12 Cyclin-Dependent Kinases (Cdk) as Targets for Cancer Therapy and Imaging Franziska Graf1, Frank Wuest2 and Jens Pietzsch1 1Institute of Radiopharmacy, Helmholtz-Zentrum…

Slide 1 The Hallmarks of Cancer Hanahan and Weinberg, Cell 100:57-70 (2000) Slide 2 Cell Regulatory Networks Important in Cancer Cells Hanahan and Weinberg, Cell 100:57-70…

Slide 1 Phosphorylation of CDK Targets Changes Their Activity Now performs a cell cycle function Slide 2 How are CDK’s Regulated? 1.By cyclin synthesis and destruction…

Slide 1 Slide 2 Abnormal Cell Proliferation,Differentiation Apoptosis and Related Disease Department of Pathophysiology Shanghai Jiao-Tong University School of Medicine Slide…

Phosphorylation of CDK Targets Changes Their Activity Now performs a cell cycle function How are CDKâs Regulated? By cyclin synthesis and destruction By phosphorylation…