Wrap Up Sk 1 Hemato Pbl A1

8/10/2019 Wrap Up Sk 1 Hemato Pbl A1

1/19

Disusun oleh:

KELOMPOK A-1

KETUA : ABDUL RAHMAN (1102013001)

EKRETAR!: AL!"!A AMANDA # (110201201$)

AN%%OTA : AB! RA"D! &HA"AR! (1102013002)

AD!T'A UR'A PRATAMA (110201300)

ADR!A PUTRA "ARHAND!KA (1102013010)

ANDRE RO&AAN " (110201302*)

!NDAH PERMATA AR! (110201212+)

!NTAN PRATAMA D' (1102012131)

,A,AN% PERMANA UBHAN (110201213)

KA'LA AUD!.!! (100201213)

UNIVERSITAS YARSI

FAKULTAS KEDOKTERAN 2014/2015

LEKAS LELAH BILA BEKERJA

0


2/19

SKENARIO 1

LEKAS LELAH BILA BEKERJA

'/ni 1 /hun eei4s/4/n 5ii 4e 5o4e 5en6/n 4eluh/n sein6 e/s/

le4/s lel/h seel/h el/4u4/n /4i7i/s8 Keluh/n ini su5/h 5i/l/i 3 9ul/n e/4hi8e9elun/ i5/4 ;en/h en6/l/i h/l se;ei ini8

P/5/ /n/nesis /9/h/n 5i5/;/4/n 4ee/n6/n 9/h


3/19

KATA&KATA SULIT

18 Heo6lo9in : su/u ;oein e4on=u6/si /n6 9e?un6si unu4

/ns;o o4si6en 5/n 4/9on5io4si5/

28 He/o4i : 4/5/ eiosi 5/l/ 5//h

38 Eiosi : sel 5//h e/h

+8 Kon=un6i7/ ;/l;e9/l: 4elo;/4 // 9/6i/n 9/


4/19

L! 18 Me/h/i 5/n en=el/s4/n en/n6 eio;oesis

1818 De?inisi

1828 "/4o-?/4o

1838 Mo?olo6i

18+8 Poses eio;oesis

L! 28 Me/h/i 5/n en=el/s4/n en/n6 heo6lo9in

2818 u4u 5/n ?un6si

2828 Biosinesis

L! 38 Me/h/i 5/n en=el/s4/n en/n6 /nei/

3818 De?inisi

3828 Kl/si?i4/si

3838 %e=/l/ 4linis

L! +8 Me/h/i 5/n en=el/s4/n /nei/ 5e?isiensi 9esi

+818 De?inisi+828 Eiolo6i

+838 P/o?isiolo6i

+8+8 M/ni?es/si

+8C8 Di/6nosis 5/n 5i/6nosis 9/n5in6

+88 Ko;li4/si

+8$8 Pen//l/4s/n//n 5/n ;ene6/h/n

+8*8 Po6nosis

SASARAN BELAJAR

3


5/19

LI 1( )em!*!mi #!" me"+e$!k!" ,e",!"- eri,r%.%ei

1(1( Dei"ii

Eio;oesis ;e9u//n eiosis ;/5/ =/nin 5/n 9/i 9/u l/hi ;oses

ini 9el/n6sun6 5ili;/ 5/n susu ul/n6 e/;i ;/5/ in5i7i5u /n6 le9ih

u/ e9//s 5i susu ul/n68

1(2( F!k,%r&!k,%r

Di;en6/uhi oleh hoon eri,r%.%ie,i"8 Eio;oiein /5/l/h su/u

6li4o;oein /n6 en6/n5un6 1C esi5u /s/ /ino 5/n + /n/i

oli6os/4/i5/ /n6 ;enin6 unu4 /4i7i/sn/ se// in 7i7o8

Eio;oiein enin64/4/n =ul//h sel in5u4 /n6 ;e4/ eio;oiein 5i

susu ul/n68 el-sel in5u4 ini 4eu5i/n 9eu9/h en=/5i ;e4uso sel

5//h e/h 5/n /4hin/ en=/5i eiosi //n68

Eio;oiein enin64/ ;/5/ s// e=/5i /nei/ hi;o4si/ insu?isiensi

;/u 5/n ;e5//h/n8 e9/li4n/ eio;oiein /4/n enuun 9il/ 7olue

5//h e/h enin64/ 5i //s no/l /4i9/ /ns?usi 5/n =u6/ /4i9/ 5/iinsu?isiensi 6in=/l8 (%/non6 200*)

&/ /n6 5i;elu4/n unu4 Eii;oiesis :

1) &/ Besi ("e)

Unu4 sinesis H9

Ke9uuh/n 2 I + 6>h/i

Disi;/n : 0 (H9) 10 (io6lo9in enGi) 30

(?eiinheosi5ein)

-* 5ise/; 5i 5uo5enu 5i;en6/uhi oleh: H#l 7i #

2) .i/in B12 5/n /s/ ?ol/

Unu4 sinesis DNA (;oein)

A9so9sin/ eelu4/n ?/4o ininsi4 (sel ;/ie/l l/9un6)

3) .i/in E B B1

+) Hoon io4sin /n5o6en

1(( )%r%$%-i Eri,r%i,

4


6/19

1( Rri$!,(;oeio9l/s):

el 9es/ ( 1C-30 )=ul/h no/ln/ J 1 5/i seluuh sel

9eini8

!ni : 9es/ 9ul/ ;oli4o/i4 noo9l/s):

Le9ih 4eil 5/i ;ou9isi

!ni: le9ih 4eil 5/i ;ou9isi 9ul/ 4o/in 4/s/ 5/n

en66u;/l

io;l/s/:le9ih 9/n/49e oo4o/i4 noo9l/s) : Le9ih 4eil 5/i u9isi

!ni: 9ul/ 4eil 4o/in ;/5/ se5i4i 9iu

"/se ini 5ise//4/n 5en6/n ei4ulosi

( Eri,r%i,:

U4u/n -*

io;l/s/ 4ee/h/n

B/6i/n en6/h ;u/ 4/en/ 9enu4 9i4on4/?

Benu4 9ul/ e;i //

1(4( Pr%e eri,r%.%ei

5


7/19

Pe9enu4/n eiosi 5ise9u =u6/ eio;oiesis8 Eio;oiesis e=/5i 5i

susu ul/n68 Pe9enu4/n 5i/u oleh su/u hoone 6li4o;oein /n6

5ise9u eio;oiein8 el ;e// /n6 5i4e/hui se9/6/i /n64/i/n

;e9enu4/n eiosi 5ise9u .r%eri,%r$!/rri$!,8 Den6/n /n6s/n6/n

/n6 sesu/i /4/ 5/i sel-sel u9/s (stem cell) ini 5/;/ 5i9enu4 9/n/4 se4/li

sel8 Poeio9l/s 4eu5i/n /4/n e9el/h 9e9e/;/ 4/li8 el-sel 9/u 5/i6ene/si ;e// ini 5ise9u se9/6/i !%i$ eri,r%$!/.r%rrii, se9/9

5/;/ 5i/ 5en6/n


8/19

O2 5ile;/s4/n /n/i 5i/i4 e;is/h eun64in4/n /su4n/ e/9oli

23 5i?os?o6lise/ (23 DP%) /n6 ene9/94/n ;enuun/n /?ini/s ole4ul

ese9u eh/5/; O28 Pe6e/4/n ini 9e/n66u =/


9/19

LI ( )em!*!mi #!" me"+e$!k!" ,e",!"- !"emi!

(1( Dei"ii

Anei/ /5/l/h 4e/5//n 5i/n/ /ss/ eiosi 5/n //u /ss/

heo6lo9in /n6 9ee5/ i5/4 5/;/ eenuhi ?un6sin/ unu4

ene5i/4/n o4si6en 9/6i =/in6/n u9uh8 e// l/9o/oiu 5i=/9/4/n

se9/6/i ;enuun/n 5i 9/


10/19

#8 Anei//4osie

18 Me6/lo9l/si4

/8 Anei/ 5e?isiensi ?ol/

98 Anei/ 5e?isiensi 7i/in B12

2 None6/lo9l/si4

/8 Anei/ ;/5/ ;en/4i h/i 4oni4

98 Anei/ ;/5/ hi;oioi5

8 Anei/ ;/5/ sin5o/ ielo5i;l/si4

Kl/si?i4/si /nei/ 9e5/s/4/n eio;/o6nesis

A8Po5u4si eiosi enuun

18 Ke4u/n6/n 9/h/n unu4 eiosi

/8 Besi : /nei/ 5e?isiensi 9esi

98 .i8 B12 5/n /s/ ?ol/ : /nei/ e6/lo9l/si4

28 %/n66u/n uilis/si 9esi

/8 Anei/ /4i9/ ;en/4i 4oni4

98 Anei/ si5eo9l/si4

38 Keus/4/n =/in6/n susu ul/n6

/8 Ao?i 5en6/n ;en66/ni/n oleh =/in6/n le/4 :

/;l/si>hi;o;l/si4

98 Pen66/ni/n oleh =/in6/n ?i9oi>uo : leu4oio9l/si4>

ielo;isi4

B8 Kehil/n6/n eiosi 5/i u9uh

18 Anei/ ;/s/ ;en5//h/n /4u

28 Anei/ ;/s/ ;en5//h/n 4oni4

#8 Penin64//n ;en6h/nu/n eiosi 5/l/ u9uh (heolsis)

18 "/o e4s/4/;sule

28 "/o in/4/;sule

/8 %/n66u/n e9/ne /nei/ /nei/

i8Hereditary spherocytosis

ii8Hereditary elliptocytosis

98 %/n66u/n ensii8 De?isiensipyruvatekinase

ii8 De?isiensi G6PD (Glocuse-6 phospate dehydrogenase)

8 %/n66u/n heo6lo9in

i8 Heo6lo9ino;/isuu/l

ii8 h/l/ssei/

(( 6e+!$! k$i"i

%e=/l/ /nei/ s/n6/ 9e7/i/si e/;i ;/5/ uun/ 5/;/ 5i9/6i

en=/5i 3 6olon6/n 9es/ /iu:

& 6e+!$! mm !"emi!

Dise9u =u6/ se9/6/i sin5o /nei/ //u /nei sn5oe8 %e=/l/uu /nei/ /5/l/h 6e=/l/ /n6 i9ul ;/5/ seu/ =enis /nei/ ;/5/ 4/5/

9


11/19

heo6lo9in /n6 su5/h enuun 5i 9/


12/19

s/lu/n 6eni/li/


13/19

18 %e=/l/ uu 5/i /nei/ /n6 sein6 5ise9u se9/6/i sin5o/ /nei/

/iu eu;/4/n 4u;ul/n 5/i 6e=/l/ /nei/ 5i/n/ h/l ini /4/n /;/4

=el/s =i4/ H9 5i 9/5l 5en6/n /n5/-/n5/ 4ele/h/n u9uh lesu

u5/h lel/h ;u/ ;usin6 ;/l;is/i ;enuun/n 5// 4onsen/si suli

n/?/s s// l/ih/n ?isi4 // 9e4un/n6-4un/n6 elin6/ en5en6in6

le/6i enuun 5// /h/n u9uh 5/n 4ein6/ 5in6in828 %e=/l/ /nei/ 5e?isiensi 9esi:

/8 Kolonhi/> 4u4u sen5o4: 4u4u 9eu9/h =/5i /;uh 9e6/is-6/is

7ei4/l 5/n =/5i e4un6 sehin66/ ii; sen5o48

98 An6ul/ heilosis: ;eu4//n li5/h /;/4 liin 5/n en64il/;

5ise9/94/n 4/en/ hil/n6n/ ;/;il li5/h

8 o/iis /n6ul/is: in?l//si se4i/ su5u ulu

58 %losiis

e8 Pi/: 4ein6in/n /4/n /n6 i5/4 9i/s/

?8 Dis?/6i/: nei el/n /n6 5ise9/94/n ;h/n6e/l ;/eson 4ell: 4u;ul/n 6e=/l/ /o?i ;/;illi5/h 5/n 5is?/6i/

38 %e=/l/ /n6 5ii9ul4/n 5/i ;en/4i /n6 en5/s/i e=/5in/ /nei/

5e?isiensi 9esi is/ln/ in?e4si /in6 /9/n6 /4/ /4/n 5i=u;/i

5is;e;si/ /n6/n


14/19

- #/5/n6/n "e TL : i5/4 /5/

- Besi eio9l/s : i5/4 /5/

- Ele4o?oesis H9 : no/l

/5iu ;/5/ /nei/ 5e?isiensi 9esi

H9

(6>5l)

!

(6>5l)

T!B#

(6>5l)

/u/si

()

"eiin seu

(6>5l)Mo?8ei8

8 1

;enuun/n

9esi

N N N > n/i4 N TuunNoosii4

noo4o

8 2

eio;oiesis

4e4u/n6/n

9esi

N Tuun N/i4 Tuun TuunNoosii4

noo4o

8 3/nei/

5e?isiensi

9esi

Tuun Tuun N/i4 Tuun TuunNoosii4

noo4o

/5iu 39

/nei/

5e?isiensi

9esi

Tuun Tuun N/i4 Tuun TuunMi4osii4

noo4o

Pi/ N 13-1 Tuun 20-+00 20-+C 30-+00Noosii4

noo4o

/ni/ N 12-1+ 20-++C 20-+C 13-1C0Noosii4

noo4o

Kiei/ enuu HO :

18 K/5/ H9 J 5 no/l sesu/i usi/

28 Konsen/si H9 eiosi //-// (31 )

38 K/5/ "e seu (C0)

+8 /u/si /ns?ei (1C)

Meo5/ enenu4/n 4/5/ H9

Menuu HO nil/i 9//s heo6lo9in (H9) /n6 5i4//4/n /nei/ 6iGi 9esi

unu4 5l 5en6/n nil/i 9esi seu J C0 6>l 5/nnil/i ?eiin J 12 6>l8 Nil/i ?eiin eu;/4/n e?le4si 5/i /5/n6/n 9esi

u9uh sehin66/ 5/;/ e9ei4/n 6/9//n s/us 9esi seseo/n68

Unu4 enenu4/n /nei/ 6iGi 9esi /iu :

/8 eu "eiin (") : "eiin 5iu4u unu4 en6e/hui s/us 9esi 5i

5/l/ h/i8 Bil/ 4/5/ " J 12 6>5l /4/ o/n6 ese9u en5ei/ /nei/

6iGi 9esi8

98 T/ns?ein /u/ion (T) : K/5/ 9esi 5/n To/l !on Bin5in6

#/;/i (T!B#) 5/l/ seu eu;/4/n s/l/h s/u enenu4/n s/us 9esi8

P/5/ s// 4e4u/n6/n G/ 9esi 4/5/ 9esi enuun 5/n T!B# enin64/

/sion/ /n6 5ise9u 5en6/n T8 T J 5/i 1 /4/ o/n6 ese9u5e?isiensi G/ 9esi8

13


15/19

8 "ee Ehoe Poo;ho;h : Bil/ 4/5/ G/ 9esi 5/l/ 5//h 4u/n6

/4/ si4ul/si "EB 5/l/ 5//h enin64/8 K/5/ no/l "EB 3C-C0 6>5l

RB#8 e// in64/s unu4 enenu4/n 4e/5//n /nei/ seseo/n6

E9!$!i SADT8- Eiosi: i4osii4 hi;o4o (i4osii4 in6/n: HJ3+> H9J106>5l

i4osii4 hi;o4o:HJ2$> H9J6>5l)5/n /niso;oi4ilosiosis: sel ;ensil sel

/6e o7/losi

- Leu4osi =ul/hn/ no/l

- To9osi: no/l //u enin64/ (4/en/ ;en5//h/n)

http://librarymedutahedu/!ebPath/"peg#/H$%$&'"pg

Di/6nosis 9/n5in6

Pemerik!!" $! ADB T*!$!emi! mi"%rA"emi! .e"7!ki,

kr%"ik

M#. N>

"e seu N

T!B# Q N

/u/si /ns?ein N

"EP Q N N>Q

"eiin seu N

14
http://library.med.utah.edu/WebPath/jpeg5/HEME084.jpghttp://library.med.utah.edu/WebPath/jpeg5/HEME084.jpg


16/19

4(( K%m.$ik!i

Bi/s/n/ /nei/ 5e?isiensi 9esi i5/4 ene9/94/n 4o;li4/si8

Te/;i /;/9il/ i5/4 5io9/i ADB 5/;/ en=/5i le9ih ;//h 5/n en6/l/i

/s/l/h 4eseh//n e/su4:

- M/s/l/h =/nun6: ADB 5/;/ ene9/94/n 5e/4 =/nun6 le9ih

e;/ //u iee6ul/ 4/en/ 4u/n6n/ O2 4ei4/ /nei/ 5/;/ ene9/94/n

;e9es//n =/nun6 //u 6/6/l =/nun68- M/s/l/h 4ei4/ /s/ 4eh/il/n: ;/5/ i9u h/il /n6

en6/l/i ADB 9/n/4 5i4/i4/n 5en6/n 4el/hi/n ;e/ue 5/n 9e/

9/5/n /n6 4u/n6 ;/5/ 9/i8 H/l ini 9is/ 5ie6/h /;/9il/ i9u h/il ese9u

enei/ su;leen 9esi ;/5/ /s/ ;en//l8

- M/s/l/h ;eu9uh/n: enin64/4/n /n64/ suse;i9ili/s

4e;/5/ in?e4si8

4(:( Pe"!,!$!k!"!!" #!" .e";e-!*!"

A8 PENATALAKANAAN

18 Te/;i 4/us/l: e6/nun6 ;ene9/9 ;en/4in/ is/ln/: ;en6o9//n

/in6 /9/n6 ;en6o9//n he/oi58 Te/;i ini h/us 5il/4u4/n

/;/9il/ i5/4 5il/4u4/n /4/ /nei/ /4/n 4/9uh 4e9/li8

28 Pe9ei/n ;e;// 9esi unu4 ;en66/ni 4e4u/n6/n 9esi 5/l/ u9uh:

/) Besi ;eo/l

?eous sul;h/ 5osis 3 @ 200 6 (u/h)

?eous 6luon/e ?eous ?u// ?eous l//e 5/n ?eos suin/e

(le9ih /h/l)

15


17/19

e9/i4n/ 5i9ei4/n ;/5/ s// l/9un6 4oson6 e/;i e?e4 s/;in6

le9ih 9/n/4 5i9/n5in6 seel/h /4/n8 E?e4 s/;in6n/ /iu u/l

un/h se/ 4onsi;/si8 Pen6o9//n 5i9ei4/n sel// 9ul/n seel/h

4/5/ heo6lo9in no/l unu4 en6isi /5/n6/n 9esi u9uh8 K/l/u i5/4

/4/ /4/n 4e9/li 4/9uh8

9) Besi ;/ene/l

E?e4 s/;in6n/ le9ih 9e9/h// 5/n h/6/n/ le9ih /h/l in5i4/si:

!nole/nsi o/l 9e/

Ke;/uh/n 9eo9/ 4u/n6

Koliis ulse/i7/

Pelu ;enin64//n H9 se// e;/

Pe;// /n6 ese5i/: ion 5e@/n o;le@ ion so9i/l ii /i5

o;le@ 5i9ei4/n se// in/us4ule //u in/7en/ ;el/n8

E?e4 s/;in6: e/4si /n/?il/4sis ?le9iis s/4i 4e;/l/ ?lushin6 u/l

un/h nei ;eu 5/n sin4o;8

) Pen6o9//n l/in

Die: /4/n/n 9e6iGi 5en6/n in66i ;oein (;oein he


18/19

P/5/ /n/4 "e 9e/s/l 5/i A! 5/n ;ene/;/nn/ le9ih e?isien

5/i;/5/ "e /n6 9e/s/l 5/i susu s/;i (5iun5/ hin66/ uu 1 /hun

5i4/en/4/n ;e5//h/n s/lu/n en/ /n6 es//4/n)

Pe9ei/n /4/n/n 4// 7i/in # 5/n e;e4en/l4/n /4/n/n

;/5/ ul/i ;/5/ usi/ +- 9ul/n

Pe9ei/ su;leen "e ;/5/ 9/i ;e/u

Pe/4/i/n susu ?oul/ /n6 en6/n5un6 9esi (PA!)

M/4/n/n /n6 5/;/ e;en6/uhi ;ene/;/n G/ 9esi /iu :

Menin64/4/n ;ene/;/n

As/ /s4o9/ 5/6in6 i4/n 5/n un66/s 5/n H#l

Menuun4/n ;ene/;/n

As/ /n/ (eh 5/n 4o;i) 4/lsiu ?i/ 9e/s 4unun6 elu ;oli?enol

o4s/l/ 5/n o9/-o9//n (/n/si5 e/si4lin 5/n 4olesi/in)

Penuluh/n 4eseh//n

Keseh//n lin64un6/n (;en66un//n =/9/n ;e/4/i/n /l/s 4/4i)

%iGi (en64onsusi /4/n/n 9e6iGi)

Konsnelin6 ;/5/ i9u //u o/n6 se4i/ unu4 eilih 9/h/n /4/n/n

5en6/n 4/5/ 9esi u4u; se=/4 9/i s/;/i e/=/

Pe9e/n/s/n in?e4si /in6 /9/n6

u;leen/si 9esi ;/5/ ;o;ul/si en/n (i9u h/il 5/n /n/4 9/li/)

"oi?i4/si 9/h/n /4/n/n 5en6/n 9esi

4iinin6 /nei/

;eei/4s//n h9 h ;/5/ 9/i 9/u l/hi 5/n ;/5/ 9/i 4u/n6 9ul/n

( ;e/u )

e9/i4n/ 5il/4u4/n ;/5/ usi/ 12 9ul/n 5en6/n ;eei4s//n

heo6lo9in (H9) 5/n ;enil/i/n isi4o 5e?isiensi 9esi //u /nei/ 5e?isiensi

9esi8

4(


19/19

Dise/i ;en/4i /n6 e;en6/uhi /9so;si 5/n ;e/4/i/n 9esi

(se;ei: in?e4si 4e6/n/s/n ;en/4i h/i ;en/4i 6in=/l ;en/4i ioi5

;en/4i 4/en/ 5e?isiensi 7i/in B12 /s/ ?ol/)

%/n66u/n /9so;si s/lu/n en/ (se;ei ;e9ei/n /n/si5 /n6

9ele9ih/n ;/5/ ul4us;e;i4u 5/;/ ene9/94/n ;en6i4//n eh/5/;

9esi8

DA"TAR PUTAKA :

Al/sie uni/ 200+8 Penunun Die E5isi B/u !nsiusi %iGi Pe=/n R

D8#i;o/n6un4usuo 5/n Asosi/si Dieisien !n5onesi/ PT8 %/e5i/

Pus/4/ U// ,/4//8

Anhon T/n 20028 o

Wrap Up Sk 1 Hemato Pbl A1

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