1. Bioinformatics Meets Systems Biology for Early Stage Drug Discovery Philip E. Bourne University of California San Diego [email_address] http://www.sdsc.edu/pb NBIC –…

Slide 1Protein Ligand Interactions: A Method and its Application to Drug Discovery PHAR 201/Bioinformatics I Philip E. Bourne Department of Pharmacology, UCSD [email protected]…

1. Polypharmacology Studied Using Structural Bioinformatics and Systems Biology Philip E. Bourne University of California San Diego [email_address] http://www.sdsc.edu/pb…

1. Polypharmacology: The Good News and Bad News of Possible Cancer Therapy Philip E. Bourne University of California San Diego [email protected] http://www.sdsc.edu/pb Cancer…

Biochemical and Functional Characterization of the Interaction between Liprin-a1 and GIT1: Implications for the Regulation of Cell Motility Claudia Asperti1., Veronica Astro1.,…

Slide 1The Role of Biopathways in Drug Repositioning and Determining Side Effects Philip E. Bourne University of California San Diego [email protected] Support Open Access…

Off-Targets Philip E. Bourne University of California San Diego [email protected] http://www.sdsc.edu/pb/edu/biom230/off-targets.ppt Support Open Access BIOM 230 Motivation…

Molecular Machinery Molecular basis of cell function Structure vs. Function Molecular mechanisms ENZYME ACTION Na+ K+ pump Cell Signalling ENZYMES Hydrolase hydrolysis Phosphatase…

Finding Ligand Binding Sites on a Proteome-wide Scale and its Implications Philip E. Bourne University of California San Diego [email protected] http://www.sdsc.edu/pb/Talks/…

PowerPoint Presentation Protein Ligand Interactions: A Method and its Application to Drug Discovery PHAR 201/Bioinformatics I Philip E. Bourne Department of Pharmacology,…