Developing a cure for Black Bone Disease Improving involvement of patients in clinical research Lessons from Black Bone Disease Dr Nicolas Sireau Chairman and CEO, AKU Society…

1. A.P Bio How Genes Transmit InformationRussab Ali Block 1 2. Why Do Fireflies Glow? Fireflies glow in order to attract mates. Males and females flash signals to each other…

Slide 1 Slide 2 DNARNA 1. Contains the sugar deoxyribose 2. Contains thymine 3. Is in the shape of a double helix 4. There is only 1 type of DNA 5. DNA can’t leave the…

* Lecture 9 One Gene One enzyme * Genes DNA sequences that code for RNA- prm, RBS, ORF, Term ---TTGACAT------TATAAT-------AT-/-AGGAGGT-/-ATG CCC CTT TTG TGA ---AACTGTA------ATATTA-------TA-/-TCCTCCA-/-TAC…

Sec 5.1 / 5.2 One Gene – One Polypeptide Hypothesis early 20th century – Archibald Garrod physician that noticed that some metabolic errors were found in numerous members…

DNA RNA Contains the sugar deoxyribose Contains thymine Is in the shape of a double helix There is only 1 type of DNA DNA canât leave the nucleus DNA is much longer Only…

Dog bones-Congenital hip dysplasia 2nd OA Congenital hip dysplasia-2nd OA, small head to neck ratio Multi epiphyseal dysplasia (w/dwarfism) 2ndOA Acromegaly=diabetes(inc…

Sir Archibald E Garrod 1857-1936 1902 – alcaptonuria – black urine - (Madness of King George) Alcaptonuria Rare disease Blackening of urine on exposure of air Alcapton…

* Lecture 9 One Gene One enzyme * Genes DNA sequences that code for RNA- prm, RBS, ORF, Term ---TTGACAT------TATAAT-------AT-/-AGGAGGT-/-ATG CCC CTT TTG TGA ---AACTGTA------ATATTA-------TA-/-TCCTCCA-/-TAC…

6 Gene Interaction WORKING WITH THE FIGURES 1. In Figure 6-1, a. what do the yellow stars represent? b. explain in your own words why the heterozygote is functionally wild…