UMCH...SYLLABUS – 3rd YEAR No. Educational activities - Objects/Disciplines 1 Pharmacology. 2 Bacteriology. Virusology. Parasitology 3 Pathology 4 Pathophysiology 5 Surgical Semiology

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FACULTATEA DE MEDICINĂ Faculty of Medicine

SYLLABUS – 3rd YEAR

No.

Educational activities - Objects/Disciplines

1 Pharmacology.

2 Bacteriology. Virusology. Parasitology

3 Pathology

4 Pathophysiology

5 Surgical Semiology (1)

6 Medical Semiology (1)

7 Clinical Biochemistry. Immunology

8 Surgical Semiology (2)

9 Medical Semiology (2)

10 Hygiene, Environmental Health and Food Safety

11 Scientific Research Methodology

12 Medical Biostatistics

13 Optional courses:

Legal Responsibility of the Medical Profession

Alternative Medicine

SYLLABUS

1. Data regarding the program

1.1 Higher education institution UNIVERSITY OF MEDICINE AND PHARMACY OF TÎRGU MUREȘ

1.2 Faculty Medicine

1.3 Department M2

1.4 Field of study Health

1.5 Study cycle Licence

1.6 Study program Medicine

2. Data regarding the discipline 2.1 Name Bacteriology-virology-parasitology 1

2.2 Course coordinator Szekely Edit

2.3 Practical activity coordinator(s) Szekely Edit,

2.4 Study year III 2.5 Semester I 2.6 Type of evaluation Exam 2.7 Type of discipline DF

3. Total estimated time (hours per semester of didactic activities)

3.1 Hours per week 4 3.2 out of which

lecture 2

3.3 laboratory practical

activity 2

3.4 Total hours in the curriculum 56 3.5 out of which

lecture 28


activity 24

Distribution of time pool per week 3

hours

Study of books, lecture materials, bibliography, notes 1

Supplemental documentation at the library, from specialized information portals and in the field 1

Preparation for seminaries/laboratories, homework, reports, portfolios and essays 1

Tutorial activities 0.5

Examinations 0.5

Other activities 1

3.7 Total hours of individual study per

week 5

3.8 Total hours per semester 56

3.9 Credits 4

4. Prerequisites (where applicable) 4.1 curricular

prerequisites

4.2 competency

prerequisites

5. Conditions (where applicable) 5.1 for lectures

5.2 for laboratory and practical

activities

6. Specific competencies acquired

Professional competencies

- suspect/recognize infectious diseases caused by bacteria

- require proper bacteriological analysis to establish etiology

- understanding results provided by the laboratory and using them

accordingly in the management of patients with infectious diseases

- understanding the medical problems caused by the emergence and

spread of antimicrobial resistance and the need for proper antibiotic use in

order to prevent further selection of resistance

- acquire basic knowledge of prophylaxis and treatment of bacterial

infections

- emergent and re-emergent bacterial infections

Transversal competencies

- develop abilities for teamwork, efficient verbal and written

communication skills

- respect for professional values and ethics,

- solving clinical problems and chosing proper therapeutical decisions

7. Objectives of the discipline (based on the grid of specific competencies)

7.1 General objective

To acquire knowledge of the basic biology of bacteria, pathogenesis

of infections caused by them and possibilities of diagnosis,

prevention and treatment.

7.2 Specific objectives

Students should become familiar with the:

- morphology, physiology and genetics of bacteria

- pathogenesis of infections caused by them

- role of immune system in defense against bacterial infections

Students should understand the basic microbiological diagnostic

principles, should know the factors that influence results and

indications for performing microbiology tests.

Students should acquire basic knowledge on the mechanism of

action of antibiotics and development of resistance against

antibiotics. They should familiarize with basic epidemiological and

immunization concepts.

They should gain knowledge about specific medically important

bacteria in respect of associated diseases, mode of transmission,

possibilities of prevention and treatment.

Students should understand the role of the human microbiota, the

concept of colonization, infection and contamination.

They should recognize:

- the importance of infection in special patient categories, such as

immune suppressed, hospitalized patients

- bioterrorism

- the role of vaccines in prevention

- therapeutic and epidemiological impact of antimicrobial resistance

8. Contents Crt. 8.1 Lecture Teaching Hours Observations ICS correlation

no. methods

First semester

1. 1. The object and purpose of medical

microbiology. History of microbiology.

Oral

presentations

PPT

2

History of

microbiology

2.

2. Bacterial morphology. Bacterial cell structure.

Chemical composition of bacteria. Growth and

multiplication of bacteria. Physical, chemical and

biological factors affecting bacteria. Bacterial

genetics.

Oral

presentations

PPT

2

Bacterial

morphology,

bacterial structure,

metabolism,

multiplication,

antimicrobial

resistance

3.

3. Pathogenesis of bacterial infections. Host

defense mechanisms. Prevention of infectious

diseases.

Oral

presentations

PPT

2 Integrated lecture –

phtysiology,

dermatology,

infectious

diseases

immunisation

immunodeficiency

infection

4.

4. Bacterial classification and nomenclature.

Gram-positive cocci: Staphylococcus genus,

Streptococcus genus, Enterococcus genus

Oral

presentations

PPT

2

bullous/vesicular

eruption, dysuria,

joint pain, joint

swelling, loose

stools, vaginal

discarge; cardiac

valve disease,

chronic renal

disease,

endocarditis,

gastroenteritis;

infectious disease

of childhood,

meningitis, oral

diseases, otitis

media, peritonitis,

respiratory tract

infection,

septicaemia, skin

infections, urinary

tract infections

5.

5. Gram-negative cocci: Neisseria gonorrhoeae,

Neisseria meningitidis; Gram-positive bacilli:

Corynebacterium genus, Bacillus genus, Listeria

genus

Oral

presentations

PPT

2

haemoptysis,

headache, raised

intracranial

pressure, loose

stools, vomiting;

disorders of

prgnancy and

deliver;

meningitis,

respiratory tract

infection,

septicaemia,

sexually

transmitted

disease, skin

infection, skin

ulceration,

pregnancy loss

6.

6 Aerobic, facultative anaerobic Gram-negative

bacilli: Escherichia coli, Shigella genus,

Salmonellagenus, Yersinia genus, Klebsiella

genus, Proteus genus

Oral

presentations

PPT

2

dysuira, loose

stools, vomiting;

gastroenteritis;

peritonitis,

respiratory tract

infections, urinary

tract infection

7.

7. Curved Gram-negative bacilli: Vibrio genus,

Campylobacter genus, Helicobacter genus;

Aerobic non-fermenter Gram-negative bacilli:

Pseudomonas aeruginosa, Acinetobacter

baumannii

Oral

presentations

PPT

2

loose stools,

vomiting;

electrolyte and

water balance,

burns, cystic

fibrosis,

gastroenteritis,

peptic ulcer,

peritonitis, skin

infections

8.

8. Gram-negative coccobacilli: Haemophilus

genus, Gardnerella genus, Bordetella pertussis,

Legionella genus

Oral

presentations

PPT

2

vaginal discharge,

sexually

transmitted

diseases,

meningitis,

respiratory tract

infections,

septicaemia

9. 9. Spore-forming (clostridia) and non-spore-

forming anaerobic bacteria

Oral

presentations

PPT

2

TBL

constipation,

dysphagia, squint,

visual impairment,

acne, oral

disorders,

peripheral nerve

disorders,

peritonitis,

septicaemia

10.

10. Bacteria that are not classified according to

Gram-staining: Mycobacterium genus,

Treponema pallidum, Borrelia burgdorferi,

Leptospira spp., Chlamydia genus, Mycoplasma

genus

Oral

presentations

PPT

2

Integrated

lecture –

phtysiology,

dermatology,

phtysiology

haemoptysis,

icterus, jpoint

pain, raised

intracranial

pressure, red eye,

acute liver

disease/failure,

meningitis,

peripheral nerve

disorders, sexually

transmitted

diseases,

tuberculosis,

urinary tract

infection

11. 11. Normal microbiota of the human body.

Specimen collection.

Oral

presentations

PPT

2

Skin, vaginal,

throat, oral cavity

microbiota,

specimens,

collection

12.

12. Diagnostic principles in infectious diseases

(respiratory tract, urogenital, digestive tract

infections, skin and soft tissue infections). Blood

cultures in bloodstream infections. Infections

caused by anaerobes.

Oral

presentations

PPT

2

TBL

Respiratory tract

infection, sexually

transmitted

diseases, skin

infections, urinary

tract infections,

septicaemia,

gastroenteritis,

candidiasis,

vaginal discharge

13. 13. Antibiotic susceptibility testing.

Antimicrobial resistance.

Oral

presentations

PPT

2

Antimicrobial

resistance

14. 14. Nosocomial infections. Emergent and

reemergent infectious diseases. Bioterrorism.

Oral

presentations

PPT

2

Nosocomial

infections,

hospital strains,

bioterrorism

Second semester

1.

2.

3.

4.

5.

6.

7.

8.

9.

10.

11.

12.

13.

14.

Bibliography:

1. Brooks G.F., Butel, J. S., Morse, S.A.: Jawetz, Melnick, Adelberg’s Medical

Microbiology,McGraw-Hill Medical, New York, 25th edition. 2010

2. Fritz H. Kayser, Kurt A. Bienz, Johannes Eckert, Rolf M. Zinkernagel: Medical Microbiology. Georg

Thieme Verlag, Stuttgart, 2005

3.Winn W, Allen S, Janda W, Koneman E, Procop G, Schreckenberger P, Woods G: Koneman's Color

Atlas and Textbook of Diagnostic Microbiology. Lippincott Williams & Wilkins, Philadelphia, 6th

edition, 2006

Crt.

no.

8.1 Seminaries/Laboratories/Practical

activities/Stages

Teaching

methods Hours Observations ICS correlation

First semester

1. 1. Laboratory safety rules. Microbial growth

control.. Decontamination

Practical

activities,

presentation

2

Decontamination,

disinfection,

antisepsis,

asepsis,

sterilisation

2. 2. Diagnostic algorithm in bacteriology. Specimen

collection and shipment.

Practical

activities,

presentation

2

Specimens,

collection,

shipment

3.

3. Study of bacterial morphology. Wet mount.

Smears. Staining techniques (simple stain, Gram

stain, acid-fast stain, Neisser stain)

Practical

activities,

presentation

2

Bacterial

morphology,

cocci, bacilli,

spiral forms,

Gram-positive,

Gram-negative,

smears, acid fast,

Neisser stain

4.

4. Cultivation of bacteria. Culture media.

Inoculation techniques. Colony morphology.

Identification of bacteria according to their

biochemical patterns.

Practical

activities,

presentation

2

Cultivation,

culture media,

colony

morphology,

identification of

bacteria

5.

5. Diagnostic methods based on antigen-antibody

reactions (agglutination, immunofluorescence,

enzyme-linked immunosorbent assay, Western

blot). Detection of bacterial nucleic acid

(hybridization, polymerase chain reaction).

Methods used for bacterial typing.Gene transfer.

Practical

activities,

presentation

2

Antigen-antibody

reactions,

molecular

biology methods,

molecular typing

6. 6. In vitro and in vivo pathogenicity tests.

Antibiotic susceptibility testing.

Practical

activities,

presentation

2

Antimicrobial

resistance,

antimicrobial

susceptibility

testing, MIC, E-

test, disk

diffusion method

7. 7. Practical exam Practical

eexam

2

8.

8. Diagnosis of infections caused by:

Staphylococcus spp., Streptococcus spp. and

Enterococcus spp

Practical

activities,

presentation

2

bullous/vesicular

eruption, dysuria,

joint pain, joint

swelling, loose

stools, vaginal

discharge;

cardiac valve

disease, chronic

renal disease,

endocarditis,

gastroenteritis;

infectious disease

of childhood,

meningitis, oral

diseases, otitis

media,

peritonitis,

respiratory tract

infection,

septicaemia, skin

infections,

urinary tract

infections

9.

9. Diagnosis of infections caused by

Enterobacteriaceae: Escherichia coli, Klebsiella

spp., Proteus spp., Shigella spp., Salmonella spp.,

Yersinia spp. Laboratory diagnosis of cholera.

Practical

activities,

presentation

2

dysuira, loose

stools, vomiting,

gastroenteritis,

peritonitis,

respiratory tract

infections,

urinary tract

infection

10.

10. Diagnosis of infections caused by Gram-

negative non-fermentative rods (Pseudomonas

aeruginosa, Acinetobacter spp.). Diagnosis of

infections caused by Bacillus spp. Diagnosis of

infections caused by anaerobic bacteria (clostridia,

endogenous anaerobes).

Practical

activities,

presentation

2

loose stools,

vomiting,

constipation,

dysphagia,

squint, visual

impairment, acne

burns,

gastroenteritis

peritonitis,

meningitis,

respiratory tract

infections,

septicaemia, skin

infections, skin

ulcerations, oral

disorders,

peripheral nerve

disorders,

peritonitis,

septicaemia

11.

11. Diagnosis of infections caused by

Haemophilus spp. Neisseria spp, Diagnosis of

syphilis. Diagnosis of tuberculosis

Practical

activities,

presentation

2

haemoptysis,

headache, raised

intracranial

pressure, loose

stools, vomiting,

vaginal discharge

disorders of

pregnancy and

deliver -

meningitis,

respiratory tract

infections,

septicaemia,

sexually

transmitted

diseases, skin

infections, skin

ulcerations,

pregnancy loss,

tuberculosis

12.

12. Human microbiota. Diagnosis of infections

(respiratory and digestive tract, urogenital, skin

and soft tissue infections, meningitis and

bloodstream infections). Control of

crosstransmission in hospital setting in order to

prevent nosocomial infections.

Practical

activities,

presentation

2

Throat swab,

sputum, nasal

swab, genital

secretions, CSF,

pus, blood

culture, stool

culture, urine

culture, hospital

flora, nosocomial

infections

13. 13. Review Practical

activities

2

14. 14. Practical exam Exam 2

Second semester

1.

2.

3.

4.

5.

6.

7.

8.

9.

10.

11.

12.

13.

14.

Bibliography:

1. Roelme, elearning

2. Online atlas: https://microbiologie.umftgm.ro/atlas

9. Correlations between the contents of the discipline and the expectations of the community representatives, professional associations and representative employers in the domain Due to advances in medicine that lead to frequent use of invasive and/or immune suppressive treatments

there is an increase of the number of patients vulnerable to bacterial infections. Mobility, intense traveling

contributes to the rapid spread of microorganisms. In this context there is a need for well trained

physicians having proper knowledge on infectious agents involved in human diseases, being able to

recognize, diagnose and treat them. The potential to cause epidemics, outbreaks should be recognized in

order to implement specific measures of prevention. On the other hand, emergence and spread of

antimicrobial resistance are of great concern, representing an increasing challenge in the management of

infections. Understanding these medical problems, learning and promoting proper antimicrobial

consumption habits are essential.

10. Evaluation

Type of activity 10.1 Evaluation criteria 10.2 Evaluation

methods

10.3 Percent of

the final grade

10.4 Evaluation

during the semester

Lecture Knowledge of medically important bacteria TBL - evaluation 10%

Practical activities Diagnostic and therapeutical principles in

microbiology Practical exam 20%

10.5 Final evaluation

Theoretical final

exam

suspect/recognize infectious diseases

caused by bacteria

- require proper bacteriological analysis to

establish etiology

Written exam

(multiple choice and

questions)

60%

Practical final

exam

Understanding of bacteriological analyses

and their use in treatment

- understanding antimicrobial resistance

and the importance of prudent use of

antimicrobials

Test 10%

10.6 Minimal performance standards

1. Grade 5 for midterm evaluations

2. Minimum requirements to sit the final exam: grade 5 of evaluations; attendance of all practical classes;

70% attendance of lectures

3. Passing the final exam: 5 is the minimum grade required to pass both the theoretical and practical final

exam

SYLLABUS




1.3 Department M2




2. Data regarding the discipline 2.1 Name Bacteriology-virology-parasitology_2

2.2 Course coordinator Székely Edit

2.3 Practical activity coordinator(s) Szekely Edit,

2.4 Study year II 2.5 Semester II 2.6 Type of evaluation Exam 2.7 Type of discipline DF



lecture 2


activity 2


lecture 28


activity 28


hours




Tutorial activities 0.5

Examinations 0.5

Other activities 1


week 5


3.9 Credits 4


prerequisites

4.2 competency

prerequisites



activities



- suspecting/recognizing infectious diseases caused by viruses, parasites

or fungi with a thorough understanding of their pathogenesis,

transmission patterns

- requiring proper microbiological analysis for establishing etiology

- understanding results provided by the microbiologist and using them

accordingly in the management of patients with infectious diseases

- knowledge of methods used for diagnostic purposes, their advantages

and limitations

- acquiring basic knowledge in prophylaxis and treatment of viral

infections

- understanding the local/national/international epidemiology of major

viral/parasitic/fungal infections

- recognizing special patient population at risk for acquiring

viral/parasitic/fungal infections

- acquiring basic knowledge of tropical and tourism-related infections


- developing abilities for teamwork, efficient verbal and written

communication skills

- respect for professional values and ethics,

- solving clinical problems and chosing proper therapeutical decisions



Providing knowledge of the basic biology of microorganisms

(viruses, parasites and fungi), pathogenesis of infections caused by

them and possibilities of diagnosis, prevention and treatment.


Students should become familiar with the:

- morphology, physiology and genetics of microorganisms (viruses,

fungi and parasites)

- pathogenesis of infections caused by these microorganisms

- role of immune system in defense against infections

Students should understand the basic microbiological diagnostic

principles. They should know the factors that influence results and

indications for performing microbiology tests.

Students should acquire basic knowledge on the mechanism of

action of antimicrobial agents, familiarize with basic

epidemiological concepts.

They should gain knowledge about specific medically important

viruses, fungi and parasites in respect of associated diseases, mode

of transmission, possibilities of prevention and treatment

They should recognize:

- the importance of infection in special patient categories, such as

immunesuppresed patients

- the role of vaccines in prevention

8. Contents Crt. 8.1 Lecture Teaching Hours Observations ICS correlation

no. methods

First semester

1.

2.

3.

4.

5.

6.

7.

8.

9.

10.

11.

12.

13.

14.

Second semester

1.

1. General properties of viruses. Virion

structure. Chemical composition of viruses.

Viral replication. Cultivation of viruses.

Oral

presentation,

PPT

2

Virus, virion,

capside, helical

symmetry type,

cubical symmetry

type, viral

replication,

cultivation, cell

cultures

2.

2. Viral genetics. Subviral agents: viroids,

prions. Bacteriophages. Viral vectors, gene

therapy.

Oral

presentation,

PPT

2

Viral genetics,

viroids, prions,

degeneratice CNS

disease, viral

vectors, gene

therapy

3. 3. Cell-virus interactions.

Oral

presentation,

PPT

2

immunization

immunodeficiency

acute infection,

chronic infection,

latent infection,

persistent infection

4.

4. Immunity in viral infections. Chemotherapy

of viral infections. Immunotherapy,

prophylaxis.

Oral

presentation,

PPT

2

Immunity

Immunodeficiency

Immunoprophylaxis,

immunotherapy,

treatment of viral

infections

5. 5 Classification of viruses. DNA viruses: Oral 2

bullous/vesicular

Adenoviridae, Herpesviridae, Parvoviridae,

Papillomaviridae, Polyomaviridae, Poxviridae

presentation,

PPT

skin eruption,

haematuria, loose

stools; carcinoma of

the head and neck,

cervical cancer;

infectious diseases

of childhood,

respiratory tract

infection, sexuallly

transmitted diseases

6.

6 RNA viruses: Arenaviridae, Bunyaviridae,

Caliciviridae, Coronaviridae, Filoviridae,

Flaviviridae, Orthomyxoviridae,

Paramyxoviridae, Picornaviridae, Reoviridae,

Retroviridae, Rhabdoviridae, Togaviridae

Oral

presentation,

PPT

2

loose stools,

gastroenteritis,

infectious diseases

of childhood,

infections of the

respiratory tract

7. 7. Human hepatitis viruses. Human

immunodeficiency virus.

Oral

presentation,

PPT

2

hepatomegaly,

jaundice, acute liver

disease/failure,

chronic liver

disease, HIV

8.

8. Oncogenic viruses. Viral infections

(Respiratory tract infections. Enteric infections.

Infections with mucocutaneous manifestations.

Haemorrhagic fevers. Central nervous system

infections)

Oral

presentation,

PPT

2

bullous/vesicular

skin eruption,

headache, loose

stools,

gastroenteritis,

infectious diseases

of childhood,

meningitis,

respiratory tract

infections

9.

9. Classification of parasites. Clinical

implications of intestinal parasitoses. Protozoa

(Amoebas. Trichomonas spp. Giardia lamblia.

Toxoplasma gondii.)

Oral

presentation,

PPT

2

Integrated

lecture,

pediatrics

loose stools, vaginal

discharge,

malabsorbtion,

pregnancy loss,

sexually transmitted

diseases

10. 10. Flat worms. Round worms.

Oral

presentation,

PPT

2

abdominal

distendion,

abdominal pain,

constipation,

hepatomegaly,

jaundice, loose

stools, pruritus,

weight loss

11. 11. Tropical parasitoses

Oral

presentation,

PPT

2 TBL loose stools malaria,

skin ulcerations

12. 12. General properties and classification of Oral 2

hair disorders, skin

fungi. Pathogenesis of fungal infections.

Dermatophytes. Systemic mycoses

presentation,

PPT

infections

septicaemia,

respiratory tract

infections

13. 13. Opportunistic fungal infections

Oral

presentation,

PPT

2

vaginal discharge

candidosis,

meningitis,

respiratory tract

infections,

septicaemia

14.

14. Infections of the immunocompromised

host. Microbiological diagnosis of various

infections.

Oral

presentation,

PPT

2 TBL Immunodeficiency

Bibliography:

1. Brooks G.F., Butel, J. S., Morse, S.A.: Jawetz, Melnick, Adelberg’s Medical

Microbiology,McGraw-Hill Medical, New York, 25th edition. 2010

2. Fritz H. Kayser, Kurt A. Bienz, Johannes Eckert, Rolf M. Zinkernagel: Medical Microbiology. Georg

Thieme Verlag, Stuttgart, 2005

3.Winn W, Allen S, Janda W, Koneman E, Procop G, Schreckenberger P, Woods G: Koneman's Color

Atlas and Textbook of Diagnostic Microbiology. Lippincott Williams & Wilkins, Philadelphia, 6th

edition, 2006

Crt.

no.


activities/Stages

Teaching


First semester

1.

2.

3.

4.

5.

6.

7.

8.

9.

10.

11.

12.

13.

14.

Second semester

1.

1. Microbial growth control. Specimen collection

and shipment for virology. Diagnostic algorithm in

virology. Study of viral morphology.

Practical

activities,

presentation

2

Decontamination,

disinfection,

antisepsis,

asepsis,

sterilisation

Specimens,

collection,

shipment

2. 2. Cultivation of viruses. Antigen-antibody

reaction based methods. Detection of nucleic acids.

Practical

activities,

presentation

2

Viral cultivation

Cell cultures,

viral vectors

3.

3. Laboratory diagnosis of herpetic infections.

Diagnosis of infections caused by human

papillomaviruses. Diagnosis of viral infections of

the respiratory tract.

Practical

activities,

presentation

2

bullous/vesicular

skin eruptions,

hematuria, loose

stools carcinoma

of the head and

neck, cervical

cancer, infectious

diseases of

childhood ,

respiratory tract

infection,

sexually

transmitted

diseases

4. 4. Laboratory diagnosis of viral hepatitis.

Diagnosis of HIV infection

Practical

activities,

presentation

2

hepatomegaly,

jaundice, acute

liver

disease/failure,

chronic liver

disease, HIV

5. 5. EXAM Exam 2

6.

6. Parasitological diagnosis. Protozoa (Entamoeba

spp., Trichomonas vaginalis, Giardia lamblia,

Toxoplasma gondii)

Practical

activities,

presentation

2

loose stools, ,

vaginal

discharge,

malabsorbtion,

pregnancy loss,

sexually

transmitted

diseases

7.

7. Flat worms (Fasciola hepatica,

Diphyllobothrium latum, Dipylidium caninum,

Echinococcus granulosus, Taenia saginata şi

Taenia solium, Hymenolepis spp.)

Practical

activities,

presentation

2

abdominal

distention,

abdominal pain,

constipation,

hepatomegaly,

jaundice, loose

stools, pruritus,

weight loss, acute

liver disease,

allergic

disorders,

anemia, eating

disorders

8.

8. Round worms (Ascaris lumbricoides, Enterobius

vermicularis, Toxocara canis, Ankylostoma

duodenale, Strongyloides stercoralis, Trichinella

spiralis)

Practical

activities,

presentation

2

abdominal

distention,

abdominal pain,

constipation,

hepatomegaly,

jaundice, loose

stools, pruritus,

weight loss, acute

liver disease,

allergic

disorders,

anemia, eating

disorders

9.

9 Laboratory diagnosis of infections caused by

yeasts. Laboratory diagnosis of infections caused

by Pneumocystis jiroveci.

Practical

activities,

presentation

2

vaginal

discharge,

candidosis,

meningitis,

respiratory tract

infection,

septicaemia

10.

10. Laboratory diagnosis of infections caused by

moulds. Laboratory diagnosis of infections caused

by dermatophytes and dimorphic fungi

Practical

activities,

presentation

2

Skin infections,

respiratory tract

infections,

septicaemia

11. 11. Microbiological diagnosis of CNS, respiratory

tract and enteric infections - case reports

Practical

activities,

presentation

2

loose stools,

vomiting, vaginal

discharge,

sputum, disorders

of pregnancy and

delivery,

meningitis,

respiratory tract

infections,

septicaemia,

sexually

transmitted

diseases, skin

infections, skin

ulcerations,

pregnancy loss

12.

12. Microbiological diagnosis of hepatitis and

infections of immunocompromised patients - case

reports

Practical

activities,

presentation

2

hepatomegaly,

jaundice, acute

liver

disease/failure,

chronic liver

disease

13. 13. Review Review 2

14. 14. Exam Exam 2

Bibliography:

www.microumftgm.ro; e-learning, Online atlas: https://microbiologie.umftgm.ro/atlas

9. Correlations between the contents of the discipline and the expectations of the community representatives, professional associations and representative employers in the domain Due to advances in medicine that lead to frequent use of invasive and/or immunsuppressive treatments

there is an increase of the number of patients vulnerable to infections caused by fungi, viruses and

parasites. In this context there is a need for well trained physicians having proper knowledge on infectious

agents involved in human diseases, being able to recognize, diagnose and treat them.

10. Evaluation


methods

10.3 Percent of

the final grade

10.4 Evaluation

during the

semester

Lecture

- Basic knowledge (morphology, pathogenesis,

associated diseases, immunity, transmission,

prevention and treatment) regarding medically

important microorganisms

TBL 10%

Practical

activities

Knowledge of: - morphology, physiology and genetics

of viruses, fungi and parasites - pathogenesis - host

defenses Understanding basic diagnostic principles in

viral, fungal, parasitic infections and factors that can

affect results - indications for diagnostics

Practical exam 20%

10.5 Final

evaluation

Theoretical

final exam

- suspecting/ recognizing infectious diseases caused

by viruses, parasites or fungi - requiring proper

microbiological analysis for establishing etiology

-current problems regarding emergent and re-

emergent infections

- acquiring basic knowledge of tropical and tourism-

related infections

Written exam:

multiple choice

+ questions

60%

Practical final

exam

-înțelegerea rezultatelor obținute și utilizarea acestora

în mod adecvat

în tratamentul pacientului

-dobandirea cunostintelor de baza in profilaxia si

tratamentul infectiilor virale, parazitologice, fungice

Written exam:

multiple choice 10%


Grade 5 for midterm evaluations;

Minimum requirements to sit the final exam: grade 5 of evaluations; attendance of all practical classes;

70% attendance of lectures

Passing the final exam: 5 is the minimum grade required to pass both the theoretical and practical final

exam

SYLLABUS



1.2 Faculty MEDICINE

1.3 Department M2

1.4 Field of study HEALTH CARE


1.6 Study program MEDICINE

2. Data regarding the discipline 2.1 Name Clinical Biochemistry, Immunology

2.2 Course coordinator Prof. Dobreanu Minodora

2.3 Practical activity coordinator(s) Univ Assist. Şular Floredana-Laura,

2.4 Study year III 2.5 Semester 2 2.6 Type of evaluation V 2.7 Type of discipline DD



lecture 1


activity 1


lecture 14


activity 14


hours




Tutorial activities

Examinations

Other activities


week 4


3.9 Credits 2


prerequisites -

4.2 competency

prerequisites -

5. Conditions (where applicable) 5.1 for lectures -


activities -



Professional competences obtained by students are in medical

interpretation of test results obtained in laboratory evaluation of water and

electrolytes balance, carbohydrates, lipids and proteins metabolism,

diagnostic value of serum enzymes analysis, coagulation tests, specific

and non-specific cellular and humoral immun system evaluation. Medical

students will learn modern laboratory methods for investigation of

biological fluids – their quality and limits.


Clinical Biochemistry and Immunology discipline aims to form student

capacity for integration of basic knowledges in biochemistry, physiology

/physiopathology and internal medicine, in producing useful correlations

at patient bedside, in reccomending and analysing laboratory

investigations in clinical context.

Analysis capacity of preanalitical influence (collecting, transportation and

storage of biological fluids) in laboratory test results, is also stimulated.


7.1 General objective General aim of our discipline is to create a logical base in asking and

interpretation of laboratory investigations.


Pathogenic mechanisms in modification of laboratory parameters in

diseases; diagnostic value of laboratory tests, correlations established

between clinical context and laboratory results.

8. Contents Crt.

no. 8.1 Lecture Teaching methods Hours Observations ICS correlation

First semester

Second semester

1.

1. Evaluation of water and

electrolytes balance: natrium and

kalium.

Lecture+

presentation .ppt 1

The main

investigations

will be

presented,

benefits and

limitations

Electrolyte and water

balance, Adrenal

excess, Adrenal failure

2. 2. Evaluation of acid-base

balance of the organism

Lecture+

presentation .ppt

1 The main investigations

will be

presented,

benefits and

limitations

Acid based disturbance,

Hyperventilation,

Cardiorespiratory arrest

3.

3. Laboratory evaluation of

calcium, phosphorus and

magnesium homeostasis.

Osteoporosis

Lecture+

presentation .ppt


will be

presented,

benefits and

limitations

Disorders of calcium

and vitamin D

metabolism,

Osteoporosis

4. 4. Evaluation of plasma proteins.

Dysproteinemias

Lecture+

presentation .ppt


will be

presented,

benefits and

limitations

Malnutrition,

Malabsorption,

Oedema, Burns,

Chronic liver disease,

Chronic lung disease,

Chronic renal disease

5.

5. Evaluation of lipid and

lipoprotein metabolism –

involvement of dyslipidemias in

atherosclerosis.

Lecture+

presentation .ppt


will be

presented,

benefits and

limitations

Disorders of lipid

metabolism, Ischemic

heart disease,

Cerebrovascular disease

6. 6. Evaluation of carbohydrate

metabolism

Lecture+

presentation .ppt

1 TBL -The main investigations

will be

presented,

benefits and

Hypoglycaemia,

Diabetes mellitus

limitations

7.

7. Specific and non-specific,

cellular and humoral defense of

the organism

Lecture+

presentation .ppt

1 Basic immunological

terminology

Immunisation,

Immunodeficiency

8.

8. Antigen and antibody.

Biological identity of superior

organisms– MHC

Lecture+

presentation .ppt

1 Immunological terminology and

knowledges

Immunisation,

Immunodeficiency

9. 9. Immune cells and lymphoid

tissues

Lecture+

presentation .ppt


will be

presented,

benefits and

limitations

Myeloproliferative

disorders,

Lymphoproliferative

disorders

10. 10.Primary and secondary

specific immune response

Lecture+

presentation .ppt


will be

presented,

benefits and

limitations

Immunisation

Immunodeficiency

11.

11.Pathological immune

reactions. Systemic and organ-

related autoimmune disorders

Lecture+

presentation .ppt

1 TBL -The main investigations

will be

presented,

benefits and

limitations

Allergic disorders,

Asthma, Drug reactions,

Rhesus haemolytic

disease

12.

12.Primary and secondary

immunodeficiency syndromes.

HIV infection, AIDS

Lecture+

presentation .ppt


will be

presented,

benefits and

limitations

Immunodeficiency.

HIV caused

Immunodeficiency

13. 13.Immune reactions in cancer.

Immune therapy in tumors

Lecture+

presentation .ppt


will be

presented,

benefits and

limitations

Immunisation

Immunodeficiency

14.

14. Immunity of transplant.

Therapeutical means in immune

disorders

Lecture+

presentation .ppt


will be

presented,

benefits and

limitations

Immunisation

Immunodeficiency

Bibliography:

1. Practical Compendium of Clinical Biochemistry and Immunology. Dobreanu Minodora, Alina

Ardelean Mărginean, Anca Bacârea, Simona Cernea, Elena Enache, Liviu Enache, Marta Andrea Fodor,

Oana Oprea, Floredana Șular,2014

2. Basic Concepts in Immunology. Minodora Dobreanu, et al.. 2015

1.William J. Marshall and Stephen K.Bangert - Clinical Chemistry - 7th Ed, MOSBY- ELSEVIER 2012

2.Roderick Nairm, Matthew Helbert - Immunology for Medical students, 2nd Ed, MOSBY- ELSEVIER

2007

3.Abdul Abbas et al -Basic Immunology, 3rd Ed, Saunders ELSEVIER, 2011.

Crt.

no.


activities/Stages

Teaching


First semester

Second semester

1. 1.Safety in Clinical Laboratory. Collecting

blood and body fluid specimens

Practical

demonstrations 1

Major risk in

laboratory

work will be

presented.

Laboratory

safety

Anemia,

Thromboembolic

disease

2.

2.Optical methods for analysis in clinical lab.

Absoption and emission spectrophotometry.

Autoanalyser. Quality control.

Practical

demonstrations

1 Actual techniques

for

investigation

in modern

laboratory,

will be

presented

Hypoglicemia,

Anemia, Jaundice

3.

3.Electroanalytical methods in medical lab.

Laboratory evaluation of Acid-Base balance

of the body

Practical

demonstrations,

case

presentations

1 Actual techniques

for

investigation

in modern

laboratory,

will be

Electrolyte and

water balance,Acid

based disturbance

presented

4. 4.Assessment of carbohydrate metabolism

Practical

demonstrations,

case

presentations

1 Actual techniques

for

investigation

in modern

laboratory,

will be

presented

Diabetes mellitus

5. 5.Laboratory evaluation of lipid metabolism.

Atherogen index

Practical

demonstrations,

case

presentations

1 Actual techniques

for

investigation

in modern

laboratory,

will be

presented

Disorders of lipid

metabolism,

Ischemic heart

disease

6. 6.Serum protein analysis in clinical

laboratory. Dysproteinemic syndromes

Practical

demonstrations,

case

presentations

1 Actual techniques

for

investigation

in modern

laboratory,

will be

presented

Malnutrition,

Malabsorption,

Oedema, Burns,

Chronic liver

disease, Chronic

lung disease,

Chronic renal

disease

7. 7.Chemical examination of urine. Urinary

sediment – microscopic examination

Practical

demonstrations,

case

presentations

1

CBL

Haematuria,

Urinary tract

infection, Urinary

tract obstruction

8. 8.Laboratory diagnosis in hemostasis.

Evaluation of anticoagulant thepary

Practical

demonstrations,

case

presentations

1 Actual techniques

for

investigation

in modern

laboratory,

will be

presented

Purpura,

Thromboembolic

disease,

Coagulation

disease

9.

9.Immunological methods – principles,

classifications: turbidimetry, nephelometry,

aglutination, ELISA, chemiluminiscence

Practical

demonstrations

1 Actual techniques

for

investigation

in modern

laboratory,

will be

presented

Immunisation

10.

10.Evaluation of unspecific cellular immune

response; phagocytosis- chemotactic and

oxidative burst activity of monocytes and

granulocytes

Practical

demonstrations,

case

presentations

1 Actual techniques

for

investigation

Immunisation,

Immunodeficiency

in modern

laboratory,

will be

presented

11.

11.Evaluation of unspecific humoral immune

response –determination of hsPCR and of

complement factors C3, C4, C1 INH.

Practical

demonstrations,

case

presentations

1 Actual techniques

for

investigation

in modern

laboratory,

will be

presented

Immunisation,

Immunodeficiency

12.

12.Evaluation of specific humoral immune

response : determination of serum and CSF

concentration of immunoglobulins

Practical

demonstrations,

case

presentations

1 Actual techniques

for

investigation

in modern

laboratory,

will be

presented

Immunisation,

Immunodeficiency

13. 13.Evaluation of specific cellular immune

response : TBNK by flowcitometry

Practical

demonstrations,

case

presentations

1 Actual techniques

for

investigation

in modern

laboratory,

will be

presented

Immunisation,

Immunodeficiency,

HIV

14.

14.Molecular biology techniques.

isolation/purification of nucleic acids.

Amplification: PCR, qPCR, RT PCR.

Practical

demonstrations

1 Actual techniques

for

investigation

in modern

laboratory,

will be

presented

Immunisation,

Immunodeficiency

Bibliography:

1) Dobreanu M. et al - Practical Compendium of Clinical Biochemistry and Immunology, Univ Press,

2014.

2) Mary L. Turgeon, Linne & Ringsrud's Clinical Laboratory Science - The basics and routine techniques,

Ed. 5, MOSBY- ELSEVIER 2007

3)Christine Dorresteyn Stevens -Clinical Immunology and serology -a LABORATORY perspective, Ed.

2, FA Davis, Philadelphia, 2003

9. Correlations between the contents of the discipline and the expectations of the community representatives, professional associations and representative employers in the domain Medical tests performed by clinical laboratories, bring 70% of useful information for diagnosis, prognosis

/ monitoring of patients health status, with less than 2% of total healthcare costs.

10. Evaluation


methods

10.3 Percent of

the final grade

10.4 Evaluation during the

semester

Lecture

Written test 15%

Practical activities

Written test 15%


Theoretical final exam În funcție de specificul

disciplinei Written exam 50%

Practical final exam În funcție de specificul

disciplinei written exam 20%


Threshold of minimum knowledge for passing exam:

1.Water and mineral compartments of the body.

2.Ionogram of serum and biological fluids.

3.Water and electrolytes distribution between different compartments . Isovolemia and isoosmosis.

Disorders of electrolyte balance .

4.Potassium homeostasis: hyper- and hypokalemia.

5.Mechanisms that maintain pH in the extracellular fluid: physiological buffer systems.

6.Physiological and pathological variations of the acid-base balance parameters

7.Mechanisms involved in the phosphorus-calcium balance of the body: parathyroidian hormone,

calcitriol (vitamin D3), calcitonin.

8.Disorders of calcium and phosphorus metabolism.

9.Assessment of calcium and phosphorus metabolism disorders.

10.Bone metabolic disorders: osteoporosis.

11.Magnesium: role in human body, hypo- and hypermagnesiemia states

12.Structure, general properties, biological functions, main characteristics and classification of plasma

proteins.

13.Main plasma proteins: Albumin, a1AT, a2Mg,Transferin,Ceruloplasmin, Haptoglobin,

Immunoglobulins G,A,M

14.Dysproteinemias. Acute phase proteins –hsCRP

15.Serum enzymes. Clasification, diagnostic properties.Izoenzymes

16.Serum lipids: physical, chemical and biological properties, biological roles of lipids.

17.Lipoproteins: structure and classification. Lipid/ lipoprotein metabolism. Lipid metabolism disorders –

dyslipidemias.

18.Atherogenic risk factors – atherosclerosis. Present conception on atherosclerosis pathogenesis

19.Origins of blood carbohydrates: nutritional glucose, glycogenogenesis-glycogenolysis, glucose

formation from other substances – gluconeogenesis.

20.Major glucose metabolic pathways in different cells.

21.Regulating mechanisms of carbohydrate metabolism. Hormonal control of the circulating level of

glucose.

22.Diabetes mellitus – clasification, diagnosis, monitorisation. Diabetes complications.

23.1. Cellular elements of non-specific immune system. Phagocytosis. The complement system.

2. Physical, chemical and biological properties of antigens. Superantigens. Immunoglobulins: structure,

properties, coding, biosynthesis.

3. Cellular markers of biological individuality: major histocompatibility complex class I and class II.

4. T and B lymphocytes, lymphocyte receptors. Primary and secondary lymphoid tissues

5. Antigen recognition, processing and presentation. Clonal selection and proliferation. Primary and

secondary immune response

6. Hereditary and acquired immunodeficiencies. HIV infection, AIDS.

7. Tumor markers. Immune response to neoplasias. Tumor immunotherapy.

8. Gell-Coombs classification of pathologic immune reactions.

9. Autoimmunity. Systemic and organ specific autoimmune diseases

Types of transplant; histocompatibility; immune mechanisms involved in graft rejection.

Immunomodulation: immunostimulation, immunosupression.

SYLLABUS



1.2 Faculty MEDICINE

1.3 Department M2

1.4 Field of study HEALTH

1.5 Study cycle LICENSE

1.6 Study program MEDICINE

2. Data regarding the discipline 2.1 Name Medical biostatistics

2.2 Course coordinator Olah Peter

2.3 Practical activity coordinator(s) Avram Calin

2.4 Study year 2 2.5 Semester I 2.6 Type of evaluation V 2.7 Type of discipline DC



lecture 1


activity 1


lecture 14


activity 14


hours

Study of books, lecture materials, bibliography, notes 0,5

Supplemental documentation at the library, from specialized information portals and in the field 0,5

Preparation for seminaries/laboratories, homework, reports, portfolios and essays 0,5

Tutorial activities 0,25

Examinations 0,25

Other activities


week 5


3.9 Credits 2


prerequisites -

4.2 competency

prerequisites -

5. Conditions (where applicable) 5.1 for lectures -


activities -



- The student must demonstrate the ability to understand and to acquire

domain specific terms for biostatistics, respectively glossary of

specialized terms used in this field

- Knowledge of the main types of statistical tests and steps for their

application and selection algorithms of a particular statistical test,

depending on the type of study / experiment

- Demonstrate ability to understand and correctly apply a specific

statististic protocol


- Ability to detect the main sources of systematic and random errors that

may occur in a clinical study / science experiment

- Ability to properly integrate statistical protocol in the context of

scientific work in the biomedical field

- Understanding the role and importance of statistical analysis in the

modern context of "evidence-based medicine evidence-based medicine"



In today's evidence-based medicine, biostatistics has become one of

the essential tools for the practitioner or researcher working in the

biomedical field. Therefore, the main objective of this subject is to

familiarize students in the biomedical field, with specialized

glossary of mathematical statistics in order to assimilate the correct

application of a statistical protocol, depending on the type of clinical

study / science experiment;


- Understanding glossary of specialized terms used in this field of

biostatistics

- Demonstrate, in the context of evidence-based medicine, the

statistical foundations of human homeostasis, namely the necessity

of providing adequate statistical tools for any study or experiment

biomedical

- Knowledge of the main types of statistical tests and steps for their

application and algorithms for selecting a particular statistical test,

depending on the type of study / experiment

- Understanding and application of a specific protocol

8. Contents Crt.

no. 8.1 Lecture

Teaching


First semester

1.

Fundamentals in biostatistics. Introduction. Types of

errors. Exactity and precision. Organisation of data

for statistical processing. Frequency distributions.

Oral +

multimedia

presentation

2

2 hours at

every 2

weeks

Biological

variability

2. Descriptive statistics

Oral +

multimedia

presentation

2

2 hours at

every 2

weeks

Homeostasis.

Laboratory

Reference

Ranges in

Healthy Adults

3.

Inferential statistics. Statistical interpretation of the

results from an experiment or a study. Tests for

outliers. Normality tests.

Oral +

multimedia

presentation

2

2 hours at

every 2

weeks

Clinical trials

4. Inferential statistics. Tests of Statistical

Significance. Parametric versus nonparametric tests

Oral +

multimedia

presentation

2

2 hours at

every 2

weeks

Clinical trials

5. Analysis of contingency tables

Oral +

multimedia

presentation

2

2 hours at

every 2

weeks

Epidemiological

studies

6. Correlations and regressions

Oral +

multimedia

presentation

2

2 hours at

every 2

weeks

7.

Analysis of variance (ANOVA). Epidemiological

and clinical studies. Statistical indicators used in

epidemiological and clinical studies

Oral +

multimedia

presentation

2

2 hours at

every 2

weeks

Bioequivalence

studies

8.

9.

10.

11.

12.

13.

14.

Second semester

1.

2.

3.

4.

5.

6.

7.

8.

9.

10.

11.

12.

13.

14.

Bibliography:

1. Bacârea Vladimir, Ghiga Dana, Măruşteri Marius, Oláh Péter, Petrişor Marius - A Primer in Research

Methodology and Biostatistics, University Press Targu Mures, 2014

2. Motulsky HJ. The InStat Guide to Choosing and Interpreting Statistical Tests, GraphPad Software Inc.,

San Diego California USA, 2001, Available at: www.graphpad.com.

3. Motulsky HJ. GraphPad Prism - Statistics Guide. GraphPad Software Inc., San Diego California USA,

2007, Available at: www.graphpad.com.

4. Cox DR. Principles of statistical inference. Cambridge University Press, 2006.

5. Marusteri M., Bacarea V., Comparing groups for statistical differences: how to choose the right

statistical test?, Biochemia Medica 2010;20(1):15–32, Available at:

http://www.kbsm.hr/klinkemija/HDMB/BiochMed/arhiva.php

6. McHugh ML. Standard error: meaning and interpretation. Biochem Med 2008;18:7-13.

7. Slavkovic A. Analysis of Discrete Data. Available at:

http://www.stat.psu.edu/online/courses/stat504/01_overview/index.html.

8. Simundic AM. Confidence interval. Biochem Med 2008;18:154-61. Available at:


9. Ilakovac V. Statistical hypothesis testing and some pitfalls. Biochem Med 2009;19:10-6. Available at:


Crt.

no.

8.1

Seminaries/Laboratories/Practical

activities/Stages

Teaching methods Hours Observations ICS correlation

First semester

1. Fundamentals in biostatistics. Types

of errors. Exactity and precision

Practical demostrations.

Synchronous/asynchronous

elearning methods

1

Biological

variability

2.

Organisation of data for statistical

processing. Raw (primary) data.

Indexed data. Tabular data.

Contingency tables



elearning methods

1

Biological

variability

3.

Descriptive statistics: Measures of

Central Tendency (mean, median,

mode); Measures of dispersion

(variance, standard deviation,

coefficient of variation);



elearning methods

1

Homeostasis.

Laboratory

Reference

Ranges in

Healthy Adults

4.

Descriptive statistics: Other

statistical indicators in descriptive

statistics. Confidence intervals.



elearning methods

1

Homeostasis.

Laboratory

Reference

Ranges in

Healthy Adults

5. Inferential statistics. Tests for

outliers



elearning methods

1

Clinical trials

6. Inferential statistics. Normality tests



elearning methods

1

Clinical trials

7.

Inferential statistics. Tests of

Statistical Significance. Parametric

versus nonparametric tests: Student t

test and its variants



elearning methods

1

Clinical trials

8.

Inferential statistics. Tests of

Statistical Significance. Parametric

versus nonparametric tests:

Wilcoxon signed-rank test. Mann–

Whitney test.



elearning methods

1

Clinical trials

9.

Analysis of contingency tables. Chi

square test and its variants (Chi

square test with Yates correction,

Fisher exact test)



elearning methods

1

Epidemiological

studies

10. Analysis of contingency tables. Odd-

ratio (OR) and Relative risk (RR).



elearning methods

1

Epidemiological

studies

11. Correlations and regressions.

Correlation coefficient



elearning methods

1

12.

Correlations and regressions.

Coefficient of determination. Linear

regression.



elearning methods

1

13.

Analysis of variance (ANOVA) -

One-way Anova. Repeated measures

Anova. Kruskal-Wallis test.

Friedman test.



elearning methods

1

Bioequivalence

studies

14.

Analysis of variance (ANOVA).

Epidemiological and clinical studies.

Statistical indicators used in

epidemiological and clinical studies



elearning methods

1

Bioequivalence

studies

Second semester

1.

2.

3.

4.

5.

6.

7.

8.

9.

10.

11.

12.

13.

14.

Bibliography:

1. Bacârea Vladimir, Ghiga Dana, Măruşteri Marius, Oláh Péter, Petrişor Marius - A Primer in Research

Methodology and Biostatistics, University Press Targu Mures, 2014

2. Marusteri M., Bacarea V., Comparing groups for statistical differences: how to choose the right

statistical test?, Biochemia Medica 2010;20(1):15–32, Available at:


3. Motulsky HJ. The InStat Guide to Choosing and Interpreting Statistical Tests, GraphPad Software Inc.,

San Diego California USA, 2001, Available at: www.graphpad.com.

4. Motulsky HJ. GraphPad Prism - Statistics Guide. GraphPad Software Inc., San Diego California USA,

2007, Available at: www.graphpad.com.

9. Correlations between the contents of the discipline and the expectations of the community representatives, professional associations and representative employers in the domain The knowledge acquired from the above mentioned curricular content will assure for the students the

proper understanding of basic statistical glossary and of some other terms related to the field of

biostatistics and will enhance their ability to understand and apply a specific statistical protocol for a

particular type of clinical trial/epidemiological study or scientific experiment. It is also provided a

theoretical and practical framework for critically reading of scientific articles published in the biomedical

field, with the proper understanding of statistical protocols used in such articles.

10. Evaluation

Type of activity 10.1 Evaluation criteria 10.2 Evaluation methods 10.3 Percent of

the final grade

10.4 Evaluation

during the semester

Lecture

Correlation between theoretical

and practical notions Capacity of

performing practical work.

Multiple choice test (TBL) 5%

Practical

activities


and practical notions Capacity of

performing practical work.

Practical skills tests during the

semester, to test student's ability to

properly apply a particular type of

statistical test.

20%

10.5 Final

evaluation

Theoretical

final exam

Understanding and integration of

all theoretical concepts

Knowledge of bibliographical

references

Multiple choice test 45%

Practical final

exam


and practical notions

Capacity of performing practical

work

Practical exam at the end of

semester. 30%


Understanding basic glossary of specialized terms in biostatistics

Ability to select and apply a statistical test correctly.

The ability to correctly determine the coordinates of a statistical protocol-specific type for clinical trial or

epidemiological / science experiment.

SYLLABUS




1.3 Department M2




2. Data regarding the discipline 2.1 Name Pharmacology and clinical pharmacology

2.2 Course coordinator Lecturer dr.Ban Erika

2.3 Practical activity coordinator(s) Lecturer dr.Ban Erika

2.4 Study year III 2.5 Semester I si

II 2.6 Type of evaluation Exam 2.7 Type of discipline DF



lecture 2


activity 2

3.4 Total hours in the curriculum 56/sem 3.5 out of which

lecture 28/sem


activity 28/sem


hours



Preparation for seminaries/laboratories, homework, reports, portfolios and essays x

Tutorial activities x

Examinations 1

Other activities x

3.7 Total hours of individual study

per week 8


3.9 Credits 4+4=8


prerequisites -

4.2 competency

prerequisites -



activities



• Understanding/knowledge of indications, contraindications, adverse

effects, pharmacokinetics, dosage, drug associations and interactions for

each drug class

Transversal competencies • Aquisition of skills and knowledge necessary for accurate drug

prescription (compound, precompound, officinal)



Pharmacology is a basic science, included in the curriculum for third

year medical students, which aim is to provide students with the

following knowledge:

• knowledge of the most important drug classes, the organotrophic

medications, the main therapeutic drug classes, correlations between

action and chemical structure


• • Understanding the mechanisms of action of the drug molecule on

the level of cells, tissues, organs and systems, on molecular and

receptorial level, and on the level of the whole human body

• knowledge of indications, contraindications, adverse effects,

pharmacokinetics, dosage, drug associations and interactions for

each drug class

• During the practical activities students learn the general rules of

medical prescriptions ( compound, precompound, officinal), and the

basics of pharmacovigilence

• Understanding of basic concepts of general pharmacology,

pharmacokinetics, pharmacodynamics, pharmacotoxicology and

dosage regardind the following drug cathegories: drugs acting on

peripheral neurotransmission and tissue active substances, drugs

acting on central nervous system, blood, respiratory system,

gastrointestinal system, urinary tract and uterus, endocrine and

metabolic processes, antiinflamatory drugs, antimicrobial and

antiparasitic chemotherapy, anticancer agents

• Aquisition of skills and knowledge necessary for accurate drug

prescription (compound, precompound, officinal)

8. Contents Crt.

no. 8.1 Lecture

Teaching


First semester

1.

1.Introduction: basic principles, importance,

historical development of pharmacology;

generalities about drugs- definitions, effects

Pharmacokinetics: sites of administration, drug

Oral +

multimedia

presentation

2

Acute kidney failure

absorbtion, distribution, metabolism, excretion,

cumulation Pharmacokinetics: sites of

administration, drug absorbtion, distribution,

metabolism, excretion, cumulation

2.

2. Pharmacodynamics: mechanisms of action,

interactions, dosage and administration, drug

safety and effectiveness. Basic and clinical

evaluation of a drug. Pharmacotoxicology:

toxicity, adverse effects, pharmacovigilance.

Oral +

multimedia

presentation

2

Drug effect on fetus

3.

3. Drugs acting on the autonomic nervous

system. Cholinergic agonists : direct and

indirect acting parasympathomimetics.

Oral +

multimedia

presentation

2

Glaucoma

4.

4. Cholinergic antagonists –

parasympatholytics; antispasmodic drugs.

Drugs that act on autonomic ganglia.

Oral +

multimedia

presentation

2

Intestinal obstruction

5. 5. Neuromuscular blocking agents

Oral +

multimedia

presentation

2

Pre-operative care

6. 6. Adrenergic drugs : sympathomimetics

Oral +

multimedia

presentation

2

Cardiorespiratory

arrest

7. 7. Sympatholytic agents : alpha-blockers, beta-

blockers, neurosympatholytics.

Oral +

multimedia

presentation

2

Hypertension

8. 8. Cardiac glycosides, other drugs used in

congestive heart failure

Oral +

multimedia

presentation

2

Acid-base

disturbance

9. 9. Antiarrhythmics

Oral +

multimedia

presentation

2

Cardiac rhythm

disorders

10. 10. Antianginal Drugs. Diuretics. Treatment of

high blood pressure.

Oral +

multimedia

presentation

2

Ischemic heart

disease

11.

11. Agents used in correction of plasma and

blood volume. Antianemic drugs : iron, vitamin

B12, folic acid

Oral +

multimedia

presentation

2

Anemia

12.

12. Antithrombotic drugs: anticoagulants,

antiplatelet agents, fibrinolytic agents.

Haemostatic agents : coagulants,

antifibrinolytics

Oral +

multimedia

presentation

2

Thromboembolic

disease

13.

13.Drugs affecting the respiratory system:

Drugs used for cough, expectorants,

antiasthmatic agents.

Oral +

multimedia

presentation

2

Asthma

14.

14. Drugs affecting the gastrointestinal system.

Stimulants and supplements of digestive

secretions. Digestive enzymes Antacids and

antiulcer drugs. Emetic and antiemetic drugs.

Purgatives, laxatives and antidiarrheal agents.

Oral +

multimedia

presentation

2

Peptic ulcer

Cholagogues and choleretics

Second semester

1. 1. Local anesthetics

Oral +

multimedia

presentation

2

Oral disorders

(caries)

2. 2.General anesthetics : inhaled and intravenous.

Oral +

multimedia

presentation

2

Post-operative care

3.

3. Sedative, hypnotic, anxiolytic drugs:

barbiturates, benzodiazepines, alcohols,

aldehides, etc

Oral +

multimedia

presentation

2

Anxiety/phobia

4.

4. Antipsychotic drugs: phenotiazines,

butyrophenones etc., Psychostimulants and

analeptic drugs.

Oral +

multimedia

presentation

2

Schizophrenia

5. 5. Antiepileptic drugs, anti-Parkinson agents,

central muscle relaxants

Oral +

multimedia

presentation

2

Epilepsy

6. 6. Antidepressants: tricyclic, atypical etc.

Oral +

multimedia

presentation

2

Depression

7. 7. Opioid analgesics and antagonists

Oral +

multimedia

presentation

2

Cerebral palsy

8.

8. Nonsteroidal antiinflammatory drugs,

antirheumatic agents, drugs used in gout

treatment

Oral +

multimedia

presentation

2

Inflammatory

arthritis

9. 9. Corticosteroids and ACTH

Oral +

multimedia

presentation

2

Adrenal failure

10.

10. Antimicrobial agents: penicillins,

cephalosporins, macrolides, chloramphenicol,

tetracyclines, aminoglycozides, polymixin

Antimicrobial chemoterapeutics

(antimycobacterials, sulfonamides and

trimethoprim)

Oral +

multimedia

presentation

2

Infectious disease of

childhood

11.

11. Urinary tract and intestinal antiseptics

(quinolones, nitrofurans, nalidixic acid),

disinfectants. Local and general antifungal

agents. Antiprotozoal agents: chemotherapy of

malaria, amibiazis, trichomoniazis.

Anthelmintic drugs, chemotherapy of

exoparasites. Antiviral agents.

Oral +

multimedia

presentation

2

Urinary tract

infection.Candidiasis

12.

12. Antidiabetic agents: insulin and oral

antidiabetics. Thyroid hormones and

antithyroid drugs.

Oral +

multimedia

presentation

2

Diabetes

13. affecting the phosphocalcic metabolism.

Anticancer drugs and immunosupressants.

Oral +

multimedia

presentation

2

Carcinoma of the

breast

14.

14. Basics of clinical pharmcology.

Introduction of a new drug, phases of the

clinical testing.

Oral +

multimedia

presentation

2

Drug reactions

Bibliography:

1.Pharmacology Course. Brassai Attila, 2014

1. Rang HP, Dale MM, Ritter JM, Moore PK: Pharmacology, Editura Churchill Livingstone, ediţia a 5-a,

(2003)

2. Hardman J, Limbord L, Gilman A: Goodman & Gilman’s – The pharmacological basis of therapeutics,

Editura The McGraw-Hill Companies, Inc. ediţia a 10-a (2001)

3. Katzung BG (red): Basic and clinical pharmacology, Editura McGraw-Hill, Boston, editia a 9-a (2004)

4. Brody TM, Larner J, Minneman KP, Harold CN: Human pharmacology- molecular to clinical, Editura

Mosby, ediţia a 4-a (2005)

Crt.

no.


activities/Stages

Teaching

methods Hours Observations

ICS

correlation

First semester

1.

1. General and official regulation of prescription,

delivery and circulation of drugs. Pharmacopeia.

Pharmacy. Medical prescription – forms, general

rules.

Practical

demonstrations,

lectures

2

2. 2. Solid dosage forms.

Practical

demonstrations,

lectures

2

3. 3. Semisolid and soft dosage forms

Practical

demonstrations,

lectures

2

4. 4. Liquid and gaseous dosage forms.

Practical

demonstrations,

lectures

2

5. 5. Cholinergic-anticholinergic agents

Practical

demonstrations,

lectures

2

6. 6. Adrenergic- antiadrenergic agents

Practical

demonstrations,

lectures

2

7. 7. Cardiac glycosides and antiarrhytmics.

Practical

demonstrations,

lectures

2

8. 8. Vasoactive agents.

Practical

demonstrations,

lectures

2

9. 9. Drugs affecting the respiratory system

Practical

demonstrations,

lectures

2

10. 10. Drugs affecting the gastrointestinal system

Practical

demonstrations,

lectures

2

11. 11. Diuretics

Practical

demonstrations,

lectures

2

12. 12. Hematologic drugs.

Practical

demonstrations,

lectures

2

13. 13. Practical test: general pharmacology and drug

prescription Examination 2

14. 14. Practical test: autonomic nervous system Examination 2

Second semester

1. 1. Local anesthetics

Practical

demonstrations,

lectures

2

2. 2. General anesthetics

Practical

demonstrations,

lectures

2

3. 3. Sedative, hypnotic, anxiolytic drugs : barbiturates,

benzodiazepines, alcohols, aldehides, etc.

Practical

demonstrations,

lectures

2

4.

4. Antipsychotic drugs: phenotiazines,

butyrophenones etc., Psychostimulants and analeptic

drugs

Practical

demonstrations,

lectures

2

5. 5. Antidepressants: tricyclic, atypical etc.

Practical

demonstrations,

lectures

2

6. 6. Opioid analgesics and antagonists

Practical

demonstrations,

lectures

2

7. 7. Nonsteroidal antiinflammatory drugs,

antirheumatic agents, drugs used in gout treatment

Practical

demonstrations,

lectures

2

8. 8. Corticosteroids and ACTH

Practical

demonstrations,

lectures

2

9.

9. Antimicrobial agents: penicillins, cephalosporins,

macrolides, chloramphenicol, tetracyclines,

aminoglycozides, polymixin Antimicrobial

chemoterapeutics (antimycobacterials, sulfonamides

and trimethoprim)

Practical

demonstrations,

lectures

2

10.

10. Urinary tract and intestinal antiseptics

(quinolones, nitrofurans, nalidixic acid),

disinfectants. Local and general antifungal agents.

Antiprotozoal agents: chemotherapy of malaria,

amibiazis, trichomoniazis. Anthelmintic drugs,

chemotherapy of exoparasites. Antiviral agents.

Practical

demonstrations,

lectures

2

11.

11. Antidiabetic agents: insulin and oral

antidiabetics. Thyroid hormones and antithyroid

drugs

Practical

demonstrations,

lectures

2

12. 12. Gonadal hormones and anabolic steroids

Practical

demonstrations,

lectures

2

13. 13. Drugs affecting the phosphocalcic metabolism.

Anticancer drugs and immunosupressants

Practical

demonstrations,

lectures

2

14. 14. Practical test- Central nervous system Examination 2

Bibliography:

1. Pharmacology Course. Brassai Attila, 2014

1. Rang HP, Dale MM, Ritter JM, Moore PK: Pharmacology, Editura Churchill Livingstone, ediţia a 5-a,

(2003)

2. Hardman J, Limbord L, Gilman A: Goodman & Gilman’s – The pharmacological basis of therapeutics,

Editura The McGraw-Hill Companies, Inc. ediţia a 10-a (2001)

3. Katzung BG (red): Basic and clinical pharmacology, Editura McGraw-Hill, Boston, editia a 9-a (2004)

4. Brody TM, Larner J, Minneman KP, Harold CN: Human pharmacology- molecular to clinical, Editura

Mosby, ediţia a 4-a (2005)

9. Correlations between the contents of the discipline and the expectations of the community representatives, professional associations and representative employers in the domain • • Understanding of basic concepts of general pharmacology, pharmacokinetics, pharmacodynamics,

pharmacotoxicology and dosage regardind the following drug cathegories: drugs acting on peripheral

neurotransmissin and tissue active substances, drugs acting on central nervous system, blood, respiratory

system, gastrointestinal system, urinary tract and uterus, endocrine and metabolic processes,

antiinflamatory drugs, antimicrobial ant antiparasitic chemotherapy, anticancer agents

• Aquisition of skills and knowledge necessary for accurate drug prescription (compound, precompound,

officinal)

10. Evaluation

Type of activity 10.1 Evaluation criteria 10.2 Evaluation methods 10.3 Percent of

the final grade

10.4 Evaluation during the semester

Lecture

Practical activities


Theoretical final exam MCQ exam – 100 questions 70%

Practical final exam Written test and experiments 30%


Knowing drugs action mechanism, general rules of medical prescriptions (compound, precompound,

officinal).

SYLLABUS




1.3 Department M2


1.5 Study cycle License


2. Data regarding the discipline 2.1 Name Pathophysiology

2.2 Course coordinator Assoc. Prof. Anca Bacârea, MD, PhD

2.3 Practical activity coordinator(s) Assoc. Prof. Anca Bacârea, MD, PhD

2.4 Study year III 2.5 Semester I 2.6 Type of evaluation Exam 2.7 Type of discipline DF



lecture 2


activity 2


lecture 28


activity 28


hours




Tutorial activities -

Examinations 0.5

Other activities 0.5


week 12


3.9 Credits 8


prerequisites

4.2 competency

prerequisites



activities



�

UMCH...SYLLABUS – 3rd YEAR No. Educational activities - Objects/Disciplines 1 Pharmacology. 2 Bacteriology. Virusology. Parasitology 3 Pathology 4 Pathophysiology 5 Surgical Semiology

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