52 | MARCH+APRIL 2011 POSITIVELYAWARE.COM 2011 HIV DRUG GUIDE DRUG INTERACTIONS FOR DETAILS, READ THE DRUG’S PAGE in the Drug Guide, or refer to the manufac- turer’s package insert for a full compre- hensive list of potential drug interactions. Also, make your pharmacist and health care providers aware of any drug that you add. Some interactions are more serious than others; some drugs may only require a dose adjustment, while others may either render the drug completely ineffective, or worse, lead to a potentially fatal reaction. Discuss any changes, however minor, with your health care providers, including your pharmacist, since small reactions may become serious. Look up your drugs with “Check my meds” at www.aidsmeds. com/cmm, which lists the effect of food as well as interactions for medications. The University of Liverpool also has an interac- tive database that allows you to look up antiretroviral drug interactions and has PDF charts of interactions between anti- retrovirals and other drugs. Remember, brand names are usually capitalized, while generic names are not. Go to www.hiv-druginteractions.org. DO YOUR MEDS PLAY WELL WITH OTHERS? NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS also called nucleoside analogs, NRTIs, or nukes Potential drug class interactions None. Combivir (Retrovir and Epivir) See Epivir and Retrovir (zidovudine). Do not take Atripla, Emtriva, Epivir, Epivir-HBV, Epzicom, Retrovir (zidovudine), rilpivirine/Truvada, Trizivir, or Truvada, since all or part of these medications are already in Combivir or have equivalent medications. Emtriva (emtricitabine, or FTC) No significant drug interactions. Do not take Emtriva with Atripla, Combivir, Epivir, Epivir-HBV, Epzicom, rilpivirine/Truvada, Trizivir, or Truvada, since they contain Emtriva or medication equivalent to Emtriva. Epivir (lamivudine, or 3TC) No significant drug interactions. Do not take Atripla, Combicir, Emtriva, Epivir-HBV, Epzicom, Trizivir, or Truvada, while taking Epivir, since they contain Epivir or medication equivalent to it. Epzicom (Epivir and Ziagen) See Epivir and Ziagen. Do not take Atripla, Combivir, Emtriva, Epivir, Epivir-HBV, rilpivirine/Truvada Trizivir, or Truvada, while taking Epzicom, since all or part of these medications are already in Epzicom or have equivalent medications. Retrovir (zidovudine, or AZT) Do not take with Combivir or Trizivir, since zidovudine is already in these medications. Amphotericin B, Benemid, Biaxin, dapsone, Depakote, doxorubicin, flucytosine, ganci- clovir, hydroxyurea, interferon-alpha, methadone, pentamidine, phenytoin (Dilantin), ribavirin, rifampin, sulfadiazine, Valcyte, and Zerit. Trizivir (Epivir, Retrovir, and Ziagen) See Epivir, Retrovir, and Ziagen. Do not take Atripla, Emtriva, Epivir, Epivir-HBV, Epzicom, Ziagen, Retrovir (zidovudine), or Truvada while taking Trizivir, since all or part of these medications are already in Trizivir or have equivalent medications. Truvada (Viread and Emtriva) See Emtriva and Viread. Do not take with Atripla, Combivir, Emtriva, Epivir, Epivir-HBV, Epzicom, rilpivirine/Truvada Trizivir, or Viread, since all or part of these medications are already in Truvada or have equivalent medications. A guide to HIV drug interactions BY SWARUP MEHTA, PHARMD AND ENID VáZQUEZ
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52 | March+april 201 1 positivelyaware.coM
2011 HIV Drug guide
Drug interactions
For DetaIls, reaD tHe Drug’s page
in the Drug Guide, or refer to the manufac-turer’s package insert for a full compre-hensive list of potential drug interactions. Also, make your pharmacist and health care providers aware of any drug that you add. Some interactions are more serious
than others; some drugs may only require a dose adjustment, while others may either render the drug completely ineffective, or worse, lead to a potentially fatal reaction.
Discuss any changes, however minor, with your health care providers, including your pharmacist, since small reactions
may become serious. Look up your drugs with “Check my meds” at www.aidsmeds.com/cmm, which lists the effect of food as well as interactions for medications. The University of Liverpool also has an interac-tive database that allows you to look up antiretroviral drug interactions and has PDF charts of interactions between anti-retrovirals and other drugs. Remember, brand names are usually capitalized, while generic names are not. Go to www.hiv-druginteractions.org.
Do your meDsplay well with others?
NucleosIDe reVerse traNscrIptase INHIbItorsalso called nucleoside analogs, NRTIs, or nukes
Potential drug class interactions None.
Combivir(Retrovir and Epivir)
See Epivir and Retrovir (zidovudine). Do not take Atripla, Emtriva, Epivir, Epivir-HBV, Epzicom, Retrovir (zidovudine), rilpivirine/Truvada, Trizivir, or Truvada, since all or part of these medications are already in Combivir or have equivalent medications.
Emtriva(emtricitabine, or FTC)
No significant drug interactions. Do not take Emtriva with Atripla, Combivir, Epivir, Epivir-HBV, Epzicom, rilpivirine/Truvada, Trizivir, or Truvada, since they contain Emtriva or medication equivalent to Emtriva.
Epivir(lamivudine, or 3TC)
No significant drug interactions. Do not take Atripla, Combicir, Emtriva, Epivir-HBV, Epzicom, Trizivir, or Truvada, while taking Epivir, since they contain Epivir or medication equivalent to it.
Epzicom(Epivir and Ziagen)
See Epivir and Ziagen. Do not take Atripla, Combivir, Emtriva, Epivir, Epivir-HBV, rilpivirine/Truvada Trizivir, or Truvada, while taking Epzicom, since all or part of these medications are already in Epzicom or have equivalent medications.
Retrovir(zidovudine, or AZT)
Do not take with Combivir or Trizivir, since zidovudine is already in these medications. Amphotericin B, Benemid, Biaxin, dapsone, Depakote, doxorubicin, flucytosine, ganci-clovir, hydroxyurea, interferon-alpha, methadone, pentamidine, phenytoin (Dilantin), ribavirin, rifampin, sulfadiazine, Valcyte, and Zerit.
Trizivir(Epivir, Retrovir, and Ziagen)
See Epivir, Retrovir, and Ziagen. Do not take Atripla, Emtriva, Epivir, Epivir-HBV, Epzicom, Ziagen, Retrovir (zidovudine), or Truvada while taking Trizivir, since all or part of these medications are already in Trizivir or have equivalent medications.
Truvada(Viread and Emtriva)
See Emtriva and Viread. Do not take with Atripla, Combivir, Emtriva, Epivir, Epivir-HBV, Epzicom, rilpivirine/Truvada Trizivir, or Viread, since all or part of these medications are already in Truvada or have equivalent medications.
A guide to HIV drug interactionsby swarup Mehta, PharmD anD eniD Vázquez
See Sustiva and Truvada (Emtriva/Viread). Do not take Combivir, Emtriva, Epivir, Epivir-HBV,Epzicom, rilpivirine/Truvada , Sustiva, Trizivir, Truvada, or Viread while taking Atripla, since all or part of these medications are already in Atripla or have equivalent medications.
54 | March+april 201 1 positivelyaware.coM
2011 HIV Drug guide
Drug interactions
FIxeD Dose regImeNs
rilpivirine/Truvada See rilpivirine and Truvada. Do not take Atrilpa, Combivir, Emtriva, Epivir, Epivir-HBV, Epzicom, rilpivirine, Sustiva, Trizivir, Truvada, or Viread while taking rilpivirine/Truvada, since all or part of these medications are already in ril pivirine/Truvada or have equivalent medications. Available data is limited due to its experimental drug status at press time.
protease INHIbItors (PIs)
Potential drug class interactions Cardiac medications, cholesterol medications, dexamethasone, erectile dysfunction drugs, ergot derivatives (vasoconstrictors), migraine medications, sedatives, tuberculosis drugs.
Aptivus(tipranavir, or TPV) (must be taken with Norvir)
There are many interactions—see the package insert for the most complete list and tell your health care professional about all the medications you are taking. Advicor, alfuzosin, Altoprev, antacids, birth control pills, bosentan, buprenorphine, bupropion, calcium channel blockers (Adalat, Norvasc, Procardia, and others), Cialis, colchicine, Coumadin (warfarin), Crestor, ergot alkaloids (Cafergot, D.H.E. 45, Methergine, Wigraine), disulfirum (Antabuse), Flagyl, fluconazole, fluticasone (Advair, Flonase, Flovent), Fuzeon, other HIV protease inhibitors, immunosuppressants, itraconazole, ketoconazole, Lescol, Levitra, Lipitor, Livalo, lovastatin, methadone, midazolam (oral), Mycobutin, Paxil, phenobarbital, phenytoin (Dilantin and others), pimozide, pravastatin, Prilosec (omeprazole), quinidine, Revatio, rifabutin, rifampin, Rythmol, salmeterol, simvastatin, St. John’s wort, Suboxone, Tambocor, Tegretol (carbamazepine), trazodone, triazolam, valproic acid, Viagra, vitamin E, Videx, Vytorin, Ziagen, Retrovir (zidovudine), and Zoloft.