies and helping to identify funding opportunities

• Facilitating knowledge transfer to bring innovation to the market

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PRRSV Research Gaps

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Avenues in the PRRSV Research Roadmap…

PRRSV attenuated

vaccine

Identify protective antigens

Identify protective pathways

Identify correlates of protection

Role of immune

effector cells

Genetic modification to remove stealth mechanisms and virulence

Identify stealth mechanisms

Identify virulence

mechanisms

Gene expression under different in

vivo environments

Identify suitable

vector

PRRSV Vector

vaccine

For further information visit www.star-idaz.net. To enquire about joining the IRC or the working groups please contact the STAR-IDAZ IRC Project Office:

Alex Morrow or Luke DaltonDefra, Area 5B, Nobel House, 17 Smith Square, London SW1P 3JRAlex.Morrow@Defra.gsi.gov.uk, Luke.Dalton@Defra.gsi.gov.uk

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