ASDI Overview PPT 07.20.2009

Welcome to ASDI Inc.

ASDI is a CRO that serves the life science industry with research-enabling technologies, services and products. Providing services such as synthetic chemistry, full-scale compound management programs, and high throughput purification/reclamation research services; ASDI strives to increase efficiencies and reduce

drug discovery cycle time and operating expense(s).

Company History & Development

• Founded in 1988 – Distribution of HTS Samples - Russia

• NMR – Provided Entrance into Service Sector

• 1993 – Weighing of HTS Samples into Tube Racks

• 1995 – NMR Services Included Weighing of 20K HTS Samples

Service Development

• Greater Than 1,800,000 HTS Weighing Operations

• Greater Than 30,000,000 Liquid Transfers

• Dynamic Collection of HTS Compounds

• Fragment Screening Collection

• Known Biological Collection

• Lead Generation Libraries

• Diversity Collection

• Greater Than 750,000 Reactive Intermediate Transfers

• Greater Than 1,500,000 Analytical Sample Analysis

Facility Development

• Compound Management and Global Distribution

• Newark, Delaware

• 1998 – 800 sq ft

• 2004 – 54,000 sq ft

• 2006 – 76,000 sq ft

• 2007 – 104,000 sq ft

• 2008 – 172,000 sq ft

• 1988 – Brokerage of HTS Samples

• 1994 – HTS Powder Weighing Services

• 2001 – Liquid Handling Services

• 2002 – Reactive Intermediate Services

• 2003 – Chemical Custom Synthesis

• 2004 – Analytical Chemistry

• 2005 – Full Materials Management Services

• 2006 – Lead Generation Libraries (Hit to Lead Custom Library Synthetic Services)

• 2007 – Bio-Analytical Services (Fragment Screening Collection & Associated Services)

Business Development – Model Expansion

• Custom Synthesis

• Advanced Synthesis Group• Acquired in 2006

• ASDI Ukraine, Ltd• ASDI Thailand, Ltd• ASDI China, Ltd

• Information Technologies• Intelligent Systems, Inc.

• Under Development• Computational Chemistry• High Throughput Screening• PK Studies

Strategic Partners – Custom Synthesis

ASDI Impacting Drug Discovery

Nature Reviews. Drug Discovery, 5(11):941-955, copyright 2006

Stoichiometric weighing service

ASDI lead generation librariesHTS screening samples

Fragment screening libraries

ASDI has extensive liquid handling& sample formatting capabilities

Intelligent Solutions (IS)IT software & support

ASDI integrated proprietary building block management

& distribution model

ASDI integrated management & distribution

of screening compounds

ASDI custom synthesis & purification laboratory (LC/MS)

ASDI bio-analytical & in-vitro ADMET

ASDI PK in-vivo assays

Drug Discovery Process: Integrated Services Custom Library Synthesis

Compound PurificationLC/MS

Shipping to MultipleScreening Groups

ADME Profiling

Compound Plating,Materials Management / Stoichiometric weighing,

Liquid Handling, etc

DatabaseCompound Storage

Neats/Liquids

Pharmacokinetics Studies

Acquisition of Biological Data

• Increase the rate, diversity and quality of compounds entering the biological screening assays.

• Provide necessary resources to enable the chemist and biologists to focus on the design, elaboration and evaluation of novel series within a therapeutic program.

• Shorten the overall time for an idea to move through the discovery process and enter development.

• Assist the pharmaceutical sector in making the most efficient use of R&D dollars in their pursuit of new drug therapies.

Enabling & Accelerating Drug Discovery

Liquid Operations Services

• Sample Dissolution & Transfer (per day)

• Vials to Plates – 23,000 / Minitube to Plate – 40,000

• Replication – 17,280 plates (per day)

• 96 well – 1,600,000 / 384 well – 6,400,000 / 1536 well – a lot

HTS Powder Operations

• Sample Transfer (per day)

• ~12,000 items vials, minitubes racks, or blocks

Operational Capacity

• Climate Controlled Repositories for the Storage of Reactive Intermediate Collections• 48,000 cu ft available – additional 24,000 cu ft being added

• High Throughput Intermediate Weighing Suite Utilizing ASDI Designed Glove Boxes• Vial to vial – 12,000 (per day)

• Intensive IT Monitoring Software for Compound Weighing• Statistical Data Retained on each Sample and Transfer

Operational Capacity – Reactive Intermediate Distribution

• Multiple LC-MS Single Quad. Mass Analyzer

• Preparative LC-MS

• Varian Mercury 300 MHz NMR Spectrometer with Zymark Auto-Sampler

• GC-MS with Auto-Sampler

• Multiple GC with Auto-Sampler

• Scheduled Expansion• Triple Quadrapole Mass Analyzer• Additional Preparative LC-MS

Operational Capacity – Analytical Services

Fast, flexible solutions for our partners in drug discovery

Our Philosophy

We adapt our programs, assays, and services to solve your problems in the most cost effective way

Pharmaceutical Research Services

• Custom chemistry

• Purification/Reclamation lab

• High throughput analytical chemistry

Pharmaceutical Research Services

• Scaffolds and Building Blocks

• Pre-clinical Tox material (500g to 2 Kg), non-GMP

• Hit to Lead Library Synthesis (parallel, solution phase)

• Lead Optimization Small Library Synthesis

Pharmaceutical Research Services – Custom Chemistry

• Work with the investigator to provide solutions

• Purification of a broad range of chemotypes in a high-throughput milieu

• Provide quality, information rich data

Pharmaceutical Research Services – Purification

• Agilent A2Prep LC-MS

• 2-valve CTC HTC auto-sampler (analytical & preparative)

• 1200 series HPLC stack with DAD

• 2-channel binary gradient cluster

• Single quad MS

• Fraction collection stack (3)

• Capacity > 500 analyses / week

Pharmaceutical Research Services – Mass-Directed Preparative LC-MS

• Waters Auto-pure

• 2767 sample manager (analytical – prep – final purity)

• Fluidics manager

• 4-channel binary gradient module

• PDA and ELSD

• Capacity > 300 analyses / week

Pharmaceutical Research Services – Mass-Directed Preparative LC-MS

• Quantities: Grams to Kilograms

• Medium pressure chromatography – Biotage

• Distillation

• Crystallization

Pharmaceutical Research Services – Bulk Purification

Comprehensive suite supporting

• ASDI Internal collections• ASDI collaborations• Synthetic chemistry

LC-MS/MS, GC-MS/MS & NMR

• Average > 300K analyses annually• Capacity ≈ 1.5M

Analytical & Bioanalytical Services

You determine ASDI’s future services and products.

What will provide the most value to you in your discovery research efforts?

Future Products & Services

Thank You.

We welcome you an opportunity for the ASDI management team(s) to provide an in depth discussion of capabilities at our Newark, DE facility. We are also able to have one of our representatives, in your focus or

expertise, meet and present at your facility.

Additionally, we would also like to offer you the ASDI available chemical catalogue, featuring a collection of reagents and building blocks, available electronically through our web based ordering system. Lastly, we would like to offer ASDI’s comprehensive structure and computational based online system for searching,

reviewing, and ordering our chemical catalogue, fragment & HTS screening collections.

All available at www.ASDI.net

ASDI Marketing & Customer Service

ASDI Inc.

601 Interchange Blvd.

Newark, DE 19711 USA

[email protected]

(p) 302-266-6891 ext 104

We look forward to working with you.