Slide 1 Autoimmunity and Tolerance Chris Lancaster, Emily Mathews, Jake Turner Questions: [email protected] [email protected] [email protected]…

Slide 1 T Cell Development ? ? ? ?? ? ? Slide 2 Slide 3 Role of the thymus in T cell development Required for T cell development –Neonatal thymectomy –Nude mice Shapes…

Slide 1 Autoimmune diseases (that you need to know for year 1) Slide 2 Immunological Tolerance: Unresponsiveness of the immune system to an antigen (Not only self-antigens,…

Slide 1 Investigation of Systemic Juvenile Idiopathic Arthritis (SJIA): a disease of dysregulated innate inflammation Betsy Mellins, MD Divisions of Human Gene Therapy and…

Slide 1 Autoimmune diseases Slide 2 CENTRAL TOLERANCE IS INDUCED AND MAINTAINED IN THE BONE MARROW AND THYMUS Clonal deletion of self agressive B and T cell clones (not complete)…

Slide 1 Autoimmune diseases Slide 2 Chronic inflammatory conditions Repair mechanisms cannot compete with tissue destruction caused by the immune system Variety of symptoms…

VII.PRIMARY DISEASES OF MYELIN PRIMARY DISEASES OF MYELIN Acquired forms Characterized by preferential damage to previously normal myelin with relative preservation of axons…

Corso CINBO Recent advances in the medical treatment of melanoma Roma 21/06/2013 Pre-clinical and clinical aspects of peptide-based melanoma vaccines Giorgio Parmiani San…

Chapter 28 Autoimmune Disorders Behavioral Objectives At the end of this lecture, the MLS and MLT student will be able to: Define tolerance Describe mechanisms for autoimmunity…

Immunological tolerance Immunological tolerance Definition: Unresponsiveness to a given antigen induced by the interaction of that antigen with the lymphocytes; Antigen specific!!!…