USF – Bioinformatics Master Project Outline Buck Institute The Mooney Lab Project Description 1.

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USF – Bioinformatics Master Project

Outline

• Buck Institute

• The Mooney Lab

• Project Description

Buck Institute for Research on Aging

History1975

19861987

1989

1996

• 1987 – the Marin Superior Court selected the Institute to receive 15% of the net income from Beryl Buck’s estate• 1989 – the Buck purchased a 488-acre parcel of undeveloped land on Mt. Burdell in Novato

• 1996 – construction began

• 1986 – The “Buck Institute on Aging” was incorporated.

• The San Francisco Foundation established.

(at the time estimated at $11 - $12 million)

1999

2010

• 2010 – the value of the Buck Trust had grown to over $700 million, generating an annual income for the Institute of approximately $6 million per year.

• 1999 – The buck opened

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Buck Institute for Research on Aging

The Future for the Buck

New construction for stem-cell lab building - $41 million project

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Buck Institute for Research on Aging

The Buck Today

• Mission – To increase the healthy years of life by investigating how

normal aging contributes to the development of diseases.

• Employees – 200

• Faculty – 18 labs

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Buck Institute for Research on Aging

o Parkinson disease

o Alzheimer

o cancer

o stroke

o nutrition

o stress

o genetics

o stem cells

o bioinformatics

Main research focus:

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The Mooney Lab

Responsibilities

• Core – support other labs in the institute to:

o handle, store, and retrieve data

o analyze biological data

o use tools to generate biological hypotheses

• Independent research –

o identify and classify diseases causing mutations

o analyze protein structure to estimate structure similarities,

predict catalytic and protein-protein interaction sites.

o using ontologies to classify gene function

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Lab’s Web Tools

Plugin - a container for a group of related resources (software components), embedded in a larger software application to extend its functionality.

ChimeraPymol

LSWPlugin

LSWPlugin

Life Science Web Services Plug-ins

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Integration

p53

Canc

er M

utati

ons

Lab’s Web Tools:• S-Blest

• CRP

• MutDB

• PPI

Chimera, Pymol:• Analyze molecular structure

• Provide: images, animations,

interactive Visualization

setuptoolsSOAP

API

Easy InstallEgg files

Packages

LSW Services:

MD5

distutils

Life Science Web Services Plug-ins

services

WSDL

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Contact info: [email protected]

USF – Bioinformatics Master Project