www.global-campaign.org www.nhv-mag.org Prevention trials pipeline 2006 2008 2009 2010 2007 2012 MOSY3. Willard Cates, HIV Prevention Research: The Optimist’s View Female Barrier- Diaphragm Male Circumcision - Susceptibili ty Microbicides – CS-1 CS-2 Carraguard Male Circumcision - Infectiousne ss Microbicides • BG/Pro2000 •Pro2000 • TDF Oral PrEP - IDU HSV-2 Treatment - Infectiousne ss HSV-2 Treatment – Susceptibili ty Oral PrEP • MSM • Heterosexual Index Partner Treatment Vaccines - Adenovirus- 1 Adenovirus- 2 Vaccines - Prime/Boost Community VCT and HIV Support Oral PrEP - West Africa
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www.global-campaign.orgwww.nhv-mag.org
Prevention trials pipeline
2006 2008 2009 20102007 2012
MOSY3. Willard Cates, HIV Prevention Research: The Optimist’s View
Female Barrier- Diaphragm
Male Circumcision - Susceptibility
Microbicides – CS-1CS-2
Carraguard
Male Circumcision - Infectiousness
Microbicides• BG/Pro2000•Pro2000• TDF
Oral PrEP - IDU
HSV-2 Treatment -
Infectiousness
HSV-2 Treatment –
Susceptibility
Oral PrEP• MSM
• Heterosexual
IndexPartner
Treatment
Vaccines -Adenovirus-1Adenovirus-2
Vaccines -Prime/Boost
Community VCT and HIV
Support
Oral PrEP -West Africa
www.global-campaign.orgwww.nhv-mag.org
Research Principles
• Research must have a potential benefit.
• Research examines a question to which the answer is unknown.
• Research must be able to answer the question or contribute meaningful information.
• Good research must be unbiased.
• Research is not the same as health care
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Decision-making about research
Community and Civil Society advocates
Ethics Review BodiesResearchers and Sponsors
Data Monitors
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Data Monitors can stop trial if evidence that
test product is definitely effective;
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Data Monitors can stop trial if evidence that
test product may be causing harm
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Data Monitors can stop trial if evidence
that it is futile -- trial can no longer answer the assigned question
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r
PrEP 2004PrEP 2004 --Political --Political controversy can controversy can stopstop trials trials
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Managing fall out of CS results
Negative press erupts in South Africa
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