Working Group on Effects, 29th Session, 22-24 September 2010

Working Group on Effects, 29th Session, 22-24 September 2010Working Group on Effects, 29th Session, 22-24 September 2010

Task Force on Health:Task Force on Health:Results: ozoneResults: ozone

Michal Krzyzanowski

TFH Chair

WHO/Europe, European Centre for Environment and Health, Bonn

http://www.euro.who.int/air

ECE/EB.AIR/WG1/2010/11

Effects of O3 exposure on health: 2010 update

• New studies confirm short term effects of O3 exposure & conclusions of WHO AQG Global Update 2005

• Emerging new evidence on health effects of long term exposure

• Studies on pathological mechanisms focused on O3 effect modification by polymorphisms in antioxidant genes, molecular mechanisms associated with vascular disease and oxidation/interaction of surfactant and airway nerves.

Effects of long term O3 exposure

Risk of asthma hospital admissions in children and mean O3 in 1995-1999, adjusted for main confounders.

Lin et al, EHP 2008

Effects of long term O3 exposure

Jerrett et al, NEJM 2009

Exposure-response curve for relation between long term O3 exposure and risk of death due to respiratory causes. Results of analysis of ACS cohort of 448,000 adults followed for up to 18 years

RR per 10 ppb = 1.040 (95% CI 1.010 - 1.067)(2-pollutant model with O3 and PM2.5)

O3 trends in Europe, 1999-2008

all stations<-2 %/yr

-2 - 0 %/yr

0 - 2 %/yr

> 2 %/yr

source: ETC/ACC-AIRBASE April -2010

O3 annual meantrend (%/yr)1999-2008

Impact indicators in 2020 vs. levels in 2000, for the baseline cases and the maximum technical feasible reductions (MTFR)

Amman et al, CIAM Report 1/2010

Based on SOMO35