Welcome! 1 [schoolafm.com]– Surgery is designed to remove the cancerous tissue, ideally with “clear margins”. Where applicable, laparoscopic surgery reduces the likelihood of

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Welcome!

This presentation is copyrighted by Purpose Inc. with all rights reserved, available for student reuse strictly subject to the terms outlined in the student program agreement.

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Tracy’s health counseling certification is from Columbia University for the Institute of Integrative Nutrition in New York.

She has completed ongoing training and is working on a certification in understanding the root causes of chronic illness with the Institute of Functional Medicine and on an additional Masters degree in Human Nutrition at Bridgeport University.

She holds a Masters degree in Engineering from MIT and a Masters degree in Management from The Sloan School at MIT.

SAFM™ Deep Dive Clinical Courses

Take lots of notes! The more often you see these connections, the more readily you will be able to recall them in your practice.

An online Q&A bulletin board for this course is available to you for follow-up at any time (on the SAFM course page). Make use of this option to expand your and others’ learning. Please note this tool is for expanding and clarifying questions on the course material itself and not detailed case study review.

Plan to review this course material again, at least once more in the short-term (and ideally a third time later in the future to help you retain this knowledge).Remember: Repetition breeds Retention.

If you ever have any technical trouble with your SAFM membership or site access, please don't hesitate to contact our team at [email protected]

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Cancer

Part 2

This presentation is copyrighted by Purpose Inc. with all rights reserved, available for student reuse strictly subject to the terms outlined in the SAFM student program agreement.

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Today's Agenda

Quick Review

Standard of Care: Conventional Cancer Treatment

Conventional Care and Metastasis Risk

Nagivating Chemotherapy, Radiation, and Treatment Fatigue

Specific Recommendations for All Cancer Patients

Boosting Natural Killer Function

The Role of Nf-KB and Curcumin

The Antioxidant Conundrum

PH Debate and Alkalinity

More Aggressive Options (for pre, post, during, or instead-of conventional therapy)

A Few More Resources

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A Quick Review

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Going Rogue!

Cancer is ultimately caused by genes from within our own genome.

“Cancer is essentially loaded into our genome, awaiting activation by an effective combination of mutations.”*

Mutations (DNA damage) can be inherited or created over time. The latter can be caused by internal (oxidative stress) and/or external (viruses, toxins/chemicals, radiation, heat) offenses.

– Oncogenes produce proteins (kinases) which drive hyperactive, unregulated cellreplication (mitosis). We have >100 of these naturally, though generally turned off.“A stuck accelerator”. These are usually heterozygous (dominant) in creating cancer.

– Tumor suppressor gene (aka anti-oncogenes) mutations produce proteins whichimpair suppression of cell growth (and perhaps DNA repair or apoptosis). “Amissing brake”. These are usually homozygous (recessive) in creating cancer.

● For example, BRAC1 & BRAC2 are inherited mutation examples which damage DNArepair and increase the risk of breast cancer by 500%.**

– Low penetrance mutations or common variants (aka “SNPs”) can increase risk ofcancer via secondary dynamics (e.g. slow detoxification, low antioxidant function,higher inflammation, higher nutrient need, obesity).

*Mukherjee, M, “The Emperor of all Maladies” is an excellent overview of the history/evolution of cancer understanding.** http://www.cancer.gov/about-cancer/causes-prevention/genetics/brca-fact-sheetPhoto: http://kintalk.org/genetics-101/

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DNA Damage

DNA damage happens every day to every cell, millions of times. Repair mechanisms are engaged constantly.

When sufficient DNA damage builds up & cannot be repaired (which naturally happens with age), a cell will do one of three things:

– Go into senescence (dormant – this happens progressively with aging)– Kill itself (apoptosis)– Create a cancer, if the DNA damage is in the right locations,

especially those affecting oncogenes and tumor suppressor genes. Cancer development nearly always requires epigenetic activation

of a group of mutated genes. A cascade of genetic signalling allows the cancer to support

itself ingeniously over time and invade other tissues– Inducing nearby blood vessels to grow

(angiogenesis)– Disloding cells to move to nearby blood or

lymphatic vessels and disguising itselfas a lymphocyte (metastasis)*

– Devious behavior to penetrate the bloodbrain barrier and avoid immune cell attack**

* http://metastasis-research.org/patients-perspective** https://www.mskcc.org/press-releases/study-reveals-mechanisms-cells-use-establish-metastatic-brain-tumors Photo: http://www.pbs.org/wgbh/nova/next/body/nanoparticles-in-cancer-treatment/ Diagram: https://en.wikipedia.org/wiki/Carcinogenesis

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Contribution to Cause: Simplifying Chaos

* http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2515569/figure/Fig1/

A: Est. Genetic Inheritance vs. Environment

B: Est. Inherited Genetic Contribution to various Cancers

C: Est. Environmental Contributors

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Optimal Health is Not Complicated

Maximize Put in what’s needed for this unique person

Raw materials your body needs to function and heal Oxygen, Water, Vitamins, Minerals, Antioxidants, Protein, Healthy Fats Belief that the therapy one is choosing is effective and safe

MinimizeTake out what’s harmful for this unique person

Toxins, Infections, Allergens, Stress, TraumaLimiting beliefs, fear, negative expectations

PrioritizeCreate an environment for healing for this unique person

Sleep, Rest, Laughter, Stress ReductionExercise, Stretching, BreathingMeaningful RelationshipsPositive visualizations and associations

And then the body will heal itself – will naturally seek wellness.

Simplifying the face of health can be very calming and inspiring to

your clients.

Of course, we are not very good at doing these three things consistently. The result? Chronic Dis-ease in the body.

This is Why Your Clients and Patients Need You!

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You Can Do this! Back to the Basics

“Worldwide, around one third of cancer deaths are due simply to the 5 leading behavioural and dietary risks: high body mass index, low fruit and vegetable intake, lack of physical activity, tobacco use, alcohol use.”**

“Diet, physical inactivity, and obesity are related to 30–35% of cancer deaths.”# “Physical inactivity is believed to contribute to cancer risk, not only through its effect on

body weight but also through negative effects on the immune and endocrine systems.” #

* http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2515569/** http://www.who.int/mediacentre/factsheets/fs297/en/ # https://www.ncbi.nlm.nih.gov/pubmed/17005596

“The evidence indicates that of all cancer-related deaths, almost 25–30% are due to tobacco, as many as 30–35% are linked to diet,about 15–20% are due to infections, and the remaining percentage are due to factors like radiation, stress, physical activity, environmental pollutants, heat, etc. “ *

- Dr. Anand Preetha

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Preventing – and Eradicating - Cancer

Minimize oxidative damage to DNA

– Reduce unnecessary or chronic inflammation

– Avoid Carcinogens

Maximize antioxidant nutrition and synthesis in the body.

Retain a strong Immune system– Maximize natural killer cells and

immune responsiveness

– Minimize stress.

– Regular, moderate exercise.

– Sleep, deeply and consistently.

** http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3865708/

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Conventional Treatment Risks, Considerations, and Support

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Standard of Care

Still Surgery, Radiation, and Chemotherapy– Surgery is designed to remove the cancerous tissue, ideally with “clear margins”. Where

applicable, laparoscopic surgery reduces the likelihood of surgery-induced metastasis andimproves long-term survival substantially. #

– Chemotherapy poisons cells. Often administered in combination. Increasingly usedpost-surgery in lower doses as adjuvant therapy. Chemosensitivity andimmunohistochemistry tests can now assess whether a given drug is effective on anindividual's specific cancer. ##

– Radiation damages cellular DNA both directly and via oxidative damage. Either externalbeam or inserted internally (e.g. pellet).

– Radiation and Chemotherapy can create more cancer stem cells. ###

Does conventional therapy work? There is much dispute as to whether cancer therapy is really improving aggregate survival, as earlier diagnosis now starts “the clock” sooner, more benign and slow-growing cancers are getting earlier (unecessary?) treatment, and survival studies seldom go past five year assessments. ***

But times are changin'...

# http://www.ncbi.nlm.nih.gov/pubmed/12103285 and http://www.ncbi.nlm.nih.gov/pubmed/18580199 and http://www.ncbi.nlm.nih.gov/pubmed/11093502 ## www.rationaltherapeutics.com and www.genzymegenetics.com *** https://www.sciencebasedmedicine.org/the-early-detection-of-cancer-and-improved-survival-more-complicated-than-most-people-think/ and http://www.nejm.org/doi/full/10.1056/NEJM199304293281706 ### http://www.foxnews.com/health/2012/09/27/common-cancer-treatments-may-create-dangerous-cancer-stem-cells/ , http://dash.harvard.edu/handle/1/10474253 and http://www.ncbi.nlm.nih.gov/pubmed/22732500

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Progressive Possibilities

Progressive research has helped treatment to become more targeted, largely by identifying proteins secreted only (or primarily) by cancer cells. ****

– Breast cancer vaccine of antibodies which target mammaglobulin-A, a protein expressedaggressively by breast tumors. *****

Monoclonoal antibodies@

Cancer vaccines * Inflammatory mediator injections (e.g. interleukins) Signal Transduction Inhibitors Immune Checkpoint Inhibitors # Hyperthermia Stem cell transplants Apoptosis-inducing agents ##

Dendritic Cell Therapy (modified “self” vaccine) ***

The encouraging question for the future appears to be how can we directly use the patient's own immune system to combat cancer and do it in an appropriately progressive way. **

@ http://www.forbes.com/sites/matthewherper/2015/04/20/immune-system-drugs-melt-tumors-leading-a-cancer-revolution/* http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309200/ and https://www.sciencenews.org/article/designer-t-cells-emerge-weapons-against-disease# http://www.ncbi.nlm.nih.gov/pubmed/25823918 and https://www.ucsf.edu/news/2014/01/111531/killing-cancer-through-immune-system ** http://www.nejm.org/doi/full/10.1056/NEJMc1501894?query=featured_home , an amazing case study (fair warning on stunning but graphic photographs) ## http://www.hindawi.com/journals/bmri/2014/150845/****http://www.nature.com/nrclinonc/journal/v11/n9/full/nrclinonc.2014.111.html ***** http://news.wustl.edu/news/Pages/27732.aspx **** http://www.dendriticcellresearch.com/denvax

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Surgery Brings Increased Risks

Primary tumor surgery can increase the risk of metastasis.* In most cases, the metastasis is more virulent than the original tumor. * Surgery reduces barriers to entry for cancer cells to migrate e.g. disrupted tissue, cut

access to blood vessels, increased cancer cell adhesion**, and suppressed cell-mediated immune function.

– In one study, binding of cancer cells to the blood vessel walls was increased by 250%, post-surgery, compared to cancer cells not exposed to surgical conditions.***

I recommend clients take time and focus to build up their body to reduce these risks prior to surgery, ideally a full 1-2 weeks prior to surgery and continuing 2-3 mos.

– Modified Citrus Pectin (MCP) binds to galectin-3 on the cancer cell, a protein which isrequired for cancer cells to dock (stick) to blood vessels walls and migrate outside them toother organs. This also can prevent cancer cells from clumping together.****

– Animal studies of MCP use show 90% reduction in metastatic cell colony size and 90%reduction in overall metastases. ****

– MCP increases radiation-sensitivity of prostate cancer cells. #– WS tip: I recommend 5 grams MCP powder three times daily on an empty stomach which

correlates which what has been used effectively in human studies. This would be especiallyimportant in the 1-2 weeks prior to surgery (and then continued afterward).

* http://www.ncbi.nlm.nih.gov/pubmed/19387333 , http://www.ncbi.nlm.nih.gov/pubmed/10862196 , http://www.ncbi.nlm.nih.gov/pubmed/9736904 ,http://www.ncbi.nlm.nih.gov/pubmed/14527919 , and http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2364103/ , http://www.ncbi.nlm.nih.gov/pubmed/16788948 ** http://www.ncbi.nlm.nih.gov/pubmed/12384057 *** http://www.ncbi.nlm.nih.gov/pubmed/15386356 **** http://www.ncbi.nlm.nih.gov/pubmed/15386356 , http://www.ncbi.nlm.nih.gov/pubmed/7853416 and http://www.ncbi.nlm.nih.gov/pubmed/1538421 # http://www.prnewswire.com/news-releases/modified-citrus-pectin-enhances-radiation-therapy-in-prostate-cancer-treatment-300070001.html

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Treatment Holding back Natural Killer Cells

Cancer surgery itself reduces NK activity. This is due to associated increases in inflammation and catecholamines (stress hormones). ***

Reduced NK count already increases the risk of cancer. Low NK cell count can also increase the risk of recurrence or metastasis post-surgery. #

– “Even transitory immune dysfunction might permit neoplasms [cancer] to enter the next stage ofdevelopment and eventually form sizable metastases.”

In one study, reduced NK cell activity was actually a better predictor of survival than the actual stage of the breast cancer. *

In another study, colon cancer patients with reduced NK cell activity before surgery had a 350% increased risk of metastasis over the following three years.**

Chemotherapy reduces the number and activity of NK cells. ###

Special labwork can assess NK count and activity (usually via IFN-y). Much ongoing research is being made into primary

NK-mediated cancer treatments. ##

# http://www.ncbi.nlm.nih.gov/pubmed/14527919 and http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(00)03231-1 * http://www.ncbi.nlm.nih.gov/pubmed/10930110** http://www.ncbi.nlm.nih.gov/pubmed/9331851 *** http://www.ncbi.nlm.nih.gov/pubmed/8402048, http://www.ncbi.nlm.nih.gov/pubmed/15145613/ , http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2565756/ ## http://www.nature.com/cmi/journal/v10/n3/full/cmi201310a.html### http://www.ncbi.nlm.nih.gov/pubmed/7715543 and http://www.nature.com/leu/journal/v23/n1/full/leu2008273a.html

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Preventing Angiogenesis

Surgery naturally increases the body's production of growth factors, to aid in tissue repair. These growth factors can promote angiogensis to support metastases, especially via VEGF (vascular endothelial growth factor).

Several natural substances have been shown to reduce VEGF substantially and impair angiogenesis e.g. curcumin, milk thistle, EGCG (green tea), melatonin, gingko, artemisia.*

Given the extent and significance of research to date, I recommend starting the following for 1-2 weeks prior to surgery and then continuing for 2-3 months .

– EGCG, as if we need another reason! WS tip: 400-500mg, twice daily. **– Melatonin. WS tip: 20mg/day, at night usually works best. ***– Curcumin. WS tip: 500mg twice daily, but be sure to

use a formula with enhanced absorption capabilitiese.g. Meriva, BCM-95. ****

* http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1891166/** http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146988/ and http://www.vascularcell.com/content/pdf/2045-824X-5-9.pdf and http://www.lifescienceglobal.com/pms/index.php/jcru/article/download/1664/1052 and http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2517785/ *** http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2517357/ and http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4233441/ and http://www.ncbi.nlm.nih.gov/pubmed/11335879/ **** http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2230271/ and http://www.ncbi.nlm.nih.gov/pubmed/17569211

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Other Surgical Considerations

Stress and lack of sleep impair the immune system. A thoughtful week of relaxation, rest, meditation, self-care, spiritual reflection, laughter, and quality time with loved ones is quite likely to promote greater healing and a stronger immune system. #

Because of blood-thinning effects, some helpful supplements should be stopped 10 days prior to surgery and resumed 10 days afterward: fish oil, garlic, nattokinase, any enzymes taken in between meals or at bedtime.

Opioid painkillers such as morphine can suppress the immune system (often administered post-surgery). A potentially helpful alternative is tramadol which provides similar relief without immunosuppressive effect. **

Intense anesthesia weakens natural killer activity. A combination of lower levels of general anesthesia along with regional anesthesia reduce substantially the metastasis-promoting effects of surgery and also reduces the need for painkiller drugs afterward.*

# http://www.ncbi.nlm.nih.gov/pubmed/12883106/ and http://www.ncbi.nlm.nih.gov/pubmed/24484432 * http://www.ncbi.nlm.nih.gov/pubmed/17473369 and http://www.ncbi.nlm.nih.gov/pubmed/11465599** http://www.ncbi.nlm.nih.gov/pubmed/17120754 and http://bja.oxfordjournals.org/content/91/2/209.full and http://bja.oxfordjournals.org/content/109/suppl_1/i17.full

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Navigating Chemo

Chemotherapy harms both cancerous and healthy cells. Death can be caused (even years later) by the damage done to noncancerous tissue.

Often the maximum tolerated dose (MTD) will be given initially, as treatment usually induces resistance. New research is looking at combining lower-dose, more frequent chemo along with remedies that prevent angiogenesis, highlighting the importance of reducing VEGF.*

Chemotherapy damage to noncancerous cells causes them to release growth factors that promote tumor growth and create treatment resistance**

Cells with frequent replication (turnover) are likely to be more heavily damaged by chemo e.g. lips, mouth, and the gut lining. WS tip: For relief, use l-glutamine, CoQ10 (100mg), and full-spectrum Vitamin E (e.g. Jarrow Tocosorb). Open capsules and mix all together in a little extra virgin olive oil. Swish in the mouth for several minutes and either spit out or swallow. Up to 3x/day.

Ginger is an effective anti-nausea agent for those using chemo. Can be tea, steeped and macerated whole ginger, eaten raw, or used in supplement. @

Quercetin can increase Chemo efficacy. # WS tip 500mg, 3x/day is consistent with study dosage. Melatonin. Chemo patients receiving melatonin had lower incidences of neuropathies,

thrombocytopenia, stomatitis, and malaise. In many of these studies, 30mg/day was used. Prostate cancer patients should monitor their prolactin. ***

For highly suppressed blood cell production (which can contraindicate chemo), stimulate synthesis with 500mg curcumin 3x/day## and a methyl-B combination daily (800mcg folate, 1000 mcg B12).

* http://www.ncbi.nlm.nih.gov/pmc/articles/PMC300842/ and http://www.ncbi.nlm.nih.gov/pubmed/11192826 andhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2669231/ ** http://www.nature.com/nm/journal/v18/n9/full/nm.2890.html *** http://www.ncbi.nlm.nih.gov/pubmed/10674014 and http://www.ncbi.nlm.nih.gov/pubmed/11862501 @ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3361530/ # http://www.ncbi.nlm.nih.gov/pubmed/21400027 and http://www.ncbi.nlm.nih.gov/pubmed/19466611 and http://www.ncbi.nlm.nih.gov/pubmed/2155185 ## http://www.jbc.org/content/286/49/42232.long

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The Effects of Radiation

Again, approach treatment from a place of strength with strong synergistic, antioxidant function. A recommended preparation regimen # includes a combination of 500mg curcumin, 500mg quercetin, 200mg alpha lipoic acid, 400IU full-spectrum Vitamin E, 400mg magnesium glycinate, 15,000 IU mixed carotenoids, all together 3x/day.

Radiation increases risk of later secondary cancer development. * Tumor cells exposed to abundant oxygen are much more

vulnerable to radiation damage than are cells deficient in oxygen (hypoxic). ** Combination antioxidant therapy can significantly increase the effectiveness of

radiotherapy, while protecting surrounding tissue. Continued use of the vitamins rendered tumors dormant. *** WS tip: 30,000 IU mixed carotenoids, 500mg niacinamide, 50+mg resveratrol (trans form) – all taken together 3x/day. Best effect if started 1 wk prior to therapy.

Radiation can be particularly damaging to blood vessels (setting the stage for or advancing atherosclerosis). **** WS tip: for protection, consider 300mg magnesium glycinate, 25mg zinc citrate, 200mcg selenomethionine, and 1500mg curcumin (divided doses) daily.

Hyperbaric oxygen therapy is a consideration both prior to and post treatment. ***** #”ibid Blaylock, P112-113. * http://www.ncbi.nlm.nih.gov/pubmed/22107741 , http://www.ncbi.nlm.nih.gov/pubmed/18546265 , http://aje.oxfordjournals.org/content/161/4/330.longhttp://www.medicaldaily.com/radiation-therapy-breast-cancer-increases-risk-lung-cancer-will-follow-274910 ** http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2752413/*** http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1250519/ and http://www.ncbi.nlm.nih.gov/pubmed/6576200 and https://www.karger.com/Article/Pdf/409532, “Nutritional factors in the Induction and Maintenance of Malignancy” by CE Butterworth, PP 169-203. **** http://www.ncbi.nlm.nih.gov/pubmed/12408314 and http://www.hindawi.com/journals/crp/2011/317659/ ***** http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185899/ and http://aor.sagepub.com/content/87/5/707.short and http://dspace.rubicon-foundation.org:8080/xmlui/handle/123456789/3900 and http://www.sciencedirect.com/science/article/pii/S0360301697000175

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Debilitating Fatigue

By far, the most common debilitating side effect of conventional cancer therapy is fatigue. Many cancer patients suffer from poor appetite and thus poor nutrition. WS tip: moderate,

outdoor exercise prior to meal time helps to stimulate appetite. Taking at least 2000mg omega-3 fats (predominantly EPA) improves appetite and arrests weight loss in chemo patients. ***

Free radical damage from the cancer itself damages mitochondria and impairs ATP production. Ongoing treatment poisons cells and impairs their ability to generate energy. *

WS tip: Boosting cellular energy production (especially of fats) often helps dramatically. Acetyl-l-carnitine, 1000mg, 3x/day **

Medium chain fatty acids (as from coconut oil) increase energy, improve appetite, and prevent cachexia in cancer patients by allowing ATP to be produced from fatty acids. This is particularly important given the need of a low-glycemic diet in cancer therapy. ****

Cannabinoids from marijuana (which are now available in prescription drugs) have been shown to be effective for nausea relief and low appetite in cancer patients.*****

* http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2684512/** http://onlinelibrary.wiley.com/doi/10.3322/canjclin.52.6.316/pdf and http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3063878/ *** http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3012235/ **** http://www.ncbi.nlm.nih.gov/pubmed/3219268 and Medium chain triglycerides. Monograph. Altern Med Rev, 7 (2002) 418-420 ***** http://onlinelibrary.wiley.com/doi/10.3322/caac.21260/full

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Anti-Cancer Choices

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Empowerment

* from “Knockout” by Suzanne Somers, p. 147-162.

“You see, the one thing that's known in oncology that the general public doesn't know is that tumors can change their characteristics based on these factors.

With good nutrition, a tumor will become very benign in its behavior. In labs, the animal will live much longer. But if you take the same animal and give it a bad diet and toxins, the tumor will change its characteristics and become highly aggressive, highly invasive, and kill the animal quite quickly.”

- Dr. Russell Blaylock, MD

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Supportive Care for All Cancer Patients

Implement all of the preventive actions covered in Part 1 of this course, especially the components of sleep, exercise, stress reduction, and spiritual connection. Express emotions.

Build up the body with strong, clean nutrition prior to any treatment. Ensure nutrient sufficiency – where possible, with labwork (e.g. zinc, magnesium, Vitamin D, Vitamin A, CoQ10, Vitamin B12, B6, Folate).

Maximize intake of healing vegetables and fruits, especially dark leafy greens, garlic/onion family, berries, (if in liquid form, try to do blended vs. juicing)

Eliminate all beverages except organic green tea, herbal teas, and clean water. Eliminate all coffee, even decaf, and carbonated beverages.

Make the diet as close to 100% organic as possible. Make the diet low glycemic. Eliminate all added sugars/sweeteners & foods made with flour. (Cancer cells thrive on glucose)

Eliminate all dairy foods (a major source of growth factors), peanuts and grains (aflatoxins, red meat (major source of iron), and alcohol (extra stress on the liver)

Ensure optimal digestion. Eating hygiene. – WS tip: as a reminder, both chemotherapy and radiation can cause major damage to the mucosal lining of the gut

and thus nutrient absorption. Support gut healing constantly. Killing cancer cells generates much debris and toxins. Thin the blood with omega-3 fats (e.g. 1500mg omega-3s,

2x/day) combined with DLGA (e.g. borage, evening primrose oils, 500mg 2x/day) and proteolytic enzymes (must be taken on an empty stomach). WS tip: a good dose for this purpose is 4 Wobenzyme tablets, 3x/day. *

Support the liver with high intake of cruciferous vegetables. Support the kidneys with fresh lemon juice in water multiple times daily. Do not be constipated.

Boost immune system effectiveness. Increase NK cells (note: the choices highlighted in this presentation are not potent antioxidants). Boost D to at least 70 ng/ml.

Increase oxygenation. Practice belly breathing. Address macrocytic anemia and/or sleep apnea.

* Contraindicated for those with ulcers or gastritis.

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Boosting Natural Killers

Boosting natural killer cell number and function is helpful regardless of treatment used.

Many natural substances have been studied and found effective in boosting natural killer cell number and action to varying degrees e.g. IP6/inositol, l-glutamine, melatonin, lactoferrin (from colostrum), garlic, curcumin, a variety of mushroom extracts (incl. AHCC and PSK), EMRB, mistletoe extract, and transfer factors.

Moderate exercise increases NK count and activity. Recommend a return to mild-to- moderate exercise as soon as possible post-surgery. #

Given everything I have researched, a few specific substances show the greatest, consistent postive impact on NK cells and/or minimizing NK suppression post-surgery. WS tip: again, ideally, begin these 1-2 wks prior to sugery and continue 2-3 mos:

– PSK, an extract from the Coriolus mushroom, dramatically improved 10-yr survival incolon cancer patients from 52% to 82%. Studied in multiple other cancers as well. WS tip: look for “Krestin PSK” in particular, 1000mg, 3x/day **

– AHCC (active hexose correlated compound) is extracted from a family of mushrooms thatincludes shitake. Increased NK cells by 2.5X after 2 wks of use in 85% of patientparticipants. WS tip: 1000mg, 3x/day. ***

# http://www.sciencedirect.com/science/article/pii/S2314853513000334** http://www.ncbi.nlm.nih.gov/pubmed/14997197 and http://www.ncbi.nlm.nih.gov/pubmed/3959339 and http://www.ncbi.nlm.nih.gov/pubmed/7910230 and http://www.ncbi.nlm.nih.gov/pubmed/18771350 and http://www.ncbi.nlm.nih.gov/pubmed/1977861 and http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2829500/ *** http://naturalmedicinejournal.net/pdf/original_research_AHCC_.pdf and http://bit.ly/1Lw1RVE and http://bit.ly/1BO7RXv http://www.ahccpublishedresearch.com/studies/AHCC_20_0103.html and http://www.ahccpublishedresearch.com/studies/AHCC_08_1002.html

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Boosting Natural Killers

Given everything I have researched, a few specific substances show the greatest, consistent postive impact on NK cells and/or minimizing NK suppression post-surgery. WS tip: again, ideally, begin these 1-2 wks prior to sugery and continue 2-3 mos:

– Mistletoe increase NK cell cytotoxicity and prevented any significant decrease in NK cellspost-surgery. Brands such as Iscador require prescription in the US. *

– EMRB (enzymatically modified rice bran) nearly doubled NK counts in multiple myelomapatients after 2 months use. Dramatically extended survival in hepatocellular carcinoma.WS tip: 2000mg/day for cancer; 500mg/day for preventive. **

* http://www.ncbi.nlm.nih.gov/pubmed/17341882 and http://onlinelibrary.wiley.com/doi/10.1046/j.1432-1033.2002.02932.x/abstract andhttp://www.medsci.org/v12p0042.htm and http://www.hindawi.com/journals/bmri/2014/785479/ ** http://www.lifeextension.com/Magazine/2015/1/Activate-Your-Natural-Killer-Cells/Page-01 and http://www.ncbi.nlm.nih.gov/pubmed/22941038 and http://www.ncbi.nlm.nih.gov/pubmed/21187503

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Powerful Role of Nf-kB

NF-kB is a transcription factor (i.e. a traffic cop for inflammation). NF-kB is triggered within a cell in response to oxidative stress,

inflammation, tobacco, viral infection, and many other threats. It upregulates DNA transcription, the overall responsiveness of the cell (including replication in cancer). *

Good guy gone wrong...– Triggers an exponentially more aggressive immune response. Helpful in combating

infections. Normally, a tightly-regulated event.– Triggers more aggressive cancer growth. Harmful because it becomes dysregulated. In

some cancers, gene mutations leave Nf-kB unregulated and consistently “turned on”.NF-kB allows cancer cells to deny apoptosis. It is already elevated in many inflammatorydiseases. #

Blocking or reducing the level of NF-kB allows natural killer cells to be more effective. It also can allow chemotherapy to be more effective. **

Many natural substances with reported “anti-cancer” properties inhibit Nf-kB e.g. aloe, resveratrol, curcumin, ginger, garlic, EPA (O3 from fish oil), clove, birch bark, milk thistle, oleander, boswellia, capsaicin.*

This may be the reason why a diet high in vegetables and fruits and spices has chemopreventive properties. ##

* http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3148942/# http://www.nature.com/nrc/journal/v2/n4/full/nrc780.html and http://www.ncbi.nlm.nih.gov/pubmed/16724054** http://www.ncbi.nlm.nih.gov/pubmed/17201139 and http://www.ncbi.nlm.nih.gov/pubmed/11896607 ## http://www.ncbi.nlm.nih.gov/pubmed/19482682 and http://www.ncbi.nlm.nih.gov/pubmed/15659827

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Curcumin

A potent, anti-inflammatory polyphenol extract from the herb turmeric. Perhaps the most heavily studied natural substance regarding cancer prevention and treatment outside

of EGCG (green tea). Aggressive NfkB inhibition is credited with curcumin’s ability to inhibit cancer cell proliferation,

invasion, new blood vessel formation, and metastasis. # Curcumin impairs VEGF and many other growth factors that promote angiogenesis. * Research shows powerful tumor regression results in both in vitro and in vivo studies across a very

wide array of cancers. However, it must be in a well-absorbed form. Theracurmin is a new colloidal form that shows impressive absorption (other good options are Meriva, BCM-95) ##

The potentially synergistic effect of curcumin and omega-3s are being studied for increasing NK cytotoxicity, especially in regard to pancreatic cancer. ***

In high doses (e.g. 2 grams, 4x/day), curcumin has a strong pro-oxidant effect which induces apoptosis in cancer cells. Adding cellular glutathione (antioxidant ) stops this effect. ###

More research is needed on the efficacy of curcumin as a synergistic part of conventional cancer treatment. There are greatly mixed results regarding curcumin being taken along with chemotherapy, varying dramatically based on the kind of cancer and the particular chemo drug(s) being used. ** WS tip: a conservative recommendation is that curcumin not be used during chemotherapy until at least 2 weeks after completion. Or the specific chemo agent can be researched. ****

# http://www.ncbi.nlm.nih.gov/pubmed/18479807 , http://www.ncbi.nlm.nih.gov/pubmed/25937435 ## http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4110570/ * http://www.ncbi.nlm.nih.gov/pubmed/18596194 and http://www.ncbi.nlm.nih.gov/pubmed/18467956** http://www.ncbi.nlm.nih.gov/pubmed/12097302 and http://www.ncbi.nlm.nih.gov/pubmed/10094841*** http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4440907/ and http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=7793062&fileId=S0007114509993667 ### http://www.ncbi.nlm.nih.gov/pubmed/17640567 **** http://www.curcuminresearch.org/cancer.html and http://www.greenmedinfo.com/disease/cancers-all?ed=5655

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The Power of Belief

Insist on choosing an oncologist and physician who understand their supportive role, work from a place of positivity, and practice positively fueling the patient's belief system.

“Telling a cancer patient they are unlikely to get well (in the name of “truth”) is about as potent of a harmful force as prescribing them days of IV toxins. It should be a prosecutable, medical crime to take someone's hope away. It is a death sentence.”

This is where the coach presents a very powerful bridge to the healing power of the mind. A powerful healing step is to encourage your client to choose the mode of treatment that

they most believe in...that resonates with them personally. Regardless of what others think. Resist giving your personal, impassioned opinions.

* I highly recommend “The Biology of Belief” by Dr. Bruce Lipton to further explore this topic.

“I don't care if it's cancer or heart disease or severe, crippling arthritis, the most important thing I can instill into the patient is the belief that he or she can get well. Once a doctor instills that confidence, the patient takes part in it. It becomes a dance. Belief is over 50% of the battle. If your intention and belief are strong enough, you can change your DNA.

- Dr. Stephen Sinatra, MD

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The Antioxidant Conundrum

Antioxidants help to keep the rest of the body healthy during treatment, but they might also interfere with the effective action of chemotherapy, in particular for drugs that work by inducing strong free radical damage to cancer cells.

A variety of antioxidants have been clinically shown to protect the heart, liver, kidney, muscles, and brain from the damaging effects of chemotherapy e.g. Co-Q10, N-acetyl-cysteine (NAC), glutathione, Vitamin A, ginkgo biloba, and Vitamin C. *

Individuals choose various strategies for supporting their bodies when choosing to use chemotherapy e.g.

1) Take a month to build up the body beforehand with aggressive antioxidant intake prior tobeginning chemotherapy. Then stop taking all antioxidants for the duration of chemo rounds andresume again 2-3 weeks post-treatment.

2) Continue throughout treatment to take high-dose antioxidants in order to maximize healthywhole-body response and promote detoxification.

3) Stop antioxidant support just for a few days before each round of chemo and ~5 days afterward(assuming one every 2-3 weeks), supporting the body intermittently for the ~10 days inbetween rounds.

● A client's belief system will play heavily into what they choose. We need to honor this!● Understanding the mode of action of the particular chemotherapy agent may help a client

to make the best decision for him/herself e.g. avoiding supplemental antioxidants for those thatact via free radical damage or avoiding supplemental folate for those that block folate metabolism.However, most chemo drugs have multiple modes of action.

* http://www.ncbi.nlm.nih.gov/pubmed/11008323 and http://www.ncbi.nlm.nih.gov/pubmed/12044557 and http://www.ncbi.nlm.nih.gov/pubmed/11603656** http://www.lifeextension.com/Protocols/Cancer/Chemotherapy/Page-03 (see table 1, half-way down the page)

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The Antioxidant Conundrum

“Most chemo drugs inhibit cancer growth and kill cancer cells by mechanisms having nothing to do with free radical damage. Even those that do have multiple modes of action. Studies have even been done to show this.” **

“The final stage of cancer development is of critical importance in understanding the value of antioxidant vitamins in cancer treatment. Even after a cancer has formed, further free radical damage can make the cancer much more aggressive. By inhibiting further free radical damage to the cell's DNA, advancement of the aggressiveness, at the least potentially, can be blocked.” *

From “Natural Strategies for Cancer Patients” by Dr. Russell Blaylock (p. 156-166)*** http://www.ncbi.nlm.nih.gov/pubmed/11795881 ** https://uviva.com/doc/PROPAX-antioxidant-interactions.pdf * http://www.ncbi.nlm.nih.gov/pubmed/9530648

“ The hypotheses that antioxidants' inhibition of free-radical activity may negate cytotoxic properties of some cancer therapies have been dependent on naïve and innacurate assumptions.” ***

- Dr. Jerome Block, MD

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Acid/Alkaline (pH) Balance

● Foods have a residue or “ash” left behind after digestion. It can be acidic (primarily phosphate andsulfur) or alkaline (typically potassium, magnesium, calcium). Neither food category is “bad”. Weneed all of these minerals!

● Generally, animal proteins, esp. dairy, and grains and processed foods are acid-producing. And fruitsand vegetables are alkaline-producing. Fats (without minerals) are neutral.

● But let's clear up some confusion regarding pH!– pH outside the body doesn't necessarily have anything to do with pH inside. Blood pH is kept very, very

stable (~7.4). Acidic foods can be quite alkalizing (e.g. fresh lemon juice, fresh green juices).– The primary buffering system in the body is bicarbonate, not bones. With the kidneys secreting excess

byproducts. Higher protein intake increases the body's ability to handle protein loadbyproducts. Historically, dietary acid load has varied highly based on geography and food sourcesavailable throughout the year.**

– Cancer cells grow perfectly well in an alkaline millieu (as in the lab). They create an acidic environmentaround them due to high lactic acid production.

● However, alkalizing extracellular tissue might help to slow the progression of cancers. There isevidence that acidification of the tumor microenvironment represents an evolutionary advantage bothfor invasion and proliferation. ***

● Adding sodium bicarbonate to mouse drinking water decreased the incidence of prostate cancerdramatically. In another study, tumor pH was increased and resulted in reduced metastases. ****

* http://www.ncbi.nlm.nih.gov/pubmed/11842948** http://ajcn.nutrition.org/content/92/4/940.full *** http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3865727/ and http://www.ncbi.nlm.nih.gov/pubmed/21376230/ and http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4244550/ **** http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3694604/ and http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2834485/

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Acid/Alkaline (pH) Balance

WS tips for Alkalinity: ● Do this primarily via food! Boost potassium with high intake of dark leafy greens and

berries and blended green vegetables.● Consume fresh lemon juice in water frequently.● As adjunct therapy, boost alkalinity (not just pH) with supplemental magnesium,

potassium bicarbonate, and sodium bicarbonate. It is VERY important to increase slowly,as higher potassium will promote cellular detoxification.

● As a potential trial plan...Begin with 1/4 tsp sodium bicarbonate once daily and slowlyincrease over time to 1 tsp spread throughout the day. Potassium bicarbonate (e.g. Designsfor Health K+2 potassium) can be started at 300mg/dayand increased slowly to 900-1200mg/day (divided doses)(not to be used at all with potassium-sparing diuretic drugs). Drink sodiumbicarbonate water on an empty stomach to minimize digestive interference.

● Monitor sodium and potassium blood levels to ensure safeand effective absorption. More is not necessarily better!Check RBC magnesium for optimal (upper 1/3 TRR).

● If using reverse osmosis or distilled water, use a trace mineraldrop formula e.g. ConcenTrace

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FOOD CATEGORY High Alkaline Alkaline Low Alkaline Low Acid Acid High Acid

BEANS, VEGETABLES,

LEGUMES

Asparagus, Onions, Vegetable Juices,

Parsley, Raw Spinach, Broccoli,

Garlic, Barley Grass,

Dark Leafy greens

Okra, Squash, Green Beans, Beets, Celery,

Lettuces, Zucchini, Sweet Potato, Carob

Carrots, Tomatoes, Mushrooms,

Cabbage, Peas, Cauliflower, Turnip,

Beetroot, Olives,Potato Skins

Cooked Spinach, Kidney Beans,Whole soybean

(edamame)

Potatoes (without skins), Pinto Beans, Navy Beans, Lima

Beans

FRUIT

Lemons, Watermelon,

Limes, Grapefruit, Mangoes, Papayas

Dates, Figs, Melons, Grapes,

Papaya, Kiwi, Berries, Apples, Pears, Raisins

Oranges, Bananas, Cherries, Pineapple, Peaches, Avocados

Plums, Pasteurized Fruit Juices

Sour Cherries, Rhubarb, Canned

Fruit

Prunes, Sweetened Fruit

Juice

GRAINS, CEREALS

Amaranth, Millet, Lentils, Wild Rice,

Quinoa

Rye Bread, Sprouted Wheat, Spelt, Brown Rice

White Rice, Corn, Buckwheat, Oats, Rye, Whole wheat

White Bread, Pastries, Biscuits,

Pasta

MEAT

Liver, Oysters, Venison, Cold Water

Fish (e.g. trout, salmon, mackerel)

Turkey, Chicken, Lamb, Tilapia

Beef, Pork, Shellfish, Tuna,

Swordfish

EGGS & DAIRY Breast Milk Soy Milk, Goat Milk, Goat Cheese, Whey

Eggs, Butter, Yogurt, Buttermilk, Cottage

CheeseRaw Milk

Cheese, Homogenized Milk, Ice Cream, Custard

NUTS & SEEDS AlmondsSoaked/sprouted

seeds, Brazil nuts, Hazelnuts, Coconut

Sunflower and Pumpkin Seeds

Pecans, Cashews, Pistachios Peanuts, Walnuts

OILS Olive Oil Flax Seed Oil Coconut oil Corn Oil, Sunflower Oil, Margarine, Lard

BEVERAGESHerb Teas,

Lemon WaterGreen Tea, White Tea Ginger Tea Black Tea, Cocoa Coffee, Wine Beer, Liquor,

Soft Drinks

SWEETENERS, CONDIMENTS

Stevia XylitolRaw Honey

Maple Syrup, Rice Syrup

Processed Honey

White Sugar, Brown Sugar, Molasses,

Jam, Ketchup, Mayonnaise,

Mustard, Vinegar

Artificial Sweeteners, Chocolate

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Potential Aggressive Anti-Cancer Choices(pre, post, instead of other therapies)

All of the previously described Preventive and Supportive steps presented in both webinars. Daily mixed veggie & berry green drink with wheatgrass, 2-3x/day, for nutrient density Daily magnesium, potassium bicarbonate, sodium bicarbonate support for alkalinity Daily PSK and AHCC to boost NK function Every other week IV high-dose Vitamin C.* 4 grams curcumin twice daily every other week High-dose antioxidants every other week, including 500mg EGCG, 300mg alpha lipoic acid,

400mg Vitamin E, and 500mg s-acetyl glutathione, 10,000 IU mixed carotenoids, 500mg

quercetin: all twice daily 1500mg O3s + 500mg DGLA twice daily 20mg melatonin nightly MCP and High-dose mixed enzymes 3x/day Routine Hyperbaric Oxygen or Ozone Therapy** Removal/replacement of all Hg-amalgam fillings Removal of root canals Twice-daily meditation* http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4388666/ and http://www.ncbi.nlm.nih.gov/pubmed/24867961 and

http://www.webmd.com/cancer/news/20140205/intravenous-vitamin-c-may-boost-chemos-cancer-fighting-power ** http://www.ncbi.nlm.nih.gov/pmc/articles/PMC442111/

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Confidence & Knowledge

Each client is one, whole, single, unique person! Not a list of separate, unconnected symptoms or diagnoses.

Everything is interconnected. Everything.

If the true root causes of dis-ease are not addressed in conjunction with the medical triage process, then the dis-ease is likely to return. Often with more virulence.

Keep your focus on what kind of person has a disease diagnosis as opposed to what kind of disease a person has.

What is the dis-ease process trying to say or achieve?

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More Information

● A fascinating article summarizing recent research showing the existence of cancer “stem cells”which are not well-targeted with chemotherapy and are inspiring a new generation of targetedtherapies.http://www.the-scientist.com/?articles.view/articleNo/32396/title/Cancer-Stem-Cells-Really-Do-Exist-/

● An inspiring article to share with clients about surgery-induced metastasis and how to prevent itproactively:http://www.lifeextension.com/Magazine/2009/12/Preventing-Surgery-Induced-Cancer-Metastasis/Page-01

● A write-up about the debate over glutamine supplementation in cancer patients that might behelpful to share with concerned clients:http://www.huffingtonpost.co.uk/aidan-goggins/glutamine-and-cancer_b_2740348.html

● An excellent overall book on nutritional support during cancer treatment (both conventional andalternative): “Natural Strategies for Cancer Patients” by Dr. Russell Blaylock, MD, TwinStreams Press, 2003.

● An in-depth report resource you or your clients can purchase which summarize the state ofresearch into specific conventional and alternative remedies, by Dr. Ralph Moss:http://cancerdecisions.com/

● A comprehensive summary of research to date into the effectiveness of compounds formarijuana in combating cancer: http://onlinelibrary.wiley.com/doi/10.3322/caac.21260/full

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