Urokinase Plasminogen Activator (uPA) and its Receptor uPAR
Urokinase Plasminogen Activator (uPA) and its Receptor uPAR.
Dec 19, 2015
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Urokinase Plasminogen Activator (uPA) and its Receptor uPAR
The Importance of Cell Movements
In Development
Early embryogenesis
Organ & tissue development
Organ & tissue remodeling throughout life
In defense & disease
Immune responses
Wound healing
Invasion & metastasis
Figure 14.24 The Biology of Cancer (© Garland Science 2007)
Hepatacyte Growth Factor (HGF) is a Powerful Inducer of Epithelial Cell Motility
Figure 14.23b The Biology of Cancer (© Garland Science 2007)
EGF Secreted by Mθs Induces Motility in Breast Carcinoma
Cells Recall:
filopodium
Rho Family Small G Proteins Play Central Roles in Cell Motility and Invasiness
Rac, Cdc42, Rho and their GEFs (eg Tiam1 Rac) are all involved in the orchestration of extension/sensing/contraction and MMP secretion that are involved in the movement of cells across surfaces.
A role for Rho proteins is demonstrated by studies of melanoma.
The Lymphatic System
Figure 14.41a The Biology of Cancer (© Garland Science 2007)
Metastasis to draining lymph node
Draining Lymph Nodes Can be Destinations for Metastatic Cells
Figure 14.42 The Biology of Cancer (© Garland Science 2007)
The ‘Seed and Soil’ Principle – Some Tissues are More Susceptible to Colonization by Particular Tumors Than Others
Figure 14.44 The Biology of Cancer (© Garland Science 2007)
Figure 14.46 The Biology of Cancer (© Garland Science 2007)
Breast Cancer Tends to be Osteolytic & Prostate Cancer Tends to be Osteoblastic
Figure 14.48 The Biology of Cancer (© Garland Science 2007)
The Osteoblastic Cascade
Table 14.4 The Biology of Cancer (© Garland Science 2007)
Figure 14.50a The Biology of Cancer (© Garland Science 2007)
Cytokeratin-free Bone Marrow Augurs Well
Figure 14.51a The Biology of Cancer (© Garland Science 2007)
Gene Expression Signatures Show Some Promise as Prognostic Indicators
Instigators & Responders – Implications for Micrometastases
McCallister et al., Cell 133:994 (2008)
Figure 14.53 The Biology of Cancer (© Garland Science 2007)
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