· Web viewTable S2. Genes regulated more than 3-fold absolute change following NF54 WT (WT) relative to bloodfed (BF) or Pfs47 KO (KO) relative to BF at 26 hours post ... Cell wall

Table S2. Genes regulated more than 3-fold absolute change following NF54 WT (WT) relative to bloodfed (BF) or Pfs47 KO (KO) relative to BF at 26 hours post-infection. Duplicate gene ID entries represent multiple probes for the same gene.

Gene ID FC AbsWT/BF

FC AbsKO/BF

Description Functional Class

AGAP013235 103.78238 AGAP012536-PA Anopheles gambiae str. PEST Uc

AGAP000151 95.17855 Hypothetical secreted protein precursor - signalP detected s/



AGAP011026 19.49875 5' nucleotidase - signalP detected s/met/nuc 5'

AGAP005689 14.572665 Trypsin-like serine protease - signalP detected s/protease


AGAP008291 11.834447 Trypsin - signalP detected s/met/aa Trypsin

AGAP012842 11.431733 Trypsin-5 pm/protease

AGAP012842 11.039069 Trypsin-5 pm/protease

AGAP001768 10.498411 Gamma-interferon inducible lysosomal thiol reductase - signalP detected s/imm Gamma-interferon

AGAP004383 10.440252 glutathione S-transferase D10 detox

AGAP001198 10.1015415 serine proteinase - signalP detected s/protease

AGAP006417 10.078912 SCP_euk: SCP-like extracellular protein domain s/antigen5

AGAP007858 9.871112 Lysyl-tRNA synthetase (class II) ps


AGAP004383 9.60058 glutathione S-transferase D10 detox


AGAP012710 9.486515 Histone H2B - NuA4 histone acetyltransferase complex - lipid particle nr

AGAP0000151

9.4513235 Hypothetical secreted protein precursor - signalP detected s/

AGAP007159 9.25539 Alpha crystallins pm

AGAP009049 9.2104025 Chitinase met/carb



AGAP001198 8.45171 serine proteinase - signalP detected s/protease

AGAP0000151

7.9903164 Hypothetical secreted protein precursor - signalP detected s/

AGAP002593 7.6491637 Apolipoprotein D/Lipocalin - signalP detected extmat

AGAP011950 7.5414495 caspase short class (AGAP011950-PA) Anopheles gambiae str. PEST st/apoptosis



AGAP010781 6.7329035 Furin 2 - ATP binding - protein amino acid phosphorylation - transmembrane receptor protein tyrosine kinase - transmembrane receptor protein

st


AGAP000586 6.590008 hypothetical protein AND_17723 uc

AGAP010198 6.393273 Ribonucleotide reductase, alpha subunit met/nuc

AGAP004916 6.3426857 Ficolin - signalP detected s/imm Ficolin

AGAP010781 6.250681 Furin 2 - ATP binding - protein amino acid phosphorylation - transmembrane receptor protein tyrosine kinase - transmembrane receptor protein

st




AGAP006818 5.752401 Ribonucleotide reductase, beta subunit met/nuc

AGAP003357 5.688296 Conserved plasma membrane protein - 7 predicted membrane helices uc/memb membrane

AGAP012710 5.6227217 Histone H2B - NuA4 histone acetyltransferase complex - lipid particle nr

AGAP005260 5.6183386 Thymidylate kinase/adenylate kinase met/nuc



AGAP010198 5.460812 Ribonucleotide reductase, alpha subunit met/nuc



AGAP003230 5.041447 NAD+ ADP-ribosyltransferase Parp, required for poly-ADP ribosylation of nuclear

tm

AGAP004880 5.03591 Lactate dehydrogenase met/energy

AGAP005056 5.021069 CDK9 kinase-activating protein cyclin T st


AGAP008915 5.0007005 Gamma-glutamyltransferase - signalP detected s/met/aa Gamma-glutamyltransferase


AGAP002593 4.9406204 Apolipoprotein D/Lipocalin - signalP detected extmat

AGAP013202 4.8186026 Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p - extracellular region - fungal-type cell wall - biological_process - - signalP detected

extmat

AGAP010363 4.8121343 Chitin-binding domain type 2 - signalP detected extmat

AGAP003758 4.7701764 AGAP003758-PA Anopheles gambiae str. PEST uc


AGAP004743 4.656021 cargo transport protein EMP24 (p24 protein family) - signalP detected - 2 predicted membrane helices

pe membrane

AGAP006522 4.630528 Vesicle coat complex COPI, zeta subunit pe


AGAP007335 4.5226965 E3 ubiquitin ligase involved in syntaxin degradation prot

AGAP007827 4.500448 Enolase met/carb

AGAP007158 4.4920444 Alpha crystallins pm

AGAP006799 4.4878664 Ferredoxin met/energy

AGAP006048 4.4658155 Cytochrome P450 CYP4/CYP19/CYP26 subfamilies - signalP detected detox/ox

AGAP001421 4.3955903 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit nr

AGAP012873 4.38718 cycle - response to starvation - circadian regulation of gene expression - DNA binding - negative regulation of transcription from RNA polymerase II

tm





AGAP005369 4.3193974 Dosage compensation complex, subunit MLE tm

AGAP011885 4.270402 tRNA splicing endonuclease ps


extmat


AGAP011615 4.1775327 Chitin binding Peritrophin-A domain - signalP detected extmat

AGAP005260 4.147243 Thymidylate kinase/adenylate kinase met/nuc

AGAP010159 4.139983 dUTPase met/nuc

AGAP001974 4.0925155 Predicted seven transmembrane receptor - rhodopsin family - 7 predicted membrane helices

st membrane


AGAP006612 4.0286136 60S ribosomal protein L29 Culex quinquefasciatus ps

AGAP002564 4.0014677 Fructose-biphosphate aldolase met/carb

AGAP002496 3.978326 E3 ubiquitin ligase, VHL component (von Hippel-Lindau tumor suppressor in humans)

pm

AGAP002690 3.9680455 DNA-binding subunit of a DNA-dependent protein kinase (Ku70 autoantigen) nr


AGAP006594 3.9190316 Permease of the major facilitator superfamily - 12 predicted membrane helices

met/carb membrane

AGAP006818 3.9181678 Ribonucleotide reductase, beta subunit met/nuc



AGAP003230 3.8963516 NAD+ ADP-ribosyltransferase Parp, required for poly-ADP ribosylation of nuclear

tm

AGAP004752 3.856655 Methyltransferase-like protein uc



AGAP008523 3.7985113 tRNA cytosine-5-methylases ps

AGAP013533 3.7644744 Haemolymph juvenile hormone binding protein - signalP detected s/

AGAP013533 3.7132466 Haemolymph juvenile hormone binding protein - signalP detected s/


AGAP004606 3.6676342 Huntingtin interacting protein HYPK uc




AGAP008481 3.6433675 ribonuclease P protein subunit p30 Culex quinquefasciatus met/nuc



AGAP003926 3.6343615 Puromycin-sensitive aminopeptidase - signalP detected s/met/aa Puromycin-sensitive

AGAP003926 3.6336925 Puromycin-sensitive aminopeptidase - signalP detected s/met/aa Puromycin-sensitive


AGAP007844 3.6280036 Aspartyl-tRNA synthetase Translation ps

AGAP013386 3.623381 DNA polymerase zeta, catalytic subunit nr

AGAP011637 3.613269 Spliceosomal protein snRNP-U1A/U2B tm

AGAP004709 3.6063602 mitochondrial ribosomal protein, L17, Aedes aegypti ps

AGAP003987 3.5979295 Complement component 1, Q subcomponent binding protein/mRNA splicing factor SF2, subunit P32

imm

AGAP003331 3.5952468 Enolase-phosphatase E-1 met/aa


AGAP001152 3.5741475 transcription factor FET5 tf

AGAP008094 3.5553365 Presenilin enhancer-2 subunit of gamma secretase - 2 predicted membrane helices - Membrane anchor detected

uc/anchor membrAnchor

AGAP004362 3.543489 Glutamate/leucine/phenylalanine/valine dehydrogenases met/aa

AGAP000468 3.522037 similar to SP:Q00451:PRF1_LYCES 36.4 kDa proline-rich protein Lycopersicon esculentum, proline-rich cell wall protein (Medicago sativa) GI:3818416; - signalP detected

s/protinh

AGAP013386 3.5074167 DNA polymerase zeta, catalytic subunit nr

AGAP001777 3.500577 Multidrug resistance-associated protein/mitoxantrone resistance protein, ABC superfamily - 9 predicted membrane helices

detox membrane

AGAP004880 3.4966652 Lactate dehydrogenase met/energy

AGAP008582 3.4908454 Glycosyl hydrolase, family 38 - alpha-mannosidase - signalP detected s/met/carb Glycosyl

AGAP001933 3.4787982 serine/threonine-protein kinase vrk Aedes aegypti st

AGAP013519 3.47355 Small nuclear ribonucleoprotein (snRNP) LSM3 tm

AGAP008013 3.4642336 Mucin family member that functions as an osmosensor in the Sho1p-mediated HOG pathway with Msb2p - osmosensor - 1,3-beta-glucan biosynthetic process - signalP detected

s/mucin extmat

AGAP000732 3.438675 synaptic vesicle protein Aedes aegypti - 12 predicted membrane helices pe membrane

AGAP010099 3.4237702 cuticular protein 84, RR-2 family (AGAP010100-PA) Anopheles gambiae str. PEST - signalP detected

extmat


AGAP011403 3.3985167 GDNF-inducible zinc finger protein 1 - intracellular - zinc ion binding - protein binding - negative regulation of transcription from RNA polymerase

tm

AGAP013609 3.389286

AGAP011159 3.3872287 Cytochrome c oxidase subunit Va met/energy



AGAP012000 3.334291 Ficolin - signalP detected s/imm Ficolin


AGAP010644 3.3164594 mitochondrial 39S ribosomal protein L39 Culex quinquefasciatus ps

AGAP012957 3.2939422 Cytochrome P450 CYP4/CYP19/CYP26 subfamilies - signalP detected detox/ox

AGAP004563 3.2693443 Angiotensin I-converting enzymes - M2 family peptidases - signalP detected s/met/aa Angiotensin

AGAP000679 3.2570648 Aminoacylase ACY1 met/aa




AGAP001974 3.2304375 Predicted seven transmembrane receptor - rhodopsin family - 7 predicted membrane helices

st membrane

AGAP006630 3.2260115 6.3 kDa salivary peptide - signalP detected s/

AGAP008798 3.2202091 small GTPase mediated signal transduction - cellular_component - guanyl-nucleotide exchange factor - zinc ion binding - vesicle-mediated transport

pe

AGAP010816 3.2189617 CD109 antigen - serine-type endopeptidase inhibitor - extracellular space - extracellular region - protein binding - plasma membrane - anchored to - signalP detected

s/protinh

AGAP009701 3.218345 Alanyl-tRNA synthetase ps

AGAP009660 3.2085764 Adenylate kinase met/nuc

AGAP005265 3.2048526 Domain in histone families 1 and 5 nr


AGAP005371 3.188427 Acetylcholinesterase/Butyrylcholinesterase - signalP detected st

AGAP010081 3.1836143 AGAP010081-PA Anopheles gambiae str. PEST - 21 NetOglyc sites uc

AGAP002713 3.1714168 mitochondrial ribosomal protein, L49, Aedes aegypti ps

AGAP003488 3.1683037 Armadillo/beta-catenin-like repeat-containing protein - signalP detected pm

AGAP012914 3.1418285 Prefoldin alpha subunit pm

AGAP009660 3.1410315 Adenylate kinase met/nuc

AGAP012982 3.1318173 rhodopsin receptor 3 (AGAP001163-PA) Anopheles gambiae str. PEST - 7 predicted membrane helices

st membrane

AGAP006044 3.126019 STE20-like serine/threonine kinase MST st

AGAP010896 3.112382 F29D11.1 CE05765 WBGene00003071 locus:lrp-1 low density lipid receptor-rlated protein status:Partially_confirmed UniProt:Q04833 protein_id:CAA98124.1

st

AGAP009234 3.1084862 Mitochondrial translation elongation factor EF-Tsmt, catalyzes nucleotide exchange on EF-Tumt

ps

AGAP012302 3.1042728 Sulfate/bicarbonate/oxalate exchanger SAT-1 - 9 predicted membrane helices tr membrane

AGAP013398 3.1040995 Conserved secreted protein precursor - signalP detected s/ucs




AGAP003581 3.0720053 Sorbitol dehydrogenase detox


AGAP002967 3.0497336 ATP-dependent DNA helicase nr



AGAP002950 3.033513 hypothetical protein AaeL_AAEL006183 Aedes aegypti uc

AGAP000523 3.0325644 ATP synthase lipid-binding protein, mitochondrial - mitochondrial membrane - mitochondrion - mitochondrial proton-transporting ATP synthase complex - - 2 predicted membrane helices

tr membrane

AGAP002804 3.0115817 Niemann-Pick type C2 - signalP detected s/imm Niemann-Pick

AGAP003537 -8.479611 bric a brac 1 - protein binding - regulation of transcription - negative regulation of developmental pigmentation - regulation of developmental - 11 NetOglyc sites

tm

AGAP002905 -7.352332 odorant binding protein (AGAP002905-PA) Anopheles gambiae str. PEST - signalP detected OBP

s/OBP

AGAP010047 -7.059107 Hypothetical secreted protein precursor - signalP detected s/

AGAP005840 -5.62455 AGAP005840-PA Anopheles gambiae str. PEST - 17 NetOglyc sites uc

AGAP006174 -5.5717125 Calmodulin st

AGAP012985 -5.0277867 rhodopsin receptor 3 (AGAP001163-PA) Anopheles gambiae str. PEST - 7 predicted membrane helices

st membrane


AGAP010731 -4.7624598 CLIP-domain serine protease subfamily A (AGAP010731-PA) Anopheles gambiae str. PEST - signalP detected

s/protease

AGAP005156 -4.3876815 retained - male courtship behavior - axon guidance - regulation of female receptivity - salivary gland development - transcription activator - - 15 NetOglyc sites

tm

AGAP011084 -4.1926856 ATP-dependent RNA helicase tm

AGAP001474 -4.1510267 Dromyosuppressin - neuropeptide signaling pathway - negative regulation of heart contraction - neuropeptide hormone - signalP detected

st

AGAP008922 -4.119931 6.9 kDa salivary secreted peptide - signalP detected s/

AGAP004723 -4.1174383 Chromobox protein homolog 3 - nuclear centromeric heterochromatin - protein domain specific binding - negative regulation of transcription - spindle

tm

AGAP003740 -3.8404331 AGAP003740-PA Anopheles gambiae str. PEST uc


AGAP001511 -3.60473 Transcription regulator dachshund, contains SKI/SNO domain - signalP detected

tm

AGAP000054 -3.5667439 Leucine-rich repeat protein uc

AGAP004036 -3.563713 peroxinectin Culex quinquefasciatus - signalP detected detox/ox


st membrane

AGAP008368 -3.4001105 CD109 antigen - serine-type endopeptidase inhibitor - extracellular space - extracellular region - protein binding - plasma membrane - anchored to

s/protinh

AGAP011966 3.3937225 RNA polymerase II transcription termination factor TTF2/lodestar, DEAD-box superfamily

tm

AGAP007523 -3.3680778 Myosin class II heavy chain cs

AGAP007552 -3.3667853 U2-associated snRNP A' protein - 24 NetOglyc sites tm

AGAP012087 -3.345633 bicoid-interacting protein 3 - olfactory behavior - regulation of transcription - nucleus - protein binding - protein amino acid methylation -

tm


AGAP006731 -3.200024 Uncharacterized conserved protein, contains laminin, cadherin and EGF st


AGAP006380 -3.1363323 Lipid exporter ABCA1 - 10 predicted membrane helices met/lipd membrane


s/protease

AGAP009217 -3.0700402 CLIP-domain serine protease subfamily B (AGAP009217-PA) Anopheles gambiae str. PEST - signalP detected

s/protease



extmat

AGAP004987 33.684986 female sterile (1) homeotic - negative regulation of gene-specific transcription - terminal region determination - protein kinase - DNA binding - - signalP detected

tm






AGAP007990 6.0001225 UDP-glucuronosyl and UDP-glucosyl transferase - signalP detected - 2 predicted membrane helices

met/carb membrane



AGAP005501 4.790435 Predicted dehydrogenase detox

AGAP012279 4.7303977 Amiloride-sensitive sodium channel tr

AGAP007347 4.314009 Alpha-lactalbumin / lysozyme C - signalP detected s/imm Alpha-lactalbumin

AGAP006603 4.134049 Hypothetical secreted mucin - signalP detected s/mucin

AGAP007990 4.131758 UDP-glucuronosyl and UDP-glucosyl transferase - signalP detected - 2 predicted membrane helices

met/carb membrane

AGAP002769 4.0708137 Uncharacterized protein C5orf4 - iron ion binding - fatty acid biosynthetic process - oxidoreductase - integral to membrane - oxidation reduction -

met/lipd

AGAP007104 3.6089995 Polyprenyl synthetase met/int


AGAP008054 3.4748445 Insect pheromone-binding family - signalP detected s/

AGAP010934 3.460939 Ankyrin extmat


AGAP003995 3.3212812 Maltase glucoamylase - signalP detected s/met/carb Maltase


AGAP007347 3.2909606 Alpha-lactalbumin / lysozyme C - signalP detected s/imm Alpha-lactalbumin


AGAP001390 3.2681725 Notch homolog 1, translocation-associated (Drosophila) - regulation of epithelial cell proliferation involved in prostate gland development - - signalP detected

st/apoptosis

AGAP004771 3.2673302 Mucin-5AC - extracellular matrix structural constituent - extracellular region - fibril - cell adhesion - fibril organization - digestion - 139 NetOglyc sites

extmat

AGAP003493 3.250789 Predicted transporter (major facilitator superfamily) - 12 predicted membrane helices

tr membrane

AGAP012166 3.1943147 Phosphatidylinositol transfer protein SEC14 met/lipd

AGAP010863 3.1920595 Hypothetical secreted mucin - signalP detected s/mucin

AGAP011216 3.1056876 oxidase/peroxidase Aedes aegypti detox/ox

AGAP006416 3.0760503 Serine protease SP24D - signalP detected - 2 predicted membrane helices s/protease membrane

AGAP006194 3.0580213 Farnesoic acid 0-methyl transferase - signalP detected s/met/lipd Farnesoic

AGAP000338 3.0250657 isoprenoid biosynthetic process - cholesterol biosynthetic process - cytoplasm - phosphomevalonate kinase

met/lipd

AGAP012166 3.0000463 Phosphatidylinositol transfer protein SEC14 met/lipd

AGAP005829 -58.559406 Microtubule-binding protein involved in cell cycle control nr


AGAP006241 -52.22314 Innexin - 3 predicted membrane helices extmat membrane

AGAP004038 -44.856796 Chorion peroxidase - signalP detected detox/ox

AGAP007365 -43.951775 exuperantia - precatalytic spliceosome - nuclear mRNA splicing, via spliceosome - anterior/posterior axis specification, embryo - regulation of pole

tm





AGAP003087 -38.557 Conserved plasma membrane protein - signalP detected - 4 predicted membrane helices

uc/memb membrane

AGAP004962 -35.68563 Cyclin B nr

AGAP007365 -34.655598 exuperantia - precatalytic spliceosome - nuclear mRNA splicing, via spliceosome - anterior/posterior axis specification, embryo - regulation of pole

tm


AGAP006609 -33.634632 Synaptic vesicle transporter SVOP - 11 predicted membrane helices tr membrane

AGAP000835 -33.389294 UDP-N-acetylglucosamine transferase subunit ALG13 homolog - carbohydrate metabolic process - carbohydrate binding -

met/carb

AGAP006609 -32.868362 Synaptic vesicle transporter SVOP - 11 predicted membrane helices tr membrane

AGAP007280 -32.3322 nudel - egg activation - peptidase - proteolysis - extracellular region - serine-type endopeptidase - oocyte dorsal/ventral axis specification - 31 NetOglyc sites

pm/protease


AGAP009976 -31.503962 Conserved plasma membrane protein - 2 predicted membrane helices - Membrane anchor detected

uc/memb membrane membrAnchor

AGAP010789 -31.23779 Notch - regulation of cell differentiation - eye-antennal disc development - R1/R6 cell differentiation - germ-line stem cell maintenance - protein

tm




AGAP009216 -26.697138 CLIP-domain serine protease subfamily B (AGAP009217-PA) Anopheles gambiae str. PEST

pm/protease

AGAP009751 -25.843576 Angiotensin I-converting enzymes - M2 family peptidases met/aa

AGAP011235 -24.481003 Predicted histone tail methylase containing SET domain nr

AGAP010547 -24.460855 Trypsin-like serine protease pm/protease




uc/memb membrane

AGAP004963 -23.638897 Cyclin B nr

AGAP000835 -23.137173 UDP-N-acetylglucosamine transferase subunit ALG13 homolog - carbohydrate metabolic process - carbohydrate binding -

met/carb

AGAP007300 -22.967684 Alkaline phosphatase homologues st

AGAP004638 -22.966158 clip-domain serine protease, Aedes aegypti - signalP detected s/protease


AGAP006023 -22.20682 Aromatic amino acid hydroxylase met/aa

AGAP012577 -22.183397 cathepsin l Culex quinquefasciatus - signalP detected pm

AGAP001124 -20.464487 Aminomethyl transferase met/aa


AGAP008912 -19.994883 GTPase-activating protein uc

AGAP000427 -19.9703 Low-density lipoprotein receptors containing Ca2+-binding EGF-like st


AGAP007320 -19.100266 Conserved plasma membrane protein - 4 predicted membrane helices uc/memb membrane

AGAP008912 -18.843801 GTPase-activating protein uc



AGAP007300 -18.583214 Alkaline phosphatase homologues st

AGAP010831 -18.272266 KOG1366, KOG1366, Alpha-macroglobulin Posttranslational modification, protein turnover, chaperones

pm

AGAP005829 -17.733114 Microtubule-binding protein involved in cell cycle control nr

AGAP004719 -17.702873 Trypsin-like serine protease - signalP detected s/protease

AGAP007411 -17.60149 C-type lectin domain family 4, member f - integral to membrane - membrane - endocytosis - sugar binding - binding - receptor - signalP detected

st


AGAP009216 -17.29522 CLIP-domain serine protease subfamily B (AGAP009217-PA) Anopheles gambiae str. PEST

pm/protease

AGAP006241 -16.273258 Innexin - 3 predicted membrane helices extmat membrane

AGAP004802 -16.215267 4-hydroxyphenylpyruvate dioxygenase met/aa

AGAP012974 -16.144 dentin matrix protein 1 - extracellular matrix binding - positive regulation of cell-substrate adhesion - extracellular matrix organization - - signalP detected

extmat

AGAP010197 -16.13331 SOCS box protein SSB-1, contains SPRY domain uc



AGAP001127 -15.687529 Membrane glycoprotein LIG-1 - signalP detected s/imm Membrane



AGAP001544 -15.636089 Predicted E3 ubiquitin ligase - 31 NetOglyc sites pm


AGAP006989 -15.527342 Kinesin-like protein cs





AGAP001336 -14.567678 Sugar transporter/spinster transmembrane protein - signalP detected - 10 predicted membrane helices

tr membrane


AGAP004263 -14.423104 Haemolymph juvenile hormone binding protein - signalP detected s/

AGAP006370 -14.373859 Dosage compensation complex, subunit MLE - signalP detected tm

AGAP003331 -14.233737 Enolase-phosphatase E-1 met/aa

AGAP010531 -14.181266 Ficolin - signalP detected s/imm Ficolin

AGAP003354 -14.068886 SCP_euk: SCP-like extracellular protein domain - signalP detected s/antigen5

AGAP012352 -13.916405 ML domain - signalP detected s/imm ML

AGAP003331 -13.718863

5

Enolase-phosphatase E-1 met/aa


AGAP003515 -13.420917 Carbon-nitrogen hydrolase met/aa

AGAP010545 -13.400516

5

Trypsin-like serine protease pm/protease


AGAP005888 -13.205099 Catecholamines up - membrane - transmembrane transport - metal ion transmembrane transporter - metal ion transport - integral to plasma membrane - - signalP detected

tr


uc/memb membrane




AGAP004018 -12.925081 Syntrophins (type gamma) - 15 NetOglyc sites extmat


AGAP008638 -12.818421 Histone H1.0 - nucleus - chromosome - nucleosome assembly - Golgi apparatus - nucleosome - DNA binding

nr

AGAP009874 -12.697316 cuticular protein 76, RR-1 family (AGAP009874-PA) Anopheles gambiae str. PEST - signalP detected

extmat

AGAP011065 -12.660797 Transcription factor SIX tf

AGAP009751 -12.654149 Angiotensin I-converting enzymes - M2 family peptidases met/aa


AGAP012040 -12.581551 Mucin-5AC - extracellular matrix structural constituent - extracellular region - fibril - cell adhesion - fibril organization - digestion - 18 NetOglyc sites

extmat


AGAP005952 -12.266135 AT4G18670 - structural constituent of cell wall - protein binding - signalP detected

extmat


AGAP001377 -12.179789 serine protease inhibitor, non-inhibitory (AGAP001377-PA) Anopheles gambiae str. PEST - signalP detected

s/protinh




s/protinh

AGAP010699 -11.927549 Chromatin remodeling complex WSTF-ISWI, small subunit tm

AGAP005245 -11.923935 Proteins containing BTB/POZ and Kelch , involved in regulatory/signal transduction processes

st



AGAP007505 -11.590027 Serine carboxypeptidases (lysosomal cathepsin A) - signalP detected s/met/aa Serine

AGAP011765 -11.455876 BPTI/Kunitz family of serine protease inhibitors - signalP detected s/protinh Kunitz


AGAP004963 -11.354855 Cyclin B nr



AGAP002198 -11.29748 Methyltransferases met/int


AGAP009221 -11.231308 serine protease inhibitor (AGAP009221-PA) Anopheles gambiae str. PEST - signalP detected

s/protinh

AGAP003691 -11.194934 serine protease Culex quinquefasciatus - signalP detected s/protease

AGAP004530 -11.124219 Leucine zipper tumor suppressor 2 - membrane - microtubule organizing center - positive regulation of cell death - mitosis - cytoplasm -

st/apoptosis



s/protinh

AGAP003015 -10.928461 Argininosuccinate synthase met/aa



AGAP013192 -10.885994 SCP_euk: SCP-like extracellular protein domain - signalP detected s/antigen5

AGAP013060 -10.865882 hypothetical protein AaeL_AAEL008802 Aedes aegypti - signalP detected s/


AGAP000650 -10.762423

5

Ribonuclease P 40kDa met/nuc

AGAP008738 -10.737859 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E - 11 NetOglyc sites

tr



AGAP012900 -10.670447 Papain family cysteine protease pm/protease

AGAP002503 -10.658615 Acyl-CoA synthetase met/lipd

AGAP005766 -10.628974 Larval serum protein 1 beta - lipid particle - transport - oxygen transporter - nutrient reservoir - extracellular region - larval serum protein - signalP detected

tr


AGAP001544 -10.507862 Predicted E3 ubiquitin ligase - 31 NetOglyc sites pm

AGAP000327 -10.47428 Tyrosine aminotransferase met/aa




AGAP011065 -10.327399 Transcription factor SIX tf

AGAP012040 -10.323953 Mucin-5AC - extracellular matrix structural constituent - extracellular region - fibril - cell adhesion - fibril organization - digestion - 18 NetOglyc sites

extmat


AGAP002503 -10.319077

5

Acyl-CoA synthetase met/lipd


AGAP007160 -10.199758 Alpha crystallins pm


s/protease

AGAP004318 -10.132616 CLIP-domain serine protease subfamily C (AGAP004318-PA) Anopheles gambiae str. PEST - signalP detected

s/protease

AGAP003250 -10.07947 Trypsin - signalP detected s/met/aa Trypsin



s/protinh

AGAP009054 -9.922854 Possible membrane-associated motif in LPS-induced tumor necrosis factor alpha factor

imm

AGAP011507 -9.883312 Acetylcholinesterase/Butyrylcholinesterase st

AGAP002134 -9.867925 Serine/threonine-protein phosphatase 1 regulatory subunit 10 - zinc ion binding - protein binding - transcription regulator - transcription - - signalP detected

tm



AGAP004534 -9.7532015 cathepsin b Aedes aegypti - signalP detected pm




s/protease


AGAP010814 -9.658356 KOG1366, KOG1366, Alpha-macroglobulin Posttranslational modification, protein turnover, chaperones - signalP detected

pm

AGAP008118 -9.639723 Serine/threonine protein kinase st

AGAP008810 -9.634033 Retinoid- and fatty acid-binding glycoprotein - microtubule associated complex - receptor binding - endocytic vesicle - lipid particle - Wnt receptor

cs


s/protinh




AGAP008355 -9.498607 Anopheles gambiae str. PEST AGAP012553-PA Anopheles gambiae str. PEST uc




s/protinh


AGAP013503 -9.419397 vitellogenin 2 - signalP detected storage/


s/protease


AGAP008012 -9.375832 Hypothetical secreted mucin - signalP detected s/mucin

AGAP003486 -9.339586 nucleolar and coiled-body phosphoprotein 1 - positive regulation of transcription - regulation of protein import into nucleus - box H/ACA snoRNA - 23 NetOglyc sites

tm

AGAP008449 -9.3229475 cuticle protein Culex quinquefasciatus - signalP detected extmat

AGAP009670 -9.313692 serine protease inhibitor (AGAP009670-PB) Anopheles gambiae str. PEST - signalP detected

s/protinh

AGAP013186 -9.245031 Protein phosphatase 1, regulatory subunit, - signalP detected s/st Protein



s/protease



s/protease


AGAP002720 -9.060272 Cysteine proteinase Cathepsin F - signalP detected pm


AGAP001753 -9.023059 15-hydroxyprostaglandin dehydrogenase met/lipd


s/protinh


AGAP007336 -8.905075 Cytoplasmic linker protein 190 - spindle microtubule - fusome - microtubule-based process - cellularization - Golgi apparatus - cell cortex

cs


AGAP000999 -8.875668 Toll-like receptor (AGAP010669-PA) Anopheles gambiae str. PEST - signalP detected

s/imm Toll-like


st membrane

AGAP003090 -8.80004 KOG0895, KOG0895, Ubiquitin-conjugating enzyme Posttranslational modification, protein turnover, chaperones

pm





AGAP010399 -8.744462 Flavin-containing monooxygenase detox

AGAP011219 -8.742361 Cell division cycle-associated protein 8 st

AGAP002198 -8.710751 Methyltransferases met/int


AGAP009128 -8.687556 Mitochondrial carrier protein - 3 predicted membrane helices met/energy membrane


AGAP010830 -8.655078 CD109 antigen - serine-type endopeptidase inhibitor - extracellular space - extracellular region - protein binding - plasma membrane - anchored to - signalP detected

s/protinh

AGAP008045 -8.647209 Transcription initiation factor IID subunit tm

AGAP010398 -8.631293 Flavin-containing monooxygenase detox





AGAP005767 -8.557229 Larval serum protein 1 beta - lipid particle - transport - oxygen transporter - nutrient reservoir - extracellular region - larval serum protein - signalP detected

tr

AGAP006098 -8.555769 Nanos uc



AGAP002268 -8.515991 cell adhesion molecule Aedes aegypti - signalP detected extmat

AGAP009128 -8.5086975 Mitochondrial carrier protein - 3 predicted membrane helices met/energy membrane


AGAP009786 -8.433315 Glycinamide ribonucleotide synthetase (GARS)/Aminoimidazole ribonucleotide synthetase (AIRS)

met/nuc


AGAP009493 -8.367952 Acetylcholine receptor - signalP detected - 4 predicted membrane helices st membrane

AGAP004170 -8.312678 hypothetical protein AND_11656 uc



AGAP008739 -8.210671 BTB (POZ) domain containing 9 - cellular_component - biological_process - molecular_function - protein binding - cell adhesion

extmat


AGAP001076 -8.209708 Cytochrome P450 CYP4/CYP19/CYP26 subfamilies detox/ox


s/protinh


AGAP002156 -8.153768 AGAP002156-PB Anopheles gambiae str. PEST - 7 predicted membrane helices st membrane

AGAP012328 -8.136521 clip-domain serine protease, Aedes aegypti pm/protease




AGAP010197 -8.070226 SOCS box protein SSB-1, contains SPRY domain uc




s/protinh



AGAP000180 -7.942948 Phosphoribosylamidoimidazole-succinocarboxamide synthase met/nuc



AGAP012375 -7.8333817 Protein aurora borealis - activation of protein kinase - cytoplasm - nucleus st

AGAP006441 -7.8187323 GTP cyclohydrolase I met/int

AGAP008015 -7.813656 Nuclear envelope protein lamin, intermediate filament superfamily - 19 NetOglyc sites

nr



AGAP004731 -7.796418 secretory Phospholipase A2, Aedes aegypti - signalP detected s/met/lipd secretory

AGAP004286 -7.76769 dentin sialophosphoprotein - cellular response to cell-matrix adhesion - odontogenesis - odontogenesis of dentine-containing tooth - biomineral

extmat


AGAP011604 -7.7276607 Haze-protective mannoprotein that reduces the particle size of aggregated proteins in white wines - fungal-type cell wall organization - fungal-type - signalP detected

extmat

AGAP011790 -7.72477 CLIP-domain serine protease subfamily A (AGAP011790-PB) Anopheles gambiae str. PEST - signalP detected

s/protease


st

AGAP006781 -7.673663 Dentin sialophosphoprotein - multicellular organismal development - collagen binding - extracellular matrix structural constituent - biomineral

extmat



AGAP009338 -7.642896 Anaphase promoting complex, Cdc20, Cdh1, and Ama1 subunits nr



s/protease




AGAP002594 -7.4937434 Apolipoprotein D - lipid metabolic process - transporter - protein binding - lipid transporter - lipid binding - extracellular space - signalP detected

tr

AGAP008118 -7.4910283 Serine/threonine protein kinase st

AGAP008843 -7.4908824 Aquaporin (major intrinsic protein family) - 6 predicted membrane helices tr membrane


AGAP003878 -7.44739 carboxypeptidase N, polypeptide 2 - biological_process - molecular_function - cellular_component - protein binding - extracellular region - signalP detected

s/protease

AGAP005388 -7.4291964 si:ch211-199i15.4 - lipid binding - cytoplasmic vesicle - Golgi apparatus - membrane - endosome - transporter

tr

AGAP010548 -7.4062114 ZC101.2e CE18424 WBGene00006787 locus:unc-52 IG (immunoglobulin) superfamily (17 ), Low-density lipoprotein receptor domain class A (3 ), Laminin

st

AGAP001989 -7.399603 hyp37.3 secreted salivary gland protein - signalP detected s/

AGAP007647 -7.3673873 Dentin sialophosphoprotein - multicellular organismal development - collagen binding - extracellular matrix structural constituent - biomineral - 13 NetOglyc sites

extmat

AGAP008638 -7.364478 Histone H1.0 - nucleus - chromosome - nucleosome assembly - Golgi apparatus - nucleosome - DNA binding

nr


AGAP001624 -7.3380995 Vacuolar H+-ATPase V0 sector, accessory subunit S1 (Ac45) - signalP detected tr


AGAP003366 -7.3038874 Predicted dual-specificity phosphatase uc

AGAP013094 -7.29905 Fatty acyl-CoA elongase/Polyunsaturated fatty acid specific elongation enzyme - 7 predicted membrane helices

met/lipd membrane


AGAP003453 -7.2817645 Conserved plasma membrane protein - 2 predicted membrane helices - 15 NetOglyc sites

uc/memb membrane


s/protease





AGAP010730 -7.1739097 CLIP-domain serine protease subfamily A (AGAP010731-PA) Anopheles gambiae str. PEST

pm/protease

AGAP000885 -7.171703 Puromycin-sensitive aminopeptidase - signalP detected s/met/aa Puromycin-sensitive

AGAP012107 -7.168085 Ubiquitin-protein ligase pm

AGAP012032 -7.1391463 ZC101.2e CE18424 WBGene00006787 locus:unc-52 IG (immunoglobulin) superfamily (17 ), Low-density lipoprotein receptor domain class A (3 ), Laminin

st

AGAP008141 -7.1362042 Argininosuccinate lyase met/aa


s/protinh


s/protinh



st


st membrane

AGAP010715 -6.963588 Actin binding protein Anillin - 13 NetOglyc sites nr




AGAP010909 -6.887632 Sequence-specific single-stranded-DNA-binding protein - 21 NetOglyc sites nr

AGAP002890 -6.879273 Lipid storage droplet-2 - microtubule associated complex - lipid metabolic process - regulation of transport - protein binding - lipid particle

cs

AGAP013215 -6.87672 Ring finger prot



AGAP012875 -6.841956 pupal-specific cuticular protein CP2c - signalP detected extmat

AGAP008694 -6.8341923 myosin, heavy chain 6, cardiac muscle, alpha - ventricular cardiac muscle tissue morphogenesis - atrial cardiac muscle tissue morphogenesis - cardiac

cs

AGAP003301 -6.827169 M-phase inducer phosphatase nr



s/protease



s/protinh



cs



AGAP009609 -6.7105107 Homogentisate 1,2-dioxygenase met/aa

AGAP011622 -6.706374 Anaphase promoting complex, Cdc20, Cdh1, and Ama1 subunits pm


AGAP012375 -6.68662 Protein aurora borealis - activation of protein kinase - cytoplasm - nucleus st


AGAP006921 -6.6778965 GULP, engulfment adaptor PTB domain containing 1 - apoptosis - phagocytosis, engulfment - lipid transport - cytoplasm - protein binding

st/apoptosis

AGAP010730 -6.663543 CLIP-domain serine protease subfamily A (AGAP010731-PA) Anopheles gambiae str. PEST

pm/protease


AGAP007123 -6.594686 Dimethylglycine dehydrogenase precursor met/aa

AGAP008061 -6.590083 Chitinase - signalP detected met/carb



s/protinh


AGAP000751 -6.4508996 Spindle assembly checkpoint protein nr

AGAP002192 -6.430813 Isocitrate dehydrogenase, gamma subunit met/aa

AGAP008444 -6.429029 Adult cuticle protein 1 - structural constituent of adult chitin-based cuticle - signalP detected

extmat


AGAP012107 -6.420297 Ubiquitin-protein ligase pm


AGAP001687 -6.405923 RhoGAP domain-containing protein - signal transduction - Rac GTPase activator - regulation of Rac protein signal transduction - intracellular

st




st

AGAP001116 -6.3231087 D-aspartate oxidase met/aa


AGAP004316 -6.261305 11.9 kDa salivary protein - signalP detected s/

AGAP003937 -6.257397 PDZ and LIM domain protein 7 - cell junction - cell differentiation - actin cytoskeleton - focal adhesion - ossification - receptor-mediated

extmat

AGAP011831 -6.257028 Uncharacterized conserved protein - 16 NetOglyc sites uc

AGAP005914 -6.2560816 Serine carboxypeptidase S28 - signalP detected s/met/aa Serine

AGAP007385 -6.2456713 AGAP007385-PA Anopheles gambiae str. PEST - signalP detected s/imm AGAP007385-PA

AGAP008694 -6.2401958 myosin, heavy chain 6, cardiac muscle, alpha - ventricular cardiac muscle tissue morphogenesis - atrial cardiac muscle tissue morphogenesis - cardiac

cs

AGAP000278 -6.234812 odorant binding protein (AGAP000278-PA) Anopheles gambiae str. PEST - signalP detected OBP

s/OBP


uc/memb membrane


AGAP011845 -6.2125406 Histone 2A nr

AGAP002925 -6.1829543 serine-type peptidase - signalP detected s/protease


uc/memb membrane

AGAP004239 -6.1758285 Polo-like serine/threonine protein kinase nr

AGAP004787 -6.173039 Acyl-CoA reductase - 2 predicted membrane helices met/lipd membrane

AGAP012154 -6.1518416 H+/oligopeptide symporter - 11 predicted membrane helices met/aa membrane


AGAP008363 -6.1322546 Cytochrome b5 met/energy


s/protinh


s/protinh

AGAP003027 -6.1049356 Neurogenic locus notch homolog protein 3 - calcium ion binding - nucleus - tissue regeneration - regulation of transcription, DNA-dependent - - signalP detected

tm

AGAP007817 -6.094748 Nuclear protein COP1 st



AGAP002075 -6.0764704 Dual specificity; serine/threonine and tyrosine kinase nr


AGAP012404 -6.053333 Alanine-glyoxylate aminotransferase AGT2 met/aa

AGAP000211 -6.0492787 pancreatic triacylglycerol lipase Culex quinquefasciatus met/lipd



AGAP010928 -6.031865 TPR repeat-containing protein uc


s/protease



s/protinh




AGAP008335 -5.858872 Synaptic vesicle transporter SVOP - signalP detected - 11 predicted membrane helices

tr membrane

AGAP009670 -5.826812 serine protease inhibitor (AGAP009670-PB) Anopheles gambiae str. PEST - s/protinh

signalP detectedAGAP008468 -5.826004 Animal-type fatty acid synthase met/lipd


AGAP002478 -5.810413 Cyclin B nr

AGAP003245 -5.758467 easter - zymogen activation - proteolysis - peptidase - defense response - serine-type peptidase - extracellular region - signalP detected

s/protease

AGAP007791 -5.7518363 C17E4.9 CE08258 WBGene00007646 locus:nkb-1 sodium\/potassium transporting ATPase beta chain status:Confirmed UniProt:Q93235 protein_id:CAB02752.1 - Membrane anchor detected

tr membrAnchor

AGAP009261 -5.749842 cAMP-regulated guanine nucleotide exchange factor - 16 NetOglyc sites st

AGAP009978 -5.7450514 Animal haem peroxidase - 6 predicted membrane helices detox/ox membrane


extmat


s/protease


s/protinh

AGAP011351 -5.633176 Uncharacterized conserved protein, contains DENN and RUN st


s/protinh


AGAP003591 -5.5903606 Leucine-rich repeat (LRR) protein, contains calponin homology domain cs


st membrane


uc/memb membrane


s/protease

AGAP005223 -5.539915 Apolipoprotein D/Lipocalin - signalP detected extmat

AGAP007045 -5.5297275 carboxypeptidase N subunit 2 Culex quinquefasciatus - signalP detected s/protease


s/protease





AGAP006186 -5.468997 endoplasmic reticulum-type (ACA6) (ECA3), nearly identical to SP:Q9SY55 Calcium-transporting ATPase 3, endoplasmic reticulum-type (EC 3.6.3.8) - 9 predicted membrane helices

tr membrane

AGAP003083 -5.4569826 Triglyceride lipase-cholesterol esterase - signalP detected s/met/lipd Triglyceride



AGAP006263 -5.403047 Arrestin st

AGAP011351 -5.392219 Uncharacterized conserved protein, contains DENN and RUN st



s/protinh

AGAP003550 -5.3735194 futsch - olfactory learning - neurofilament cytoskeleton organization - negative regulation of neuron apoptosis - axon cargo transport -

st/apoptosis



s/protinh

AGAP006781 -5.349425 Dentin sialophosphoprotein - multicellular organismal development - collagen binding - extracellular matrix structural constituent - biomineral

extmat

AGAP002830 -5.344905 C1-tetrahydrofolate synthase met/int


s/protease


s/protease

AGAP002721 -5.2750063 Tryptophan 2,3-dioxygenase met/aa


AGAP007500 -5.2622356 Lachesin - plasma membrane - morphogenesis of embryonic epithelium - septate junction - homophilic cell adhesion - maintenance of epithelial - signalP detected - 2 predicted membrane helices

extmat membrane


AGAP007122 -5.246978 Alpha tubulin cs

AGAP005763 -5.2361465 Tyrosine kinases st

AGAP012599 -5.216844 Nucleotide excision repair complex XPC-HR23B, subunit XPC/DPB11 nr


st membrane

AGAP002890 -5.209918 Lipid storage droplet-2 - microtubule associated complex - lipid metabolic process - regulation of transport - protein binding - lipid particle

cs

AGAP005125 -5.19475 Predicted E3 ubiquitin ligase pm


extmat


cs

AGAP011070 -5.1350446 Ras guanine nucleotide exchange factor - regulation of small GTPase mediated signal transduction - sexual reproduction - positive regulation of

cs

AGAP007473 -5.124663 FK506-binding protein 1 - microtubule associated complex - negative regulation of autophagy - negative regulation of macroautophagy - peptidyl-prolyl

cs

AGAP013180 -5.123962 DNA repair protein RHP57 nr

AGAP003418 -5.1088243 Fatty acid desaturase - 4 predicted membrane helices met/lipd membrane

AGAP012900 -5.1036253 Papain family cysteine protease pm/protease



s/protease


AGAP001356 -5.0593014 Acetylcholinesterase/Butyrylcholinesterase - signalP detected st

AGAP004408 -5.043615 DNA replication licensing factor, MCM5 component nr


s/protease




s/protease

AGAP008468 -4.962826 Animal-type fatty acid synthase met/lipd



s/protease

AGAP002913 -4.907524 Conserved secreted protein precursor - signalP detected s/ucs


AGAP011845 -4.8411317 Histone 2A nr

AGAP002783 -4.8281407 UDP-glucuronosyl and UDP-glucosyl transferase - signalP detected - 2 predicted membrane helices

met/carb membrane


s/protease


AGAP003702 -4.805796 integral to membrane - zinc ion binding - metallopeptidase - calcium ion binding - proteolysis - metalloendopeptidase - signalP detected

s/protease

AGAP001281 -4.791852 inwardly rectifying k+ channel, Aedes aegypti - 2 predicted membrane helices tr membrane

AGAP013147 -4.791689 Centrosome-associated protein CEP250 - microtubule organizing center - cytoskeleton - protein complex - protein localization - perinuclear region of - signalP detected

cs

AGAP013186 -4.77996 Protein phosphatase 1, regulatory subunit, - signalP detected s/st Protein

AGAP010077 -4.7539873 Cytochrome P450 CYP2 subfamily detox/ox


s/protease

AGAP006702 -4.7332525 Predicted RNA-binding protein involved in translational regulation - 18 NetOglyc sites

ps


AGAP005009 -4.718783 Pyrroline-5-carboxylate reductase met/aa


AGAP008141 -4.7026796 Argininosuccinate lyase met/aa



AGAP003583 -4.635225 Sorbitol dehydrogenase detox


s/protease





uc/memb membrane

AGAP000994 -4.570581 lysosomal Pro-X carboxypeptidase Culex quinquefasciatus - signalP detected s/met/aa lysosomal

AGAP013290 -4.562265 Conserved secreted protein precursor - signalP detected s/ucs


st membrane


AGAP006835 -4.530045 Mastermind-like protein 2 - nuclear speck - regulation of transcription - Notch signaling pathway - transcription coactivator - nucleus - positive - signalP detected

tm


s/protinh


s/protinh

AGAP007407 -4.507594 Macrophage mannose receptor 1 - mannose binding - integral to plasma membrane - plasma membrane - receptor - sugar binding - receptor-mediated - signalP detected

st


AGAP011604 -4.4827213 Haze-protective mannoprotein that reduces the particle size of aggregated proteins in white wines - fungal-type cell wall organization - fungal-type - signalP detected

extmat


AGAP010018 -4.463968 Uncharacterized conserved protein uc

AGAP011324 -4.4606876 Glycosyltransferase - signalP detected extmat

AGAP001506 -4.460502 G protein beta-subunit 76C - plasma membrane - cytoplasm - activation of phospholipase C - G-protein coupled receptor protein signaling pathway -

st

AGAP011621 -4.448377 WD40-repeat-containing subunit of the 18S rRNA processing complex tm


AGAP006921 -4.442514 GULP, engulfment adaptor PTB domain containing 1 - apoptosis - phagocytosis, engulfment - lipid transport - cytoplasm - protein binding

st/apoptosis


met/lipd membrane



AGAP001423 -4.4173813 AICAR transformylase/IMP cyclohydrolase/methylglyoxal synthase met/nuc


AGAP007413 -4.393066 Microcephalin - intracellular - microtubule organizing center - cytoskeleton - cytoplasm - 18 NetOglyc sites

cs

AGAP004008 -4.378837 Catalytic domain of Protein Kinases - 15 NetOglyc sites st

AGAP004585 -4.3736067 Translin-associated protein X uc

AGAP004018 -4.3697762 Syntrophins (type gamma) - 15 NetOglyc sites extmat


s/protinh


AGAP001511 -4.312197 Transcription regulator dachshund, contains SKI/SNO domain - signalP detected

tm


AGAP009459 -4.304614 Cyclin-dependent kinase CDK5 pe

AGAP001993 -4.3025136 RNA-binding protein musashi/mRNA cleavage and polyadenylation factor I complex, subunit HRP1

tm


s/protease

AGAP001010 -4.279555 Chondroitin synthase 1 - signalP detected met/carb


uc/memb membrane

AGAP009364 -4.27037 Clavesin-1 - transporter - trans-Golgi network - phosphatidylinositol-3,5-bisphosphate binding - endosome - early endosome membrane - lysosome

tr

AGAP005783 -4.2679453 anillin, actin binding protein - cytokinesis - actin binding - actin cytoskeleton - actomyosin contractile ring - protein binding - cell division

cs

AGAP008165 -4.2670493 Phosphatidylinositol transfer protein SEC14 met/lipd

AGAP000751 -4.2593727 Spindle assembly checkpoint protein nr


s/protease

AGAP001280 -4.2439427 inwardly rectifying k+ channel, Aedes aegypti - 3 predicted membrane helices - Membrane anchor detected

tr membrane membrAnchor

AGAP000628 -4.2392383 Transcriptional coactivator p100 tm



AGAP001980 -4.2209134 MFS-type transporter C6orf192 - transmembrane transport - integral to membrane - membrane - signalP detected - 12 predicted membrane helices

tr membrane


AGAP011088 -4.1777434 Transcriptional coactivator p100 tm

AGAP004787 -4.174392 Acyl-CoA reductase - 2 predicted membrane helices met/lipd membrane


AGAP010703 -4.146112 Uncharacterized conserved protein nr

AGAP010725 -4.14461 Sulfate/bicarbonate/oxalate exchanger SAT-1 - 12 predicted membrane helices

tr membrane


uc/memb membrane



st




s/protease

AGAP001657 -4.1105704 Larval serum protein 2 - lipid particle - transport - oxygen transporter - extracellular region - nutrient reservoir - larval serum protein complex - signalP detected

tr


AGAP006165 -4.109052 SNF2 family DNA-dependent ATPase - 11 NetOglyc sites nr


AGAP005986 -4.08931 Acyl-CoA reductase met/lipd

AGAP006702 -4.0863147 Predicted RNA-binding protein involved in translational regulation - 18 NetOglyc sites

ps


AGAP000650 -4.0750527 Ribonuclease P 40kDa met/nuc

AGAP004008 -4.0702124 Catalytic domain of Protein Kinases - 15 NetOglyc sites st


AGAP001687 -4.0479946 RhoGAP domain-containing protein - signal transduction - Rac GTPase activator - regulation of Rac protein signal transduction - intracellular

st


AGAP005763 -4.0268965 Tyrosine kinases st


AGAP001065 -4.0234694 Glycine/serine hydroxymethyltransferase met/aa



AGAP004572 -4.0154552 Fatty acid desaturase - 4 predicted membrane helices met/lipd membrane

AGAP008245 -4.0030355 Apx/Shroom domain ASD2 - 21 NetOglyc sites cs

AGAP003190 -4.0004725 Mismatch repair ATPase MSH6 (MutS family) nr


AGAP004585 -3.9850602 Translin-associated protein X uc


met/lipd membrane

AGAP000011 -3.9818213 Branched chain aminotransferase BCAT1, pyridoxal phosphate enzymes type IV superfamily

met/aa

AGAP005510 -3.977417 Oxysterol-binding protein st

AGAP003025 -3.9679787 60S acidic ribosomal protein P2 Aedes aegypti - signalP detected ps


AGAP003205 -3.9364798 Monocarboxylate transporter - 12 predicted membrane helices tr membrane


AGAP004957 -3.9229608 Origin recognition complex, subunit 1, nr

AGAP004639 -3.9226594 clip-domain serine protease Culex quinquefasciatus - signalP detected s/protease



AGAP002075 -3.9105582 Dual specificity; serine/threonine and tyrosine kinase nr

AGAP008807 -3.908144 Predicted lipoprotein met/lipd

AGAP008783 -3.9011116 Arginase met/aa

AGAP009978 -3.885895 Animal haem peroxidase - 6 predicted membrane helices detox/ox membrane


AGAP011347 -3.839343 Sulfatase - signalP detected detox

AGAP004500 -3.8319676 Protein predicted to be involved in spindle matrix formation, contains DM13, DoH, and DOMON - signalP detected

nr

AGAP011361 -3.8316252 Checkpoint 9-1-1 complex, HUS1 component met/energy

AGAP013038 -3.817554 S-M checkpoint control protein CID1 - signalP detected nr



AGAP013027 -3.781876 Toll-like receptor (AGAP010669-PA) Anopheles gambiae str. PEST - signalP detected

s/imm Toll-like


s/protinh

AGAP013215 -3.7589693 Ring finger prot

AGAP005244 -3.7568393 bab2 - protein binding - polytene chromosome chromocenter - polytene chromosome - regulation of transcription - transcription factor - DNA binding - 14 NetOglyc sites

tf

AGAP001061 -3.7502913 Espin - parallel actin filament bundle assembly - locomotory behavior - stereocilium - brush border - actin cytoskeleton - sensory perception of sound

cs



AGAP010406 -3.7410064 Origin recognition complex, subunit 3 nr



s/protease


AGAP001731 -3.7226894 Zn-finger protein - 45 NetOglyc sites uc

AGAP001899 -3.7047563 Animal-type fatty acid synthase met/lipd


extmat

AGAP008127 -3.6918898 Protein tyrosine phosphatase st

AGAP000005 -3.6878796 Dorsal switch protein 1 - negative regulation of antimicrobial humoral response - leg disc development - DNA bending - chromatin remodeling -

imm

AGAP004203 -3.6870105 Lipoprotein amino terminal region - signalP detected storage/

AGAP011940 -3.6813245 Acid sphingomyelinase and PHM5 phosphate metabolism protein met/lipd

AGAP006762 -3.680155 Diacylglycerol kinase met/lipd


AGAP010234 -3.6693327 Microsomal triglyceride transfer protein - signalP detected s/met/lipd Microsomal

AGAP009034 -3.6649144 Ca2+/calmodulin-dependent protein kinase, EF-Hand protein superfamily st

AGAP010676 -3.6535964 Nostrin - nucleus - plasma membrane - endocytosis - transcription repressor - cytoplasm - cytoplasmic membrane-bounded vesicle

tf



AGAP002248 -3.6262505 Kinesin (KAR3 subfamily) cs




AGAP013476 -3.6055598 RNA polymerase II, large subunit - 57 NetOglyc sites tm

AGAP002741 -3.6010618 Histone H3 (Lys4) methyltransferase complex, subunit SET1 - 29 NetOglyc sites

nr

AGAP000907 -3.6002283 Acyl-CoA synthetase met/lipd



AGAP004239 -3.5759346 Polo-like serine/threonine protein kinase nr

AGAP013147 -3.562314 Centrosome-associated protein CEP250 - microtubule organizing center - cytoskeleton - protein complex - protein localization - perinuclear region of -

cs

signalP detectedAGAP003051 -3.5607817 Fatty acid desaturase - 4 predicted membrane helices met/lipd

membraneAGAP001053 -3.5500274 Troponin I cs

AGAP007045 -3.533916 carboxypeptidase N subunit 2 Culex quinquefasciatus - signalP detected s/protease


st

AGAP008654 -3.5220942 KOG1366, KOG1366, Alpha-macroglobulin Posttranslational modification, protein turnover, chaperones

pm





AGAP004579 -3.478467 Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, kinase subunit CDK7

nr

AGAP010220 -3.4744668 DNA polymerase delta processivity factor (proliferating cell nuclear antigen) nr


AGAP010673 -3.4717495 enabled - compound eye development - actin cytoskeleton organization - border follicle cell migration - cytoplasmic transport, nurse cell to oocyte - - 17 NetOglyc sites

cs


s/protinh


AGAP003937 -3.4499428 PDZ and LIM domain protein 7 - cell junction - cell differentiation - actin cytoskeleton - focal adhesion - ossification - receptor-mediated

extmat

AGAP003261 -3.4457047 Vesicle coat complex COPII, subunit SEC31 - 249 NetOglyc sites pe

AGAP000223 -3.4452305 Coeffector of mDia Rho GTPase, regulates actin polymerization and cell adhesion turnover

st



AGAP012197 -3.4405599 Histones H3 and H4 nr

AGAP012928 -3.4393768 capicua homolog (Drosophila) - DNA binding - transcription - nucleus - regulation of transcription - 13 NetOglyc sites

tm

AGAP007497 -3.4303508 Copper/zinc superoxide dismutase detox/ox


s/protease


AGAP005176 -3.4182186 Pre-initiation complex, subunit CDC6, AAA+ superfamily ATPase nr

AGAP001587 -3.415386 Vacuolar H+-ATPase V0 sector, subunit a - 6 predicted membrane helices tr membrane


AGAP007775 -3.4035335 DNA helicase PIF1/RRM3 nr

AGAP002429 -3.4013553 Cytochrome P450 CYP11/CYP12/CYP24/CYP27 subfamilies detox/ox

AGAP003187 -3.3869393 Protein tyrosine phosphatase - signalP detected - 2 predicted membrane helices

st membrane

AGAP005325 -3.383719 Spermidine synthase met/aa


AGAP010048 -3.3629477 Predicted transporter - 11 predicted membrane helices tr membrane

AGAP010495 -3.352227 Alternative splicing factor ASF/SF2 (RRM superfamily) tm

AGAP004846 -3.3507502 Plasma membrane glycoprotein CD36 - signalP detected - 2 predicted membrane helices

st membrane





extmat


st

AGAP006548 -3.330533 Glycine cleavage system H protein (lipoate-binding) - signalP detected s/met/aa Glycine

AGAP008469 -3.3277276 Myosin-13 - myosin filament - actin binding - microfilament motor - protein binding - nucleotide binding - myofibril

cs


AGAP009526 -3.3219116 Cytochrome c oxidase subunit VIIa - Membrane anchor detected met/energy membrAnchor

AGAP008948 -3.3173985 Serine/Threonine protein kinases st


s/protease


s/protease



s/protinh


extmat


s/protinh


AGAP005716 -3.2767453 Plasma membrane glycoprotein CD36 - 2 predicted membrane helices st membrane


AGAP012537 -3.2744005 NEM-sensitive fusion protein 2 - ATP binding - nucleoside-triphosphatase - regulation of synaptic growth at neuromuscular junction - neuromuscular

pe

AGAP008467 -3.2710078 Sodium-neurotransmitter symporter - 12 predicted membrane helices st membrane




s/protinh

AGAP002429 -3.253298 Cytochrome P450 CYP11/CYP12/CYP24/CYP27 subfamilies detox/ox

AGAP003571 -3.2395568 Threonine/serine dehydratases met/aa

AGAP003000 -3.2334814 Predicted transporter ADD1 (major facilitator superfamily) - 12 predicted membrane helices

tr membrane

AGAP000731 -3.2260964 LIM domain only 1 - nucleolus - metal ion binding - regulation of transcription - zinc ion binding - nucleus - signalP detected

tm



st


extmat


AGAP007402 -3.208809 Protein involved in DNA repair uc

AGAP008862 -3.2066617 Germ-line stem cell division protein Hiwi/Piwi; negative developmental regulator

nr


AGAP008726 -3.2001224 eyes absent - response to light stimulus - salivary gland morphogenesis - mesoderm development - ovarian follicle cell development - compound eye - 12 NetOglyc sites

st


s/protease

AGAP008420 -3.195028 inhibitor of apoptosis protein (AGAP008420-PA) Anopheles gambiae str. PEST st/apoptosis

AGAP008412 -3.181117 40S ribosomal protein S3a Aedes aegypti ps

AGAP003860 -3.1783931 Proline oxidase met/aa

AGAP001259 -3.1575427 Src homology 2 st

AGAP007552 -3.1531181 U2-associated snRNP A' protein - 24 NetOglyc sites tm


st

AGAP010070 -3.1506603 Neural proliferation, differentiation and control protein - signalP detected st

AGAP007400 -3.1463804 Lysosomal & prostatic acid phosphatases - signalP detected s/met/lipd Lysosomal

AGAP008990 -3.1454396 Lecithin:cholesterol acyltransferase (LCAT)/Acyl-ceramide synthase met/lipd

AGAP011758 -3.1378999 PR domain containing 9 - methyltransferase - chromosome - regulation of transcription - meiosis - nucleus - transferase

tm


AGAP007299 -3.1338904 Nuclear transport receptor RANBP7/RANBP8 (importin beta superfamily) ne

AGAP008532 -3.1314323 Adaptor protein Enigma st

AGAP003771 -3.1230104 DNA polymerase sigma DNA replication nr

AGAP009232 -3.1196575 Actin regulatory (gelsolin/villin family) cs



AGAP001644 -3.1113477 N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 - cytoplasm - nitric oxide mediated signal transduction - catalytic - arginine catabolic process

st

AGAP010862 -3.110171 sodium-dependent nutrient amino acid transporter 2 - signalP detected - 2 predicted membrane helices

tr membrane

AGAP010406 -3.1080294 Origin recognition complex, subunit 3 nr

AGAP004524 -3.1076777 Cdc15/Fes/CIP4 domain-containing protein, PCH family protein, RhoGAP domain-containing protein - intracellular - regulation of Rac protein signal

st

AGAP005223 -3.1058266 Apolipoprotein D/Lipocalin - signalP detected extmat


s/protease

AGAP012637 -3.0908453 DNA-directed RNA polymerase (EC 2.7.7.6) II largestchain - mouse, PIR2:A28490 - chr4:6295604-6299755 REVERSE - Aliases: F28M11.1 - signalP detected

tm

AGAP002032 -3.0809004 Predicted lipoprotein - signalP detected s/met/lipd Predicted

AGAP008578 -3.0807629 ATP-dependent RNA helicase tm

AGAP001280 -3.0788004 inwardly rectifying k+ channel, Aedes aegypti - 3 predicted membrane helices - Membrane anchor detected

tr membrane membrAnchor

AGAP011386 -3.0763316 Amino acid transporters - 12 predicted membrane helices tr membrane

AGAP002807 -3.0728104 Transcription initiation factor TFIID, subunit BDF1 - 52 NetOglyc sites tm


AGAP004426 -3.0478919 Fasciclin - signalP detected extmat


AGAP004524 -3.0339148 Cdc15/Fes/CIP4 domain-containing protein, PCH family protein, RhoGAP domain-containing protein - intracellular - regulation of Rac protein signal

st


AGAP010234 -3.0141199 Microsomal triglyceride transfer protein - signalP detected s/met/lipd Microsomal


extmat

Gene ID, along with the absolute fold-change, putative description and functional class are listed. Abbreviated titles of classes include: cs, cytoskeletal; extmat, extracellular matrix and adhesion; tr, transporters and channels; tf, transcription factor; tm, transcription machinery; ps, protein synthesis; pm, protein modification machinery; pe, protein export machinery; ne, nuclear export; prot, proteasome machinery; st, signal transduction; nr, nuclear regulation; met/aa, amino acid metabolism; met/carb, carbohydrate metabolism; met/lipd, lipid metabolism; met/energy, energy metabolism; met/nuc, nucleotide metabolism; met/int, intermediary metabolism; detox, detoxification; detox/ox, oxidant metabolism/detox; imm, immunity; uk, unknown; uc, unknown conserved; s/, secreted; te, transposable element; s/protinh, protease inhibitor; pm/protease, peptidases; st/apoptosis, apoptosis; vir, viral product.

· Web viewTable S2. Genes regulated more than 3-fold absolute change following NF54 WT (WT) relative to bloodfed (BF) or Pfs47 KO (KO) relative to BF at 26 hours post ... Cell wall

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