Susan Smith Allergies and Sensitivities Fitness Nutrition and Metabolism Personality Skin Care 09.30.2019
Susan Smith� Allergies and Sensitivities� Fitness� Nutrition and Metabolism� Personality� Skin Care
09.30.2019
Table of Contents
Allergies and Sensitivities 1
� Predisposition Summary 2
� Indoor Allergies 3
Allergy to Cockroaches 3
Allergy to Dust Mites 4
Allergy to Mold 5
Allergy to Pets 6
Allergy to Eggs 7
Allergy to Milk 8
Allergy to Peanuts 9
General Food Sensitivities 11
Gluten Sensitivity 13
Lactose Intolerance 15
Birch Pollen Allergy Resistance 16
Grass Allergy Resistance 17
Hay Fever 18
Histamine Intolerance 19
Mugwort Allergy Resistance 20
Misophonia 21
Motion Sickness 22
Noise-induced Hearing Loss 23
Resistance to Stomach Flu 24
Table of Contents
Seasonality 25
Sensitivity to Benzene 26
Sensitivity to Mercury 27
Sensitivity to PCB 28
Fitness 29
� Predisposition Summary 30
� Injury Potential 31
Achilles Tendinopathy 31
Anterior Cruciate Ligament Rupture 33
Joint Injury Risk 35
Overall Tendon and Ligament Injury Risk 36
Stress Fracture 37
Aerobic Performance 38
Endurance 39
Exercise Aversion 40
Joint Flexibility 41
Lean Body Mass Potential 42
Power 43
Exercise Benefits for Blood Pressure 44
Exercise Benefits for Lowering Cholesterol 45
Exercise Benefits for Maximal Oxygen Uptake Response 46
Heartbeat Reduction Difficulty 47
Table of Contents
Lower Exercise Benefits for Heart Pump Function 48
Overall Fitness Benefits 49
Muscle Cramping 50
Muscle Damage Risk 51
Muscle Response to Resistance Training 52
Muscle Soreness 53
Muscle Strength Loss 55
Muscular Strength 56
Skeletal Muscle Performance 57
Slow Muscle Repair 58
Nutrition and Metabolism 59
� Predisposition Summary 60
� Diet And Metabolism 61
Bitter Taste Sensitivity 61
Caffeine Metabolism Impairment 62
Carb Overconsumption 63
Difficulty in Losing Weight 64
Fat Overconsumption 65
Fat Taste Perception 66
Low Protein Intake Risk 67
Low Vegetable Intake 68
Low-carb Diet Effectiveness 69
Table of Contents
Low-fat Diet Effectiveness 70
Mediterranean Diet Effectiveness 71
Monounsaturated Fats Increased Benefits 72
Overweight Potential 73
Polyunsaturated Fats Increased Benefits 74
Risk from Saturated Fats 75
Satiety Impairment 76
Snacking 77
Starch Metabolism 78
Sweet Snack Preference 79
Sweet Tooth 80
Trans Fats Sensitivity 81
Calcium Deficiency 82
Choline Deficiency 83
Coenzyme Q10 Deficiency 85
Copper Deficiency 86
Glutathione Deficiency 87
Iron Deficiency 88
Iron Overload 89
Magnesium Deficiency 90
Phosphorus Deficiency 91
Selenium Deficiency 92
Table of Contents
Sensitivity to Salt 93
Lutein and Zeaxanthin Deficiency 94
Lycopene Deficiency 95
Vitamin A (Carotene) Deficiency 96
Vitamin A (Retinol) Deficiency 97
Vitamin B1 Deficiency 98
Vitamin B12 Deficiency 99
Vitamin B3 Deficiency 100
Vitamin B5 Deficiency 101
Vitamin B6 Deficiency 102
Vitamin B7 Deficiency 103
Vitamin B9 Deficiency 104
Vitamin C Deficiency 105
Vitamin D Deficiency 106
Vitamin E Deficiency 107
Vitamin K Deficiency 108
Zinc Deficiency 109
Personality 110
� Predisposition Summary 111
� Personality Profile 112
Addictive Personality 112
Anger Response 113
Table of Contents
Exploratory Behavior 114
Impulsivity 115
Morning Person 116
Optimism 117
Warrior Personality 118
Worrier Personality 119
Agreeableness 120
Empathy 121
Extraversion 122
Leadership Potential 123
Sociability 124
Creativity 125
Experiential Learning Impairment 126
Mathematical Aptitude 127
Memory Performance 128
Music Performance Aptitude 129
Musical Creativity 130
Reading Aptitude 131
Skin Care 132
� Predisposition Summary 133
� Skin Profile 134
Acne 134
Table of Contents
Protection from Skin Cellulite 135
Skin Antioxidant Deficiency 136
Skin Inflammation 137
Skin Rosacea 138
Skin Stretch Marks 139
Collagen Breakdown 140
Sagging Eyelids Risk 141
Skin Glycation 142
Youthfulness 143
Contact Skin Sensitivity 144
Dermal Sensitivity 145
Pollution Defense Impairment 146
Skin Barrier Sensitivity 147
Skin Detoxification Impairment 148
Facial Pigmented Spots 149
Photoaging 150
Poor Tanning Ability 151
Sensitivity to Sun 152
Terms of Use 153
Allergies andSensitivities
� Indoor Allergies
� Food Allergies
� Outdoor Allergies
� Other Sensitivities
� Sensitivities To Chemicals
We live in a world that constantly challenges us with
allergens, toxins, bacteria and viruses. Hundreds of new
chemicals enter our food supply every year. Many more
are released into our environment. Ever-increasing noise
levels put our bodies under constant stress. But why do
some of us get sick constantly, suffer from allergies and
just barely make it through life, while others seem to
easily adapt to anything the environment throws at
them? Genetics has a lot to do with it. This report will
reveal your risks of various sensitivities based on your
unique genetic makeup.
1
Predisposition Summary
My Good Genes
AdvantagedBirch Pollen Allergy
Resistance
SlightlyAdvantagedGrass Allergy
Resistance
AdvantagedMugwort Allergy
Resistance
SlightlyAdvantagedResistance toStomach Flu
My Risky Genes
ElevatedAllergy to
Cockroaches
Slightly ElevatedAllergy to Dust Mites
ElevatedAllergy to Eggs
Slightly ElevatedAllergy to Milk
ElevatedGluten Sensitivity
ElevatedLactose Intolerance
Slightly ElevatedHay Fever
Slightly ElevatedHistamine
Intolerance
ElevatedMotion Sickness
ElevatedSensitivity to Mercury
2
Indoor Allergies
Allergy to Cockroaches
Elevated
Cockroaches live in many locations around the world, in all types of buildings and all kinds of neighborhoods. TheNational Pest Management Association reports that over 60 percent of homes in the United States contain cockroachallergens. This number rises to 80-90 percent in urban areas. The saliva, feces and shedding body parts of cockroachescontain a protein that can trigger allergies and even asthma in some people. A cockroach allergy is a trigger ofyear-round allergy and asthma. Common cockroach allergy symptoms include runny stuffy or itchy nose, itchy or redeyes, skin rash, cough, mucus. People with some genetic variations have higher risk of developing allergies tocockroaches.
Our Recommendations
� You may have a higher genetic risk of allergy to cockroaches, but genetics is only part of the equation.
� A cockroach allergy is a trigger of year-round allergy and asthma. Common cockroach allergy symptoms includerunny stuffy or itchy nose, itchy or red eyes, skin rash, cough, mucus. If you suspect that you have a cockroach allergy,you may try over-the-counter medicines such as nasal corticosteroids, antihistamines, decongestants
� Talk to your doctor about allergy test and what medications may be right for you
� In any case it is a good idea to minimize your exposure to cockroaches: fix leaky pipes under the sinks and in thebasement, seal cracks in the walls
� Store food in airtight containers, keep tables and floors free from crumbs, cover trash cans
� Do not use sprays as they can irritate allergies and trigger asthma
� Use cockroach baits and traps. Consult a pest control company.
2 Genetic Variations
rs12136904, rs2243123
3
Indoor Allergies
Allergy to Dust Mites
Slightly Elevated
Dust mites are microscopic creatures, related to ticks and spiders that live in house dust. The proteins in dust mite bodyparts and feces cause allergic reactions in some people. Dust allergy symptoms are similar to those of pollen allergiesand include red, itchy, watery eyes, runny, itchy, stuffy nose, sneezing. These symptoms persist all year round and feellike endless cold or even asthma. It is estimated that up to 20 million Americans have dust mite allergy. When inhaled,dust mite allergen triggers asthma attacks and is one of the most common causes of asthma attacks worldwide. This isprimarily because dust mites are found nearly everywhere, especially indoors. All homes contain some amount of dustmites. Because dust mites feed on dead human skin, the allergen tends to be concentrated in mattresses, bedding,upholstered furniture, carpets. Pets contribute dander to the dust and increase the food source for mites. Severalgenetic variations have been found to be associated with increased risk of allergy to dust-mites.
Our Recommendations
� While your genetics-based score is still within typical range, other factors may contribute to the risk of allergy
� If you have year round allergy-like symptoms, dust mites are likely to blame
� Even if you do not have these symptoms, reducing your exposure to dust is a good idea
� Use natural fiber rugs that can be cleaned easily
� Keep air in your house cool and clean
3 Genetic Variations
rs10174949, rs12924667, rs1800872
4
Indoor Allergies
Allergy to Mold
Normal
Mold are fungi that thrive both outside (in logs, fallen leaves, compost piles, grasses) and inside (in moist places likebathroom, kitchen, basement). There are many different types of mold, some are visible by eye, others are not. Moldsmake spores that float in the air like pollen. But unlike plants that produce pollen, mold do not die with the first frost.They simply slow down or stop growing during this time and they start growing in the spring. Some people are allergicto molds: when they inhale the spores they develop typical allergy symptoms. Genetic variations associated withallergies to two types of mold fungus (Cladosporium and Alternaria) have been identified.
Our Recommendations
� Take basic steps to reduce the mold in your house
� It is important to keep your house dry: molds thrive in moist conditions
� Do not use carpets in bathrooms and basement
� Fix water leaks
� Clean the garbage often and de-clutter (mold can grow in piles of old newspapers and clothing)
2 Genetic Variations
rs10189629, rs17388568
5
Fitness
� Injury Potential
� Fitness Profile
� Fitness Benefits
� Muscle Characteristics
Are you a sprinter or a marathon runner? Do you hit a
plateau easily and never reach your fitness goals? Get
injured often and for no apparent reason? Need extra
time between workouts because of sore muscles?
Haveto cut your workouts short or even skip them
altogether because of muscle cramps? Your DNA
makeup may hold the answers. Knowing your genetic
predispositions can help choose the right sport and
physical activity, adjust your exercise routine and avoid
pain. Working with your genes rather than against them
will help you stay ahead of the game.
29
Predisposition Summary
My Good Genes
SlightlyAdvantaged
Aerobic Performance
AdvantagedExercise Benefits for
Blood Pressure
AdvantagedExercise Benefits forLowering Cholesterol
AdvantagedExercise Benefits for
Maximal OxygenUptake Response
AdvantagedOverall Fitness
Benefits
My Risky Genes
ElevatedAchilles
Tendinopathy
ElevatedAnterior Cruciate
Ligament Rupture
Slightly ElevatedJoint Injury Risk
ElevatedOverall Tendon andLigament Injury Risk
Slightly ElevatedStress Fracture
Slightly ElevatedExercise Aversion
Slightly ElevatedMuscle Soreness
ElevatedMuscle Strength Loss
30
Injury Potential
Achilles Tendinopathy
Elevated
Achilles tendon injury includes degenerative and painful conditions that affect athletes in a wide range of sports,including up to 20% of runners. This is a multifactorial condition for which various genetic risk factors have beenidentified. Genetic variants in the FBGN2, TNC and ADAMTS14 (metallopeptidase with thrombospondin) gene contributeto the reisk of achilles tendinopathy, while genetic variant in the MMP3 has been found to be protective.
Our Recommendations
� Your genetic risk for Achilles tendon injury seems to be slightly higher than average so you may need to extrameasures to protect your tendons.
� Try the following exercise to strengthen your calf muscles: � Use a resistance loop band or tie a long band into aloop 12" to 15" or 30 to 40 cm in diameter. Then, loop the resistance band around your foot with your toes pointed uptoward the ceiling. Holding the band tight, push your foot and ankle down against the band as far as comfortable.
� Hold the position for a second, then return back to your starting position slowly. Do 10 repetitions, then switch to yourother foot.
� Avoid an abrupt change of exercise intensity.
� Try to minimize high-impact sports, such as running which pose a higher risk for Achilles tendon injury.
� Switch to low-impact sports, such as walking, biking or swimming, which can both strengthen your muscles and poseless of an injury risk.
2 Genetic Variations
rs143383, rs4789932
31
Fitness Profile
Aerobic Performance
Slightly Advantaged
VO2 max (maximal aerobic capacity) is the maximum rate of oxygen uptake as measured during incremental exercise,most typically on a motorized treadmill. Maximal oxygen uptake reflects the aerobic physical fitness of the individual,and is an important determinant of their endurance capacity during prolonged, submaximal exercise. . Just a few of thebenefits of aerobic fitness are lower blood pressure, lower cholesterol and less risk of obesity, Type II diabetes andheart disease. Aerobic performance measured as the maximal rate of oxygen consumption (VO2max) is an importantdeterminant of the endurance capacity during prolonged exercise. VO2 max (V - volume, O2 - oxygen, max - maximum)is measured during incremental exercise. Overall, maximal oxygen consumption reflects the aerobic physical fitness ofthe individual, and it is widely accepted as the single best measure of cardiovascular fitness and maximal aerobicpower. Absolute values of VO2 max are typically 40-60% higher in men than in women. Starting at about the age of 30,our lung capacity begins to decrease. By the time we are 50 our lung capacity may be half of what it was in our youth.Decreased lung capacity means respiratory function is impaired and less oxygen is getting into our cells. This explainswhy shortness of breath, decreased endurance, and susceptibility to respiratory illness commonly increases with age.We check for several genetic variants that are associated with aerobic performance.
Our Recommendations
� You have a slightly elevated advantage likelihood for this trait. This means your lung capacity may be higher than anaverage adult. As such you may be able to do more strenuous exercises than the average population. However beforechanging any part of your fitness routine, always consult with a certified personal trainer.
� To improve your aerobic fitness even further, exercise intensity needs to be between 70 and 85 percent of yourtarget heart rate. In order to calculate your target heart rate, you must first determine your maximum heart rate, whichis 220 minus your age in years.
� If you are new to exercise you should aim for 10 to 20 minutes of aerobic exercise per session. Over time, graduallyincrease your exercise time until you can exercise continuously for 60 minutes.
� This will allow you to do more strenuous exercises with the same amount of oxygen uptake capacity.
2 Genetic Variations
rs7191721, rs9922134
38
Nutrition and Metabolism
� Diet And Metabolism
� Minerals
� Vitamins
Even a quick look around a restaurant on a busy night
makes it obvious we all have different tastes as well as
appetites. Are we born that way? Scientific evidence
shows that our preferences are swayed by our DNA. And
genetic influences don't stop there. They run much
deeper: our nutritional requirements, metabolic rate, the
ability to digest and absorb different types of food and
maintain proper levels of vitamins and minerals all have a
strong hereditary component. Even our propensity to
indulge in unhealthy food habits or benefit from healthy
diets are encoded in our genes.
59
Predisposition Summary
My Good Genes
AdvantagedLow-fat DietEffectiveness
AdvantagedPolyunsaturated Fats
Increased Benefits
My Risky Genes
Slightly ElevatedFat Taste Perception
ElevatedOverweight Potential
ElevatedSatiety Impairment
Slightly ElevatedSnacking
Slightly ElevatedStarch Metabolism
ElevatedSweet SnackPreference
ElevatedSweet Tooth
Slightly ElevatedTrans Fats Sensitivity
ElevatedCholine Deficiency
+20
more
60
Diet And Metabolism
Bitter Taste Sensitivity
Normal
Taste perception plays a fundamental role in our dietary preferences and behaviors, by shaping aversions (or cravings)to foods and drinks. Adverse responses to bitterness are instinctive and drive rejection and avoidance behaviors. Theperception of bitterness is due to genetic variations in several bitter taste receptors: when food enters the mouth, themolecules, like phenylthiocarbamide (PTC) compound, interact with saliva, and then bind to taste receptors in themouth, giving the sensation of bitter taste. People with these genetic variations are sensitive to bitter vegetables thatare beneficial (like broccoli, Brussel sprouts, cabbage) or drinks (like coffee and dark beers). There is a growingevidence that taste genes play a much broader role in human health. A new study found that people who are naturallymore sensitive to bitterness are more likely to add sodium to their food, often exceeding recommended daily dietaryguidelines. At the same time, these people are more likely to avoid ingredients that are beneficial for health, includingdark leafy greens and broccoli.
Our Recommendations
� You are less likely to experience bitter taste sensitivity when consuming vegetables.
� Continue to eat a variety of vegetables to meet your daily needs.
1 Genetic Variations
rs978739
61
Minerals
Glutathione Deficiency
Slightly Elevated
Glutathione is a powerful antioxidant that is produced naturally by the liver. It is involved in tissue building, immuneresponse, nutrient metabolism, and regulation of cellular events, including cell proliferation and apoptosis. Glutathioneis often called the master antioxidant as it scavenges free radicals, peroxides, lipid peroxides and heavy metals.Glutathione is required for proper utilization and functioning of other antioxidants such as vitamins C, E, selenium andcarotenoids. Glutathione deficiency contributes to oxidative stress, which plays a key role in aging and the age-relateddiseases. Genetic variations (and deletions) in genes (GPX1 GSTP1 GSTT1 GSTM1) lead to lower production and activityof glutathione compromising its detoxification capacity. There is a growing scientific evidence that glutathione helpscontrol inflammation, fight infections, and boost immune system. It has been used to treat acne and as a skin lighteningagent. Glutathione occurs naturally in many foods but its absorption from fruits and vegetables may be low. Adequateamounts of protein increases the production of glutathione in our bodies.
Our Recommendations
� You may need to boost your body's production of glutathione by consuming the following food sources: beef, pork,poultry, fish, cheese, tofu, legumes. These foods are high in essential amino acids that provide building blocks forproducing glutathione.
� Studies showed that the expression and activity of GSTT1and GSTM1 genes coding for glutathione can be induced bythe consumption of cruciferous vegetables (cauliflower, cabbage, garden cress, bok choy, broccoli, Brussels sprouts).
� Regular exercise boosts glutathione production, however athletic over-training may result in lower glutathione.
� The use of intravenous glutathione injections is becoming popular, albeit controversial.
� Glutathione supplements are readily available but as always discuss it with your healthcare provider.
3 Genetic Variations
rs1050450, rs713041, rs7483
87
Minerals
Iron Deficiency
Elevated
Iron is an essential mineral that our bodies need for many functions. Iron is a key element in the metabolism of almostall living organisms. It is a part many proteins, including oxygen-carrying proteins, hemoglobin (found in red blood cells)and myglobin (found in muscle cells). Iron is also an essential component of antioxidant enzymes and metabolizingenzymes (cytochromes). Absorption, transport and storage of iron are tightly regulated, as iron is both an essential andpotentially toxic. Iron deficiency is the most common nutrient deficiency in the world. Symptoms of iron deficiency mayinclude fatigue, rapid heart rate and palpitations. Iron deficiency may interfere with physical and athletic performance.Young children, women of childbearing age, as well as vegetarians and vegans, are at higher risk of iron deficiency.
Our Recommendations
� You may want to consider increasing your iron intake through iron-rich foods. Hpowever be careful since too muchiron is also bad for the body.
� Typically, iron deficiency is diagnosed through blood tests, so discuss with your doctor about the need for screening.Depending on the screening results, your doctor might recommend an oral iron supplement.
� There are two types of iron: heme iron from animal sources and non-heme iron from plant sources. Heme iron isabsorbed more readily. Foods rich in heme iron include beef, poultry, liver, oysters, salmon, tuna. Good sources ofnon-heme iron include beans, fortified cereals, and dark leafy greens like spinach.
� If you are into strenuous physical activity, make sure your iron levels are within the norm.
� Do not take iron supplements without supervision of a healthcare professional as too much iron is harmful to thebody. Excessive intake of iron supplements can impair zinc absorption, increase risk for vascular disease, liver problemsand systemic iron overload.
3 Genetic Variations
rs13194491, rs228916, rs411988
88
Vitamins
Vitamin B12 Deficiency
Elevated
Vitamin B12 (cobalamin) is required for normal functioning of brain, nervous and digestive systems, red blood cellformation. It is involved in DNA synthesis, fatty acid and amino acid metabolism. Vitamin B12 can be only manufacturedby bacteria, and generally it can be found in animal food sources. Slight imbalances in vitamin B-12 can lead to anemia,fatigue, stomach inflammation, and affect nervous system. No toxic or adverse effects have been associated with largeintakes of vitamin B12 from food or supplements in healthy people. Genetic variants in several genes, including FUT2,MTHFR, MTRR, TCN2, have been linked to levels of vitamin B12.
Our Recommendations
� You are likely to benefit from increased intake of vitamin B12. Recommended dietary amounts (RDAs) are 2.4micrograms daily for ages 14 years and older, 2.6 micrograms daily for pregnant females, and 2.8 micrograms daily forbreastfeeding females.
� Top foods that contain vitamin B12 are liver, red meat, fish and shellfish, milk and dairy products, fortified soy, almondor rice beverages and products, fortified cereals, nutritional yeast and eggs.
� Since Vitamin B12 is found primarily in animal products, strict vegetarians and vegans in particular are at risk for adeficiency.
� Consult a registered dietitian or physician to make sure you are meeting your daily requirements for vitamin B12intake, in particular if you are a vegetarian or vegan.
3 Genetic Variations
rs1801131, rs1801198, rs1801222
99
Personality
� Personality Profile
� InterpersonalCharacteristics
� Learning Personality
Why are we all different? Leaders and followers, team
players and lone wolves, math geniuses and visual
artists, happy-go-lucky people and those always with a
chip on their shoulder... The list can go on. A lot of the
differences have to do with our surroundings and the
way we were raised. And yet, an ever-growing body of
scientific evidence shows that genetics plays a major role
in our personality traits and mental abilities. We are all
makers of our own destiny, but knowing your natural
predispositions may make life choices easier and the
path to success a bit shorter.
110
Predisposition Summary
My Good Genes
AdvantagedWarrior Personality
AdvantagedAgreeableness
AdvantagedEmpathy
SlightlyAdvantaged
Leadership Potential
+2
more
My Risky Genes
111
Personality Profile
Addictive Personality
Normal
This trait measures whether you have genetic predispositions that would increase your likelihood of having an addictivepersonality. Addictions can come in a wide range of forms, including food, drugs, alcohol, gambling, pornography, oreven fitness/exercise. Addictive personality refers to a particular set of personality traits that make an individualpredisposed to developing addictions. Addictions can come in a wide range of forms, including food, drugs, alcohol,gambling, pornography, or even fitness/exercise. In addition to gene DRD2 that is implicated in reduced pleasureresponse, several other genetic variants have been found to be associated with addictive behaviors such as excessivealcohol consumption and smoking.
Our Recommendations
You do not seem to have known genetic predispositions for addictive personality.
3 Genetic Variations
rs10891549, rs1344694, rs1451240
112
Personality Profile
Anger Response
Normal
Individuals with higher anger response are more irritable and likely to get angry as a result of unsettling external stimuli.This is partially a result of the sensitivity of the central nervous system and the amygdala to external shocks and can beinfluenced by your genetics.
Our Recommendations
� You seem to have a typical predisposition likelihood for anger response.
� This doesn't mean you don't ever get angry, but it may mean that your anger outbursts may not be caused by knowngenetic variations.
� While anger is a natural and legitimate emotion, it is important to manage it to avoid hurting others or one's ownsense of peace.
3 Genetic Variations
rs2844775, rs555017, rs6012564
113
InterpersonalCharacteristics
Agreeableness
Advantaged
Agreeableness is a personality trait manifesting itself in individual behavioral characteristics that are perceived as kind,sympathetic, cooperative, warm and considerate. It is one of the Big Five personality traits. A person with a high level ofagreeableness in a personality test is usually warm, friendly, and tactful. They generally have an optimistic view ofhuman nature and get along well with others. We learn agreeableness within our family structures and the socialenvironments we grow up with. However research shows that agreeableness is partially influenced by our genetics.Interestingly, the agreeableness has been shown to be correlated with morningness. Indeed, the morningness allele ofthe circadian gene CLOCK is significantly associated with agreeableness.
Our Recommendations
� You score has advantaged for predisposition likelihood for agreeableness.
� If you are in a leadership position at work, this may help you build strong teams that have high cohesion.
� On the potentially negative side, you may dread making tough decisions and provide negative feedback even if it isnecessary.
3 Genetic Variations
rs1055356, rs1801260, rs2540226
120
Skin Care
� Skin Profile
� Skin And Aging
� Skin And The Environment
� Skin And The Sun
The skin is the largest organ in our body. Its importance is
hard to understate. Our skin is the first protective barrier
stopping pathogens, toxins and harmful UV rays from
entering our system and doing major damage. The
appearance of the skin is also an indicator of our health
and age. Our genes play a major role in our skin's ability
to fend off irritants and recover from damage. Wrinkles,
rashes, sunburn, acne, stretch marks - these areall
encoded in our DNA. Knowing your genetic
predispositions may help you keep your skin healthy and
looking great for many years.
132
Predisposition Summary
My Good Genes
AdvantagedProtection from Skin
Cellulite
AdvantagedYouthfulness
My Risky Genes
ElevatedSkin Antioxidant
Deficiency
Slightly ElevatedSkin Inflammation
ElevatedSkin Rosacea
Slightly ElevatedSkin Stretch Marks
ElevatedCollagen Breakdown
ElevatedSkin Glycation
ElevatedDermal Sensitivity
Slightly ElevatedSkin BarrierSensitivity
ElevatedFacial Pigmented
Spots
+2
more
133
Skin Profile
Protection from Skin Cellulite
Advantaged
Cellulite is a condition when skin on thighs, hips, buttocks, and abdomen appears lumpy because of excess of fatbeneath the skin. It is most common in women than men and even thin people are prone to it.There are many causes ofcellulite including excessive weight, total body fat, poor diet, fad dieting, lack of physical activity, dehydration, hormonechanges, and genetic predisposition. A small study of 200 lean women with cellulite and 200 BMI-matched controlsidentified two variations in ACE and HIF1A genes that were significantly associated with appearance of cellulite. Manytreatments for cellulite, include massages, cellulite creams, lasers, and injections.Most of these treatments can workonly in combination with a healthy, active lifestyle.
Our Recommendations
� Follow general rules to minimize cellulite by maintaining a healthy weight: stay active and eat a healthy diet.
� Stay hydrated.
� For improved circulation, try daily dry skin brushing in circular motions.
� Use anti-cellulite creams. Recent clinical studies have suggested that caffeine-containing creams are effective inreducing the orange skin appearance caused by cellulite.
0 Genetic Variations
135
Skin Profile
Skin Antioxidant Deficiency
Elevated
A balance between free radicals and intrinsic antioxidants is necessary for proper physiological functioning as well as tomaintain youthful and healthy skin. Increased amounts of free radicals contribute to a dangerous chain of reactions thattarget tissues and organs in the body, including skin. This can trigger many chronic and late-onset diseases while alsoleading to premature aging by damaging the skin’s proteins and lipids. To prevent such an occurrence, a masterregulator gene, NRF2 (NF-E2-Related Factor 2), prompts the activation of SOD2/CAT(enzyme/protein) when it istriggered by oxidative stress and electrophiles. These enzymes convert free radicals into less harmful products. Geneticvariations in NRF2, SOD2, and CAT can result in reduced antioxidant activities which then increases risk of damage tothe skin’s lipids and proteins.
Our Recommendations
� Follow skin care recommendations that are infused with natural antioxidants (vitamin C, carotene, vitamin E, glutathione,green tea extract) which boost your skin’s intrinsic antioxidant capacity.
� During the day, practice wearing antioxidant-rich day creams and sunscreen to help create a strong defense againstaging. For the night, use antioxidant-infused night creams which promote cellular repair and healing.
� Consume more antioxidant-rich foods in your diet such as blueberries, red berries, dark green leafy vegetables, sweetpotatoes, oranges, nuts, whole grains, and green tea.
� Consider intake of supplements that boost antioxidant NRF2 after consulting your physician.
3 Genetic Variations
rs35652124, rs6721961, rs769214
136