KARYA TULIS AKHIR Pengaruh Pemberian Ekstrak Cacing Tanah (Lumbricus rubellus) Peroral Terhadap Kadar Enzim SOD dan Pertanda Inflamasi Kronis Esofagus Tikus Putih Jantan Wistar yang Diinduksi oleh DMBA Sebagai Agen Karsinogenik Disusun oleh : SISMI YUNIARTI 09020127 UNIVERSITAS MUHAMMADIYAH MALANG FAKULTAS KEDOKTERAN 2013
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KARYA TULIS AKHIR
Pengaruh Pemberian Ekstrak Cacing Tanah (Lumbricus rubellus) Peroral
Terhadap Kadar Enzim SOD dan Pertanda Inflamasi Kronis Esofagus Tikus
Putih Jantan Wistar yang Diinduksi oleh DMBA Sebagai Agen
Karsinogenik
Disusun oleh :
SISMI YUNIARTI
09020127
UNIVERSITAS MUHAMMADIYAH MALANG
FAKULTAS KEDOKTERAN
2013
HASIL PENELITIAN
Pengaruh Pemberian Ekstrak Cacing Tanah (Lumbricus rubellus) Peroral
Terhadap Kadar Enzim SOD dan Pertanda Inflamasi Kronis Esofagus Tikus
Putih Jantan Wistar yang Diinduksi oleh DMBA Sebagai Agen
Karsinogenik
KARYA TULIS AKHIR
Diajukan kepada Universitas Muhammadiyah
Malang untuk Memenuhi Salah Satu
Persyaratan dalam Menyelesaikan Program
Sarjana Fakultas Kedokteran
Oleh :
Sismi Yuniarti
09020127
UNIVERSITAS MUHAMMADIYAH MALANG
FAKULTAS KEDOKTERAN
2013
i
LEMBAR PENGESAHAN
LAPORAN HASIL PENELITIAN
Telah disetujui sebagai hasil penelitian
untuk memenuhi persyaratan
Pendidikan Sarjana Fakultas Kedokteran
Universitas Muhammadiyah Malang
Tanggal: 22 Maret 2013
Pembimbing I
dr. Fathiyah Safithri, M. Kes
Pembimbing II
dr. Maryam Abdullah
Mengetahui,
Fakultas Kedokteran
Dekan,
dr. Irma Suswati, M.Kes
ii
LEMBAR PENGUJIAN
Karya Tulis Akhir oleh Sismi Yuniarti ini
Telah diuji dan dipertahankan di depan Tim Penguji
Ginekologi. 3rd ed. Jakarta: Pustaka Spirit : p. 157-70.
Anita J, Indira AJ, 2012, Nutritional and Antioxidant Evaluation of Earthworm Powder, International Journal Research of Pharmacy, India, pp: 177-180.
Anonim. 2004. PolycyclicAromatic Hydrocarbon (online). Department of The Environment, Water, Heritage and Arts Ausralia. (Diunduh 25 Juli 2011).
Alatas, Zubaidah. 2007. Faktor Genetik dalam Karsinogenesis yang Diinduksi oleh Radiasi Pengion. PTKMR-BATAN.
Al Yassin T, Toner PG. 1977. Fine Structure of Squamous Epithelium and Submucosal Glands of Human Esophagus. J anat ; 123:705.
Farhadi A, Jeremy, F., Ali, B., Ali, K. 2002. Reactive Oxygen Species : are They Involved in Pathogenesis of GERD, Barret’s Esophagus, and Latter’s Progression Toward Esophageal Cancer?. American J Gartroenterology 97, 22-26.
Asikin N, 2001, Antioksidan Endogen dan Penilaian Status Antioksidan, Makalah Dalam Kursus Penyegaran dan Pelatihan Radikal Bebas dan Antioksidan: Dasar, Aplikasi, dan Pemanfaatan Bahan Alam. Bagian Biokimia, Fakultas Kedokteran Universitas Indonesia, Jakarta. Hal 1-6.
Arthur JR. 2000. The glutathione peroxidases. Cell Mol Life Sci 57: 1825-1835.
Archer MC. 1992. Chemical Carcinogenesis. Dalam: Tannock IF, Hill RP (eds). The Basic Sciences of Oncology 2nd Ed. New York. Mc Graw Hill Inc : 102-118.
Augustin W., Wiswedel I., Noack H., Reinheckel T., Reichelt O. 1997. Role of Endogenous and Exogenous Antioxidant in the Defence Against Functional Damage and Lipid Peroxidation in Rat Liver Mithocondria. Germany: Mol Cell Biochem. 174(1-2): 199-205.
81
Awayda, NS., Bengrine A, Tobey NA, Stockand JD, Orlando RC. 2004. Nonselective Cation Transport in Native Esophageal Epithelia. Am J Physiol Cell Physiol ; 287 (2): C 395-402.
Barlow WJ., Orlando RC. 2005. The Pathogenesis of Heartburn Non-erosive Refluks Disease : a Unifying Hypothesis. Gastroenterology: 128(3): 771-778. (DOI : 10.1016/J.Gastro.2004.08.014).
Bass, BL et al. 1987. HCl Back Diffusion Interferes with Intrinsic Reactive Regulation of Esophageal Mucosal Blood Flow. Surgery ;96:404.
Bertin, G., and Averbeck, D. 2006. Cadmium: cellular effects, modifications of biomolecules, modulation of DNA repair and genotoxic consequences a review). Biochimie 88: 1549-59.
Bowman, W. C., and M. J., Rand. 1989. Neoplastic Disease and Anticancer Drugs, in Text Book of Pharmacology. 2nd Ed, Blackwell Scientific Publications, Melboume, 1-23.
Boyce, H., Boyce G. 2003. Esophagus : Anatomy and Structural Anomalies. In : Yamada T, Alpers DH, Kalowitz N, Laine L, Owyang C, Powell DW, eds. Textbook Gastroenterology, 4th ed., vol1. Philadephia. Lippincott Williams and Wilkins; 1148-1165.
Bowman, W. C., and M. J., Rand. 1989. Neoplastic Disease and Anticancer Drugs, in Text Book of Pharmacology, 2nd Ed, Blackwell Scientific Publications, Melbourne, 1-23.
Buttar, N.S., Kenneth, K.W., Leotovitch, O., Westcott, J.Y., Pacifico, R.J., Anderson, M.A., Krishnadath, K.K., Lutzke, L.S., Budgart, L.J. 2002. Chemoprevention of Esophageal Adenocarcinoma by COX-2 Inhibitor in an Animal Model of Barret's Esophagus. Gasfoenterology 122 : 1101-1112 .
Castellsague, X., Munoz, N., De Stefani, E., Victoria C.G., Castelletto, R., Rolon, P.A. et al. 1999. Independent and joint effects of tobacco smoking and alchohol drinking on the risk of esophageal cancer in males and females. Int J Cancer; 82 (5) : 657-64.
Chen H., Shoichi T., Michio I., Eiko O., Zhang zhi –guo., Kazuaki C., Chen Bao. 2007. Earthworm Fibrinolytic Enzyme: antitumor Activity on Human Hepatoma Cells in vitro and in vivo. Chin Med J. 120(10) : 898-904.
Christensen J, et al. 1984. Comparative Anatomy of the Myenteric Plexus of the distal Colon in Eight Mammals. Gastroenterology ; 86(4):706-713.
82
Chu, EW., Malmgren RM, 1965, An Inhibitory Effect of Vitamin A on The Induction of Tumors of Forestomach and Cervix in The Syrian Hamster by Carcinogenic Polycyclic Hydrocarbons, Cancer Res 25(6): 884-895.
Church SL., Grant JW., Ridnour LA.1993. Increased Manganese Superoxide Dismutase Expression Suppresses the Malignant Phenotype of Human Melanoma Cells. Proc Natl Acad Sci USA, 90, 3113-7.
Costantinou AI, Mehta R, Husband A. Phenoxodiol. 2003. A Novel Isoflavone Derivate, Inhibits 7,12-Dimethilbenz (α) anthrancene (DMBA)-induced Mammary Carcinogenesis in Female Sprague Dawley Rats. European Journal of Cancer. (39):1012-18.
Dandekar S, Sukumar S, Zaebl H, 1986, Specific Activation of The Cellular Harvey-Ras Oncogene in DMBA-Induced Mouse Mammary Tumors, Mol. Cell Biol., 6, 11, 4104-4108.
DeBacker A, Haentjens P, Williems G. 1985. Hydrochloric Acid : A Trigger of Cell Proliferationin the Esophagus of Dogs. Dig Dis Sci ; 30:884.
Delattre, JF., et al. 2000. Functional Anatomy of the Gastroesophageal Junction. Surg Clin North Am; 80(1): 241-260.
Dixon J, Strugala V, Griffin SM, et al. 2001. Esophageal Mucin : An Adherent Mucus Gel Barrier is Absent in the Normal Esophagus but Present in Barret’s Esophagus. Am J Gastroenterol ; 96: 2575.
Earthworm. 2007. Lumbricus genus “assorted species, including: Lumbricus terrestris and Lumbricus rubellus” (online). (Diunduh 25 Juli 2011).
Eiro N., Vizoso FJ. 2012. Inflammation and Cancer. World Journal of Gastrointestinal Surgery, vol. 4, no. 3: 62-72.
Engel, L.S., Chow, W.H. & Vuhan, T.L. et al. 2003. Population Attribute Risks of Esophageal and Gastric Cancer. Journal of the National Cancer Institute, Vol. 95. 18: 14404-1413.
Enzinger PC, RJ Mayer. 2003. Esophageal Cancer. N Engl J Med 349(23) :2241-52.
Evans R. 2004. Flavanoids and Isoflavones: Absorbtion, Metabolism, and Bioactivity. Free Rad . Biol. Med; 36: 827-282.
83
Fass, R. 2004. Sensory Testing of the Esophagus. J Clin Gastroenterol ; 38 (8); 628-641.
Fass, R., et al. 1998. Differential Effect of Long –Term Esophageal Acid Exposure on Mechanosensitivity and Chemosensitivity in Humans. Gastroenterology;115(6); 1363-1373.
Feldman, MJ., Morris, GP., Patterson, WG. 2001. Role of Substance P and Calcitonin Gene-Related Peptide in Acid- Induced Augmentation of Opossum Esophageal Blood Flow. Dig Dis Sci ; 46:1194.
Fieldman, M., Orlando, RC., eds. 2002. Atlas of Esophageal Disease, 2nd ed. Philadelphia: Current Medicine : 99.
Frenkel, K. 1992. Carcinogen-mediated oxidant formation and oxidative DNA damage. Pharmacol Ther 53,127-66.
Fridovich, I., 1986, Superoxide Dismutase, Advance in Enzymology and Related Areas of Molecular Biology, 58: 61-97.
Garcia, L.A., Langergren, J., Lindbland, M. 2006. Gastric Acid Suppression and Risk of Oesophageal and Gastric Adenocarcinoma : a Nested Case Control Study in the UK. Gut 55:1538-1544.
Gillen, P., Keeling, P., Byrne, PJ., West AB, Hennessy TP. 1988. Experimental columnar metaplasia in the canine oesophagus. Br J Surg; 75: 113-5.
Gitawati, R., 1995, Radikal Bebas: Sifat dan Peranan Dalam Menimbulkan Kerusakan atau Kematian Sel, Cermin Dunia Kedokteran, 102:33-36.
Gerhardt, D, et al. 1980. Human Upper Esophageal Sphincter Pressure Profile. Am J Physiol; 239(1): G49-52.
Ghosh, SK, et al. 2006. Pysiology of the Esophageal Pressure Transition Zone: Separate Contraction Waves Above and Below. Am J Physiol Gastrointest Liver Physiol; 290(3) : G568-576.
Goyal, R, Sivaro D. 1999. Functional Anatomy and Physiology of Swallowing and Esophageal Motility. In : Catell OD, Richter JE, eds. The Esophagus, 3rd ed. Philadelpia: Lippincott Williams & Wilkins; 24-26.
Hahn, WC. 2003. Role of Telomeres and Telomerase in The Pathogenesis of Human Cancer. J Clin Oncol ; 21(10) : 2034 -43.
Harris, RE. 2003. Cyclooxygenase-2 Blockade in Cancer Preventionand Therapy. Totowa: NJ 341-65.
Hannahan, D., Weinberg RA. 2000. The Hallmarks of Cancer. Cell ; 100: 57-70.
84
Hascheck, WM., Rosseux CG. 1991. Handbook of Toxicology Pathology. London. Academic Press Inc.
Hollwarth, ME., Smith, M., Kvietys, PR., Granger, DN. 1986. Esophageal Blood Flow in the Cat. Gastroenterology; 90:622.
Hornby, PJ., Abrahams, TP. 2000. Central Control of Lower Esophageal Sphincter Relaxation. Am J Med; 108 (suppl 4a): 90S-98S.
Hunt, C. R., Sim, J. E., Sullivan, S. J., Featherstone, T., Golden, W., Von Kapp-Herr, C., Hock, R. A., Gomez, R. A., Parsian, A. J., and Spitz, D. R. 1998. Genomic instability and catalase gene amplification induced by chronic exposure to oxidative stress. Cancer Res 58, 3986-92.
Hu, YL., Xu, M., Zhang, SQ. et al. 2002. Study of earthworm extracts on the immunologic activity and anti-tumor effects. Biotechnology 12: 9-10.
Hwang, E. S., Bowen, P. E. 2007. DNA damage, a biomarker of carcino-genesis: Its measurement and modulation by diet and environment. Crit Rev Food Sci Nutr 47, 27-50.
Iijima, K. et al. 2002. Dietary nitrate generates potentially mutagenic concentrations of nitric oxide at the gastroesophageal junction. Gastroenterol-ogy, 122, 1248-1257.
Ishikawa, K., Takenaga, K., Akimoto, M., Koshikawa N., Yamaguchi, A., Imanishi, H., Nakada K., Honma Y., and Hayashi, J. 2008. ROS-generating mitochondrial DNA mutations can regulate tumor cell metastasis. Science 320, 661-44.
Ismail, SA., Pulandiran K, Yegnanarayan R. 1992. Anti-inflammatory Activity of Earthworm Extracts. Soil Biol Biochem. 24: 1253 : 1254.
Ismail, BF., Horton PF, Pope CEII. 1977. Histological Consequences of Gastroesophageal Refluks Man . Gastroenterology: 73:1315.
Jiemenz P, Lanas A, Piazuelo E, Esteva F. 1999. Effects of Extracellular Ph on Restitution and Proliferation of Rabbit Esophageal Epithelial Cell. Aliment Pharmachol Ther : 13: 545.
Jordan, LB., Harrison, DJ. (2000) Apoptosis: a distinctive form of cell death. In: Schunkert H and Riegger GAJ (eds). In: Apoptosis in cardiac biology. Kluwer Academic Publishers, Massachusetts, USA: 123–35.
Kakizoe, T. 2003. Chemoprevention of Cancer Focusing on Cinical Trial. Nationa Cancer Center, Jpn. J. Clin. Oncol., 33(9): 421-442.
85
Kamangar, F., Dores, G.M., Anderson, W.F. 2006. Pattern of Cancer Incidence, Mortality, and Prevqlence Across Five Continents : Defining Priorities to Reduce Cancer Disparities in Different Geographic Regions of the World. J. Clin. Oncol. 24 : 2137-2150.
Kartikawati D, 1999, Studi Efek Protektif Vitamin C Terhadap Respon Imun dan Enzim Antioksidan pada Mencit yang Dipapar Paraquat [tesis], Bogor: Program Pascasarjana, Institut Pertanian Bogor.
Kasno, Prasetyo A. 2005. Patologi rongga mulut dan traktus gastrointestinalis. Semarang: Badan Penerbit Universitas Diponegoro.
Khalbuss WE, Marousis CG, Subramanyam M, Orlando RC. 1995. Effect of HCl on Transmembrane Potentials and Intracellular PH in Rabbit Esophageal Epithelium. Gastroenterology; 118: 662.
Kollarova, H., Machova, L., Horacovao D. Janoutov, G., Janout, Y. 2007. Epidemiology of Esophageal Cancer - An Overtiw Article. Bio Pap Med, 151 (1) : 17:28.
King, R.J.B. 2000. Cancer Biology. Second Edition, Pearson: Prentice Hall, London.
Kubatka, P., Ahlersova E., Ahlers I., Bojkova B., Kalicka K., Adamekova E., Markova M., Chamilova, M. and Cermakova, M., 2002. Variability of Mammary Carsinogenesis Induction in Female Sprague-Dawley and Wista: Han Rats : the Effect of Season and Age. Physiol. Res. , 51,633-640.
Kumagai, H.; Mukaisho, K.; Sugihara, H.; Miwa, K.; Yamamoto, G.; Hattori, T. 2004. Thioproline inhibits development of esophageal adenocarcinoma induced by gastroduodenal refluks in rats. Carcinogenesis. 25: 723-727 .
Kumar, B., Koul, S., Khandrika L., Meacham, R. B., and Koul, H. K. 2008. Oxidative stress is inherent in prostate cancer cells and is required for aggressive phenotype. Cancer Res 68, 01777-85.
Lacy ER, Tobey NA, Cowart K, Orlando RC. 1989. The Esophageal Mucosal Barrier: Structural Correlates. Gastroenterology; 96:A281.
Lampe JW.2003. Spices and Cancer Prevention in Am J Clin Nutrition Bulletin. Vol. 78. American Society for Clinical Nutrition Inc, pp: 579-583.
Li H, Walsh TN, O'Dowd G, Gillen P, Byrne PJ, Hennessy TP. 1994. Mechanisms of columnar metaplasia and squamous regeneration in experimental Barrett's esophagus. Surgery ; 115 : 176-81.
Liebermann, MD., et al. 1979. Muscular Equivalent of the Lower Esophageal Sphincter. Gastroenterology; 79(1) : 31-38.
86
Livstone EM, Sheahan DG, Behar J. 1977. Studies of Epithelial cell Proliferation in Patients with Refluks Esophagitis. Gastroenterology; 73: 1315.
Long JD, Orlando RC. 2002. Anatomy, Histology, Embriology, and Developmental Abnormalities of the Esophagus. In : Fieldman M, Fieldman LS, Sleisenger MH, eds. Gastrointestinal and Liver Disease. Philadelphia: WB Saunders:551-560.
Long JD, Orlando RC. 1999. Esophageal Submucosal Glands : Structure and Function. Am J Gastroenterol ;94(10): 2818-2824.
Lu, H., Weiming O.,Chuanshu H. 2006. Inflammation, a Key Event in Cancer Development. Mol Cancer Res 2006;4:221-233.
Lukitaningsih E, Noegrohati S. 2000. Studi Pemisahan senyawa hidrokarbon poliaromatik secara kromatografi gas kolom kapiler. MFI 11(1): 31-Laurence DR, Bacharach AL. 1964. Evaluation of Drug Activities: Pharmachometrics, Vol 1. New York/London: Academis Press.
Macdonald F, Ford CHJ, Casson A.G, 2004, Molecular Biology of Cancer, 2nd Ed, London and New York: Garland science/BIOS scientific, pp: 141-151.
of Curcumin and Piperin During 7, 12- dimethylbenz[a]anthracene-Induced Hamster Buccal Pouch Carcinogenesis. Singapore Med J, 50, 139-46.
Mayer EA, Gebhart GF. 1994. Basic and Clinical Aspects of Viceral Hyperalgesia. Gastroenterology; 107(1) : 271-293.
Marques JP, Leblond CP. 1965. Mitosis and Differentiation in the Stratified – Squamous Epithelium of the Rat Esophagus . Am J Anat; 117:73.
Martin R.C., Liu Q., Wo J.M., Ray M.B., Li, Y. 2007. Chemoprevention of Carcinogenic Progression of Esophageal Adenocarcinoma by the Manganese Superxide Dismutase Supplementation. Clin Cancer Res 13:5176-5182.
Mates., JM., Jimenez., F. 1999. Antioxidant Enzymes and Their Implication in Pathophysiologic Processes. Front Biose. 4, 339-345.
Meissier B, Leblond CP. 1960. Cell Proliferation and Migration as Revealed by Radioautography after Injection of Thymidine- H3 into Rats and Mice. Am Anat ; 106:247.
Meiyanto, E., Susilowati, S., Tasminatun, S., Murwanti, R., Sugiyanto. 2007. Efek Ekstrak Etanolik Gynura procumbens (Lour.) Merr. Terhadap
87
Penghambatan Pertumbuhan Tumor Payudara yang Diinduksi DMBA. Majalah Farmasi Indonesia, 18(4) : 169-175.
Melhado, Rachel E., Alderson Derek, Tucker Olga. 2010. The Changing Face of Esophageal Cancer. Cancers 2 ; 1379-1404.
Melendez,V., Luch,A., Seidel, A., and Baird, W. M., 1999. Cancer Initiation by Polycyclic Aromatic Hydrocarbon Results from Formation of Stable DNA Adducts rather than Apurinic Sites. Carcinogenesis, 20 (10), 1885-1891.
Mihara H. Sumi, T. Yoneta, et a1. 1991. A novel fibrinolytic enzyme extracted from the earthworm, Lumbricus rubellus. Japanese Joumal of Physiology, vol. 41, no. 3, pp. 461-472.
Miyata, M., Kudo, G., Lee, Y.H., Yang, T.J., Gelboin, H.V., Fernandez-Salguero, P., Kimura S., Gonzalez, F.J. 1999. Targeted disruption of the microsomal epoxide hydrolase gene. Microsomal epoxide hydrolase is required for the carcinogenic activity of 7,12-dimethylbenz[α]anthracene. J. Biol. Chem. 274, 23963-239 68.
Mirvish SS. 1986. Effects of Vitamin C and E on N-nitroso Compound Formation, Carcinogenis, and Cancer. Cancer. 58 : 1842-50.
Mittal RK, Balaban DH. 1997. The Esophagogastric Junction. N eng J Med ; 336(13): 924-932.
Muto T., Takasaki S., Takahashi H., et al., 2003, Initial Changes of Hepatic Glycogen Granules and Glycogen Phosporylase á After Exposure to 7, 12-Dimethylbenz (α) Anthracene in Rats, Japan Toxicol Pathol 16(2): 153-160.
Muqbil I, Azmi AS, Banu N, 2006, Prior Exposure to Restraint Stress Enhances 7,12- Dimethylbenz(a)anthracene (DMBA) Induced DNA Damage in Rats, FEBS Letters 580(2): 3995–3999.
Lee MJ., Hyun Ju S., Jun YJ., Sun YP., Uy Dong S. 2013. Anti-Oxidative and Anti- Inflammatory Effects of QGC in Cultured Feline Esophageal Epithelial Cells. Korean J Physiol Pharmachol 17 : 81-87.
Norat, T, E Riboli. 2002. Fruit and Vegetable Consumption and Risk of Cancer of the Digestive Tract: meta-analysis of Published Case-Control and Cohort Studies. IARC Sci Publ: 156:123-5.
Orlando RC , Powell DW. 1984. Studies of Esophageal Epithelial Electrolyte Transport and Potential difference in Man. In: Allen A, et al., eds. Mechanism of Mucosal Protection in the Upper Gastrointestinal Tract . New York: Raven Press : 75 .
Orlando RC. 1996. Why is the Higest Grade Inhibition of Acid Secretion Afforded by Proton Pump Inhibitors Often Required for Healing of Refluks Esophagitis? An Ephitelial Perspective. Am J Gastroenterol; 91: 1692-1696.
Orlando RC, Powell DW . 1984. Studies Esophageal Ephithelial Electrolyte Transport and Potential Difference in Man. In : Allen A, et al., eds. Mechanisms of Mucosal Protection in the Upper Gastrointestinal Tract. New York: Raven Press : 75.
Orlando RC. 1988. Pathology of Refluks Oesophagitis and its Complications. In : Jamieson CG, ed. Surgery of the Oesophagus. New York: Churchill-Livingston : 189.
Pan, M.H., Chen, W.J., Lin, S., Ho, C.H., Lin, J.K. 2002. Tangeretin Induces Cell Cycle Through Inhibiting Cyclin Dependent Kinase 2 & 4 Activities As Well As Elevating Cdk Inhibitor p2l in Human Colorectal Carcinoma Cells. Carsinogenesis, Oxford University. Press, 23 : 1677 -1684.
Palungkun R. 1999. Sukses Beternak Cacing Tanah Lumbricus rubellus. Jakarta: Penebar Swadaya38.
Park, E. Ryu, H. Kim, et al. 1999. Characterization of antithrombotic activity of lumbrokinase-immobilized polyurethone valves in the total artificial heart. Artifi cial Organs, vol. 23, no. 2, pp. 210-214.
Pecorico L, 2005, Molecular biology of cancer, mechanism, targets and therapeutics. New york: Oxford university press inc. pp: 4-9.
Perkins AS., Ster DF., 1997. Molecular Biology of Cancer : Oncogenes. In:
Devita VT., Hellman S, Rosenberg SA. (eds) Cancer : Princicples and Practice. Philadelphia, Lippincott-Raven Publ : 79-102.
Piazuelo E, Cebritin C, Escartin A, Jimdnez P, Soteras F, Ortego J, Lanas A. 2005. Superoxide dismutase prevents development of adenocarcinome in a rat model of Barrett's esophagus. World J Gastroenterol; 11(47): 7436-7443.
89
Piazuelo E, Jimenez P, Lanas A, Esteva F. 1999. Effect of Growth Factors and Prostaglandin E2 in Restitution and Proliferation of Rabbits Epithelial Cell. Aliment Pharmachol Ther; 13:545.
Powell DW. 1981. Barrier Function of Epithelia. Am J Physiol; 241-G275.
Priyanto, Sunaryo H. Toksikologi Mekanisme, Terapi Antidotum, dan Penilaian Resiko. Edisi 1. Depok: Leskonfi; 2009.
Prangdimurti E, 1999, Efek Perlindungan Ekstrak Jahe Terhadap Respon Imun Mencit yang Diberi Stress Oksidatif oleh Pestisida Paraquat [tesis], Bogor: Program Pascasarjana, Institut Pertanian Bogor.
Prakash M, Balamurugan M, Parthasarathi K, Gunasekaran G, Cooper EL, Ranganathan LS. 2007. Anti- ulceral and anti-oxidative properties of “eartlrworm paste” of Lampito mauritii (Kinberg) on Rattus norvegicus. Eur Rev Med Pharmacol Sci; 11 : 9.
Price SA, Wilson LM. Patofisiologi: Konsep Klinis Proses-Proses Penyakit. Edisi 6. Jakarta : EGC; 2005.
Qu Y, Zhang H, Zhao S, et al 2010. The effect on radioresistance of manganese superoxide dismutase in nasopharyngeal carcinoma. Oncol Rep, 23, 1005-11.
Ren, W., Qiao, Z., Wang, H., Zhu, L., Zhang, L. 2003. Flavonoids: Promising Anticancer Agents. Medicinal Research Review, 23(4): 519-534.
Rodrigo J, Hernandez DJ, Vidal MA, Pedrosa JA. 1975. Vegetative Innervation of the Esophagus III. Intraepithelial Endings. Acta Anat: 92:242.
Ryo, S. Park, M. Kim, D. K. Han, Y. H. Kim, and B. Min. 1994. Antithrombogenicity of Lumbrokinase-immobilized Polyurethane. Journal of Biomedical Materials Research 28 : no.9, pp. 1069-1077.
Savill J., Dransfield I., Gregory C., Haslett C.2002. A blast from the past: clearance of apoptotic cells regulates immune responses. Nat Rev Immunol;2:965 – 75.
Sivarao DV, Goyal RK. 2000. Functional Anatomy and Physiology of the Upper Esophageal Sphincter. Am J Med; 108(suppl 4a): 27S-37S.
Sigma aldrich. 2011. 7,12-Dimethylbenz(α)anthracene (online). (Diunduh 25 Juli 2011).www.sigmaaldrich.com/catalog/ProductDetail.do?N4=D3254|SIGMA&N5=SEARCH_CONCAT_PNO|BRAND_KEY&F=SPEC
90
Serrano M., Massague J. 2000. Network of Tumor Suppressor Genes. EMBO Reports ; 11(21) : 115-119.
Siregar P, 1992, Metabolit Oksigen Radikal Bebas dan Kerusakan Jaringan. Cermin Dunia Kedokteran, 80:112-115.
Sharp L, Chilvers CED, Cheng KK, et al. 2007. Risk factors for squamous cell carcinoma of the oesophagus in women : a case-control study. Br J Cancer 85 : 1667-70
Shao J, Sartor B R, Dial E, et al., 2000, Expression of Intrinsic Factor in Rat and Murine Mucosal Cell Lineages is Modified by Inflammation, Am J Pathol 157(4):1197- 1205
Shi, H., Shi, X., and Liu, K. J. 2004. Oxidative mechanism of arsenic toxicity and carcinogenesis. Mol Cell Biochem 255, 67-78 .
Soini Y., Vakkala M., Kahlos K., Paakko., Kinnula V. 2001. MnSOD expressio is Less Frequent in Tumour Cells of Invasive Breast Carcinomas than in In situ Carcinomas or Non-Neoplastic Breast Epithelial Cells. J Pathol ;195 (2): 156-62.
Snell, Richard S. 2006. Anatomi Klinik untuk Mahasiswa Kedokteran; alih bahasa Liliana Sugiharto. Edisi 6. Jakarta: EGC.
Spechler SJ. 2002. Barrett's esophagus. N Engl J Med; 346:83642.
Steinmetz KA and Potter JD. 1991. Vegetable, Fruits, and Cancer. II. Mechanism, Cancer cause control. 2: 427-8 .
Solcia E, Villani L, Liunetti O, et al. 2000. Altered Intracellular Glycoconjugates and Dilated Intercellular Spaces of Esophageal Epithelium in Refluks Disease. Virchows Arch ; 436: 207-216.
Subekti EM, 1997, Pengaruh Pemberian Vitamin Antioksidan A, E, dan C, Serta Minyak Sawit Mentah (CPO) Terhadap Proliferasi Limfosit dan Kadar Malonildehida Plasma Tikus Percobaan yang Diberi Ransum Mengandung Malathion [tesis], Bogor: Program Pascasarjana, Institut Pertanian Bogor.
Sun GG., Wang YD., Chen LQ., et al .2011. Novel cancer suppressor gene for esophageal cancer: manganese superoxide dismutase. Dis esophagus, 24, 346-53.
Terry P, Lagergren J, Hansen H, Wolk A, Nyren O. 2001. Fruit and Vegetable consumption in the prevention of oesophageal and cardia cancer. Eur J Cancer Prev. 10: 365-9.
91
Tejasari, 2000, Efek Proteksi Bioaktif Oleoresin Rimpang Jahe (Zingiber Officinale Roscoe) Terhadap Fungsi Limfosit Secara Invitro [disertasi], Bogor: Program Pascasarjana, Institut Pertanian Bogor.
Tobey NA, Hosseini SS, Argote CM, et al. 2004. Dilated intercellular spaces and Shun permeability in nonerosive acid-damaged esophageal epithelium. Am J Gastroenteroll; 99 : 13-22.
Tobey NA, Hosseini SS, Caymaz – Bor C, Awayda M, Orlando RC.2002. Effect of luminal Acidity on the apical Membrane Na Channel in Rabbit Esophageal Epithelium. Gastroenterology; 118: A883.
Tobey NA, Carson JL, Alkiek RA, Orlando RC. 1996. Dilated Intracellular Spaces: A morphological Feature of Acid Refluks-damage Human Esophageal Epithelium. Gastroenterology ; 111: 1200.
Tobey NA, Reddy SP, Khalbuss WE, Silvers SM, Cragoe EJJr, Orlando RC. 1993. Na (+) – Dependent and –independent Cl-/HCl- Exchangers in Cultured Rabbit Esophageal Epithelial Cell. Gastroenterology; 104:185 -195.
Tobey NA, Hosseini SS, Argote CM, Dobrucali AM, Awayda MS, Orlando RC. 2004. Dilated Intercellular Spaces and Shunt Permeability in Nonerosive Acid-damaged Esophageal Epithelium. Am J Gastroenterol; 99:13-22.
Turner KS, Powell DW, Carney CN, Orlando RC, Bozymski EM. 1978. Transmural Electrical Potential Difference in the Mammalian Esophagus in vivo. Gastroenterology; 75-286.
Underwood JCE. 2000.Sistem pencernaan. Dalam : Patologi umum dan sistemik vol 2. Edisi 2. Jakarta: EGC.
Villanacci V, Grigolato PG, Cestari R, et al. 2001. Dilated Intercellular Spaces as Markers of Refluks Disease : Histology, Semiquantitaive Score and Morphometry upon Light Microscopy. Digestion ; 64:1 -8.
Wang, G.Q., Abnet, C.C., Shen, Q., Lewin, K.J., Sun, X.D., Roth, M.J., Qiao, Y.L., Mark, S.D., Dong, Z.W., Taylor, P.R., et al. 2005. Histological precursors of esophageal squamous cell carcinoma: results from a 13 year prospective follow up study in a high riskpopulation. Gut. 54 : 187-192.
92
Wang MC., Guo MF., Zhao GQ. 2006. Research on mRNA expression level of MnSOD gene in prostate cancer and benign prostatic hyperplasia tissue. Chin J Gerontology, 26, 164-5.
Wang Y., Kuroda M., Gao XS., et al. 2005. Hydrogen peroxide overload increases adriamycin-induced apoptosis of SaOS(2) FM, a manganese superoxide dismutase-overexpressing human osteosarcoma cell line. Int J Oncol, 26, 1291-300.
Wattenberg LW, 1993, Prevention, Therapy, and Basic Science and The Resolution of the Cancer Problem, Cancer Rs, 53, 5890-5896.
Weinberg RA., Hanahan D. 1996. The Molecular Pathogenesis of Cancer. In : Bishop JM., Weinberg Ra. (eds). Molecular Oncology New York Scientific American : 179-204.
Wikipedia. 2011. Lumbricus rubellus (online). (Diunduh 25 Juli 2011).
Wink, DA., Mitchell, JB. 1998. Chemical Biology of Nitric Oxide : Insights into Regulatory, Cytotoxic, and Cytoprotective Mechanisms of Nitric Oxide. Free Rad Biol Med; 25 (4-5) : 434-56.
Wresdiyati T, 2003, Deteksi Secara Imunohistokimia Oxygen-Free Radikal Scavenger Copper, Zinc Superoxide Dismutase (Cu,Zn-SOD) pada Hati Tikus Dibawah Kondisi Stress., Biota 8(3):107-112.
Wu, W. S. 2006. The signaling mechanism af ROS in tumor progression. Cancer Metastasis Rev 25, 695-705.
Yamada T, et al. 1999. Textbook of Gastroenterologt, Esophageal Neoplasms. Lippincott Williams & wilkins. 1278-86.
Yan T, Oberley LW, Zhong W, et al. 1996. Manganese-containing superoxide dismutase overexpression causes phenotypic reversion in SV40-transforme.
Ye, W., Held, M., Lagergren, J., Engstrand, L., Blot, W.J., Mclaughlin, J.K., Nyren, O. 2004. Helicobacter pylori Infection and Gastric Atrophy: Risk of Adenocarcinoma and Squamous-Cell Carcinoma of the Esophagus and Adenocarcinoma of the Gasnic Cardia. J. Natl. Cancer Inst. 96: 388-396 .
Yoshida N. 2007. Inflammatory and oxidative in Gastroesophageal Reflux Disease. J Clin Biochem Nutr 602-8566.
Zhang Y, Smith BJ, Oberley LW. 2006. Enzymatic activity is necessary for the tumor-suppressive effects of MnSOD. Antioxid Redox Signal, 8, 1283-93.
93
Zejnilovic J., Akev N., Yilmaz H., et al .2009. Association between manganese superoxide dismutase polymorphism and risk of lung cancer. Cancer Genet Cytogenet, 189, 1-4.