ASDI Overview PPT 07.20.2009
Post on 20-Jan-2015
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Welcome to ASDI Inc.
ASDI is a CRO that serves the life science industry with research-enabling technologies, services and products. Providing services such as synthetic chemistry, full-scale compound management programs, and high throughput purification/reclamation research services; ASDI strives to increase efficiencies and reduce
drug discovery cycle time and operating expense(s).
Company History & Development
• Founded in 1988 – Distribution of HTS Samples - Russia
• NMR – Provided Entrance into Service Sector
• 1993 – Weighing of HTS Samples into Tube Racks
• 1995 – NMR Services Included Weighing of 20K HTS Samples
Service Development
• Greater Than 1,800,000 HTS Weighing Operations
• Greater Than 30,000,000 Liquid Transfers
• Dynamic Collection of HTS Compounds
• Fragment Screening Collection
• Known Biological Collection
• Lead Generation Libraries
• Diversity Collection
• Greater Than 750,000 Reactive Intermediate Transfers
• Greater Than 1,500,000 Analytical Sample Analysis
Facility Development
• Compound Management and Global Distribution
• Newark, Delaware
• 1998 – 800 sq ft
• 2004 – 54,000 sq ft
• 2006 – 76,000 sq ft
• 2007 – 104,000 sq ft
• 2008 – 172,000 sq ft
• 1988 – Brokerage of HTS Samples
• 1994 – HTS Powder Weighing Services
• 2001 – Liquid Handling Services
• 2002 – Reactive Intermediate Services
• 2003 – Chemical Custom Synthesis
• 2004 – Analytical Chemistry
• 2005 – Full Materials Management Services
• 2006 – Lead Generation Libraries (Hit to Lead Custom Library Synthetic Services)
• 2007 – Bio-Analytical Services (Fragment Screening Collection & Associated Services)
Business Development – Model Expansion
• Custom Synthesis
• Advanced Synthesis Group• Acquired in 2006
• ASDI Ukraine, Ltd• ASDI Thailand, Ltd• ASDI China, Ltd
• Information Technologies• Intelligent Systems, Inc.
• Under Development• Computational Chemistry• High Throughput Screening• PK Studies
Strategic Partners – Custom Synthesis
ASDI Impacting Drug Discovery
Nature Reviews. Drug Discovery, 5(11):941-955, copyright 2006
Stoichiometric weighing service
ASDI lead generation librariesHTS screening samples
Fragment screening libraries
ASDI has extensive liquid handling& sample formatting capabilities
Intelligent Solutions (IS)IT software & support
ASDI integrated proprietary building block management
& distribution model
ASDI integrated management & distribution
of screening compounds
ASDI custom synthesis & purification laboratory (LC/MS)
ASDI bio-analytical & in-vitro ADMET
ASDI PK in-vivo assays
Drug Discovery Process: Integrated Services Custom Library Synthesis
Compound PurificationLC/MS
Shipping to MultipleScreening Groups
ADME Profiling
Compound Plating,Materials Management / Stoichiometric weighing,
Liquid Handling, etc
DatabaseCompound Storage
Neats/Liquids
Pharmacokinetics Studies
Acquisition of Biological Data
• Increase the rate, diversity and quality of compounds entering the biological screening assays.
• Provide necessary resources to enable the chemist and biologists to focus on the design, elaboration and evaluation of novel series within a therapeutic program.
• Shorten the overall time for an idea to move through the discovery process and enter development.
• Assist the pharmaceutical sector in making the most efficient use of R&D dollars in their pursuit of new drug therapies.
Enabling & Accelerating Drug Discovery
Liquid Operations Services
• Sample Dissolution & Transfer (per day)
• Vials to Plates – 23,000 / Minitube to Plate – 40,000
• Replication – 17,280 plates (per day)
• 96 well – 1,600,000 / 384 well – 6,400,000 / 1536 well – a lot
HTS Powder Operations
• Sample Transfer (per day)
• ~12,000 items vials, minitubes racks, or blocks
Operational Capacity
• Climate Controlled Repositories for the Storage of Reactive Intermediate Collections• 48,000 cu ft available – additional 24,000 cu ft being added
• High Throughput Intermediate Weighing Suite Utilizing ASDI Designed Glove Boxes• Vial to vial – 12,000 (per day)
• Intensive IT Monitoring Software for Compound Weighing• Statistical Data Retained on each Sample and Transfer
Operational Capacity – Reactive Intermediate Distribution
• Multiple LC-MS Single Quad. Mass Analyzer
• Preparative LC-MS
• Varian Mercury 300 MHz NMR Spectrometer with Zymark Auto-Sampler
• GC-MS with Auto-Sampler
• Multiple GC with Auto-Sampler
• Scheduled Expansion• Triple Quadrapole Mass Analyzer• Additional Preparative LC-MS
Operational Capacity – Analytical Services
Fast, flexible solutions for our partners in drug discovery
Our Philosophy
We adapt our programs, assays, and services to solve your problems in the most cost effective way
Pharmaceutical Research Services
• Custom chemistry
• Purification/Reclamation lab
• High throughput analytical chemistry
Pharmaceutical Research Services
• Scaffolds and Building Blocks
• Pre-clinical Tox material (500g to 2 Kg), non-GMP
• Hit to Lead Library Synthesis (parallel, solution phase)
• Lead Optimization Small Library Synthesis
Pharmaceutical Research Services – Custom Chemistry
• Work with the investigator to provide solutions
• Purification of a broad range of chemotypes in a high-throughput milieu
• Provide quality, information rich data
Pharmaceutical Research Services – Purification
• Agilent A2Prep LC-MS
• 2-valve CTC HTC auto-sampler (analytical & preparative)
• 1200 series HPLC stack with DAD
• 2-channel binary gradient cluster
• Single quad MS
• Fraction collection stack (3)
• Capacity > 500 analyses / week
Pharmaceutical Research Services – Mass-Directed Preparative LC-MS
• Waters Auto-pure
• 2767 sample manager (analytical – prep – final purity)
• Fluidics manager
• 4-channel binary gradient module
• PDA and ELSD
• Capacity > 300 analyses / week
Pharmaceutical Research Services – Mass-Directed Preparative LC-MS
• Quantities: Grams to Kilograms
• Medium pressure chromatography – Biotage
• Distillation
• Crystallization
Pharmaceutical Research Services – Bulk Purification
Comprehensive suite supporting
• ASDI Internal collections• ASDI collaborations• Synthetic chemistry
LC-MS/MS, GC-MS/MS & NMR
• Average > 300K analyses annually• Capacity ≈ 1.5M
Analytical & Bioanalytical Services
You determine ASDI’s future services and products.
What will provide the most value to you in your discovery research efforts?
Future Products & Services
Thank You.
We welcome you an opportunity for the ASDI management team(s) to provide an in depth discussion of capabilities at our Newark, DE facility. We are also able to have one of our representatives, in your focus or
expertise, meet and present at your facility.
Additionally, we would also like to offer you the ASDI available chemical catalogue, featuring a collection of reagents and building blocks, available electronically through our web based ordering system. Lastly, we would like to offer ASDI’s comprehensive structure and computational based online system for searching,
reviewing, and ordering our chemical catalogue, fragment & HTS screening collections.
All available at www.ASDI.net
ASDI Marketing & Customer Service
ASDI Inc.
601 Interchange Blvd.
Newark, DE 19711 USA
Marketing@asdi.net
(p) 302-266-6891 ext 104
We look forward to working with you.
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