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Monitoring vaccine matching A/ASIA/Sea-97 viruses from Southeast and East Asia
Traffic lights
Recent results:
Kazakhstan: FMD Threats (South East Asia)
Spread of two different serotype O lineages and serotype A
• O/ME-SA/PanAsia – Kazakhstan (2010) – also reported in China
• A/ASIA/Sea-97 – Kazakhstan (2013) – also reported in China
and South Korea
• O/SEA/Mya-98 – a number of outbreaks in China (west), Russia,
Mongolia, N&S. Korea, Japan
Kurchum
Urdzhaz
(New) connections between The Middle East and East Asia
Kazakhstan: FMD Threats
Spread of two different serotypes from South Asia/Middle East • O/ME-SA/PanAsia-2 - in Kazakhstan (2010-2012) • A/ASIA/Iran-05 - in Kazakhstan (2012) also recent incursions into
Russia (North Caucasus)
(New) connections between The Middle East and East Asia
Changing global patterns: Spread of new antigenic variants in the Middle East
• Emergence of a new Asia 1 lineage
(Sindh-08) with poor match Asia 1
Shamir (ISR/3/89) • First recognised in Pakistan (2008)
• Natural immunity may be low in
Middle East
• Lineage has now spread westward
into Afghanistan, Iran, Turkey and
Bahrain
• Spread mirrors recent trans-
boundary movements of O/PanAsia
and A/Iran-05
• Can we predict when/where these
events will occur?
Differences (in red) between Asia 1 Shamir
(ISR/3/89) and Asia 1 PAK/29/2009 (Sindh-08)
Vaccines
Asia1 Shamir (normal payload)
Asia1 Shamir
(high payload)
Asia 1 Ind 8/79
Field Viruses
TUR 2/2013
TUR 13/2013
PAK 10/2012
PAK 29/2012
PAK 30/2012
PAK35/2012
PAK 37/2012
PAK 91/2011
PAK 5/2012
AFG 66/2011
AFG 78/2011
IRN 54/2011
IRN 10/2012
Sindh-08 lineage: Lack of protection of existing Asia 1 vaccines
Match
No Match
• Established in 2010
• Important forum for antigen/vaccine banks stakeholders
• Exchange of information/new developments
• Harmonisiation of standards
• Pont of contact with vaccine manufacturers
• EU, QUAD countries, Mexico
• Annual Report 2013
• Current Chair (from 1st October) – Dr Hernando Duque (APHIS, USA)
• Next meeting (teleconference) scheduled within the next 4 weeks
• Opportunities for increased coordination in other areas?
• Diagnostic reserve (commercial NSP/SP assays)
Working together: International FMD Vaccine Strategic Reserves Network
WRLFMD: The future
Pirbright Institute Redevelopment: High Containment Laboratory (DP1)
Building infrastructure will be completed by Q1 2014