University of Groningen Modifications of collagen and chromatin in ECM-related disease Gjaltema, Rutger Almer Friso IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below. Document Version Publisher's PDF, also known as Version of record Publication date: 2016 Link to publication in University of Groningen/UMCG research database Citation for published version (APA): Gjaltema, R. A. F. (2016). Modifications of collagen and chromatin in ECM-related disease: Uncovering therapeutic targets for fibrosis and cancer. [Groningen]: Rijksuniversiteit Groningen. Copyright Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons). Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum. Download date: 25-04-2020
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University of Groningen
Modifications of collagen and chromatin in ECM-related diseaseGjaltema, Rutger Almer Friso
IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite fromit. Please check the document version below.
Document VersionPublisher's PDF, also known as Version of record
Publication date:2016
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):Gjaltema, R. A. F. (2016). Modifications of collagen and chromatin in ECM-related disease: Uncoveringtherapeutic targets for fibrosis and cancer. [Groningen]: Rijksuniversiteit Groningen.
CopyrightOther than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of theauthor(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons).
Take-down policyIf you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediatelyand investigate your claim.
Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons thenumber of authors shown on this cover page is limited to 10 maximum.
Modifications of collagen and chromatin in ECM-related disease
Uncovering therapeutic targets for fibrosis and cancer
Proefschrift
ter verkrijging van de graad van doctor aan deRijksuniversiteit Groningen
op gezag van de rector magnificus prof. dr. E. Sterken
en volgens besluit van het College voor Promoties.
De openbare verdedigen zal plaatsvinden op
woensdag 9 november 2016 om 14:30 uur
door
Rutger Almer Friso Gjaltema
geboren op 29 maart 1982te Zwolle
PromotoresProf. dr. R.A. BankProf. dr. M.G. Rots
BeoordelingscommissieProf. dr. F.J. Dekker Prof. dr. H. van GoorProf. dr. G.J.V.M. van Osch
Paranimfen:Bram PiersmaMendel Kaelen
Voor mijn vader
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Contents
Chapter 1: Introduction and aims
PARt I: NOVEL FEAtURES OF COLLAGEN MODIFYING ENZYMES
Chapter 2: Molecular Insights Into Prolyl And Lysyl Hydroxylation Of Fibrillar Collagens In Health And Disease
Chapter 3: Disentangling Mechanisms Involved In Collagen Pyridinoline Cross-linking: The Immunophilin FKBP65 Is Critical For Dimerization Of Lysyl Hydroxylase 2
Chapter 4: Lysyl hydroxylase 2 splice variants are chromatin-associated proteins that regulate transcription of target genes
PARt II: tRANSCRIPtIONAL REGULAtION OF PRO-FIBROtIC PROCESSES
Chapter 5: Procollagen Lysyl Hydroxylase 2 Expression is Regulated by an Alternative Downstream Transforming Growth Factor Beta-1 Activation Mechanism
Chapter 6: Enhancer of zeste homolog-2 (EZH2) methyltransferase regulates transgelin/smooth muscle-22 alpha expression in endothelial cells in response to interleukin-1 beta and transforming growth factor-beta 2
Chapter 7: Targeting TET methylcytosine dioxygenases induces a wide spectrum of anti-fibrotic effects
PARt III: tRANSCRIPtIONAL MODULAtION BY tARGEtED REwRItING OF thE EPIGENOME
Chapter 8: KRAB-induced heterochromatin is more effective than targeted DNA methylation in achieving efficient and mitotically stable gene repression
Chapter 9: Writing of H3K4Me3 permanently overcomes silencing in a context-dependent manner
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Chapter 10: Summary & general discussion
Chapter 11: Nederlandse samenvatting
Appendices:AbbreviationsCurriculum vitae and list of publicationsDankwoord