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What must I do about abnormal LFT? KEVIN ROSENFELD Consultant Radiologist West Hertfordshire Hospitals Spire Hospital Harpenden Spire Hospital Bushey
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What must I do about abnormal LFT?

Dec 30, 2015

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What must I do about abnormal LFT?. KEVIN ROSENFELD Consultant Radiologist West Hertfordshire Hospitals Spire Hospital Harpenden Spire Hospital Bushey. Abnormal LFT. Symptomatic or incidental finding Symptoms Pain,nausea,LOW,known malignancy Ultrasound Pathology Gallstones neoplasm. - PowerPoint PPT Presentation
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Page 1: What must I do about abnormal LFT?

What must I do about abnormal LFT?KEVIN ROSENFELD

Consultant Radiologist

West Hertfordshire Hospitals

Spire Hospital Harpenden

Spire Hospital Bushey

Page 2: What must I do about abnormal LFT?

Abnormal LFT

Symptomatic or incidental finding Symptoms

– Pain,nausea,LOW,known malignancy Ultrasound Pathology

– Gallstones– neoplasm

Page 3: What must I do about abnormal LFT?

Asymptomatic abnormal LFT

Incidental finding

Page 4: What must I do about abnormal LFT?

CASE 1

40 M Insurance medical Bloods:GGT 240 rest bloods normal What do next?

• Ultrasound• GI referral• Counsel patient• nothing

Page 5: What must I do about abnormal LFT?

CASE 2

55F Pneumonia Treated A/B Still unwell Bloods : AST 95 alk phos normal GGT 150 What next

• GI referral• Ultrasound• Stop AB and recheck bloods in 4 weeks

Page 6: What must I do about abnormal LFT?

Management of asymptomatic abnormal LFT

Draft guidelines BSG Not universally accepted West Herts adopted for primary care

Page 7: What must I do about abnormal LFT?

F i g u r e 1 . S u g g e s t e d M a n a g e m e n t o f A b n o r m a l L F T s

C L I N I C A L S I T U A T I O N

A C T I O N S U G G E S T E D

M A N A G E M E N T S U G G E S T E D

A b n o r m a l a l k a l i n e p h o s p h a t a s e o r s e r u m t r a n s a m i n a s e s < 2 x u p p e r l i m i t o f n o r m a l

L I V E R S C R E E N i . e F u l l h i s t o r y , H B S A g , H C V A b ,

1 A T A u t o i m m u n e P r o f i l e , F e r r i t i n , C a e r u l o p l a s m i n , I m m u n o g l o b u l i n s U l t r a s o u n d a b d o m e n

D i l a t e d b i l e d u c t s

2 . S t o p h e p a t o t o x i c d r u g s

3 . A d v i s e w e i g h t l o s s i f B M I > 2 5

5 . R e c h e c k L F T i n 3 - 6 m o n t h s

P E R S I S T E N T L Y A B N O R M A L L F T

I n c r e a s e d G T o n l y A l c o h o l a b s t i n e n c e

I n c r e a s e d B i l i r u b i n o n l y

R e c h e c k w i t h c o n j u g a t e d b i l i r u b i n , e x c l u d e h a e m o l y s i s E

R e a s s u r e a s l i k e l y G i l b e r t s S y n d r o m e

4 . C h e c k G T i f R a i s e d A L P

1 . A l c o h o l a b s t i n e n c e

A l c o h o l a d v i c e

C h o l a n g i o g r a p h y M R C P o r E R C P

N o n - d i l a t e d b i l e d u c t s

C o n s i d e r t r e a t i n g u n d e r l y i n g d i s o r d e r e g P B C , h a e m o c h r o m a t o s i s o r a L i v e r B i o p s y

A b n o r m a l a l k a l i n e p h o s p h a t a s e o r s e r u m t r a n s a m i n a s e s > 2 x u p p e r l i m i t o f n o r m a l

Page 8: What must I do about abnormal LFT?
Page 9: What must I do about abnormal LFT?
Page 10: What must I do about abnormal LFT?
Page 11: What must I do about abnormal LFT?

Liver Metastases U/S

Page 12: What must I do about abnormal LFT?

Liver Metastases CT

Page 13: What must I do about abnormal LFT?

Fatty Liver

Common ultrasound finding

Page 14: What must I do about abnormal LFT?

F i g u r e 1 . S u g g e s t e d M a n a g e m e n t o f A b n o r m a l L F T s

C L I N I C A L S I T U A T I O N

A C T I O N S U G G E S T E D

M A N A G E M E N T S U G G E S T E D

A b n o r m a l a l k a l i n e p h o s p h a t a s e o r s e r u m t r a n s a m i n a s e s < 2 x u p p e r l i m i t o f n o r m a l

L I V E R S C R E E N i . e F u l l h i s t o r y , H B S A g , H C V A b ,

1 A T A u t o i m m u n e P r o f i l e , F e r r i t i n , C a e r u l o p l a s m i n , I m m u n o g l o b u l i n s U l t r a s o u n d a b d o m e n

D i l a t e d b i l e d u c t s

2 . S t o p h e p a t o t o x i c d r u g s

3 . A d v i s e w e i g h t l o s s i f B M I > 2 5

5 . R e c h e c k L F T i n 3 - 6 m o n t h s

P E R S I S T E N T L Y A B N O R M A L L F T

I n c r e a s e d G T o n l y A l c o h o l a b s t i n e n c e

I n c r e a s e d B i l i r u b i n o n l y

R e c h e c k w i t h c o n j u g a t e d b i l i r u b i n , e x c l u d e h a e m o l y s i s E

R e a s s u r e a s l i k e l y G i l b e r t s S y n d r o m e

4 . C h e c k G T i f R a i s e d A L P

1 . A l c o h o l a b s t i n e n c e

A l c o h o l a d v i c e

C h o l a n g i o g r a p h y M R C P o r E R C P

N o n - d i l a t e d b i l e d u c t s

C o n s i d e r t r e a t i n g u n d e r l y i n g d i s o r d e r e g P B C , h a e m o c h r o m a t o s i s o r a L i v e r B i o p s y

A b n o r m a l a l k a l i n e p h o s p h a t a s e o r s e r u m t r a n s a m i n a s e s > 2 x u p p e r l i m i t o f n o r m a l