MultiOmyx TM Tumor Infiltrating Lymphocyte Panel* Comprehensive Immunophenotyping from a Single Slide Immunotherapy is a promising new cancer treatment approach. In order to develop effective precision immunotherapies, it is important to identify immune checkpoint targets and the types and locations of immune cells in the tumor microenvironment; e.g., B cells, T cells, others. The MultiOmyx Tumor Infiltrating Lymphocyte Panel provides the ideal solution: Quantitative analytical results from every cell on your single FFPE slide. • Comprehensive immune profiling on a single FFPE slide Tissue samples are precious. Unlike IHC assays which must be performed on serial tissue sections, the MultiOmyx Tumor Infiltrating Lymphocyte Panel evaluates 12 key markers on a single slide. • Unambiguous individual cell phenotyping The MultiOmyx Tumor Infiltrating Lymphocyte Panel definitively differentiates cell phenotypes and characterizes immune activation and suppression in relation to tumor and stromal regions. • Advanced bio-image informatics Analysis algorithms provide quantitative expression, co-expression, and co-localization of markers. • Rigorous quality management system The MultiOmyx Tumor Infiltrating Lymphocyte Panel is offered by Clarient a NeoGenomics Company, which is CAP accredited and CLIA certified. Quality management overseen by dedicated pathologist and Medical Director. 12 cancer immune markers on a single FFPE slide. Provides quantitative analytical results from every cell. Figure courtesy of Dr. Luster, Cancer Immunol Res; 2(12); 1125-31. 2014 AACR CD3 T cell CD4 TH (helper) CD8 TC (cytotoxic) CD20 B cell CD68 Macrophage CD56 NK cell CD45RO Memory T cell PD-L1 PD1 Ligand PD1 Inhibit T cell activation CTLA-4 Inhibit T cell activation FOXP3 Treg pan-CK Epithelial Cell MultiOmyx Comprehensive immune profiling Evaluate 12 key markers on a single slide. Immune markers shown: CD4 (green), CD8 (red), PD-L1 (magenta), CD68 (cyan), pan-CK (yellow). IF Color Blends Unambiguous individual cell phenotyping Differentiates cell phenotypes and characterizes immune activation and suppression in relation to tumor and stromal regions. Classification Color Blends
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MultiOmyxTM Tumor Infiltrating Lymphocyte Panel*Comprehensive Immunophenotyping from a Single Slide
Immunotherapy is a promising new cancer treatment approach. In order to develop effective precision immunotherapies, it is important to identify immune checkpoint targets and the types and locations of immune cells in the tumor microenvironment; e.g., B cells, T cells, others.
The MultiOmyx Tumor Infiltrating Lymphocyte Panel provides the ideal solution: Quantitative analytical results from every cell on your single FFPE slide.
• Comprehensive immune profiling on a single FFPE slideTissue samples are precious. Unlike IHC assays which must be performed on serial tissue sections, the MultiOmyx Tumor Infiltrating Lymphocyte Panel evaluates 12 key markers on a single slide.
• Unambiguous individual cell phenotypingThe MultiOmyx Tumor Infiltrating Lymphocyte Panel definitively differentiates cell phenotypes and characterizes immune activation and suppression in relation to tumor and stromal regions.
• Advanced bio-image informaticsAnalysis algorithms provide quantitative expression, co-expression, and co-localization of markers.
• Rigorous quality management systemThe MultiOmyx Tumor Infiltrating Lymphocyte Panel is offered by Clarient a NeoGenomics Company, which is CAP accredited and CLIA certified. Quality management overseen by dedicated pathologist and Medical Director.
12 cancer immune markers on a single FFPE slide. Provides quantitative analytical results from every cell.
Figure courtesy of Dr. Luster, Cancer Immunol Res; 2(12); 1125-31. 2014 AACR
CD3 T cell
CD4 TH (helper)
CD8 TC (cytotoxic)
CD20 B cell
CD68 Macrophage
CD56 NK cell
CD45RO Memory T cell
PD-L1 PD1 Ligand
PD1 Inhibit T cell activation
CTLA-4 Inhibit T cell activation
FOXP3 Treg
pan-CK Epithelial Cell
MultiOmyx
Comprehensive immune profilingEvaluate 12 key markers on a single slide. Immune markers shown: CD4 (green), CD8 (red), PD-L1 (magenta), CD68 (cyan), pan-CK (yellow).
IF Color Blends
Unambiguous individual cell phenotypingDifferentiates cell phenotypes and characterizes immune activation and suppression in relation to tumor and stromal regions.
Classification Color Blends
Customer will receive a report summarizing cell counts, percentage, and density for the sample
For additional information and ordering, please contact Rafael Casiano at [email protected], 813-330-7555.
In addition, a data package will accompany the report including:• Cell count data in common spreadsheet format → Tab-delimited text files• Registered, normalized AF removed IF images → One per marker per ROI• Image QC mask images → One per marker per ROI• Positive-cell masks → One per marker per ROI• Pre-specified color blends → One per marker per ROI consisting of IF stain (red), cell positive call (green), nuclear mask (blue)• Concatenated multiple sample data