University of Toronto & InCor Cardiovascular Conference

University of Toronto & InCor

Cardiovascular Conference

5-6 Julho, 2013

Anfiteatro, Instituto do Coração

InCor-HC.FMUSP

ATTENDEES

University of Toronto

Mailing address:

Primary OfficePeter Munk Cardiac Centre, University

Health Network585 University Avenue, Room 4N474

Toronto, Ontario M5G 2N2

[email protected]

Area of interest: Prevention, Diabetes and Heart Disease

Conference: Revascularization strategies for diabetic patients with CAD

Michael E. Farkouh, MD, MSc

The Director of the Heart and Stroke/ Richard Lewar Centre of Excellence in Cardiovascular Investigation and thePeter Munk Chair in Multinational Clinical Trials at the Peter Munk Cardiac Centre, University of Toronto. He is agraduate of the Schulich School of Medicine at Western University. Dr. Farkouh completed his internal medicine andcardiology training at the Mayo Clinic and the Icahn School of Medicine at Mount Sinai New York and holds an MScin Clinical Epidemiology from McMaster University. He has published over 130 papers largely on acute coronarysyndromes and cardiovascular prevention. He has mentored many fellows and is active in teaching clinical researchmethodology. Dr. Farkouh is internationally known for his work on the management of acute coronary syndromes inthe emergency room. He has a special interest and expertise in the field of cardiovascular disease in diabeticpatients. He is currently the project officer for numerous clinical trials on questions related to diabetes and heartdisease including the NIH-sponsored FREEDOM trial and coordinates clinical studies in Grenada and Colombia. Dr.Farkouh has received the gold medal from John Paul II Hospital in Krakow and was the Teacher of the Year at theMayo Clinic.

Mailing address:

Primary OfficeToronto General Hospital

6th Floor Rm. 248200 Elizabeth St.Toronto, OntarioCanada M5G 2C4

[email protected]

Area of interest: Interventional Cardiology and Acute Coronary Syndromes

Conference: Advances in the interventional management of ACS

Vlad Džavík, MD, FRCPC, FAHA

A graduate of the Faculty of Medicine at the University of Alberta, Class of 1983. After completing his Cardiology and InterventionalCardiology training at the Ottawa Heart Institute in 1991, he joined the faculty at the University of Alberta. In 2000 he moved toToronto where he served as Director of the Cardiac Catheterization Laboratories and Interventional Cardiology at the Peter MunkCardiac Centre, University Health Network in Toronto for 11 years. Currently, he is now Deputy Head of the Division of Cardiology atthe University Health Network and Mount Sinai Hospital, and Professor of Medicine at the University of Toronto. He continues todirect the research program in interventional cardiology. He has had an active research career, having authored or co-authoredmore than 160 manuscripts in peer-reviewed journals and more than 140 abstracts in national and international scientific meetings.His research interests range from percutaneous coronary intervention during and after acute myocardial infarction, study of optimaltherapy for cardiogenic shock, outcomes in high-risk PCI. He was the Canadian Leader and Executive Committee member of theOccluded Artery Trial (OAT), an international collaboration studying the late open artery hypothesis, and serves as PrincipalInvestigator of TOSCA-2, the OAT angiographic ancillary study, having received a National Institutes of Health (US) grant to conductthis study. He was also Principal Investigator of the international multicentre SHOCK-2 Phase 2 Trial of L-NMMA in cardiogenicshock, and Executive Committee Member and Canadian Country Leader of TRIUMPH, the subsequent phase 3 study. He is currentlyco-principal investigator of TOTAL, an international randomized trial of manual thrombectomy in patients with acute myocardialinfarction undergoing primary PCI, and study chair of EMPRES a Canadian randomized trial of exenatide to improve heart functionin also in patients undergoing primary PCI, that will begin enrolling patients shortly. Dr. Džavík is a member of the Editorial Board ofthe American Heart Journal and the Canadian Cardiology Journal, and a reviewer for Circulation, Journal of the American College ofCardiology, the American Journal of Cardiology, American Heart Journal, Critical Care Medicine and the European Heart Journal, theCanadian Journal of Cardiology, the International Journal of Cardiology and Eurointervention, as well as the CanadianCardiovascular Congress, and the American College of Cardiology, American Heart Association and Transcatheter CardiovascularTherapeutics Scientific Sessions. He has also played a leadership role in the Canadian Interventional Cardiology community, havingserved as President of the Canadian Association of Interventional Cardiology between 2005 and 2007.

Bradley Strauss, M.D., Ph.D.

ProfessorDepartment of Medicine, University of Toronto

Laboratory Medicine and Pathobiology, University of TorontoSenior scientist, Molecular and cellular biology – Schulich heart research program, Sunnybrook Research Institute

Reichmann Chair, cardiovascular sciences, Sunnybrook Health Sciences Centre and University of TorontoDirector, Interventional cardiology research, Sunnybrook Health Sciences Centre

Mailing address:

Primary OfficeSunnybrook Health Sciences Centre

2075 Bayview Ave., Room A2 53Toronto, ONM4N 3M5

email: [email protected]

Area of interest: Translational Research and Interventional Cardiology

Conference: Pre-clinical and Clinical Research in Chronic Total Occlusions

Dr. Bradley Strauss has developed a novel approach to treatingpatients with blocked arteries.He has been experimenting with this application of collagenasesince the 1990s. In addition to proving the enzymes are effectivein softening plaque in coronary arteries, he has also produced agrade of collagenase safe for use in humans.

Terrence M. YauB.A., M.D., C.M., M.Sc., FRCSC

Angelo and Lorenza DeGasperis Chair in Cardiovascular Surgery ResearchDirector, Cardiac Stem Cell Therapy Program

Director of Research, Division of Cardiovascular Surgery, Peter Munk Cardiac CentreProfessor, Department of Surgery, University of Toronto

Attending Cardiac Surgeon, Peter Munk Cardiac Centre at the University Health Network

Mailing address:

Primary OfficeToronto General Hospital

University Health Network200 Elizabeth St.Toronto, OntarioCanada M5G 2C4

[email protected]

Area of interest: CT Surgery

Conference: Stem cell therapy for myocardial repair

Dr. Yau obtained his B.A. (Honors) from Johns Hopkins University in molecular biology prior to medical schoolat McGill University and his surgical training at the University of Toronto. In 1998 he joined the faculty of theDivision of Cardiovascular Surgery at Toronto General Hospital. Since 1999, Dr. Yau has been the Director ofResearch in the division, and is also the holder of the Angelo and Lorenza DeGasperis Chair in CardiovascularSurgery Research. He is a Professor in the Department of Surgery at the University of Toronto.Dr. Yau’s clinical interests include cardiac transplantation, mechanical circulatory support, perioperative bloodconservation and cardiac intensive care. Dr. Yau conducts a number of clinical research protocols includingstudies of perioperative myocardial protection, cellular transplantation for advanced heart failure, and noveltechnology assessment in cardiac surgery.In addition, Dr. Yau runs a basic science laboratory with a focus in the combination of stem cell transplantationwith gene therapy and transmyocardial revascularization, developing novel interventions for treatment of end-stage heart failure. He has published extensively on a variety of clinical and basic science aspects of cardiacsurgery.

Heather J Ross, MD, MHSc, FRCP(C)

Director of Cardiac TransplantToronto General Hospital

Research interests: Pharmacokinetic evaluation of immunosuppressive therapiesHeart failure and transplantation

Conference: End of Life Care in Heart Failure

Heather Ross, MD, MHSc, FRCP (C), is a Professor of Medicine at the University of Toronto, and Director of the CardiacTransplant Program at Toronto General Hospital. She is the Ted Rogers and Family Chair in Heart Function. She is theHead of the Ted Rogers Centre of Excellence in Heart Function and Director of Education for the University of TorontoTransplant Institute. She received her medical degree from the University of British Columbia, Canada, her cardiologytraining at Dalhousie University, and a postdoctoral fellowship in Cardiac Transplantation at Stanford University,California. She earned her Masters Degree in Bioethics from the University of Toronto.Dr. Ross served as the President of the Canadian Society of Transplantation in 2005, and an executive member of theInternational Society for Heart & Lung Transplantation from 2002 through 2005 and Secretary Treasurer 2007-2010.Since 2002, she has been a Supervisor for the CIHR Training Program in Regenerative Medicine, the Course Directorsince 2007 and Program Advisory Committee Chair and Co-Investigator from 2008. She Chaired the ISHLT MasterAcademy in Heart Failure in 2010. She was Associate Editor for the American Journal of Transplantation (2007-2010) andis an Associate Editor for the Journal of Heart and Lung Transplantation. She served 5 years on the CanadianCardiovascular Society Council, 3 years on the Canadian Cardiovascular Society Executive and on the Board of theCanadian Cardiovascular Society Academy. She was the Secretary Treasurer for the Canadian Cardiovascular SocietyAcademy 2010-2012. She is currently on the executive of the Heart Failure Society of America and the Vice President ofthe Canadian Cardiovascular Society. She has published over 200 articles and won numerous teaching awards.

Area of interest: Structural Heart Disease and TAVR

Conference: Toronto experience with TAVR: a large single centre registry

Mailing address:

Eric Horlick MDCM FRCPC, Director;Structural Heart Disease InterventionProgram, Assistant Professor of Medicine,Peter Munk Cardiac Centre, Toronto GeneralHospital – University Health Network, Room6E-249, 200 Elizabeth Street, Toronto,Ontario, M5G 2C4.

email: [email protected],k

Eric Horlick, MD CM, FRCPC, FSCAI

An interventional cardiologist at the Peter Munk Cardiac Centre and an Associate Professor of Medicine atUniversity of Toronto. His interests include percutaneous therapies for structural and congenital heart disease andpercutaneous valve therapy. He has delivered over 300 lectures internationally since joining the Cardiology Divisionat PMCC in 2004. He has published over 70 peer reviewed papers and a number of book chapters. Dr Horlickperformed the first percutaneous pulmonary valve implant in North America with Dr Lee Benson, the firstpercutaneous mitral valve repair in Canada, and the first transcatheter aortic valve in Toronto. He was intimatelyinvolved in the development of the Sapien pulmonary valve system and educated physicians all over Europe andthe Middle East in the use of this new system. Dr Horlick has traveled extensively in North America, Europe and theMiddle East to proctor and educate physicians in structural heart disease procedures. He has served on theprogram committee of several major international meetings, and is a Co-Chair of the American College ofCardiology Structural Heart Disease Program Committee. He has been involved in developing Canadian andInternational guidelines for Congenital Heart Disease and Percutaneous Valve Therapy.

J.E. Davies BDS, PhD, DSc, FSBE

Davies is a Full Professor at the Faculty of Dentistry, University of Toronto, and is cross-appointedto the Institute of Biomaterials and Biomedical Engineering, and also the Faculties of bothApplied Science and Engineering, and Medicine. He is the founding President of TissueRegeneration Therapeutics Inc. a mesenchymal stem cell company based in Toronto. Daviestrained as an anatomist, dental surgeon and oral surgeon in the UK. His PhD, in solid-state andsurface physics, was focused on understanding electron and ion transition events in calciumphosphates. In 1998 Davies was awarded a DSc by the University of London, England, for hissustained contributions over 20 years to the field of Biomaterials.Davies was recruited by the University of Toronto in 1988. He was the recipient of theprestigious Clemson Award for Basic Research in 2000. He has edited 2 books, The Bone-Biomaterial Interface and Bone Engineering – both of which have been heralded as keyreference works. He has also published over 200 hundred scientific papers and book chapters.He is best known internationally for his work in understanding bone healing around implanteddevices. His most recent research has focused on the harvesting, characterization, and utility ofmesenchymal stem cells; and his discovery of the richest source of such cells in human tissue,from the perivascular region of the umbilical cord.

Area of interest: Biomaterials and biomedical engineering

Conference: IBBME at the University of Toronto and the development of MSC therapeutics

Address

J.E. DaviesProfessor, Bone Interface Group, Faculty of Dentistry and Institute for Biomaterials and Biomedical Engineering, University of Toronto, 4 Taddle Creek Road, Toronto, Ontario, Canada M5S 3G9.Email: [email protected]

Howard Hu, M.D., M.P.H., Sc.D.

Dean & Professor, Dalla Lana School of Public HealthUniversity of Toronto

Mailing address:

Primary OfficeDalla Lana School of Public

Health155 College Street, 6th Floor

Toronto, OntarioCanada M5T 3M7

[email protected]

Area of interest: • Impacts of exposure to potentially toxicants that are of critical importance to public health

and medicine• Gene-environment interactions; epigenetic dysregulation

Conference: Air Pollution and Cardiovascular Disease: Health Impacts, Mechanisms, and Research Opportunities

Dr. Hu came to the University of Toronto as the Dalla Lana School of Public Health's second permanent Director and Professor in July of2012. He is a physician-scientist, trained as an internist, occupational and environmental medicine specialist, andepidemiologist. Previously, Dr. Hu had been Professor of Occupational and Environmental Medicine and Founding Director and PI ofthe NIEHS/EPA Center for Children’s Environmental Health and Disease Research at the Harvard School of Public Health and theChanning Laboratory of the Brigham & Women's Hospital in Boston, Massachusetts from 1988 to 2006. Most recently, Dr. Hu was theNSF International Chair of the Department of Environmental Health Sciences, Professor of Environmental Health, Epidemiology &Internal Medicine at the University of Michigan Schools of Public Health & Medicine from 2006 to 2012. During his tenure, theDepartment recruited 14 new faculty, re-built programs, and launched several innovative initiatives in areas such as environmentalepigenetics and nutrient-toxicant interactions. Dr Hu was also the Founding Director and PI of the NIEHS P30 Core EnvironmentalHealth Sciences Center at the University of Michigan and served as the Chair of the School-wide steering committee on global health.

Greg Evans, M.A.Sc., Ph.D., P.Eng.

Director of the Southern Ontario Centre for Atmospheric Aerosol Research (SOCAAR)University of Toronto, Faculty of Applied Science & Engineering

Dr. Evans is a Professor of Chemical Engineering and Applied Science and a former Vice-Dean Undergraduate and Chair First Year in the Faculty of Applied Science andEngineering at the University of Toronto. He is also the founding Director of theSouthern Ontario Centre for Atmospheric Aerosol Research (SOCAAR), aninterdisciplinary research centre studying the environmental and health impacts of airpollutants. Finally, he is the Co-Leader of Engineering Leaders of Tomorrow, a leadershipdevelopment program for engineering students based in the Faculty of Applied Scienceand Engineering, Leaders of Tomorrow.

[email protected]

Area of interest: Connections between emissions of pollutants, the quality andcomposition of urban air, and the impact of aerosols on humanhealth and the environment.

Conference: Every breath you take: air pollution exposure and its impacts on health

Area of interest: Electrophysiology

Conference: The update on atrial fibrillation: from rhythm to anticoagulation (videoconference)

Paul Dorian, MD, MSc, FRCPC

The Department Director, Division of Cardiology, University of Toronto and Staff Cardiac Electrophysiologist at St.Michael's Hospital. He is Professor of Medicine in the Division of Cardiology and in the Division of Clinical Pharmacology atthe University of Toronto, and a Staff Scientist at the Li Ka Shing Knowledge Institute.

Dr. Dorian received his medical degree from McGill University in Montreal in 1976. He continued training in InternalMedicine and Cardiology at the University of Toronto, and received certification by the Royal College of Physicians andSurgeons of Canada in Internal Medicine in 1983 and certification in Cardiology in 1984. He completed training in ClinicalPharmacology at the University of Toronto in 1982, and received an MSc in Pharmacology from the University of Torontoin 1982. From 1983 to 1985, he completed a Fellowship in Cardiac Electrophysiology at Stanford University MedicalCentre in California.

His research interests include basic science research in advanced cardiac life support and atrial fibrillation, the clinicalpharmacology of antiarrhythmic drugs, and clinical research on implanted devices, antiarrhythmic drugs, and quality oflife in patients with arrhythmias.

He is a Co-PI on the NIH funded Resuscitation Outcomes Consortium, and serves on the steering committee of multiplemulticenter clinical trials in arrhythmia care.

He has published over 300 peer reviewed papers and is Associate Editor of the textbook Electrophysiological Disorders ofthe Heart.

Mailing address:

St. Michael´s Hospital

Division of Cardiology

Rm 6-050 Queen Wing

30 Bond Street

Toronto, Ontario

Canada M5B 1W8

[email protected]

Adam Herman, Bio.

Adam Herman, BSc, graduated from the University of British Columbia in 2010. He

then worked at the BC Children’s Hospital as a Medical Laboratory Assistant for two

years before moving to Toronto in the summer of 2012. Since moving to Toronto,

Adam has worked as a Clinical Research Data and Regulatory Coordinator for Dr.

Michael Farkouh in the division of Cardiology. Adam is enrolled in a master’s

program in the fall as he continues to pursue his goal of working as a

clinician/scientist.