CASE REPORT Uterine Tumors Resembling Ovarian Sex Cord Tumor in Postmenopausal Woman Byun Jung Mi • Kim Ki Tae • Yoon Hye Kyoung • Jeong Dae Hoon • Kim Young Nam • Lee Kyung Bok • Sung Moon Su Received: 14 January 2014 / Accepted: 22 April 2014 / Published online: 27 May 2014 Ó Federation of Obstetric & Gynecological Societies of India 2014 About the Author Introduction Uterine tumors resembling ovarian sex cord tumors (UT- ROSCTs) are a rare group of stromal neoplasms containing prominent sex cord-like elements. Since they were first described in 1945 by Morehead and Bowman [1], no more than 100 such tumors have been reported [2]. In a report by Clement and Scully [3], these neoplasms were divided into 2 groups on the basis of clinical and histologic patterns. The first group (group I) included endometrial stromal tumors with less than 50 % sex cord-like elements, and the second group (group II) included UTROSCTs exhibiting sex cord-like differentiation of more than 50 %. In the latest, according to the World Health Organization classi- fication of uterine neoplasms, UTROSCTs were placed in a miscellaneous category of tumors of the uterine corpus because of their different morphology and benign clinical behaviors [4]. More recently, UTROSCTs have been sug- gested to be unusual neoplasms of uncertain malignancy with polyphenotypic immunohistochemical expression, characterized by positivity for sex cord, epithelial, and myoid markers [5, 6]. These tumors usually occur in pre- menopausal or menopausal women. Most patients have symptoms such as abnormal vaginal bleeding, abdominal pain, and enlarged uterus or a palpable uterine mass on physical examination [7]. In most cases, UTROSCT is diagnosed incidentally after hysterectomy for a clinical Byun J. M. (&) Á Kim K. T. Á Jeong D. H. Á Kim Y. N. Á Lee K. B. Á Sung M. S. Department of Obstetrics and Gynecology, Busan Paik Hospital, Inje University, 633-165 Gaegeum-dong Busanjin-gu, Busan 614-735, South Korea e-mail: [email protected]Kim K. T. Á Jeong D. H. Á Kim Y. N. Paik Institute for Clinical Research, Busan Paik Hospital, Inje University, Busan, South Korea Yoon H. K. Department of Pathology, Busan Paik Hospital, Inje University, Busan, South Korea Jung Mi Byun , MD is an Assistant Professor of Obstetrics and Gynecology at Inje University, School of Medicine. Dr. Byun received her medical degree from the Inje University in 2004 and completed her residency training in Obstetrics & Gynecology at Busan Paik hospital, Inje University in Busan from 2005 to 2009. She continued with subspecialty training as a fellow in Gynecology Oncology at the Inje University. She is an expert in laparoscopic operation and management of gynecologic cancer. Her clinical research interests include management and epidemiology of gynecologic cancer. Dr. Byun is a member of the International Gynecological Cancer Society (IGCS) and Korean Cancer Association for gynecologic oncology. The Journal of Obstetrics and Gynecology of India (July–August 2015) 65(4):273–277 DOI 10.1007/s13224-014-0545-0 123
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CASE REPORT
Uterine Tumors Resembling Ovarian Sex Cord Tumorin Postmenopausal Woman
Byun Jung Mi • Kim Ki Tae • Yoon Hye Kyoung • Jeong Dae Hoon •
Kim Young Nam • Lee Kyung Bok • Sung Moon Su
Received: 14 January 2014 / Accepted: 22 April 2014 / Published online: 27 May 2014
� Federation of Obstetric & Gynecological Societies of India 2014
About the Author
Introduction
Uterine tumors resembling ovarian sex cord tumors (UT-
ROSCTs) are a rare group of stromal neoplasms containing
prominent sex cord-like elements. Since they were first
described in 1945 by Morehead and Bowman [1], no more
than 100 such tumors have been reported [2]. In a report by
Clement and Scully [3], these neoplasms were divided into
2 groups on the basis of clinical and histologic patterns.
The first group (group I) included endometrial stromal
tumors with less than 50 % sex cord-like elements, and the
second group (group II) included UTROSCTs exhibiting
sex cord-like differentiation of more than 50 %. In the
latest, according to the World Health Organization classi-
fication of uterine neoplasms, UTROSCTs were placed in a
miscellaneous category of tumors of the uterine corpus
because of their different morphology and benign clinical
behaviors [4]. More recently, UTROSCTs have been sug-
gested to be unusual neoplasms of uncertain malignancy
with polyphenotypic immunohistochemical expression,
characterized by positivity for sex cord, epithelial, and
myoid markers [5, 6]. These tumors usually occur in pre-
menopausal or menopausal women. Most patients have
symptoms such as abnormal vaginal bleeding, abdominal
pain, and enlarged uterus or a palpable uterine mass on
physical examination [7]. In most cases, UTROSCT is
diagnosed incidentally after hysterectomy for a clinical
Byun J. M. (&) � Kim K. T. � Jeong D. H. � KimY. N. � Lee K. B. � Sung M. S.
Department of Obstetrics and Gynecology, Busan Paik Hospital,