Wednesday, 14 September Chapter 11 The Endocrine System • Classes of hormones • The adrenal gland • Fates of hormones • Control of hormone secretion • Hormone interactions (permissive effects) • Hypothalamus & Pituitary • The story of Aunt Dot • Endocrine disorders (lab next week)
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Wednesday, 14 September Chapter 11 The Endocrine System
Wednesday, 14 September Chapter 11 The Endocrine System. Classes of hormones The adrenal gland Fates of hormones Control of hormone secretion Hormone interactions (permissive effects) Hypothalamus & Pituitary The story of Aunt Dot Endocrine disorders (lab next week). 1QQ # 4 8:30 am. - PowerPoint PPT Presentation
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Wednesday, 14 SeptemberChapter 11 The Endocrine System
• Classes of hormones• The adrenal gland• Fates of hormones• Control of hormone secretion• Hormone interactions (permissive effects)• Hypothalamus & Pituitary• The story of Aunt Dot• Endocrine disorders (lab next week)
1QQ # 4 8:30 am1. What changes in hepatocyte metabolism are
produced by glucagon?
2. A) What advise would you give to a person who is a reactive hypoglycemic and B) provide the reasons for your advise.
3. Your patients plasma glucose level is 45 mg/dl. A) What hormone is responsible for her rapid heart rate, pale clammy skin, and irritability? B) Why does she have a headache?
1QQ # 4 9:30 am1. Explain in some detail how beta cells of the Islets of
Langerhans are affected by anticipating an excellent meal.
2. A) Describe a situation that would lead to the activation of the sympathetic nervous system. B) How does sympathetic stimulation affect the secretion from beta cells in the Islets of Langerhans? C) Why is this beneficial for the person in terms of fuel supply?
3. After an overnight fast, a patient arrives for an Oral Glucose Tolerance Test. The first blood sample (even before ingestion of the Tru-Glu cola shows a plasma glucose concentration of 150 mg/dl. A) Do you have the patient drink the Tru-Glu? Why or why not? B) What might you do next to determine what is “wrong” with your patient?
Class activity
• 24 students were hormones and we classified these hormones as amines, peptides or steroids, considered how they are synthesized and stored (or not) in secretory cells, transported in the plasma, the locations of their receptors in/on target cells, the nature of the response in target cells (latency & duration),
What regulates the secretion of cortisol and aldosterone?
Fig. 11.06Gonadal Steroids(not adrenal cortex)
King DS, Sharp RL, Vukovich MD, Brown GA, Reifenrath TA, Uhl NL, Parsons KA . Effect of oral androstenedione on serum testosterone and adaptations to resistance training in young men: a randomized controlled trial. JAMA 1999; 281(21):2020-8
Estrogens
Fast if freeSlow if bound
Be able to giveExamples.
T4 to T3 and Testosterone to Estradiol
Ex: Renin
What happens to hormones once released?
Factors that affect hormone secretion
Recall example: beta cells of Islets of Langerhans
Secretion is usually pulsative, may be diurnal.
Integrator!
Na+, K+, Ca++, etc. NE, ACh, etc. TRH, TSH, DA, etc.
Fig. 11.08
Thyroid hormone stimulates production of beta-adrenergic receptors, which increases the target cell’s responsiveness to EPI.