A brief on: Domain Families & Classification The discovery of domains in protein structures Domains at the sequence level Examples of “Domain Resources” Domain fusion…

PROTEIN STRUCTURE CLASSIFICATION PROTEIN STRUCTURE CLASSIFICATION SUMI SINGH (sxs5729) Levels of Protein Structure 2 2 Thanks to: Frank Lloyd Wright for graphics WOOD, BRICK…

Remote homology detection Remote homologs: low sequence similarity, conserved structure/function A number of databases and tools are available BLAST, FASTA PDB HOMSTRAD SCOP…

Protein Structure Similarity Secondary Structure Elements: a helices, b strands/sheets, & loops Structure Prediction/Determination Computational tools Homology, threading…

PowerPoint Presentation Structure superposition Structure superposition ≠ Structure alignment Lecture 11 Chapter 16, Du and Bourne “Structural Bioinformatics” 1 Why?…

Slide 1 Protein threading algorithms 1.GenTHREADER Jones, D. T. JMB(1999) 287, 797-815 2.Protein Fold Recognition by Prediction-based Threading Rost, B., Schneider, R. &…

Protein structure and homology modeling Morten Nielsen, CBS, BioCentrum, DTU Objectives Understand the basic concepts of homology modeling Learn why even sequences with very…