Why are Acinetobacter and Pseudomonas so antibiotic resistant? Robert A. Bonomo, MD Chief, Medical Service Director VISN 10 GRECC Louis Stokes Cleveland VAMC Vice Chairman, Department of Medicine University Hospitals Case Medical Center Professor, Case Western Reserve University School of Medicine
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Why are Acinetobacter and Pseudomonas so antibiotic resistant? Robert A. Bonomo, MD Chief, Medical Service Director VISN 10 GRECC Louis Stokes Cleveland.
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Transcript
Why are Acinetobacter and Pseudomonas so antibiotic
resistant?
Robert A. Bonomo, MDChief, Medical Service
Director VISN 10 GRECCLouis Stokes Cleveland VAMC
Vice Chairman, Department of MedicineUniversity Hospitals Case Medical Center
Professor, Case Western Reserve University School of Medicine
Appreciation and Disclosures• NIH and VA for supporting • Research grants from Case Western Reserve
University, LSCDVAMC Foundation for Medical Research,
• Pfizer, Steris Corporation, Rib-X, and Check-Points
• Collaborators
Objectives
• Overview of the problem (and crisis) of ATBR in Gram negative bacteria– MDR A. baumannii and Pseudomonas
aeruginosa, • Summarize the rapidly expanding
landscape of resistance determinants• Use this knowledge to devise effective
treatment strategies
Part I
MDR and PDR Ab
Multi-Drug Resistant (MDR) A. baumannii are among the most “problematic
pathogens” encountered by clinicians
Acinetobacter has evolved many molecular strategies to
escape ALL ANTIBIOTICS that resemble more the
tactics of organized crime than traditional warfare