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Zhao et al Cell 105:587-, 2001 - UTokyo OpenCourseWare+ Mouse lgG 0.58% (n=2044) Rabbit lgG + Mouse lgG . A+T/pau Targeting Vector Probes Wild Type Allele 9.0 kb Knockout Allele 2.1

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Page 1: Zhao et al Cell 105:587-, 2001 - UTokyo OpenCourseWare+ Mouse lgG 0.58% (n=2044) Rabbit lgG + Mouse lgG . A+T/pau Targeting Vector Probes Wild Type Allele 9.0 kb Knockout Allele 2.1
Page 2: Zhao et al Cell 105:587-, 2001 - UTokyo OpenCourseWare+ Mouse lgG 0.58% (n=2044) Rabbit lgG + Mouse lgG . A+T/pau Targeting Vector Probes Wild Type Allele 9.0 kb Knockout Allele 2.1

Zhao et al．Cell 105:587-, 2001

Page 3: Zhao et al Cell 105:587-, 2001 - UTokyo OpenCourseWare+ Mouse lgG 0.58% (n=2044) Rabbit lgG + Mouse lgG . A+T/pau Targeting Vector Probes Wild Type Allele 9.0 kb Knockout Allele 2.1
Page 4: Zhao et al Cell 105:587-, 2001 - UTokyo OpenCourseWare+ Mouse lgG 0.58% (n=2044) Rabbit lgG + Mouse lgG . A+T/pau Targeting Vector Probes Wild Type Allele 9.0 kb Knockout Allele 2.1
Page 5: Zhao et al Cell 105:587-, 2001 - UTokyo OpenCourseWare+ Mouse lgG 0.58% (n=2044) Rabbit lgG + Mouse lgG . A+T/pau Targeting Vector Probes Wild Type Allele 9.0 kb Knockout Allele 2.1
Page 6: Zhao et al Cell 105:587-, 2001 - UTokyo OpenCourseWare+ Mouse lgG 0.58% (n=2044) Rabbit lgG + Mouse lgG . A+T/pau Targeting Vector Probes Wild Type Allele 9.0 kb Knockout Allele 2.1
Page 7: Zhao et al Cell 105:587-, 2001 - UTokyo OpenCourseWare+ Mouse lgG 0.58% (n=2044) Rabbit lgG + Mouse lgG . A+T/pau Targeting Vector Probes Wild Type Allele 9.0 kb Knockout Allele 2.1
Page 8: Zhao et al Cell 105:587-, 2001 - UTokyo OpenCourseWare+ Mouse lgG 0.58% (n=2044) Rabbit lgG + Mouse lgG . A+T/pau Targeting Vector Probes Wild Type Allele 9.0 kb Knockout Allele 2.1
Page 9: Zhao et al Cell 105:587-, 2001 - UTokyo OpenCourseWare+ Mouse lgG 0.58% (n=2044) Rabbit lgG + Mouse lgG . A+T/pau Targeting Vector Probes Wild Type Allele 9.0 kb Knockout Allele 2.1
Page 10: Zhao et al Cell 105:587-, 2001 - UTokyo OpenCourseWare+ Mouse lgG 0.58% (n=2044) Rabbit lgG + Mouse lgG . A+T/pau Targeting Vector Probes Wild Type Allele 9.0 kb Knockout Allele 2.1
Page 11: Zhao et al Cell 105:587-, 2001 - UTokyo OpenCourseWare+ Mouse lgG 0.58% (n=2044) Rabbit lgG + Mouse lgG . A+T/pau Targeting Vector Probes Wild Type Allele 9.0 kb Knockout Allele 2.1
Page 12: Zhao et al Cell 105:587-, 2001 - UTokyo OpenCourseWare+ Mouse lgG 0.58% (n=2044) Rabbit lgG + Mouse lgG . A+T/pau Targeting Vector Probes Wild Type Allele 9.0 kb Knockout Allele 2.1

Setou et al. Science 288:1796-, 2000

Page 13: Zhao et al Cell 105:587-, 2001 - UTokyo OpenCourseWare+ Mouse lgG 0.58% (n=2044) Rabbit lgG + Mouse lgG . A+T/pau Targeting Vector Probes Wild Type Allele 9.0 kb Knockout Allele 2.1
Page 14: Zhao et al Cell 105:587-, 2001 - UTokyo OpenCourseWare+ Mouse lgG 0.58% (n=2044) Rabbit lgG + Mouse lgG . A+T/pau Targeting Vector Probes Wild Type Allele 9.0 kb Knockout Allele 2.1
Page 15: Zhao et al Cell 105:587-, 2001 - UTokyo OpenCourseWare+ Mouse lgG 0.58% (n=2044) Rabbit lgG + Mouse lgG . A+T/pau Targeting Vector Probes Wild Type Allele 9.0 kb Knockout Allele 2.1
Page 16: Zhao et al Cell 105:587-, 2001 - UTokyo OpenCourseWare+ Mouse lgG 0.58% (n=2044) Rabbit lgG + Mouse lgG . A+T/pau Targeting Vector Probes Wild Type Allele 9.0 kb Knockout Allele 2.1
Page 17: Zhao et al Cell 105:587-, 2001 - UTokyo OpenCourseWare+ Mouse lgG 0.58% (n=2044) Rabbit lgG + Mouse lgG . A+T/pau Targeting Vector Probes Wild Type Allele 9.0 kb Knockout Allele 2.1
Page 18: Zhao et al Cell 105:587-, 2001 - UTokyo OpenCourseWare+ Mouse lgG 0.58% (n=2044) Rabbit lgG + Mouse lgG . A+T/pau Targeting Vector Probes Wild Type Allele 9.0 kb Knockout Allele 2.1
Page 19: Zhao et al Cell 105:587-, 2001 - UTokyo OpenCourseWare+ Mouse lgG 0.58% (n=2044) Rabbit lgG + Mouse lgG . A+T/pau Targeting Vector Probes Wild Type Allele 9.0 kb Knockout Allele 2.1
Page 20: Zhao et al Cell 105:587-, 2001 - UTokyo OpenCourseWare+ Mouse lgG 0.58% (n=2044) Rabbit lgG + Mouse lgG . A+T/pau Targeting Vector Probes Wild Type Allele 9.0 kb Knockout Allele 2.1
Page 21: Zhao et al Cell 105:587-, 2001 - UTokyo OpenCourseWare+ Mouse lgG 0.58% (n=2044) Rabbit lgG + Mouse lgG . A+T/pau Targeting Vector Probes Wild Type Allele 9.0 kb Knockout Allele 2.1
Page 22: Zhao et al Cell 105:587-, 2001 - UTokyo OpenCourseWare+ Mouse lgG 0.58% (n=2044) Rabbit lgG + Mouse lgG . A+T/pau Targeting Vector Probes Wild Type Allele 9.0 kb Knockout Allele 2.1
Page 23: Zhao et al Cell 105:587-, 2001 - UTokyo OpenCourseWare+ Mouse lgG 0.58% (n=2044) Rabbit lgG + Mouse lgG . A+T/pau Targeting Vector Probes Wild Type Allele 9.0 kb Knockout Allele 2.1
Page 24: Zhao et al Cell 105:587-, 2001 - UTokyo OpenCourseWare+ Mouse lgG 0.58% (n=2044) Rabbit lgG + Mouse lgG . A+T/pau Targeting Vector Probes Wild Type Allele 9.0 kb Knockout Allele 2.1
Page 25: Zhao et al Cell 105:587-, 2001 - UTokyo OpenCourseWare+ Mouse lgG 0.58% (n=2044) Rabbit lgG + Mouse lgG . A+T/pau Targeting Vector Probes Wild Type Allele 9.0 kb Knockout Allele 2.1
Page 26: Zhao et al Cell 105:587-, 2001 - UTokyo OpenCourseWare+ Mouse lgG 0.58% (n=2044) Rabbit lgG + Mouse lgG . A+T/pau Targeting Vector Probes Wild Type Allele 9.0 kb Knockout Allele 2.1
Page 27: Zhao et al Cell 105:587-, 2001 - UTokyo OpenCourseWare+ Mouse lgG 0.58% (n=2044) Rabbit lgG + Mouse lgG . A+T/pau Targeting Vector Probes Wild Type Allele 9.0 kb Knockout Allele 2.1
Page 28: Zhao et al Cell 105:587-, 2001 - UTokyo OpenCourseWare+ Mouse lgG 0.58% (n=2044) Rabbit lgG + Mouse lgG . A+T/pau Targeting Vector Probes Wild Type Allele 9.0 kb Knockout Allele 2.1
Page 29: Zhao et al Cell 105:587-, 2001 - UTokyo OpenCourseWare+ Mouse lgG 0.58% (n=2044) Rabbit lgG + Mouse lgG . A+T/pau Targeting Vector Probes Wild Type Allele 9.0 kb Knockout Allele 2.1
Page 30: Zhao et al Cell 105:587-, 2001 - UTokyo OpenCourseWare+ Mouse lgG 0.58% (n=2044) Rabbit lgG + Mouse lgG . A+T/pau Targeting Vector Probes Wild Type Allele 9.0 kb Knockout Allele 2.1
Page 31: Zhao et al Cell 105:587-, 2001 - UTokyo OpenCourseWare+ Mouse lgG 0.58% (n=2044) Rabbit lgG + Mouse lgG . A+T/pau Targeting Vector Probes Wild Type Allele 9.0 kb Knockout Allele 2.1
Page 32: Zhao et al Cell 105:587-, 2001 - UTokyo OpenCourseWare+ Mouse lgG 0.58% (n=2044) Rabbit lgG + Mouse lgG . A+T/pau Targeting Vector Probes Wild Type Allele 9.0 kb Knockout Allele 2.1
Page 33: Zhao et al Cell 105:587-, 2001 - UTokyo OpenCourseWare+ Mouse lgG 0.58% (n=2044) Rabbit lgG + Mouse lgG . A+T/pau Targeting Vector Probes Wild Type Allele 9.0 kb Knockout Allele 2.1
Page 34: Zhao et al Cell 105:587-, 2001 - UTokyo OpenCourseWare+ Mouse lgG 0.58% (n=2044) Rabbit lgG + Mouse lgG . A+T/pau Targeting Vector Probes Wild Type Allele 9.0 kb Knockout Allele 2.1

KIF5(KHC)

GRIP1

GluR2

Microtubule

KIF

cargo vesicle

receptor

adaptor/Scaffolding

proteins

+-

AP-1

KIF17

mLin-7

NR2B

mLin-2mLin-10

M6PR

σμ

γ adaptin

β-1 adaptin

KIF13A

Setou et al. Science 288:1796－,2000Nakagawa et al. Cell 103:569－,2000Setou et al. Nature 417:83－,2002

Page 35: Zhao et al Cell 105:587-, 2001 - UTokyo OpenCourseWare+ Mouse lgG 0.58% (n=2044) Rabbit lgG + Mouse lgG . A+T/pau Targeting Vector Probes Wild Type Allele 9.0 kb Knockout Allele 2.1

Wong et al．PNAS99:14500－，2002

Wong et al. PNAS99:14500-2002

Page 36: Zhao et al Cell 105:587-, 2001 - UTokyo OpenCourseWare+ Mouse lgG 0.58% (n=2044) Rabbit lgG + Mouse lgG . A+T/pau Targeting Vector Probes Wild Type Allele 9.0 kb Knockout Allele 2.1

Spatial memoryWorking memory

Page 37: Zhao et al Cell 105:587-, 2001 - UTokyo OpenCourseWare+ Mouse lgG 0.58% (n=2044) Rabbit lgG + Mouse lgG . A+T/pau Targeting Vector Probes Wild Type Allele 9.0 kb Knockout Allele 2.1
Page 38: Zhao et al Cell 105:587-, 2001 - UTokyo OpenCourseWare+ Mouse lgG 0.58% (n=2044) Rabbit lgG + Mouse lgG . A+T/pau Targeting Vector Probes Wild Type Allele 9.0 kb Knockout Allele 2.1
Page 39: Zhao et al Cell 105:587-, 2001 - UTokyo OpenCourseWare+ Mouse lgG 0.58% (n=2044) Rabbit lgG + Mouse lgG . A+T/pau Targeting Vector Probes Wild Type Allele 9.0 kb Knockout Allele 2.1

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