www.wjpr.net 216 FORMULATION AND EVALUATION OF ONCE-DAILY SUSTAINED RELEASE ACECLOFENAC DENDROPTHOE FALCATA GUM MATRIX TABLETS Pravin K. Bhoyar* 1 , Jagdish R. Baheti 2 , Harish R. Lukkad 2 , Shweta H. Mishra 3 , Saras S. Jain 3 1. Department Of Pharmaceutical Sciences, NIMS University, Jaipur, Rajastan, India 2. Shriman Suresh Dada Jain College of Pharmacy, Chandwad, Nasik, Maharashtra, India. 3. Department of Pharmacy, GIKIST College of pharmacy, Dist: Jabalpur, Madhya Pradesh, India ABSTRACT The main aim of the present investigation was to develop matrix tablets of aceclofenac with dendropthoe falcata gum and to study its functionality as a matrix forming agent for once daily sustained release tablet formulations. Physicochemical properties of dried powdered dendropthoe falcata gum were studied. Various formulations of aceclofenac dendropthoe falcate gum were prepared. The formulated tablets found to have better uniformity of weight and drug content with low sd values. The swelling behavior and release rate characteristics were studied. The dissolution study proved that the dried dendropthoe falcata gum can be used as a matrix forming material for making once daily sustained release matrix tablets. Key words: Aceclofenac, Dendropthoe falcata, matrix tablets, once daily sustained release. INTRODUCTION Aceclofenac is a potent non-steroidal anti-inflammatory drug, which is a commonly prescribed drug for the treatment of patients suffering with pain, rheumatoid arthritis, osteoarthritis and ankylosing spondylitis. [1] It is a weak acid (pka = 4.7) practically insoluble in water and acidic environment but highly permeable (class 2) according to the World Journal of Pharmaceutical Research Volume 1, Issue 2,216-223. Research Article ISSN 2277 – 7105 Article Received on 10 March 2012, Revised on 27 March 2012, Accepted on 14 April 2012 *Correspondence for Author: * Pravin K. Bhoyar Department Of Pharmaceutical Sciences, NIMS University, Jaipur, Rajastan, INDIA [email protected]o m
8
Embed
World Journal of Pharmaceutical Research Pravin K. Bhoyar ...
This document is posted to help you gain knowledge. Please leave a comment to let me know what you think about it! Share it to your friends and learn new things together.
Transcript
www.wjpr.net 216
Pravin K. Bhoyar et al. World Journal of Pharmaceutical research
FORMULATION AND EVALUATION OF ONCE-DAILY SUSTAINED
RELEASE ACECLOFENAC DENDROPTHOE FALCATA GUM
MATRIX TABLETS
Pravin K. Bhoyar*1, Jagdish R. Baheti 2, Harish R. Lukkad 2, Shweta H. Mishra3, Saras
S. Jain3
1. Department Of Pharmaceutical Sciences, NIMS University, Jaipur, Rajastan, India
2. Shriman Suresh Dada Jain College of Pharmacy, Chandwad, Nasik, Maharashtra, India.
3. Department of Pharmacy, GIKIST College of pharmacy, Dist: Jabalpur, Madhya Pradesh,India
ABSTRACT
The main aim of the present investigation was to develop matrix
tablets of aceclofenac with dendropthoe falcata gum and to study its
functionality as a matrix forming agent for once daily sustained
release tablet formulations. Physicochemical properties of dried
powdered dendropthoe falcata gum were studied. Various
formulations of aceclofenac dendropthoe falcate gum were prepared.
The formulated tablets found to have better uniformity of weight and
drug content with low sd values. The swelling behavior and release
rate characteristics were studied. The dissolution study proved that the
dried dendropthoe falcata gum can be used as a matrix forming
material for making once daily sustained release matrix tablets.
Key words: Aceclofenac, Dendropthoe falcata, matrix tablets, once
daily sustained release.
INTRODUCTION
Aceclofenac is a potent non-steroidal anti-inflammatory drug, which is a commonly
prescribed drug for the treatment of patients suffering with pain, rheumatoid arthritis,
osteoarthritis and ankylosing spondylitis. [1] It is a weak acid (pka = 4.7) practically insoluble
in water and acidic environment but highly permeable (class 2) according to the
World Journal of Pharmaceutical Research
Volume 1, Issue 2,216-223. Research Article ISSN 2277 – 7105
Article Received on10 March 2012,
Revised on 27 March 2012,Accepted on 14 April 2012