Yeast like fungal infections in medical intensive care unit in Poland

Wojciech Francuzik

Aleksandra Skłodowska Tutor: Prof. Zygmunt Adamski

Dermatology Interest Group, Student Scientific Society of Poznan University of Medical Sciences

EPIDEMIOLOGY

TIME

GEOGRAPHICAL REGION

RESISTANCE TO ANTIMYCOTICS

Examination of

medical

histories of ICU

patients with

fungal infections

Database

creation based

on mycological

diagnosis

Exclusion of

non-Candida

species

Div

isio

n into

gro

ups C. albicans

C. glabrata

C. Tropicalis

C. krusei

Mixed group

1) mycological diagnosis given by the mycology lab based on samples acquired in the medical ICU,

2) patient age and gender,

3) medical procedures that the patient underwent,

4) comorbid conditions that the patient suffered from.

1. What were the most common pathogenic factors?

2. Did the occurence differed in various age groups?

3. Did diferent species were related to different comorbid conditions

4. Did infection corellated with higher death risk? And for what comorbid conditions.

0

10

20

30

40

50

60

70

80

Our Study

1996-2000

Histogram of patients’ age

Age

0

10

20

30

40

50

60

70

80

90

18 – 39 40 – 59 60 – 79 80 +

C. albicans [N (%)]

C. glabrata [N (%)]

C. tropicalis [N (%)]

C. krusei [N (%)]

Mixed

0

10

20

30

40

50

60

70

80

90

Diabetes

mellitus

Renal

insufficiency

Cirrhosis Renal

replacement

therapy

C. albicans

C. glabrata

C. tropicalis

C. krusei

mixed group

Factor p value/

Age above 80 years 0.0011

Male gender 0.0070

Renal insufficiency 0.0120

Diabetes mellitus 0.0203

Hepatic insufficiency 0.0053

Renal replacement therapy 0.0388

C. glabrata increases in numbers and is linked to diabetes

Emergence of previously uncommon species

C. krusei and concomitant diseases

Fatal therapy outcomes

Drug susceptibility (AST)

Fluconazole prophylaxis