XVIII International AIDS Conference Novel HIV-1 Protease Inhibitors Containing bis- Tetrahydrofuran or a Novel Polycyclic Ligand, Pyranofuran 1 Depts of Hematology and Infectious Diseases, Kumamoto Univ; 2 Kumamoto Health Science Univ; 3 Depts. of Chem & Med Chem, Purdue Univ; 4 Experimental Retrovirology Section, NCI, NIH. Kazuhiko Ide 1 , M. Aoki 1,2 , Y. Koh 1 , M. Amano 1 , S. Kulkarni 3 , D.D. Anderson 3 , B. Chapsal 3 , R. Yedidi 4 , D. Das 4 , A.K. Ghosh 3 , and H. Mitsuya 1,4
XVIII International AIDS Conference. Novel HIV-1 Protease Inhibitors Containing bis -Tetrahydrofuran or a Novel Polycyclic Ligand, Pyranofuran. Kazuhiko Ide 1 , M. Aoki 1,2 , Y. Koh 1 , M. Amano 1 , - PowerPoint PPT Presentation
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XVIII International AIDS Conference
Novel HIV-1 Protease Inhibitors Containing bis-Tetrahydrofuran or a
Novel Polycyclic Ligand, Pyranofuran
1Depts of Hematology and Infectious Diseases, Kumamoto Univ;
2Kumamoto Health Science Univ; 3Depts. of Chem & Med Chem, Purdue Univ; 4Experimental Retrovirology Section, NCI, NIH.
Kazuhiko Ide1, M. Aoki1,2, Y. Koh1, M. Amano1, S. Kulkarni3, D.D. Anderson3, B. Chapsal3, R. Yedidi4,
D. Das4, A.K. Ghosh3, and H. Mitsuya1,4
BackgroundHAART made a major impact on the morbidity of HIV-1-infected individuals and significantly extended their survival.
The emergence of multi-drug-resistant viruses (HIV-1MDR) is still one of the major
concerns.
Continuous efforts are required to develop more potent and safer therapeutics with high genetic barrier.