Adrenal crisis and mortality rate in adrenal insufficiency and congenital adrenal hyperplasia
Post on 28-Apr-2023
2 Views
Preview:
DESCRIPTION
Primary adrenal insufficiency (PAI) is characterized by the inability of the adrenal cortex to produce
sufficient amounts of glucocorticoids and/or mineralocorticoids. Addison’s disease (AD) and congenital
adrenal hyperplasia (CAH) are the most frequent disorders in adults and children, respectively. Despite
the diagnostic advances and the availability of glucocorticoid and mineralocorticoid replacements,
adrenal crisis (AC) is still a potentially lethal condition contributing to the increased mortality, not
only during the first year of life, but also throughout life. Failure in increasing glucocorticoid doses
during acute stress, when greater amounts of glucocorticoids are required, can lead to AC and an
increase morbimortality rate of PAI
top related