What is apoptosis?? Apoptosis is a morphological term Apoptosis and programmed cell death frequent are used interchangeably Apoptotic death is characterized by: nuclear condensation membrane blebbing phosphotidylserine flipping DNA degradation into nucleosomal fragments new gene synthesis in some instances
What is apoptosis?? Apoptosis is a morphological term Apoptosis and programmed cell death frequently are used interchangeably Apoptotic death is characterized.
Dec 21, 2015
Welcome message from author
This document is posted to help you gain knowledge. Please leave a comment to let me know what you think about it! Share it to your friends and learn new things together.
Transcript
What is apoptosis??
• Apoptosis is a morphological term
• Apoptosis and programmed cell death frequently are used interchangeably
• Apoptotic death is characterized by:nuclear condensationmembrane blebbingphosphotidylserine flippingDNA degradation into nucleosomal fragmentsnew gene synthesis in some instances
Normalthymocyte
ApoptoticThymocyte
(induced todie by Dex)
Transmission EM Scanning EM
Morphological features of apoptosis
Figure 9.18a The Biology of Cancer (© Garland Science 2007)
Apoptosis Involves Biochemical As Well As Morphological Changes
Table 9.3 The Biology of Cancer (© Garland Science 2007)
Not in all cases
Figure 9.19 The Biology of Cancer (© Garland Science 2007)
Apoptosis plays a key role in regulating lymphocyte cell numbers
How do we get rid of corpses??
Why do we get rid of corpses??
Find me and eat me signal and phagocyte receptors
Lorenz & Ravichandran
LPC = lipid lysophosphatidylcholine
Lorenz & Ravichandran
Engulfment of apoptotic cells requires cytoskeletal rearrangment
Induction of Apoptosis – an Overview
Figure 9.28 The Biology of Cancer (© Garland Science 2007)
The Apoptosome
Caspase family tree**
**There are now at least twelve caspases
Caspases must be cleaved to be activated
Caspases
Initiator & Effector Caspases
Induction of Apoptosis – an Overview
Figure 9.25a The Biology of Cancer (© Garland Science 2007)
The Bcl-2 Family – Key Modifiers of Apoptosis
*
*
*
*
Bcl-2 family members play an important role inmany life and death decisions
Figure 9.27c The Biology of Cancer (© Garland Science 2007)
Engineering the Mice
Influence of Cooperation on Survival
Influence of anti-Apoptotic Gene on Outcome of Oncogene Challenge
Exrinsic and Intrinsic Death Pathways
Figure 9.31a The Biology of Cancer (© Garland Science 2007)
Death Receptors of the Extrinsic Pathway
Figure 9.33 The Biology of Cancer (© Garland Science 2007)
Figure 9.34 The Biology of Cancer (© Garland Science 2007)
Related Documents
