Validity of maternal recall of prescription drug use during pregnancy Marleen van Gelder 1 Iris van Rooij 1 , Hermien de Walle 2 , Nel Roeleveld 1 , Marian Bakker 2 1) Department of Epidemiology, Biostatistics and HTA Radboud University Nijmegen Medical Centre 2) Eurocat Northern Netherlands, Department of Genetics, University Medical Center Groningen EUROCAT 2011 symposium, June 17 20 2011, Antwerp
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Validity of meternal recall of prescription drug use during pregnancy
Validity and reliability of maternal recall of prescription drug use during pregnancy
By Marian Bakker
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Validity of maternal recall of prescription drug use during pregnancy
Marleen van Gelder1
Iris van Rooij1, Hermien de Walle2,
Nel Roeleveld1, Marian Bakker2
1) Department of Epidemiology, Biostatistics and HTARadboud University Nijmegen Medical Centre
2) Eurocat Northern Netherlands, Department of Genetics, University Medical Center Groningen
EUROCAT 2011 symposium, June 17 20 2011, Antwerp
Study design in birth defects epidemiology
• Majority of studies used case-control design
• Method of data collection:Medical records
Self-administered questionnaire
Interview
• Often data collection takes place monthsto years after delivery
• Data on the accuracy of recall of prescription drug use during pregnancy are scarce
Research questions
1. What is the validity of a self-administered questionnaire to assess prescription drug use just before and during pregnancy?
2. Do maternal and pregnancy characteristics influence the accuracy of questionnaire data on prescription drug use during pregnancy?
Methods (1): Study population
• Imbedded in Eurocat Northern Netherlands Population-based birth defects registry
Covers provinces of Groningen, Friesland, and Drenthe
Annually 18,000 births (10% of all births in Netherlands)
• Infants younger than 16 years and fetuses with birth defects and genetic disorders eligible for registration
• Validation study: cases registered between 01-01-2009 and 30-06-2010 (n = 1,105)
Methods (2): Data collection
• Extensive questionnaire sent to parents
• Separate questionnaire on prescription drug use Screening question: “Did you use any…”
Questions on specific indications / drug groups
o Specify drug in open-ended question
o Timing of use
• Pharmacy records checked for compliance by maternal interviews
Methods (3): Statistical analyses
• Drugs ordered in three mutually exclusive categories:* For chronic conditions