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Documents Macrocycles As Bace 1 Inhibitors

1. Design and Synthesis of Macrocycles as  -Secretase (BACE-1) Inhibitors for the Treatment of Alzheimer’s Disease 2. Alzheimer’s Disease Pathophysiology Alzheimer’s…

Business Session 4 part 3

1. Druggability Considerations for GPCRs and Ion ChannelsShaun R. Stauffer6th Drug Discovery for Neurodegeneration Conference February 12-14, 2012 2. Outline1. CNS drug development…

Documents Amyloid beta protein may initiate a cascade leading to AD pathology.

Slide 1 Amyloid beta protein may initiate a cascade leading to AD pathology. Slide 2 APP secretases AA nucleus aggregation, fibrils and amyloid plaques other substrates…

Documents Zinc-binding motif (active site) VIGHEITHGF NH 2 -COOH NNNNN 750 transmembrane domain...

Zinc-binding motif (active site) VIGHEITHGF - 7 5 0 transmembrane domain cytoplasmic lumen/extracellular membrane Animation 1. Schematized structure of the major Ab-degrading…