UpToDate ® Editorial Board Adult and Pediatric Emergency Medicine Co-Editors-in-Chief Gary R. Fleisher, MD Harvard Medical School John A. Marx, MD University of North Carolina, Chapel Hill Ron M. Walls, MD, FRCPC, FAAEM Harvard Medical School Brigham and Women’s Hospital Deputy Editors Jonathan Grayzel, MD, FAAEM University of Massachusetts Medical School James F. Wiley, II, MD, MPH University of Connecticut School of Medicine Section Editors Adult Cardiology Emergencies James Hoekstra, MD Wake Forest University Adult Environmental Emergencies Daniel F. Danzl, MD University of Louisville School of Medicine Adult Orthopedics Patrice Eiff, MD Oregon Health Sciences University Karl B. Fields, MD University of North Carolina at Chapel Hill Adult Procedures Catherine B. Custalow, MD, PhD University of Virginia School of Medicine Allan B. Wolfson, MD University of Pittsburgh Adult Resuscitation Ron M. Walls, MD, FRCPC, FAAEM Harvard Medical School Brigham and Women’s Hospital Adult Signs and Symptoms Robert S. Hockberger, MD, FACEP David Geffen School of Medicine at UCLA Adult Toxicology Stephen J. Traub, MD Harvard Medical School Adult Trauma John A. Marx, MD University of North Carolina, Chapel Hill Bone Radiology Mary Hochman, MD Harvard Medical School Calculators Louis Leff, MD, FACP University of Pittsburgh School of Medicine Emergency Medical Services/ Disaster Medicine Richard D. Zane, MD Harvard Medical School Pediatric Critical Care Medicine Adrienne G. Randolph, MD, MSc Harvard Medical School Pediatric Environmental Emergencies Daniel F. Danzl, MD University of Louisville School of Medicine Pediatric Procedures Anne M. Stack, MD Harvard Medical School Pediatric Psychosocial Emergencies Daniel M. Lindberg, MD Harvard Medical School Pediatric Resuscitation Susan B. Torrey, MD Baylor College of Medicine Pediatric Signs and Symptoms Gary R. Fleisher, MD Harvard Medical School Stephen J. Teach, MD, MPH George Washington University School of Medicine and Health Sciences George A. Woodward, MD University of Washington School of Medicine Pediatric Surgical Emergencies Jonathan I. Singer, MD Wright State University Boonshoft School of Medicine UpToDate is an evidence-based, physician-authored clinical information resource. With UpToDate, physicians can answer questions quickly, increase their clinical knowledge and improve patient care. Adult and Pediatric Emergency Medicine 1 Adult Primary Care and Internal Medicine 2 Allergy and Immunology 2 Cardiology 3 Dermatology* 3 Endocrinology 4 Family Medicine 4 Gastroenterology and Hepatology 5 Hematology 5 Infectious Diseases 6 Nephrology 7 Neurology 7 Obstetrics, Gynecology and Women’s Health 8 Oncology 8 Pediatrics 9 Psychiatry* 10 Pulmonary, Critical Care and Sleep Medicine 10 Rheumatology 11 Surgery* 11 Evidence-based Medicine Advisory Group 12 UpToDate Faculty 12 *in development
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UpToDate® Editorial Board
Adult and Pediatric Emergency MedicineCo-Editors-in-ChiefGary R. Fleisher, MD
Harvard Medical SchoolJohn A. Marx, MD
University of North Carolina, Chapel Hill
Ron M. Walls, MD, FRCPC, FAAEMHarvard Medical SchoolBrigham and Women’s Hospital
Deputy EditorsJonathan Grayzel, MD, FAAEM
University of Massachusetts Medical School
James F. Wiley, II, MD, MPHUniversity of Connecticut School of Medicine
Adult Environmental EmergenciesDaniel F. Danzl, MD
University of Louisville School of Medicine
Adult OrthopedicsPatrice Eiff, MD
Oregon Health Sciences UniversityKarl B. Fields, MD
University of North Carolina at Chapel Hill
Adult ProceduresCatherine B. Custalow, MD, PhD
University of Virginia School of Medicine
Allan B. Wolfson, MDUniversity of Pittsburgh
Adult ResuscitationRon M. Walls, MD, FRCPC, FAAEM
Harvard Medical SchoolBrigham and Women’s Hospital
Adult Signs and SymptomsRobert S. Hockberger, MD, FACEP
David Geffen School of Medicine at UCLA
Adult ToxicologyStephen J. Traub, MD
Harvard Medical School
Adult TraumaJohn A. Marx, MD
University of North Carolina, Chapel Hill
Bone RadiologyMary Hochman, MD
Harvard Medical School
CalculatorsLouis Leff, MD, FACP
University of Pittsburgh School of Medicine
Emergency Medical Services/Disaster MedicineRichard D. Zane, MD
Harvard Medical School
Pediatric Critical Care MedicineAdrienne G. Randolph, MD, MSc
Harvard Medical School
Pediatric Environmental EmergenciesDaniel F. Danzl, MD
University of Louisville School of Medicine
Pediatric ProceduresAnne M. Stack, MD
Harvard Medical School
Pediatric Psychosocial EmergenciesDaniel M. Lindberg, MD
Harvard Medical School
Pediatric ResuscitationSusan B. Torrey, MD
Baylor College of Medicine
Pediatric Signs and SymptomsGary R. Fleisher, MD
Harvard Medical SchoolStephen J. Teach, MD, MPH
George Washington University School of Medicine and Health Sciences
George A. Woodward, MDUniversity of Washington School of Medicine
Pediatric Surgical EmergenciesJonathan I. Singer, MD
Wright State University Boonshoft School of Medicine
UpToDate is an evidence-based, physician-authored clinical information resource. With UpToDate, physicians can answer questions quickly, increase their clinical knowledge and improve patient care.
Adult and Pediatric Emergency Medicine 1
Adult Primary Care and Internal Medicine 2
Allergy and Immunology 2
Cardiology 3
Dermatology* 3
Endocrinology 4
Family Medicine 4
Gastroenterology and Hepatology 5
Hematology 5
Infectious Diseases 6
Nephrology 7
Neurology 7
Obstetrics, Gynecology and Women’s Health 8
Oncology 8
Pediatrics 9
Psychiatry* 10
Pulmonary, Critical Care and Sleep Medicine 10
Rheumatology 11
Surgery* 11
Evidence-based Medicine Advisory Group 12
UpToDate Faculty 12
*in development
2
Pediatric ToxicologyMichele Burns Ewald, MD
Harvard Medical School
Pediatric TraumaRichard G. Bachur, MD
Harvard Medical SchoolSusan B. Torrey, MD
Baylor College of Medicine
Adult Primary Care and Internal MedicineCo-Editors-in-Chief Mark D. Aronson, MD
Harvard Medical SchoolRobert H. Fletcher, MD, MSc
Harvard Medical SchoolSuzanne W. Fletcher, MD
Harvard Medical School
Deputy EditorsPracha Eamranond, MD, MPH
Harvard Medical SchoolDavid M. Rind, MD
Harvard Medical SchoolH. Nancy Sokol, MD
Harvard Medical School
Section EditorsCalculatorsLouis Leff, MD, FACP
University of Pittsburgh School of Medicine
DermatologyRobert P. Dellavalle, MD, PhD, MSPH
University of Colorado Denver and Colorado School of Public Health
General MedicineMark D. Aronson, MD
Harvard Medical SchoolRobert H. Fletcher, MD, MSc
Harvard Medical SchoolSuzanne W. Fletcher, MD
Harvard Medical School
GeneticsBenjamin A. Raby, MD, MPH
Harvard Medical School
GeriatricsKenneth E. Schmader, MD
Duke UniversityDurham Veterans Affairs Medical Centers
LipidsMason W. Freeman, MD
Massachusetts General Hospital Lipid Metabolism Unit
NutritionTimothy O. Lipman, MD
Veterans Affairs Medical Center
OphthalmologyJonathan Trobe, MD
University of Michigan Kellogg Eye Center
OtorhinolaryngologyDaniel G. Deschler, MD, FACS
Harvard Medical School
PsychiatryThomas L. Schwenk, MD
University of Michigan Health System
Spinal Disease and Back PainSteven J. Atlas, MD, MPH
Harvard Medical School
Substance AbuseMark S. Gold, MD
University of Florida College of Medicine
UrologyMichael P. O’Leary, MD, MPH
Brigham and Women’s Hospital
Allergy and ImmunologyCo-Editors-in-ChiefBruce S. Bochner, MD
Johns Hopkins University School of Medicine
E. Richard Stiehm, MD David Geffen School of Medicine at UCLA
Robert A. Wood, MD Johns Hopkins University School of Medicine
Deputy EditorsAnna M. Feldweg, MD
Harvard Medical SchoolElizabeth TePas, MD, MS
Harvard Medical School
Section EditorsAdult AllergyBruce S. Bochner, MD
Johns Hopkins University School of Medicine
AnaphylaxisF. Estelle R. Simons, MD, FRCPC
University of Manitoba
AsthmaPeter J. Barnes, DM, DSc, FRCP, FRS
National Heart and Lung Institute Imperial College, London
Bruce S. Bochner, MDJohns Hopkins University School of Medicine
Basic SciencePeter H. Schur, MD
Harvard Medical School
CalculatorsLouis Leff, MD, FACP
University of Pittsburgh School of Medicine
Drug AllergyN. Franklin Adkinson, Jr., MD
Johns Hopkins University School of Medicine
Food AllergyScott H. Sicherer, MD, FAAAAI
Mount Sinai School of Medicine
ImmunologyE. Richard Stiehm, MD
David Geffen School of Medicine at UCLA
ImmunotherapyPeter S. Creticos, MD
Johns Hopkins University School of Medicine
Philip S. Norman, MD Johns Hopkins University School of Medicine
P.O. Box 42400 MA Alphen aan den Rijn,The Netherlands
Tel: +31 172 641440
Fax: +31 172 641486
Email:international@ uptodate.com
Evidence-based Medicine Advisory GroupGordon Guyatt, MD
McMaster UniversityRoman Jaeschke, MD
McMaster UniversityHolger Schunemann, MD
Italian National Cancer Institute in RomeMcMaster University
Yngve Falck-Ytter, MDCase Western Reserve University
UpToDate FacultyFounding Editor, UpToDateBurton D. Rose, MD
Harvard Medical School
Editor-in-Chief, UpToDateDenise S. Basow, MD
Chief Medical OfficerPeter A.L. Bonis, MD
Executive EditorsTheodore W. Post, MDDavid M. Rind, MD
Senior Deputy EditorsVanessa A. Barss, MDMelanie S. Kim, MDKathryn A. Martin, MDMichael E. Ross, MDH. Nancy Sokol, MDMary M. Torchia, MDJanet L. Wilterdink, MD
Deputy EditorsElinor L. Baron, MD, DTMHKathryn A. Collins, MD, PhD, FACSRebecca F. Connor, MDJohn F. Dashe, MD, PhDRosemary B. Duda, MD, MPH, FACSPracha Eamranond, MD, MPHSandy J. Falk, MDAnna M. Feldweg, MDCarla H. Ginsburg, MD, MPH, AGAFJonathan Grayzel, MD, FAAEMJerry M. Greene, MDRichard Hermann, MDHelen Hollingsworth, MDAlison G. Hoppin, MDStephen A. Landaw, MD, PhDRachel Lerner, MD, MSBarbara H. McGovern, MDLeah K. Moynihan, RNC, MSNJean E. Mulder, MDAbena O. Ofori, MD, FAADSusan E. Pories, MD, FACSPaul L. Romain, MDGordon M. Saperia, MD, FACCDiane M.F. Savarese, MDAlice M. Sheridan, MDDavid Solomon, MDElizabeth TePas, MD, MSAnna R. Thorner, MDAnne C. Travis, MD, MSc, FACGConstanza Villalba, PhDJames F. Wiley, II, MD, MPHKevin C. Wilson, MDSusan B. Yeon, MD, JD, FACCJonathan M. Zand, PharmD