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RealWorldDataOpportunityandChallenges
OracleConfidenCal–Internal/Restricted/HighlyRestricted
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Intel,theIntellogo,Xeon,andXeonInsidearetrademarksorregisteredtrademarksofIntelCorporaConintheU.S.and/orothercountries.
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SafeHarborStatementThefollowingisintendedtooutlineourgeneralproductdirecCon.ItisintendedforinformaConpurposesonly,andmaynotbeincorporatedintoanycontract.Itisnotacommitmenttodeliveranymaterial,code,orfuncConality,andshouldnotberelieduponinmakingpurchasingdecisions.Thedevelopment,release,andCmingofanyfeaturesorfuncConalitydescribedforOracle’sproductsremainsatthesolediscreConofOracle.
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OutcomesMaSer
“The biggest influence of health reform is that there is no new money for health care delivery. There is money only for improved outcomes. You can explain it in four words: no outcome, no income. It’s that simple”
- David B Nash, Founding Dean of Thomas Jefferson School of Population Health
2
The ability to demonstrate the needed outcomes to payers will be the differentiator as our system
continues to evolve and address costs
“The biggest influence of health reform is that there is no new money for health care delivery. There is money only for improved outcomes. You can explain it in four words: no outcome, no income. It’s that simple”
- David B Nash, Founding Dean of Thomas Jefferson School of Population Health
2
The ability to demonstrate the needed outcomes to payers will be the differentiator as our system
continues to evolve and address costs
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PharmaceuCcalsOpportuniCes5Opportuni+estoCreateValuewithData
BusinessDevelopmentR&D
SAFETY MARKETACCESS
FindUnmetMedicalNeed
TargetIdenCficaCon
ManageDiversePartnerData
FindAllRelated
Research
LeverageSignalsinThird-PartySources
RapidlyDiscoverLargerContextof
Care
EnterNewMarkets
DefendPricing
ImproveAdherence
IdenCfyKOLsmoreprecisely
MANUFACTURING
CLINICALTRIALS
AccelerateAdapCveClinical
Trials
RapidlyIdenCfyandValidateTargetCohort
TrackandImprove
Adherence
ReduceBadBatches
BeSerPredictVatfailures
RootCauseacrossALL
SupplyChain
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OutcomesMaSer
“Ialsostartedtoshi_ourbusinessawayfromatransacConalmodelthatwasfocusedonphysicallysellingthedrugstodeliveringanoutcome-basedapproachtoaddvaluebeyondjustthepill.Ireallybelievethatinthefuture,companieslikeNovarCsaregoingtobepaidonpa+entoutcomesasopposedtosellingthepill.”
– Joseph Jimenez, CEO, Novartis
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“YoucanbuildabeSermousetrapbutcanyouproveit”AnonymousEpidemiologist
EvidenceMaSers
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Source:WSJStudiosSurvey2015
96%
DataCapitalChallenge
98%81%
GrowthinSupplyofandDemandforData
ReportIncreaseinDataVolumeInLastYear
PlantoExpandTheirAnaly+csTeams
CiteLosingRevenueDueto
Ineffec+veuseofInforma+on
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Source:WSJStudiosSurvey2015
62%
DataCapitalChallengeinPharma
72%73%
GrowthinSupplyofandDemandforData
Source:WSJStudiosSurvey2015
ReportIncreaseinDataVolumeInLastYear
PlantoExpandTheirAnaly+csTeams
CiteLosingRevenueDueto
Ineffec+veuseofInforma+on
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Source:WSJStudiosSurvey2015
DataCapitalChallengeinPharma
72%
GrowthinSupplyofandDemandforData
MoreData
MoreAnalyCcs
LostRevenue?
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What’sGoingOnTheChallengeofDataSupply
OracleConfidenCal–Internal 10
Whatareyoulosingwhileyouwaitfordata?
74%ofresponderssaysittakedaystogetaccesstonewlycaptureddatawhile40%indicateweeks.1
1RexerAnalyCcsSurvey
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CommuniCesGeneraCngDataSupplyNotinyourWarehouseoryourapplica+on
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Whatareyoulosingwhileyouwait?
60%ofrespondentsindicateittakesbetween3weeksand1yeartodeploynewmodelsintoproducCon.1
1RexerAnalyCcsSurvey.
What’sgoingonTheChallengeofOpera+onalizingAnaly+cs
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Thistakestoolong
DataSupply AnalyCcsDemand
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HowfastcanyouturnRealWorldDataintoRealWorldEvidence
RealWorldData AnalyCcsEvidence
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ResultsfromClientCaseStudy
20%to80%LessAccurateAnaly+cs
Act1:Workaroundtheproblembutcreateanother
DataSupply AnalyCcsDemandWorkWithSample Sizeittoyourlaptop
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ResultsfromClientCaseStudy
40%to500%MoreAccurate
Act2:Co-locatealldatawithanalyCcengines
DataSupply AnalyCcsDemand
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Step1:ManageandBuyOnce,AnalyzeManyTimesRealWorldDataReservoir
InsuranceClaimsData
ClinicalData
Prescrip+onData
FAERS,MAUDE
Argus
Siebel
§ RealWorldEvidence§ Biomarkerdiscovery
§ ProtocolvalidaConandpaCentrecruitment
§ PaCentstraCficaCon§ SafetyandcomparaCveeffecCveness
§ PopulaConhealth§ Precisionmedicine
§ …
ENABLES
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Step2:MachineLearningLabBringAnalyCcsTOtheDataReservoir
OracleConfidenCal–Internal/Restricted/HighlyRestricted
MachineLearningDirectlyonDataReservoir
CloneDatatoLab
OracleCloudPlaoormCombinesDataManagement,MachineLearningand
ComputeResources
ProtectedProduc+onBIandDataWarehouse
RealWorldData
MachineLearningIncluded
BringYourOwn
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Step3:Opera+onalizeBringAnalyCcsTOtheapplicaConsandfrontline
OracleConfidenCal–Internal/Restricted/HighlyRestricted
MachineLearningDirectlyonDataReservoir
CloneData
ManageAnyDataAccessViaSQL
ScaleComputeOn-Demand
ProtectedProduc+onApplica+onsandDataWarehouse
MachineLearningIncluded
BringYourOwn
SynctoProd
RealWorldApplicaCons
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DataScienceLab
CreateEnvironment
AccelerateData+Analy+csMakeExis+ngTeamProduc+ve
Analy+csSharedService
ProvideAnaly+cSkills
DevelopSkillsPartnerforSkills
Analy+csProductFactory
Analy+cProducts
EmbeddedandSharedAcrosstheEnterprise
CapabilityRoadmap
HybridDeployment
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PrescripCons:Tacklingfraudanderrors
• 2million‘ghostpaCents’costNHS£540m
• 8millionprescripConsprocessedperday
• Opportunityformisuseofdrugs
• PrescripCons,reimbursementsandbenefitspayments–errorscauseover&underpayments
• IntegraConofstructured&unstructuredtoenablemorepowerfulinsightsintobehavioranduseofdrugsthroughprescripCons
• Geomappingtoshowareasofhotspots–highusersanddrugcosts
ReducingfraudanderrorwithintheNHSprescrip+onservice
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Business Challenge • Link database information on genes,
proteins, metabolic pathways,compounds, ligands, etc. to original sources.
• Increase productivity for accessing, sharing, searching, navigating, cross-linking, analyzing internal /external data
ConsolidatedKnowledgeLayer
Solution • Semantic integration layer using RDF graph • Rich domain-specific terminology (biology,
chemistry and medicine) 1.6 M terms • Terminology Hub: 8 GB of referential data
(ontologies) that cross-reference various data repositories.
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EUPublicaConsOfficeLinkedMetadataPlaoormforEuropeanUnion
Objectives § Commonmetadatamodelsupports:
§ SearchanddiscoveryofEUPublicaCons§ MulCpledomainsandlanguages
Solution § ValidateandtagEUlaw,tenders,andpublicitytostandardizedvocabularies
§ UnifiedRDFgraphmetadatamodel§ Supportsdiscoveryofcontentthroughuser’sterminologyandlanguage
§ ProvidesvarietyofdisseminaConmodes
§ Evolvingdatamodelthatflexiblysupportsavarietyofbusinessusecases
§ Scalability:§ OverbillionRDFtriplesinOracleGraphDB§ 2.5TBofcompresseddatainOracleDB§ Linksto3.9TB(60M)filesofEUpubs
§ Reliabilityandmaintainability§ OracleASM(AutomaCcStorageManagement)§ Twofailoversystems
Benefits
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EnablingServiceLayers
UnifiedDataManagementasaService
IntelligenceasaService
MachineLearningasaService
DataIngestandOriginaConasaService
IntelligentApplicaConsandBusinessInsight
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Developer
Security
InfrastructureasaService–Compute,Storage,Archive
OracleConfidenCal–Internal/Restricted/HighlyRestricted 25
OracleCloudPlaoormDataManagement
UnifiedDataManagementasaService
IntelligenceasaService
MachineLearningasaService
DataIngestandOriginaConasaService
IntelligentApplicaCon
OpenAPI’s
DR/BackUp
Dev/Test
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DataManagementMaturityModel:CREATEVALUEfromDATAforPharma
QuickWins DataManagementPlaoorm BusinessInsight Business
OpCmizaConBusiness
TransformaCon
DataStagingforanydatafrompartnersandinformaConvendorsSimplifyDataCaptureDeliveryforAnalyCcsScaleSASpredicCveanalyCcs
ImplementaCollaboraCveDataReservoirfordataAs-IsExtendDataWarehousetohandlenewdatatypes
SelfServiceDataIngestandData-DrivenDiscoverySupportanalyCcsonalldatastructuredandunstructured
AccelerateMarketAccesswithRealWorldDataImproveSafetySignalDetecCon
CompleteViewofDiseaseTreatmentfromDiagnosCcstoAdherenceOutcome-BasedPrecisionMedicine
Maturity&Capability