Week 2 SpesificInfectionoftheLung - 5 November 2012.ppt

7/25/2019 Week 2 SpesificInfectionoftheLung - 5 November 2012.ppt

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Specifc inection o the

lung

Suga T. Anggawidjaja SpPA

UPH


2/41

DEFENSE MECHANSMS


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6/41

Cau!ed "# Mico"acte$iu%tu"e$culo!i! &tu"e$cle "acillu!'T()

The lung! a$e %o$e co%%onl#a*ected "# T(

ncidence +, due to ADS

D$ug $e!i!tant !t$ain! oM#co"acte$iu% a$e an inc$ea!ingp$o"le%


7/41

Mucocilia$# "lan-et

Epitel colu%na$/to$a- "e$ting-at"e$!ilia "e$!el go"letepithelSchneide$ian

Di!po!e! o pa$ticle! 0 to 123%

Cilia$# "eat d$i4e! %ucou! "lan-et

t$achea !wallowed 5 cough up


8/41

Al4eola$ %ac$ophage! p$otect al4eola$!pace

de$i4ed $o% "one %a$$owunde$go%atu$ation di4i!ion in in!te$!titiu% olung 6 ente$ al4eola$ !pace

Dealing pa$ticle! D 7 03%

8e$# !%all pa$ticle! Notphagoc#to!ed 5 a$e e9haled


9/41

NFECT:NS

No che!t di!ea!e ha! had a!d$a%atic a hi!to$# a! tu"e$culo!i!


10/41

0 patte$n'

P$i%a$#

Seconda$#


11/41

P;MA;< TU(E;CU=:SS

Ac>ui$ed

nitial e9po!u$e to %. tu"e$culo!i!

nhaling inected ae$o!ol "# coughing"# a pe$!on with ca4ita$# t"c.

nhaled o$gani!%! %ultipl# in al4eoli,

wh# al4eola$ %ac$ophage! cannot $eadil#

-ill the "acte$ia


12/41

p$i%a$#


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15/41

PU=M:NA;< TU(E;CU=:SS

P$i%a$# T(C

U!uall# child$en

A!#%pto%atic, ?H:N co%ple9

Pul%ona$# le!iondia%ete$ 12%%

Con!i!t o' cent$al @one o ca!eou! nec$o!i! !u$ounded"# pali!aded epitheloid hi!tioc#te!, =anghan! giant cell,l#%phoc#te!

=ea4ing a f"$ocalcifc nodule in the lung, no clinical!e>uelae

Tu"e$cle "acilli %a# "e !till p$e!ent, pe$!i!t a! 4ia"leo$gani!%! o$ #ea$! &e!p i%%unoco%p$o%i!ed)


16/41

P$i%a$# nection

U!uall# child$en

inhalation


17/41


18/41

Seconda$# T(C

;eacti4ation o old p$i%a$# in

=ocated in =ung apice!, !o%eti%e!"ilate$al

Hi!tologicall#' g$anulo%a!, cent$al@one o ca!eou! nec$o!i!

P$og$e!!ion B ho!t 5 4i$ulence Mo!t le!ion f"$ocalcifc !ca$!

&autop!#)


19/41

M=A;< T(C

idel# di!!e%inated, !%allg$anulo%a! in %an# o$gan! &lung,%eninge!, -idne#!, "one%a$$ow,li4e$


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St$i4e o$ e9cellenceto glo$i# ?:D

Week 2 SpesificInfectionoftheLung - 5 November 2012.ppt

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