Jan Felix Drexler Institute of Virology, University of Bonn Zoonotic transmission of HEV
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Jan Felix Drexler
Institute of Virology, University of Bonn
Zoonotic transmission of HEV
Dalton, Lancet ID, 2008
Purcell, J Hepatol, 2008
Hepatitis E virus: The only hepatitis virus with a known zoonotic reservoir
Dalton, Lancet ID, 2008
HEV: 4 genotypes
Gt 3 and 4 in humans,
swine, deer, rabbits…
Family Hepeviridae: Also contains avian and rodent viruses
Virus taxonomy, 9th ed.
HEV and bats? 3,869 fecal, blood and liver specimens from
85 bat species and 5 continents
Consensus primers for hemi-nested RT-PCR targeting the Hepeviridae RdRp
Vampyrodes caraccioli
Hipposideros abae
Eptesicus serotinus
Myotis bechsteinii
Myotis daubentonii
…7 (0.18%) positive bats 5 species 3 continents
…covering major bat evolutionary lineages.
Pathogenicity? Likely hepatic tropism in one E. serotinus
Despite host and geographic diversity: bat hepeviruses formed one monophyletic clade
Full genome amplification from clinical specimen confirmed Hepeviridae classification
„Bats, the great natural reservoir for viruses.“
CID, 2007
Science, 2005
No cross-recognition of human HEV antigens by bat sera…
Testing of ca. 90,000 human blood donations from Germany sampled 2009-2010 (GfE Blut) –
no bat-related hepevirus…
…but geographical clustering of pig and human Gt3 HEV
Corman et al., Vox sang, 2012
…as in a simultaneous study from Germany
Dreier et al, JCM, 2012
HEV sequences from German
donors sampled 2011:
Clustering with pig and human
strains from Germany and the
Netherlands
…and a preceding one.
„Closest sequence match between an HEV strain from a wild boar and samples 6 and
7 from German donors.“
Should risk groups such as hunters, butchers or abattoir workers be specifically screened for HEV infection?
The association of animal hosts and hepevirus lineage is very strict…
…peridomestic animal viruses closely related to human HEV:
secondary acquisitions
from humans?
Dalton, LID, 2008
Are there „original“ swine / deer... viruses?
Virus ecology group, Bonn Annika Seelen Victor Corman Monika Eschbach-Bludau Sebastian Brünink Christian Drosten…
Molecular Virology Marcel Müller Doreen Muth
Field work Florian Gloza-Rausch Antje Seebens Peter Vallo
CIRMF, Gabon Eric Leroy
Veterinary Medicine, Brazil Roberto Franke
Pathology, Bonn Reinhard Büttner
Chumakov Institute, Russia Alexander Lukashev Ecology, Ulm
Elisabeth Kalko Stefan Klose Veronika Cottontail Marco Tschapka
KCCR, Ghana, Augustina Annan Samuel Oppong
Virology, TiHo Hannover Georg Herrler Andrea Rasche
Virology, Marburg Andrea Maisner
RIVM, Netherlands Chantal Reusken
Virology, Berlin Detlef Krüger
FLI, Germany Rainer Ulrich
Bernhard Nocht Institut, HH Thomas Kruppa Jonas Schmidt-Chanasit
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