UvA-DARE (Digital Academic Repository) Ovarian stimulation ... · and disorders among secondary school adolescents in Egypt. A cross-sectional survey. BMC Womens Health. 2015; 15:70.

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Ovarian stimulation in IVF in relation to ovarian response

Youssef, M.A.F.M.

Link to publication

Citation for published version (APA):Youssef, M. A. F. M. (2016). Ovarian stimulation in IVF in relation to ovarian response.

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240

Appendices

241

List of co-authors and affiliations

Aboulfoutouh I, Department of Obstetrics & Gynecology, Faculty of Medicine, Cairo University,

Egypt

Aboulghar M, Department of Obstetrics & Gynecology, Faculty of Medicine, Cairo University,

Egypt

Abou- Setta AM, University of Alberta Evidence-based Practice Centre (UA-EPC), Alberta Research

Centre for Health Evidence (ARCHE), Edmonton, Canada

Akhondi M, Reproductive Biotechnology Research Center, Avicenna Research Institute,

Tehran, Iran

Alhalabi M, Division of Embryology and Reproductive Medicine, Faculty of Medicine, and

Assisted Reproduction Unit, Orient Hospital, Damascus, Syria

Al-inany H, Department of Obstetrics & Gynecology, Faculty of Medicine, Cairo University,

Egypt

Ansaripour S, Reproductive Biotechnology Research Center, Avicenna Research Institute, Tehran,

Iran

Ayeleke RO, Department of Obstetrics & Gynecology, University of Auckland, Cairo University,

New Zealand

Broekmans FJ, Department of Reproductive Medicine and Gynecology, University Medical Center,

Utrecht, Netherlands

Brown J, Liggins institute, University of Auckland, New Zealand

El-Mohamedy M, Department of Obstetrics & Gynecology, Faculty of Medicine, Cairo University,

Egypt

Fouda UM, Department of Obstetrics & Gynecology, Faculty of Medicine, Cairo University,

Egypt

Griesinger G, 5UK-SH, Campus Luebeck, Luebeck, Germany

Jahangiri N, Department of Endocrinology and Female Infertility, Reproductive Biomedicine

Research Center, Royan Institute for Reproductive Biomedicine, Tehran, Iran

Hassan M, Department of Obstetrics & Gynecology, Faculty of Medicine, El-fayoum University,

242

Egypt

Khattab M, Department of Obstetrics & Gynecology, Faculty of Medicine, Cairo University,

Egypt

Khodabakhshi S, Reproductive Biotechnology Research Center, Avicenna Research Institute, Tehran,

Iran

Lam WS, Department of Obstetrics & Gynecology, University of Auckland, Cairo University,

New Zealand

Madani T, Department of Endocrinology and Female Infertility, Reproductive Biomedicine

Research Center, Royan Institute for Reproductive Biomedicine, Tehran, Iran

Mochtar M, Centre for Reproductive Medicine, Academic Medical Centre, University of

Amsterdam, Netherlands

Mourad S Radboud University Medical center, Nijmegen, Netherlands

Nagi Mohesen M, Department of Obstetrics & Gynecology, Faculty of Medicine, Beni-suef University,

Egypt

Rizk A, Department of Obstetrics & Gynecology, Faculty of Medicine, Banha University,

Egypt

Shaeer E, Department of Obstetrics & Gynecology, Faculty of Medicine, Cairo University,

Egypt

Shaltout A, Department of Obstetrics & Gynecology, Faculty of Medicine, Cairo University,

Egypt

Shohyab A, Department of Obstetrics & Gynecology, Faculty of Medicine, Cairo University,

Egypt

Tokhmechy R, Reproductive Biotechnology Research Center, Avicenna Research Institute, Tehran,

Iran

van der Veen F, Centre for Reproductive Medicine, Academic Medical Centre, University of

Amsterdam, Netherlands

van Wely M, Centre for Reproductive Medicine, Academic Medical Centre, University of

Amsterdam, Netherlands

243

Zarandi L, Reproductive Biotechnology Research Center, Avicenna Research Institute, Tehran,

Iran

244

List of publications

1. Fouda UM, Sayed AM, Elshaer HS, Hammad BE, Shaban MM, Elsetohy KA, Youssef MA. GnRH antagonist rescue protocol combined with cabergoline versus cabergoline alone in the prevention of ovarian hyperstimulation syndrome: a randomized controlled trial. J Ovarian Res. 2016; 9 (1):29.

2. Youssef MA, Abou-Setta AM, Lam WS. Recombinant versus urinary human chorionic gonadotrophin for final oocyte maturation triggering in IVF and ICSI cycles.Cochrane Database Syst Rev. 2016; 4:CD003719.

3. Youssef MA, Abdelsalam L, Harfoush RA, Talaat IM, Elkattan E, Mohey A, Abdella RM, Farhan MS, Foad HA, Elsayed AM, Elkinaai NA, Ghaith D, Rashed ME, Ghafar MA, Khamis Y, Hosni AN. Prevalence of human papilloma virus (HPV) and its genotypes in cervical specimens of Egyptian women by linear array HPV genotyping test.Infect Agent Cancer. 2016;11:6

4. Youssef MM, Mantikou E, van Wely M, Van der Veen F, Al-Inany HG, Repping S,Mastenbroek S. Culture media for human pre-implantation embryos in assisted reproductive technology cycles. Cochrane Database Syst Rev. 2015;11:CD007876.

5. Youssef MA, Van der Veen F, Al-Inany HG, Mochtar MH, Griesinger G, Aboulfoutoh I, van Wely M. The updated Cochrane review 2014 on GnRH agonist trigger: an indispensable piece of information for the clinician.Reprod Biomed Online.2016;32(2):259-60

6. Abdelmoty HI, Youssef MA, Abdallah S, Abdel-Malak K, Hashish NM, Samir D,Abdelbar M, Hosni AN, Abd-El Ghafar M, Khamis Y, Seleem M. Menstrual patternsand disorders among secondary school adolescents in Egypt. A cross-sectionalsurvey. BMC Womens Health. 2015; 15:70.

7. Abdelbary AM, El-Dessoukey AA, Massoud AM, Moussa AS, Zayed AS, Elsheikh MG, Ghoneima W, Abdella R, Yousef M. Combined Vaginal Pelvic Floor Electrical Stimulation (PFS) and Local Vaginal Estrogen for Treatment of Overactive Bladder (OAB) in Perimenopausal Females. Randomized Controlled Trial (RCT). Urology.2015 Sep; 86(3):482-6. doi: 10.1016/j.urology.2015.06.007

8. Rana M. A. Abdella, Hatem I. Abdelmoaty, Rasha H. Elsherif, Ahmed Mahmoud Sayed, Nadine Alaa Sherif, Hisham M. Gouda, Ahmed El Lithy, Maged Almohamady,Mostafa Abdelbar, Ahmed Naguib Hosni, Ahmed Magdy, and Youssef MA. Screening for Chlamydia trachomatis in Egyptian women with unexplained infertility, comparing real-time PCR techniques to standard serology tests: case control study. BMC Womens Health. 2015; 15: 45.

9. Ghada Abdel Fattah Abdel Moety, Maged Almohamedy, Nadine Alaa Sherif, Aymen N.Rasalan, Tarek Fawazy Mohamed, Hazem Mohamed Abdel Mohsen, Abeer Mohamed Mohy, and Mohamed A.F.M.Youssef. Could first-trimester assessment of placental functions predict preeclampsia and intrauterine growth restriction? A prospective cohort study. J Matern Fetal Neonatal Med. 2016;29(3):413-7

10. Youssef MA, Abdelmoty HI, Elashmwi HA, Abduljawad EM, Elghamary N, Magdy A, Mohesen MN, Abdella RM, Bar MA, Gouda HM, Ali AM, Raslan AN, Youssef D, Sherif NA, Ismail AI. Oral antioxidants supplementation for women with unexplained

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infertility undergoing ICSI/IVF: Randomized controlled trial. Hum Fertil (Camb). 2015 Mar;18(1):38-42.

11. Hashish N, Hassan A, El-Semary A, Gohar R, Youssef MA. Could 3D placental volume and perfusion indices measured at 11-14 weeks predict occurrence of preeclampsia in high-risk pregnant women? J Matern Fetal Neonatal Med.2015;28(9):1094-8.

12. Saleh WF, Gamaleldin SF, Abdelmoty HI, Raslan AN, Fouda UM, Mohesen MN, Youssef MA. Reproductive health and HIV awareness among newly married Egyptian couples without formal education. Int J Gynaecol Obstet. 2014; 126(3):209-12.

13. Hashish NM, Badway HS, Abdelmoty HI, Mowafy A, Youssef MA. Does flushing the endometrial cavity with follicular fluid after oocyte retrieval affect pregnancy rates in subfertile women undergoing intracytoplasmic sperm injection? A randomizedcontrolled trial. Eur J Obstet Gynecol Reprod Biol. 2014; 176:153-7.

14. Abdel-Mohsen IIK, Youssef MAFM, Elashmwi H, Darwish A, Khattab SM (2013) Clomiphene Citrate plus Modified GnRH Antagonist Protocol for Women with Poor Ovarian Response Undergoing ICSI Treatment Cycles: Randomized Controlled Trial. Gynecol Obstet 3:158.

15. Mantikou E, Youssef MA, van Wely M, van der Veen F, Al-Inany HG, Repping S,Mastenbroek S. Embryo culture media and IVF/ICSI success rates: a systematic review. Hum Reprod Update. 2013; 19(3):210-20.

16. Samah Aboul Gheit, Ahmed Naguib Hosny, Mahmoud Sedki Yassin,Shahira Gemei,Mostafa Ahmed Zaki Shokry, Mohamed AFM Youssef Argon beam coagulator versus cystectomy for endometrioma treatment in infertile women and the impact on ovarian reserve. A case control study. MEFS. 2013; 19 (1): 22-25.

17. Mohamed A.F.M. Youssef: Is evidence based medicine (EBM) applicable in our reallife? Middle East Fertility Society Journal 2013; 18 93); 217-219.

18. Mahmoud Youssef MA, van Wely M, Aboulfoutouh I, El-Khyat W, van der Veen F,Al-Inany H. Is there a place for corifollitropin alfa in IVF/ICSI cycles? A systematic review and meta-analysis. Fertil Steril. 2012.

19. Mohamed A.F.M. Youssef: Obstructed hemivagina and ipsilateral renal anomaly syndrome with uterus didelphys (OHVIRA). Middle East Fertility Society Journal 2013; 18 (1):58-61

20. Sherif M. Khattab, Mohamed Abdel Fattah Mahmoud Youssef. Primary anterior vaginal wall pure ammonium acid urate stone. Case report. Middle East Fertility Society Journal 2013; 18(3): 217-219.

21. Tarek A. A. Moussa, Rasha Hamed Elsherif, Youssef Abdelfattah Mohamed,Mohamed E. A. Dawoud and Asmaa Mohamed AboElAref. Group B streptococcus colonization of pregnant women: comparative molecular and microbiological diagnosis. Comparative Clinical Pathology 2013; 22 (6): 1229-1234.

22. Rasha Hamed Elsherif and Mohamed Abdl Fatah Youssef. Real-time PCR improve detection of Trichomonas vaginalis compared to conventional techniques.

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Comparative Clinical Pathology. 2013; 22 (2): 295-300.

23. Mohamed AFM Youssef: The Controversy Over the Final Maturation Trigger in GnRH Antagonist Treated IVF/ICSI Cycles. KAJOG 2012

24. Mohamed AFM Youssef et al., Mild ovarian stimulation in women with poor ovarian response undergoing IVF and ICS. Evidence Based Women’s Health Society 2012.

25. Mohamed Abdelfattah Mahmoud Youssef. Peer review of manuscript submitted to medical journals. Middle East Fertility Society Journal 2012; 17 (2): 139-143

26. Al-Inany HG, Youssef MA, Aboulghar M, Broekmans F, Sterrenburg M, Smit J, Abou-Setta AM. GnRH antagonists are safer than agonists: an update of a Cochrane review. Hum Reprod Update. 2011 Jul-Aug; 17(4):435. Review. PubMed PMID: 21646384.

27. Al-Inany HG, Youssef MA, Aboulghar M, Broekmans F, Sterrenburg M, Smit J, Abou-Setta AM. Gonadotrophin-releasing hormone antagonists for assisted reproductive technology. Cochrane Database Syst Rev. 2011 ;( 5):CD001750.

28. Youssef MA, Al-Inany HG, Aboulghar M, Mansour R, Abou-Setta AM. Recombinant versus urinary human chorionic gonadotrophin for final oocyte maturation triggering in IVF and ICSI cycles. Cochrane Database Syst Rev. 2011;(4):CD003719.

29. Youssef MA, Al-Inany HG, Evers JL, Aboulghar M. Intra-venous fluids for the prevention of severe ovarian hyperstimulation syndrome. Cochrane Database Syst Rev. 2011 ;( 2):CD001302.

30. Aboulfotouh II, Youssef MA, Mady AF, Abdelhak AM, Khattab SM. Non-mosaic Klinefelter syndrome and successful testicular sperm extraction-intracytoplasmic sperm injection procedure: case report. Gynecol Endocrinol. 2011; 27(11):874-5.

31. Khattab S, Mohsen IA, Aboul Foutouh I, Ashmawi HS, Mohsen MN, van Wely M, van der Veen F, Youssef MA. Can metformin reduce the incidence of gestational diabetes mellitus in pregnant women with polycystic ovary syndrome? Prospective cohort study. Gynecol Endocrinol. 2011; 27(10):789-93.

32. Youssef MA, Van der Veen F, Al-Inany HG, Griesinger G, Mochtar MH, van Wely M. Gonadotropin-releasing hormone agonist versus HCG for oocyte triggering in antagonist assisted reproductive technology cycles. Cochrane Database Syst Rev. 2010; (11):CD008046.

33. M.A.F Youssef. Effective sample size calculation: How many patients will I need to include in my study? Middle East Fertility Society Journal, (2011) 16, 295–296

34. Abdelrahman Elnashar, Amr M. Gadallah, Alaa A. Abdelaal, Islam F. Soliman, Mohamed A.F.M. Youssef. Can the International Index of Erectile Function (IIEF-5) be used as a diagnostic tool to the severity of vasculogenic erectile dysfunction? Middle East Fertility Society Journal 2012; 17:101–104.

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PORTFOLIO

Workshops

2014 Training of Trainers "ToT" organized by the German Academic Exchange Service (DAAD), Cairo

2014 Change Agents for Egypt-Network Activity for Future University Leaders. the German Academic Exchange Service (DAAD), Cairo

2013 UNILEAD Egypt program: University Leadership and Management Training Course by the German Academic Exchange Service (DAAD), Cairo and the Carl von Ossietzky University of Oldenburg in Germany.

2013 Project management professional training course in Cairo by Knowledge Huthttp://www.knowledgehut.com/course/302/PMP/Egypt/901/workshop-Dec

2013 Improving standards - Adapting RCOG guidelines for local use workshop arranged by RCOG at 1st FIGO Africa Regional Conference of Gynaecology and Obstetrics. October 2-5, 2013 • Addis Ababa, Ethiopia

2013 Pre-congress course 12: Task Force Management of Fertility Units in conjunction with the Special Interest Groups Andrology / Embryology / Reproductive Surgery & Safety and Quality in ART “Total quality management (TQM) in an IVF Centre” organized by ESHRE -2013-UK

2013 “ Your Future in Science: Writing and Publishing a Scientific Paper “organized by Prof. Dr. Mary M. Christopher at JARCU-Cairo University - Egypt 23 April 2013

2013 “Evidence based medicine in clinical Drug safety and Effectiveness” organized by FDA at Cairo University from 8-9 April 2013

2013 Pre-congress workshop-(Assisted reproductive technology) - Cairo University- Cairo- Egypt. As speaker

2012 “ Authorship and Reviewing “ presented by Ewa Kittel-Prejs Journals Publishing Director Elsevier and organized by the Academy of Scientific Research and Technology

2012 “ Biostatistics II academics” online course organized by Statistics.com

2012 “Power-analysis for Cluster-randomized and Multi-site Studies" online course organized by Statistics.com

2012 German Academic Exchange Service (DAAD) Funding Opportunities and How to evaluate candidates for DAAD. At Kasr Al-Aini Conference Center, Hall B, 28th May 2012

2012 How to write a proposal: The Technical Support Office for projects & Grants in collaboration with German Scientific Exchange Service (DAAD). Monday 4 June 2012, from 9:00 am -4:00 pm. Venue: Learning Resource Center (LRC) at Kasr AlAiny

2011 UNFPA Arab States Regional Office “Reproductive Health and Health Systems Strengthening Synergies” Workshop (29 May 2011- 02 June 2011) organized by Maha El-Adawy, RH Technical Advisor, UNFPA, ASRO Margaret Kruk, Columbia University

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2012Pre-congress workshop-(Assisted reproductive technology) - Cairo University- Cairo- Egypt. As speaker

2012Pre-congress workshop (Intensive Workshop in Urogynecology and Reconstructive Pelvic Surgery)10-12 April 2011- Cairo University- organizing committee and speaker

2011Pre-congress workshop-(Assisted reproductive technology) - Cairo University- Cairo- Egypt. As speaker

2011Pre-congress workshop (Intensive Workshop in Urogynecology and Reconstructive Pelvic Surgery)10-12 April 2011- Cairo University- organizing committee and speaker

2010 Training workshop for journal editors organized by Prof. Dr. Mary M. Christopher at STMPU-Cairo -Egypt

2009 Advanced clinical epidemiology course- University of Amsterdam (UVA)-Netherlands.

2009 Oral presentation course - University of Amsterdam (UVA)-Netherlands.

2009 Clinical data management - University of Amsterdam (UVA)-Netherlands.

2009 Basic course “the AMC World of Science”- University of Amsterdam (UVA) - Netherlands.

2009 Mild IVF precongress course - ESHRE - Amsterdam - Netherlands

2009 Pub Med biomedical sciences University of Amsterdam (UVA)-Netherlands

2009 Reference Manager 12 Advanced course. University of Amsterdam (UVA)-Netherlands

2008 Cochrane database Workshop – Dutch Cochrane Centre- University of Amsterdam (UVA)-Netherlands.

2008 Scientific Writing Workshop- University of Amsterdam (UVA)-Netherlands.

2008 Evidence based medicine course- how to use Pub med, Web of science and Reference manager -University of Amsterdam (UVA)-Netherlands.

2008 Essential clinical epidemiology course- University of Amsterdam (UVA)-Netherlands.

2008 Practical and advanced biostatistics course- University of Amsterdam (UVA)-Netherlands.

2004 Evidence based medicine course- Cairo university- Egypt

2004 Quality control course - Cairo University – Egypt

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Oral and poster presentations

2015 The 31th Annual Meeting of European Society of Human Reproduction &Embryology - Lisbon 2015.

2015 The 29th Annual scientific meeting for obstetrics & gynaecology department- Faculty of Medicine-Alexandria University, Egypt. Oral presentation- Speaker

2014 21th Annual meeting of Middle East Fertility Society (MEFS) - Dubai- UAE-2014, 2oral presentations & chairperson

2014 The 30th Annual Meeting of European Society of Human Reproduction &Embryology - Munich 2014. 1oral presentation accepted

2014 11th International Symposium on GnRH the hypothalamic-pituitary-gonadal axis in cancer and reproduction- Salzburg- Austria: Accepted oral presentation, Speaker

2014 Ismailia Obstetrics & Gynaecology Syndicate symposium

2014 8th Annual Meeting of Department of Obstetrics & Gynaecology- Sohag University

2014 Annual Meeting of department of Obstetrics& Gynaecology- South Vally University

2013 1st FIGO Africa Regional Conference of Gynaecology and Obstetrics. October 2-5, 2013 • Addis Ababa, Ethiopia. 2 Oral presentations, Speaker & chairperson

2013The 69th ASRM Annual Meeting - Boston-USA. 3 Poster presentations

2013The 29th Annual Meeting of European Society of Human Reproduction &Embryology - London 2013.1 poster presentation

20131st International Medical writing congress- Dubai-UAE- Oral presentation, Speaker

2013The third Annual International Meeting of Egyptian Representative Committee ERC, Egypt, oral presentation – Oral presentation, Speaker

2013The 27th Annual scientific meeting for obstetrics & gynaecology department- Faculty of Medicine-Alexandria University, Egypt.3-4 May 2012- Oral presentation- Speaker

201311th annual meeting of obstetrics & gynaecology departments - Faculty of Medicine-Al- Azhar University, Egypt. 2 Oral presentations& Speaker

201212nth Annual Scientific Meeting for Obstetrics & Gynaecology, Department Faculty of Medicine - Cairo University, Egypt: oral presentations & Speaker

2012The Egyptian fertility society conference- Cairo -Egypt. 1 Oral presentation & Speaker

201219th Annual meeting of Middle East Fertility Society (MEFS) - Dubai- UAE-2013, 2oral presentations & speaker

2012The 28th Annual Meeting of European Society of Human Reproduction &- Istanbul 2012. 2 POSTERS presentations

201210th annual meeting of obstetrics & gynaecology departments-Faculty of Medicine- Al-Azhar University, Egypt. June 14-15/2012- Oral presentation & speaker

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2012The Second Annual International Meeting of Egyptian Representative Committee ERC, Egypt, oral presentation – Oral presentation & speaker

2012 26th Annual scientific meeting for obstetrics & gynecology department- Faculty of Medicine-Alexandria University, Egypt. 3-4 May 2012- oral presentations andspeaker

2012 11nth Annual Scientific Meeting For Obstetrics & Gynecology Department Faculty of Medicine - Cairo University, Egypt : oral presentations& speaker

2011 18th Annual meeting of Middle East Fertility Society – Lebanon, 2 oral presentations &speaker

2011 67th ASRM (American society of reproductive medicine- USA ): 3 posters presentation

2011 7th Royan International Twin Congress Reproductive Biomedicine & Stem Cell-Tehran Iran

2011 The 27th Annual Meeting of European Society of Human Reproduction- Stockholm-SWEDEN: 2 oral presentations and speaker

2011 25th Annual Scientific Meeting For Obstetrics & Gynecology Department Faculty of Medicine - Alexandria University 4-6 May 2011 : 2 oral presentations and speaker

2011 Alexandria workshop for women health, oral presentation

2011 10nth Annual Scientific Meeting For Obstetrics & Gynecology Department Faculty of Medicine - Cairo University : oral presentations & speaker

2011 10th International Symposium on GnRH the hypothalamic-pituitary-gonadal axis in cancer and reproduction- Salzburg- Austria: 2 oral presentation, speaker and 1 poster

2010 The 28th Annual Meeting of European Society of Human Reproduction- ROME): 2oral presentations & speaker

2010 66th ASRM (American society of reproductive medicine ASRM (American society of reproductive medicine): poster presentation

2010 17th Annual meeting of Middle east fertility society- Damascus: 3 oral presentations &speaker

2009 The 27th Annual Meeting of European Society of Human Reproduction &ESHRE -Amsterdam - Netherlands. Oral presentation

2010 9nth Annual Scientific Meeting For Obstetrics & Gynaecology Department Faculty of Medicine - Cairo University : Oral presentation & speaker

2010 Suzan Mubarak for women health and development ,Alexandria conference- Oral presentation& speaker

2009 ESHRE (European society for human reproduction and embryology) - Amsterdam -Netherlands. Oral presentation (01 July 2009)

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Awards and grants

2016 Incentive award of state Egypt

2016 International publication awards Cairo University, Egypt

2015 Middle East Fertility society conference (Dr. samir Abbas Award)

Sharm Elshikh-Egypt

2015 International Publication Miser Elkhair Foundation, Egypt

2015 International publication awards Cairo University , Egypt

2014 Best poster presentation Award Egyptian Fertility & Sterility Society (EFSS)- Egypt

2014 International Publication Miser Elkhair Foundation, Egypt

2013 State award “ Dr. Mohamed Fakhry Mekawy” Science & technology & development foundation ( STDF)

2013 International publication awards Cairo University, Egypt

2012 Merck Sorono Infertility innovation award Egyptian fertility society

2012 Cairo University incentive award Cairo University, Egypt

2012 International publication awards Cairo University, Egypt

2012 Egyptian grant for post MD research Egypt

2011 Award of the best article presented at middle east fertility society conference

MEFS conference - Lebanon

2011 International publication awards Cairo University , Egypt

2011 International Publication Miser Elkhair Foundation, Egypt

2013 STDF grant for short term fellowships Science & technology & development foundation ( STDF)

2011 NUFFIC Grant for Reproductive Medicine PhD Netherlands

2010 Grant for clinical & research fellowship at AMC-Center for Reproductive Medicine- Amsterdam- Netherlands

Egypt

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Acknowledgements

My interest in the female infertility & assisted reproduction arena started to grow since the

early beginnings of my residency in Cairo university hospital. Since then, I started a non-stop

quest for a learning opportunity in this field. Fortunately, I landed on an Egyptian grant which

allowed me to carry out my MD research project in the field of my passion, in addition to a

training opportunity abroad. Then I started to contact many experts in the field. I was thrilled

when I got a reply from Prof. dr. Fulco with his acceptance to supervise my research project

in the AMC.

Fulco, Madelon and Monique, I would like to express my deep gratitude for the opportunity;

not only did I come to work in a topic that I love but I was also part of a big dynamic and

diverse team. It has always been a pleasure to work with you, facing the challenges that

came our way. You have contributed in many ways to this thesis.

Fulco, - the dignified mentor of CVV- you taught me the secrets of proper scientific thinking,

writing and how to incorporate evidence based medicine in my daily practice with patients.

You give me the opportunity to be part of your team for more than 8 years and encouraged

me to proceed in my PhD projects with patience. I learned from you how to be enthusiastic

and persistent to do my work perfectly. Your advice on both research, as well as my career

has been priceless. When I went back to Egypt in 2010, you advised me to establish my

team and try to continue my research work and to expand my knowledge and experience.

You supported me and my colleagues to hold our first symposium “Upper Egypt ART” which

was successful and fruitful. I could not wish for a better advisor and mentor for my Ph.D

study; it was a truly life changing opportunity for me.

Madelon “Bescherm angel” I cannot have enough words to express my gratitude to the effort

and time that you spent to teach me how to write a manuscript, understand statistics and

how to deal with reviewers and editors comments. You always solved my problems and fixed

my frequent mistakes with your warm smile and kind heart. I would like to greatly thank you

for answering all my questions whenever I brought them to you. Not only that, I cannot forget

how much you helped me to overcome my stress and disappointments during my first year in

AMC, you were always concerned about me and my family.

Monique, the strong and dynamic lady of CVV, you monitored my first ovum-pickup training

attempts in CVV clinic. I would like thank you for your continuous support during my Ph.D

research, for your patience, motivation, and immense knowledge. Your guidance helped me

during the research work and writing of this thesis. You spent a lot of time editing many

253

manuscripts included in this thesis, you used to give me the hope that this work will come to

light soon & here it is.

Hesham -my great professor-, I would like to express my sincere gratitude for your

continuous support to me when I was in the AMC. You are the first person who helped me to

come to Netherlands, meet Fulco and start my entire career in the AMC. You spent many

days showing to me what should I do and what is the best way to be a good clinician, as well

as a researcher. Because of your professional network, many IVF centers accepted to

participate in PRIMA study, the topic of my PhD. Without your help & continuous persistence

& negotiation, I would not be able to defence my PhD.

Beatrix and Marjolein, you have always been there for me, I would like to thank you for your

valuable help on all administrative works of my thesis. Of course, this was only a small part

of your continuous help you kindly offered me, which I’ll never forget and will always be

grateful to you.

I would like to thank the rest of my committee members, Prof. dr. Broekmans, Prof. dr.

Elgindy, Prof. dr. Goddijn, Dr. Khalaf, and Prof. dr. Lambalk. Thank you for accepting to be

part of the committee and I am looking forward to our discussion as well.

To all researchers, doctors, nurses and other colleagues from the CVV, Cairo university

hospital-Egypt, Royan institute-Iran, Avicenna institute-Iran, Orient hospital-Syria and Banha

university hospital-Egypt thank you for your contribution to PRIMA study described in this

thesis.

A special thanks to all couples that have participated in studies described in this thesis.

Femke and Miriam; I would like to thank you separately for accepting to be my paranymphs

and stand next to me at this special day. Thank you for all the help with the organization and

for keeping up the motivation.

A special thanks to my family. Words cannot express how grateful I am to my mother, father

brothers and sisters for all of your sacrifices to me. Your prayers were the driving force that

pushed so far. I would also like to thank all my friends who supported me in writing, and

motivated me to strive towards my goal. I dedicate this thesis to the memory of my mother,

whose role in my life was, and remains, immense.

At the end I would like express appreciation to my beloved wife Neveen stood by me all

these years and made them the best years of my life, you have been caring and patient and

loving. Youssef, Leena and Layla, my lovely family, raising you up is the greatest blessing

254

and the sweetest adventure and challenge of my life. May be you will not read this book but I

am sure you will read these few lines to see how much I love you.

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About the author

The author of this thesis was born on August 6th, 1973 in Giza,

Egypt. He did his Master and M.D of Obstetrics and Gynecology

at Cairo University between 2002 and 2010. In 2008 he started at

the Center of Reproductive Medicine of the Academic Medical

Center as a research fellow on the topic ovarian stimulation under

the supervision of prof. dr F.van der Veen, prof. dr Hesham

Alinany, and dr M.van Wely and dr M. Mochtar.

Currently, he is working as an assistant professor at the department of Obstetrics and

Gynecology at the Faculty of Medicine, Cairo University, Egypt. He is married from Nevin

Abdul-Aziz Gad and has three children, Youssef, Leena and Laila.