Tugas Mandiri Ilmu Faal I.doc

8/17/2019 Tugas Mandiri Ilmu Faal I.doc

1/20

TUGAS MANDIRI ILMU FAAL I

PERAN KALSIUM TERHADAP KONTRAKSI OTOT

Oleh:

AUDINA THALIA

021511133066

ILMU FAAL I – DEPARTEMEN BIOLOGI ORAL

FAKULTAS KEDOKTERAN GIGI – UNIVERSITAS AIRLANGGA

Semester Gasal-20!"20#

i


2/20

KATA PENGANTAR

Puji Syuku ke h!"i!# Tuh!# $!#% M!h! &'! !(!' li)*!h!# !h)!( "!#

hi"!y!h+Ny! 'ehi#%%! !khi#y! *e#uli' "!*!( )e#yele'!ik!# (u%!' )!#"ii il)u

,!!l II y!#% -eju"ul Pe#%!uh .!l'iu) Teh!"!* ./#(!k'i O(/( D!l!)

*e#uli'!# (u%!' )!#"ii i#i 'u"!h "iu'!h!k!# "e#%!# 'e)!k'i)!l )u#%ki# "!#

(e#(u#y! "e#%!# -!#(u!# -e-!%!i *ih!k 'ehi#%%! (u%!' )!#"ii i#i "!*!( 'ele'!i

"e#%!# l!#! U#(uk i(u *e#uli' )e#y!)*!ik!# (ei)! k!'ih ke*!"!:

1 D% A'! Sjuh!"! M.e' 'el!ku "/'e# *e)-i)-i#%

2 .elu!%! "!# (e)!#+(e)!# 'ej!4!( y!#% (el!h )e)-eik!# "uku#%!#

ke*!"! *e#uli' u#(uk )e#yele'!ik!# )!k!l!h i#i

D!l!) *e#uli'!# (u%!' )!#"ii i#i *e#uli' )/h/# )!!, jik! !"!

keku!#%!# "!i 'e%i (!(! -!h!'! )!u*u# 'e%i y!#% l!i# Oleh k!e#! i(u *e#uli'

"e#%!# (e-uk! )e#ei)! '!!# "!# ki(ik "!i *e)-!! Sehi#%%! *e#uli' "!*!(

)e)-e#!k!# ke'!l!h!# y!#% !"! "!# )e#j!"ik!# )!k!l!h (u%!' )!#"ii i#i

"e#%!# le-ih -!ik

Akhi#y! *e#uli' )e#%h!!*k!# !%! )!k!l!h i#i -e)!#,!!( )e)-ei

*e#%e(!hu!# "!# hik)!h -!%i *e)-!! Sehi%%! *e)-!! )e)!h!)i *e#%!uh

k!l'iu) (eh!"!* k/#(!k'i /(/(

Su!-!y! 31 De'e)-e 2015

Pe#uli'

ii


3/20

Da$tar Is%

.!(! Pe#%!#(!ii

D!,(! I'iiii

D!,(! G!)-!i

D!,(! T!-el

A-'(!k i

A I P&NDAHULUAN

11 L!(! el!k!#%1

12 Tuju!# Pe#uli'!#2

13 M!#,!!(2

A II TIN7AUAN PUSTA.A

21 .!l'iu)3

211 De,i#i'i .!l'iu)3

212 Pe!# .!l'iu) "!l!) Tu-uh8

22 ./#(!k'i O(/(5

221 Mek!#i')e ./#(!k'i O(/(5

222 F!k(/ Me)*e#%!uhi ./#(!k'i O(/(9

23 Pe!# .!l'iu) (eh!"!* ./#(!k'i O(/(

A III P&MAHASAN11

A I; P&NUTUP

81 Si)*ul!#18

DAFTAR PUSTA.A 15

iii


4/20

DAFTAR GAMAR

G!)-! 1 .e!"!!# el!k'!'i 'u!(u '!k/)e <

G!)-! 2 Mek!#i')e k/#(!k'i /(/( 9

G!)-!3 ./)-i#!'i =!>> "!# .!l)/"uli# 11

iv


5/20

ABSTRAK

.!l'iu) !"!l!h 'e-u!h ele)e# ki)i! "e#%!# 'i)-/l =! "!# #/)/ !(/)

20 .!l'iu) )eu*!k!# '!l!h '!(u l/%!) !lk!li (!#!h "!# )eu*!k!# )i#e!l

y!#% !)!( *e#(i#% -!%i )!#u'i! .!l'iu) !"!l!h #u(i'i *!li#% *e#(i#% y!#%

'!#%!( -e%u#! -!%i (u-uh Pe!# k!l'iu) "!l!) (u-uh le-ih k/)*lek' "!i

'eke"! )e#ye-!-k!# %i%i "!# (ul!#% )e#j!"i ku!( Fu#%'i u(!)! "!i k!l'iu) "i

"!l!) (u-uh !"!l!h k/#(!k'i /(/( .e(ik! /(/( )e#ei)! 'i#y!l k/#(!k'i i/#

k!l'iu) )e#%i#i'i!'i keku!(!# )e#!ik !#(!! ,il!)e# !k(i# "!# )i/'i# 'ehi#%%!

ke"u! ,il!)e# (e'e-u( -e%e'e '!(u '!)! l!i# "!# )e#%h!'ilk!# */'e'

k/#(!k'i Se(el!h i(u i/# k!l'iu) !k!# "i*/)*! ke)-!li ke "!l!) e(iulu)

'!)*!i */(e#'i!l !k'i /(/( y!#% -!u "!(!#% l!%i I/# k!l'iu) '!#%!( "i*eluk!#

u#(uk )e#j!%! k/#(!k'i /(/( !%! (i"!k (ehe#(i

.!(! ku#i: .!l'iu) k/#(!k'i /(/( ,il!)e# !k(i# )i/'i# */(e#'i!l !k'i

Calcium is a chemical element with the symbol Ca and atomic number 20.

Calcium is one of the alkaline earth metal and a mineral that is essential for humans. Calcium is the most important nutrient which is very useful for the body.

The role of calcium in the body is more complex than just cause teeth and bones

strong. The main function of calcium in the body is contraction of muscle. When

the muscles receiving signals contraction calcium ions initiate attractive force

between the filamens of actin and miosin filamens so that both are shifted to one

another and produce a contraction process. !fter that the calcium ions are

pumped back into the reticulum until the new action potential of muscle came

back again. "ons of calcium is needed to maintain muscle contraction that does

not stop.

#eywords$ calcium contraction of muscle filamens of actin and miosin

action potential

v


6/20

BAB I

PENDAHULUAN

& Latar Bela'a()

.!l'iu) !"!l!h ele)e# ki)i! )e)iliki -!#y!k #u(i'i y!#% -e)!#,!!(

-!%i (u-uh ?@i"u! 2001 .!l'iu) )eu*!!k!# k/,!k(/ *e#(i#% -!%i */'e'

'elule "!# -!#y!k u'!h! y!#% (el!h "il!kuk!# u#(uk )e#%uku =!2> y!#%

(e"!*!( "i"!l!) 'el hi"u* ?li#k' e( !l 192 Sej!uh i#i y!#% "i*el!j!i *!"!

'i'(e) /(/( !#%k! !"!l!h =!2> y!#% )e#%ik!( */(ei# (/*/#i# "!# )e#%!k(i,k!#

i#(ek!'i !#(!! ,il!)e# !k(i# "!# )i/'i# 'ehi#%%! (ej!"i k/#(!k'i ?e% Hi%-e"

!#" Te#(h!) 196

.!l'iu) )eu*!k!# '!l!h '!(u #u(ie# y!#% '!#%!( "i-u(uhk!# u#(uk

-e-!%!i ,u#%'i (u-uh ?G/-i#!(h!# e( !l200 S!l!h '!(u ,u#%'i k!l'iu) -!%i(u-uh !"!l!h #u(i'i u#(uk (u)-uh "!# )e#u#j!#% *eke)-!#%!# ,u#%'i )/(/i

!%! le-ih /*(i)!l "!# -eke)-!#% "e#%!# -!ik O!#% "e4!'! )e)eluk!#

k!l'iu) 'e-!#y!k 900 )%Bh!i .eku!#%!# k!l'iu) *!"! )!'! *e(u)-uh!#

"!*!( )e#ye-!-k!# %!#%%u!# *e(u)-uh!# (ul!#% /'(e/*//'i' "!#

/'(e/)!l!'i! ?Niee' 2002

O(/( )e#%!#"u#% ,il!)e# !k(i# "!# )i/'i# Pe#eli(i!# ki)i!4i

)e#u#jukk!# -!h4! ,il!)e# !k(i# "!# )i/'i# y!#% -e!'!l "!i /(/( '!li#%

-ei#(e!k'i !#(!! '!(u '!)! l!i# Sel!#ju(#y! */'e' k/#(!k'i "i!k(i,k!# /leh

i/# k!l'iu) "!# !"e#/'i' (i,/',!( ?ATP "i*e!h )e#j!"i !"e#/'i#e "i,/',!(

?ADP u#(uk )e)-eik!# e#e%i -!%i k/#(!k'i ?ei"%e M7 2009 N!)u#

(e"!*!( *e-e"!!# -e'! !#(!! 'u'u#!# ,i'ik /(/( */l/' "!# /(/( !#%k! "e)iki!#

ju%! *e-e"!!# *!"! !#%!k!i! ek'i(!'i+k/#(!k'i *e#%!(u!# */'e' k/#(!k'i

/leh i/# k!l'iu) l!)!#y! k/#(!k'i "!# ju)l!h e#e%i y!#% "i-u(uhk!# u#(uk

k/#(!k'i

Pe!# *e#(i#% k!l'iu) y!#% "i-u(uhk!# "!l!) )ek!#i')e k/#(!k'i /(/('!#%!( )e#!ik u#(uk "i(eli(i .!e#! ku!#% le-ih 80 *e'e# "!i 'eluuh (u-uh

(e"ii !(!' /(/( !#%k! "!# 10 *e'e# l!i#y! -eu*! /(/( */l/' "!# j!#(u#% Pi#'i*

"!'! y!#% '!)! )e#%e#!i k/#(!k'i "!*!( "i(e!*k!# *!"! ke(i%! je#i' /(/( y!#%

-e-e"! S!l!h '!(u *i#'i* "!'! y!#% '!)! !"!l!h *e%e!k!# ,il!)e# !k(i# "!#

)i/'i# y!#% "ii#i'i!'i /leh *e%e!k!# i/# k!l'iu)

M!k!l!h i#i )e)-!h!' le-ih l!#ju( (e#(!#% -!%!i!)!#! k!l'iu) -e*e!#

(eh!"!* k/#(!k'i /(/( *!"! (u-uh )!#u'i!

&2 T*+*a( Pe(*l%sa(

1


7/20

Tuju!# "!i *e#uli'!# )!k!l!h i#i !"!l!h :

1 U#(uk )e#%e(!hui *e!# k!l'iu) (eh!"!* k/#(!k'i /(/(

&, Ma($aat

Se(el!h )e)-!! )!k!l!h i#i "ih!!*k!# *e)-!! )e#%e(!hui "!#

)e)!h!)i -!%!i)!#! *e!# k!l'iu) (eh!"!* k/#(!k'i /(/( *!"! (u-uh

)!#u'i!

2


8/20

BAB II

TINAUAN PUSTAKA

2& Kals%*m

2&& De$%(%s% Kals%*m

.!l'iu) )eu*!k!# ele)e# "!l!) (u-uh y!#% )eli)*!h *!"! (u-uh

)!#u'i! "!# (e"!*!( "i"!l!) (u-uh /!#% "e4!'! 'e-!#y!k 1000 %!) .!l'iu)

-e*e!# *e#(i#% "!l!) )i#e!li'!'i '('(uk(u ke!' "!# ,u#%'i -i/l/%i .!l'iu)

)eu*!k!# ele)e# y!#% h!#y! "i"!*!( "!i 'u)-e )!k!#!# Rek/)e#"!'i

k!l'iu) -eki'! !#(!! 900+1000 )%Bh!i -e%!#(u#% *!"! u'i! ?Niee' 2002

.e-u(uh!# k!l'iu) -e%!#(u#% *!"! )e(!-/li') k!l'iu) y!i(u !-'/-' i#(e'(i#u)

e!-'/*'i %i#j!l "!# *e%!#(i!# (ul!#% Me(!-/li')e (e'e-u( "i!(u /leh

i#(e!k'i h/)/#e y!i(u h/)/#e *!!(i/i" ?PTH 125+"ihi"/k'ii(!)i# D i/#

k!l'iu) "!# e'e*(/ y!#% 'e'u!i "!l!) u'u' %i#j!l /(/( "!# (ul!#% ?Pe!/k

2010

.!l'iu) )eu*!k!# ele)e# i#/%!#ik y!#% *!li#% *e#(i#% "!# (e"!*!(

"!l!) (u-uh "!l!) ju)l!h y!#% -!#y!k Se)-il!# *uluh 'e)-il!# *e'e# k!l'iu)

(e"!*!( "!l!) (ul!#% y!#% -e,u#%'i 'e-!%!i (e)*!( *e#yi)*!#!# y!#% !k!#

(ele*!' jik! j!i#%!# lu#!k )e)-u(uhk!# M!y/i(!' k!l'iu) (u-uh -e!"! "!l!)

(ul!#% 'e-!%!i k!l'iu)+,/',!( (eu(!)! 'e-!%!i hi"/k'i!*!(i( y!#% -e(!#%%u#%

j!4!- (eh!"!* 'eluuh )!(ei!l "!l!) (ul!#% .!l'iu) )e)*u#y!i "u! (uju!#

u(!)! y!i(u )e#ye"i!k!# keku!(!# (ul!#% "!# )e#ye"i!k!# *e#yi)*!#!#

"i#!)ik u#(uk )e)*e(!h!#k!# '!lu!# k!l'iu) i#(!"!# ek'(!'elule ?Pe!/k

2010

.!l'iu) )eu*!k!# )!k/ ele)e# y!i(u )i#e!l y!#% "i-u(uhk!# /leh

(u-uh "!l!) ju)l!h le-ih "!i 100 )% *eh!i M!k/ ele)e# -e,u#%'i 'e-!%!i

C!( y!#% !k(i, "!l!) )e(!-/li')e !(!u -!%i!# *e#(i#% "!i '(uk(u 'el "!#

j!i#%!# ?Su#i(! A 2005

3


9/20

2&&2 Pera( Kals%*m .alam T*/*

Pe!#!# k!l'iu) "i "!l!) (u-uh "!*!( "i-!%i )e#j!"i "u! y!i(u

)e)-!#(u )e)-e#(uk (ul!#% "!# %i%i "!# )e#%uku */'e' -i/l/%i "!l!) (u-uh

.e-u(uh!# k!l'iu) )!'ih "i(eu'k!# )e'ki*u# 'u"!h "e4!'! D!i 'eluuh

k!l'iu) y!#% (e"!*!( "!l!) (u-uh )!#u'i! (e"!*!( *!"! (ul!#% "!# %i%i

7e#i' )i#e!l (e'e-u( )e)-ei '(uk(u (ul!#% "!# %i%i ?FG @i#!#/ 2008

.!l'iu) '!#%!( -e*e!# "!l!) (u-uh )!#u'i! Te'e"i!#y! k!l'iu)

"i"!l!) (u-uh i(u *e#(i#% 'ehu-u#%!# "e#%!# *e!#!##y! y!i(u :

! U#(uk *e)-e#(uk!# (ul!#% "!# %i%i Sel!)! kehi"u*!# (ul!#%

'e#!#(i!'! )e#%!l!)i *eu-!h!# -!ik "!l!) -e#(uk )!u*u#

ke*!"!(!# 'e'u!i "e#%!# u'i! "!# *eu-!h!# -e!( -!"!# ?Su#i(! A

2003

- Me#%!(u *e)-eku!# "!!h il! (ej!"i luk! i/# k!l'iu) "i "!l!)

"!!h )e!#%'!#% *e)-e-!'!# ,/',/li*i"! (/)-/*l!'(i# "!i *l!(e(

"!!h y!#% (eluk! T/)-/*l!'(i# i#i )e#%k!(!li' *eu-!h!#

*/(/)-i# -!%i!# "!!h #/)!l )e#j!"i (h/)-i# Th/)-i# keu"i!#

)e)-!#(u *eu-!h!# ,i-i#/%e# -!%i!# l!i# "!i "!!h )e#j!"i ,i-i#

y!#% )eu*!k!# %u)*!l!# "!!h ?G .!(!'!*u(! e( !l 15 P!"! -e-!%!i */'e' ,i'i/l/%i "!# -i/ki)i! "i "!l!) (u-uh ?G

.!(!'!*u(! e( !l 15

" .!l'iu) -e,u#%'i 'e-!%!i k!(!li'!(/ -e-!%!i e!k'i -i/l/%ik 'e*e(i

!-'/-' i(!)i# 12 (i#"!k!# e#Ci) *e)e!h le)!k ek'ke'i i#'uli#

/leh *!#e!' *e)-e#(uk!# "!# *e)e!h!# !'e(ilk/li# y!#%

"i*eluk!# "!l!) )e)i#"!hk!# 'u!(u !#%'!#%!# "!i '!(u 'e!-u( ke

'e!-u( '!!, y!#% l!i# ?G .!(!'!*u(! e( !l 15

e ./#(!k'i /(/( P!"! 4!k(u /(/( -ek/#(!k'i i/# k!l'iu) -e*e!#

"!l!) i#(e!k'i */(ei# "i "!l!) /(/( y!i(u !k(i#"!# )i/'i# il! "!!h

k!l'iu) ku!#% "!i #/)!l /(/( (i"k! -i'! )e#%e#"/ 'e'u"!h

k/#(!k'i Tu-uh !k!# k!ku "!# "!*!( )e#i)-ulk!# kej!#% Fu#%'i

k!l'iu) y!#% l!i# !"!l!h )e#i#%k!(k!# ,u#%'i (!#'*/( )e)-!# 'el

ke)u#%ki#!# "e#%!# -e(i#"!k 'e-!%!i '(!-ili'!(/ )e)-!# "!#

(!#')i'i i/# )el!lui )e)-!# /%!#el 'el ?Guy(/# !#" H!ll 2013

4


10/20

Sehu-u#%!# "e#%!# *e!#!##y! i(u )!k! ,u#%'i k!l'iu) "i "!l!) (u-uh

!"!l!h :

! e'!)! ,/',/ )e)-e#(uk )!(ik' (ul!#% *e)-e#(uk!# i#i"i*e#%!uhi /leh i(!)i# D

- U#(uk )e)-!#(u */'e' *e#%%u)*!l!# "!!h

U#(uk )e)*e#%!uhi *e#ei)!!# !#%'!#%!# *!"! /(/( "!# '!!, ?G

.!(!'!*u(! e( !l 15

2&2 K1(tra's% Ot1t

2&2& Me'a(%sme K1(tra's% Ot1t

Mek!#i')e u)u) k/#(!k'i /(/( (i)-ul "!# -e!khi "i "!l!) uu(!#

uu(!# ?Guy(/# !#" H!ll 2013 y!i(u:

1 Su!(u */(e#'i!l !k'i -ej!l!# "i 'e*!#j!#% 'e-u!h '!!, )/(/ik '!)*!i

ke uju#%#y! *!"! 'e!-u( /(/(

2 Di 'e(i!* uju#% '!!, )e#yeke'i C!( #eu/(!#')i((e y!i(u

!'e(ilk/li# "!l!) ju)l!h 'e"iki(

3 A'e(ilk/li# -ekej! *!"! "!e!h 'e(e)*!( *!"! )e)-!#e 'e!-u( /(/(

u#(uk )e)-uk! -!#y!k k!#!l k!(i/# E-e*i#(u !'e(ilk/li# )el!lui

*/(ei# y!#% (e!*u#% *!"! )e)-!#e

8 Te-uk!#y! k!#!l -e*i#(u !'e(ilk/li# )e)u %ki#k!# 'eju)l!h -e'!

i/# #!(iu) u#(uk -e"i,u'i ke -!%i!# "!l!) )e)-!#e 'e!-u( /(/(

H!l i#i )e#ye-!-k!# "e*/l!i'!'i 'e(e)*!( y!#% ke)u"i!#

)e#ye-!-k!# *e)-uk!!# k!#!l #!(iu) -e*i#(u li'(ik ?voltagegated

sodium channels Pei'(i4! i#i !k!# )e#i)-ulk!# 'u!(u */(e#'i!l !k'i

*!"! )e)-!#e

5 P/(e#'i!l !k'i !k!# -ej!l!# "i 'e*!#j!#% )e)-!#' e!-u( /(/( "e#%!#

!! y!#% '!)! 'e*e(i */(e#'i!l !k'i -ej!l!# "i 'e*!#j!#% )e)-!#e

'e!( '!!,

6 P/(e#'i!l !k'i !k!# )e#i)-ulk!# "e*/l!i'!'i )e)-!#e /(/( "!#

-!#y!k !li!# li'(ik */(e#'i!l !k'i )e#%!li )el!lui *u'!( 'e!-u( /(/(

Di'i#i */(e#'i!l !k'i )e#ye-!-k!# e(iulu) '!k/*l!')!

)ele*e!'k!# 'eju)l!h -e'! i/# k!l'iu) y!#% (el!h (e'i)*!# "i

"!l!) e(iulu) i#i


11/20

9 Se(el!h ku!#% "!i '!(u "e(ik i/# k!l'iu) "i */)*! ke)-!li ke "!l!)

e(ikulu) '!k/*l!')! /leh */)*! )e)-!#e =!>> "!# i/# i#i (e(!*

"i'i)*!# "!l!) e(ikulu) '!)*!i */(e#'i!l !k'i /(/( y!#% -!u "!(!#%

l!%i *e#%elu!!# i/# k!l'iu) "!i )i/,i-il !k!# )e#ye-!-k!#

k/#(!k'i /(/( (ehe#(i

Gam/ar .e!"!!# el!k'!'i 'u!(u '!k/)e

?'u)-e : h((*:BB-i/)e"i!-e%/('!#(/'//)B(e/i+-i/l/%iB)ek!#i')e+

k/#(!k'i+/(/(

G!)-! 1 )e#u#jukk!# )ek!#i')e "!'! (ej!"i#y! k/#(!k'i /(/( P!"!

ke!"!!# el!k'!'i uju#%+uju#% ,il!)e# !k(i# y!#% )e)!#j!#% "!i "u! le)*e#%

y!#% -euu(!# 'e"iki( '!li#% (u)*!#% (i#"ih '!(u '!)! l!i# Se-!lik#y! *!"!

ke!"!!# k/#(!k'i ,il!)e# !k(i# i#i (e(!ik ke "!l!) "i!#(!! ,il!)e# )i/'i#

'ehi#%%! uju#%+uju#%#y! 'ek!!#% '!li#% (u)*!#% (i#"ih '!(u '!)! li# "e#%!#

*e)!#j!#%!# y!#% )!k'i)!l Le)*e#% ju%! "i(!ik /leh ,il!)e# !k(i# '!)*!i

ke uju#% ,il!)e# )i/'i# 7!"i k/#(!k'i /(/( (ej!"i "e#%!# !"!#y! mekanisme

pergeseran filamen. ?Guy(/# !#" H!ll 2013

Mek!#i')e kej! /(/( *!"! "!'!#y! )eli-!(k!# 'u!(u *eu-!h!# "!l!)

ke!"!!# y!#% el!(i, "!i ,il!)e#+,il!)e# !k(i# "!# )i/'i# Sel!)! k/#(!k'i /(/(

,il!)e#+,il!)e# (i*i' !k(i# (eik!( *!"! "u! %!i' y!#% -e%e!k ke Pi(! A

)e'ki*u# ,il!)e# (e'e-u( (i"!k -e(!)-!h -!#y!k N!)u# %e!k!# *e%e'e!#

i(u )e#%!ki-!(k!# *eu-!h!# "!l!) *e#!)*il!# '!k/)e y!i(u *e#%h!*u'!#

'e-!%i!# !(!u 'eluuh#y! %!i' H Sel!i# i(u ,il!)e# )i/'i# le(!k#y! )e#j!"i

'!#%!( "ek!( "e#%!# %!i'+%!i' "!# *i(!+*i(! A 'e(! le-! '!k/)e )e#j!"i

6

http://biomedia.begotsantoso.com/teori-biologi/mekanisme-kontraksi-otothttp://biomedia.begotsantoso.com/teori-biologi/mekanisme-kontraksi-otothttp://biomedia.begotsantoso.com/teori-biologi/mekanisme-kontraksi-otothttp://biomedia.begotsantoso.com/teori-biologi/mekanisme-kontraksi-otot


12/20

-eku!#% 'ehi#%%! k/#(!k'i (ej!"i ./#(!k'i -el!#%'u#% *!"! i#(e!k'i !#(!!

!k(i# )i/'i# u#(uk )e)-e#(uk k/)*lek !k(i#+)i/'i#

?4/"-i/l/%y4/"*e''/)

Gam/ar 2 Mek!#i')e ./#(!k'i O(/(

?Su)-e : h((*:BB4444/"-i/l/%y4/"*e''/)Bk/#(!k'i+/(/(B

$!#% )e#ye-!-k!# ,il!)e#+,il!)e# !k(i# -e%e'e ke"!l!) "i! !#(!!

,il!)e#+,il!)e# )i/'i# !"!l!h keku!(!# y!#% "i-e#(uk /leh i#(e!k'i je)-!(!#

'il!#% "!# ,il!)e# )i/'i# "e#%!# ,il!)e# !k(i# P!"! ke!"!!# i'(i!h!( keku!(!#

i#i (i"!k !k(i, (e(!*i -il! 'e-u!h */(e#'i!l !k'i -ej!l!# "i 'e*!#j!#% )e)-!#e

'e!-u( /(/( h!l i#i !k!# )e#ye-!-k!# e(ikulu) '!k/*l!')! )ele*!'k!# i/#

k!l'iu) "!l!) ju)l!h -e'! y!#% "e#%!# e*!( )e#%elili#%i )i/,i-il I/#+i/#

k!l'iu) i#i ke)u"i!# )e#%!k(i,k!# keku!(!# "i !#!(!! ,il!)e# !k(i# "!# )i/'i#

"!# )ul!i (ej!"i k/#(!k'i Te(!*i e#e%i ju%! "i*eluk!# u#(uk -el!#%'u#%#y!

*/'e' k/#(!k'i e%i i#i -e!'!l "!i ik!(!# -ee#e%i (i#%%i *!"! )/lekul ATP

7

http://www.wordbiology.wordpress.com/kontraksi-otot/http://www.octc.kctcs.edu/gcaplan/anat/images/Image286.gifhttp://www.wordbiology.wordpress.com/kontraksi-otot/


13/20

y!#% "iu!ik!# )e#j!"i !"e#/'i#e "i,/',!( ?ADP u#(uk )e)-e-!'k!# e#e%i

?Guy(/# !#" H!ll 2013

2&2&2 Fa't1r mem3e()ar*% '1(tra's% Ot1t

A"! ,!k(/+,!k(/ y!#% )e)*e#%!uhi keku!(!# k/#(!k'i /(/( ./#(!k'i

/(/( !k!# le-ih ku!( -il! 'e"!#% e%!#% "!# -il! 'uhu#y! uku* *!#!' .el!l!h!#

"!# "i#%i# )e)*ele)!h keku!(!# k/#(!k'i eiku( ,!(/ y!#% )e)*e#%!uhi

k/#(!k'i /(/(:

1 Te**e !(!u '(!i!'e e,,e( y!i(u )e#i#%k!(#y! keku!(!# k/#(!k'i

-eul!#% k!li *!"! 'u!(u 'e!-u( /(/( k!e#! '(i)ul!'i -euu(!# -e'eli#%

-e-e!*! "e(ik Pe#%!uh i#i "i'e-!-k!# k!e#! k/#'e#(!'i i/# =!2> "i"!l!) 'e!-u( /(/( y!#% )e#i#%k!(k!# !k(ii(!' )i/,i-il

2 Su))!'i -e-e"! "e#%!# (e**e *!"! 'u))!'i (i!* /(/( -ek/#(!k'i

"e#%!# keku!(!# -e-e"! y!#% )eu*!k!# h!'il *e#ju)l!h!# k/#(!k'i

"u! j!l!# ?'u))!'i u#i( )/(/ -e%!#"! "!# 'u))!'i -e%el/)-!#%

3 F!(iue !"!l!h )e#uu##y! k!*!'i(!' -ekej! k!e#! *ekej!!# i(u 'e#"ii

8 Te(!#i !"!l!h *e#i#%k!(!# ,ekue#'i '(i)ul!'i "e#%!# e*!( 'ehi#%%! (i"!k

!"! *e#i#%k!(!# (e%!#%!# k/#(!k'i

5 Ri%/ (ej!"i -il! 'e-!%i!# (e-e'! ATP "!l!) /(/( (el!h "ih!-i'k!#

'ehi#%%! k!l'iu) (i"!k l!%i "!*!( "ike)-!lik!# ke RS )el!lui )ek!#i')e

*e)/)*!!# ?4/"-i/l/%y4/"*e''/)

Me(/"e *e%e'e!# ,il!)e# "ijel!'k!# )el!lui )ek!#i')e k/#(!k'i

*e#!)*u!# !k(i# "!# )i/'i# )e)-e#(uk k/)*lek' !k(/+)i/'i# y!#%

"i*e#%!uhi /leh ATP Mi/'i# )eu*!k!# */"uk "!# */'e' (e'e-u( )e)*u#y!i

ik!(!# "e#%!# ATP Sel!#ju(#y! ATP y!#% (eik!( "e#%!# )i/'i# (ehi"/li'i'

)e)-e#(uk k/)*lek' )i/'i# ADP+Pi "!# !k!# -eik!(!# "e#%!# !k(i#

Sel!#ju(#y! (!h!* el!k'!'i k/#,/)!'i/#!l k/)*lek' !k(i# )i/'i# ADP+*i

'e!! -e(!h!* )ele*!'k!# ik!(!# "e#%!# Pi "!# ADP */'e' (ek!i( "!#

(ele*!'#y! !k(i# )e#%h!'ilk!# %!y! ,ek(/i!l ?&ely# = 200

2&, Pera( Kals%*m tera.a3 1t1t

8


14/20

Se*e(i y!#% (ej!"i "i /(/( *!"! u)u)#y! '(i)ulu' y!#% )e)iu

'e-!%!i!# -e'! k/#(!k'i /(/( !"!l!h !"!#y! *e#i#%k!(!# i/# k!l'iu) i#(!'elul!

Pe#i#%k!(!# i#i "!*!( "i(i)-ulk!# *!"! je#i' /(/( */l/' y!#% -e-e"! /leh

*e!#%'!#%!# '!!, *!"! 'e!-u( /(/( '(i)ul!'i h/)/#e e%!#%!# 'e!-u( !(!u

*eu-!h!# *!" !li#%ku#%!# ki)i!4i 'e!-u( ?Guy(/# !#" H!ll 2013

I/# k!l'iu) )e#%i#i'i!'i keku!(!# )ek!#ik !#(!! ,il!)e# !k(i# "!#

)i/'i# y!#% )e#ye-!-k!# ke"u! ,il!)e# (e'e-u( -e%e'e '!(u '!)! l!i#

'ehi#%%! )e#%h!'ilk!# */'e' k/#(!k'i Se(el!h ku!#% "!i '!(u "e(ik )!k! i/#

k!l'iu) "i*/)*! ke)-!li ke "!l!) e(ikulu) '!k/*l!')! /leh */)*!

)e)-!#e =!>> "!# i/# i#i (e(!* "i'i)*!# "!l!) e(ikulu) '!)*!i */(e#'i!l !k'i

/(/( y!#% -!u "!(!#% l!%i *e#%elu!!# i/# k!l'iu) "!i )i/,i-il !k!#)e#ye-!-k!# k/#(!k'i /(/( (ehe#(i ?Guy(/# !#" H!ll 2013

P!"! /(/( */l/' k/#(!k'i /(/( "i!k(i,k!# /leh 'u!(u )ek!#i')e y!#%

'eluuh#y! -e-e"! y!i(u *e#%%!#(i (/*/#i# 'el+'el /(/( */l/' )e#%!#"u#%

'eju)l!h -e'! */(ei# *e#%!(u l!i# y!#% "i'e-u( k!l)/"uli# ?G!)-! 2

@!l!u*u# */(ei# k!l)/"uli# 'eu*! "e#%!# (/*/#i# k!l)/"uli# )e)*u#y!i

!! y!#% -e-e"! "!l!) )e)iu k/#(!k'i .!l)/"uli# )el!kuk!# k/#(!k'i

/(/( "e#%!# )e#%!k(i,k!# je)-!(!# 'il!#% )i/'i# P/'e' !k(i!'i /(/( */l/'

"i!4!li "e#%!# i/# k!l'iu) -eik!(!# "e#%!# k!l)/"uli# ?Guy(/# !#" H!ll

2013

9


15/20

Gam/ar , ./)-i#!'i =!>> "!# .!l)/"uli#

?'u)-e : Guy(/# !#" H!ll 2013 H!l 9

./#'e#(!'i i/# k!l'iu) ?=!>> i#(!'elul! )e#i#%k!( ke(ik! =!>>

)e)!'uki 'el )el!lui k!#!l k!l'iu) *!"! )e)-!#e 'el !(!u e(ikulu)

'!k/*l!')! ?SR =!>> -eik!(!# "e#%!# k!l)/"uli# )e)-e#(uk k/)*lek' =!>> +

.!l)/"uli# y!#% ke)u"i!# )e#%!k(i!'i !#(!i i#%!# )i/'i# ki#!'e ?)i/'i#

li%h( h!i# ki#!'eB ML=. ML=. )e),/',/il!'i !#(!i i#%!# )i/'i# ?ML=

)e#ye-!-k!# k/#(!k'i /(/( */l/' .e(ik! k/#'e#(!'i =!>> )e#uu# k!e#!

*e)/)*!!# =!>> kelu! 'el */'e' )e#j!"i (e-!lik "!# )i/'i# ,/',!(!'e

)ele*!'k!# ,/',!( "!i ML= )e#ye-!-k!# k/#(!k'i ?Guy(/# !#" H!ll 2013

10


16/20

BAB III

PEMBAHASAN

.!l'iu) )eu*!k!# ele)e# y!#% *!li#% *e#(i#% y!#% "i-u(uhk!# /leh

(u-uh "!l!) ju)l!h -!#y!k .!e#! Se)-il!# *uluh Se)-il!# *e'e# k!l'iu)

(e"!*!( *!"! (ul!#% y!#% u)u#y! -e,u#%'i 'e-!%!i *e#y!#%%! (u-uh Te(!*i

k!l'iu) (i"!k h!#y! u#(uk (ul!#% S!l!h '!(u "!i -e-e!*! )!#,!!( k!l'iu)

!"!l!h u#(uk k/#(!k'i /(/(

&)*!( *uluh *e'e# "!i 'eluuh (u-uh (e"ii !(!' /(/( !#%k! "!#

)u#%ki# 'e*uluh *e'e# l!i##y! -eu*! /(/( */l/' "!# j!#(u#% Pi#'i* "!'! y!#%

'!)! )e#%e#!i k/#(!k'i "!*!( "i(e!*k!# *!"! ke(i%! je#i' /(/( y!#% -e-e"!

O(/( 'kele( (e"ii "!i -e-e!*! ik!( )u'le ,i-e' Mu'le ,i-e

)eu*!k!# 'el 'ili#"e y!#% *!#j!#% y!#% (e"ii "!i -e-e!*! #uleu' O(/( !k!#

)el!kuk!# k/#(!k'i "!# el!k'!'i k!e#! )e#"!*!( 'i#y!l "!i 'i'(e) '!!,

S!!, 'e#'/ik )e)-!4! i)*ul' "!i (u-uh ke /(!k -!%i!# )/(/ik -e!khi *!"!

)u'le ,i-e S!(u )u'le ,i-e (e"ii "!i )y/,i-il S!(u )y/,i-il (e"ii "!i

-e-e!*! '!k/)e S!(u '!k/)e (e"ii "!i (hik !#" (hi# ,il!)e# Thik ,il!)e# !"!l!h )i/'i# "!# (e#%!h#y! "i'e-u M+li#e M/lekul )i/'i# (e"ii !(!'

e#!) !#(!i */li*e(i"!+"u! rantai berat )!'i#%+)!'i#% "e#%!# -e!( )/lekul

ki!+ki! 200000 "!# e)*!( rantai ringan "e#%!# -e!( )/lekul )!'i#%+)!'i#%

'eki(! 20000 Du! !#(!i -e!( '!li#% )elili( '!(u '!)! l!i# u#(uk )e)-e#(uk

helik' %!#"! y!#% "i'e-u( 'e-!%!i ekor )/lekul )i/'i# S!l!h '!(u uju#% "!i

!#(!i i#i )eli*!( 'e!! -il!(e!l ke "!l!) 'u!(u '(uk(u */li*e*(i"! %l/-ul!

y!#% "i'e-u( kepala miosin 7!"i (e"!*!( "u! ke*!l! -e-!' *!"! )/lekul )i/'i#

helik' %!#"! &)*!( !#(!i i#%!# ju%! -!%i!# "!i ke*!l! )i/'i# y!i(u "u! 'e(i!*

ke*!l! R!#(!i+!#(!i i#%!# i#i )e)-!#(u )e#%!(u ,u#%'i ke*!l! 'el!)!

k/#(!k'i /(/(

Se-u!h ,il!)e#( !k(i# )u#i (!#*! !"!#y! k/)*lek' (/*/#i#+(/*/)i/'i#

!k!# -eik!(!# 'e!! e*!( "!# ku!( "e#%!# ke*!l! )/lekul )i/'i# L!lu jik!

k/)*lek' (/*/#i#+(/*/)i/'i# "i(!)-!hk!# *!"! ,il!)e#( !k(i# ik!(!# !#(!!

!k(i# "!# )i/'i# i#i (i"!k !k!# (e-e#(uk Oleh k!e#! i(u "i"u%! -!h4! -!%i!#

!k(i, *!"! ,il!)e#( !k(i# #/)!l "!i /(/( y!#% 'e"!#% el!k'!'i !k!# "ih!)-!(

11


17/20

!(!u 'e!! ,i'ik "i(u(u*i /leh k/)*lek' (/*/#i#+(/*/)i/'i# Aki-!(#y! (e)*!(

i#i (i"!k "!*!( )elek!( *!"! ke*!l! ,il!)e#( )i/'i# u#(uk )e#i)-ulk!#

k/#(!k'i Se-elu) (ej!"i k/#(!k'i e,ek *e#%h!)-!(!# k/)*lek' (/*/#i#+

(/*/)i/'i# i(u h!u' "ih!)-!( .e!"!!# (e'e-u( )e)-!4! ki(! ke*!"! *e!#

i/# k!l'iu) De#%!# !"!#y! i/# k!l'iu) "!l!) ju)l!h -e'! e,ek *e#%h!)-!(!#

(/*/#i#+(/*/)i/'i# (eh!"!* ,il!)e#( !k(i# i(u 'e#"ii "ih!)-!( il! i/#

k!l'iu) -e%!-u#% "e#%!# (/*/#i# = "!# 'e(i!* )/lekul (/*/#i# = "!*!(

-eik!(!# 'e!! ku!( "e#%!# e)*!( i/# k!l'iu) k/)*lek' (/*/#i# !k!#

)e#%!l!)i *eu-!h!# -e#(uk y!#% )e#!ik )/lekul (/*/)i/'i# "!#

)e)i#"!hk!##y! le-ih "!l!) kelekukk!# !#(!! "u! u#(!i !k(i# .e!"!!# i#i

E)e)-uk! -!%i!# !k(i, "!i !k(i# 'ehi#%%! )e)u#%ki#k!# k/)*lek' i#i

)e#!ik ke*!l! je)-!(!# 'il!#% )i/'i# "!# )e#ye-!-k!# (ej!"i#y! k/#(!k'i

il! 'e-u!h /(/( -ek/#(!k'i (i)-ul 'u!(u kej! y!#% )e)-u(uhk!#

e#e%i Seju)l!h -e'! ATP "i*e!h )e)-e#(uk ADP 'el!)! */'e' k/#(!k'i

'e)!ki# -e'! ju)l!h kej! y!#% "il!kuk!# /leh /(/( 'e)!ki# -e'! ju)l!h ATP

y!#% "i*e!hk!# y!#% "i'e-u( efek %enn Se-elu) k/#(!k'i (ej!"i ke*!l!

je)-!(!# 'il!#% -eik!(!# "e#%!# ATP Ak(ii(!' ATP!'e "!i ke*!l! )i/'i# 'e%e!

)e)!h ATP (e(!*i )e#i#%%!l!k!# h!'il *e)e!h!##y! y!i(u ADP "!# i/# ,/',!(

y!#% !k!# (eik!( *!"! ke*!l! ./)*l/k (/*/#i#+(/*/)i/'i# -eik!(!# "e#%!#

i/# k!l'iu) )!k! -!%i!# !k(i, *!"! ,il!)e# )e#j!"i (e-uk! "!# ke*!l! )i/'i#

ke)u"i!# -eik!(!# "e#%!# -!%i!# i#i

Ik!(!# !#(!! ke*!l! je)-!(!# 'il!#% "!# -!%i!# !k(i, ,il!)e# !k(i#

)e#ye-!-k!# *eu-!h!# -e#(uk ke*!l! )e#ye-!-k!# ke*!l! )e#ekuk ke! !h

le#%!# je)-!(!# 'il! .e"u"uk!# i#i )e)-eik!# power stroke u#(uk )e#!ik

,il!)e# !k(i# e%i y!#% e)#%!k(i,k!# !"!l!h e#e%i y!#% "i'i)*!# /leh

*eu-!h!# -e#(uk y!#% (ej!"i *!"! ke*!l! '!!( )/lekul ATP (el!h "i*e!hk!#

e%i(u ke*!l! je)-!(!# 'il!#% )e#ekuk )!k! ATP "!# i/# ,/',!( (ele*!' "!i

ke*!l! Se(el!h ke*!l! (e*i'!h "!i !k(i# )/lekul ATP y!#% -!u "i*e!h u#(uk

)e)ul!i 'iklu' -!u y!#% )e#i)-ulk!# 'u!(u */4e '(/ke y!#% -!u il!

ke*!l! y!#% (ek/k!#% ?"i'e(!i "e#%!# e#e%i 'i)*!#!##y! y!#% -e!'!l "!i

*e)e!h!# ATP -eik!!(!# "e#%!# -!%i!# !k(i, y!#% -!u *!"! ,il!)e# !k(i#

ke*!l! )e#j!"i (i"!k (ek/k!#% "!# !khi#y! (ej!"i power stroke l!%i

12


18/20

./#(!k'i /(/( y!#% (ej!"i k!e#! '!!, 'e#'/ik )e)-!4! i)*ul' "!i

(u-uh ke /(!k -!%i!# )/(/ik -e!khi *!"! )u'le ,i-e Mek!#i')e kej! /(/(

"i)ul!i "!i i)*ul' y!#% -ej!l!# "!i /(!k '!)*!i (e)i#!l -u((/# )e#ye-!-k!#

i/# =! )!'uk )e#%!k(i,k!# k!l)/"uli# .!l)/"uli# )e#%!k(i,k!# e#Ci) */(ei#

ki#!'e 'ehi#%%! *i#(u =! (e-uk! "!# I/# =! )!'uk I/# =! y!#% )!'uk

)ele-uk!# e'ikel e-e!*! Ae(yh/li#e "ih!#uk!# /leh e#Ci)

!(ylhl/i#e'(e!'e "i #eu/)u'ul! ju#(i/# "!# -e-e!*! "i(!#%k!* e'e*(/

Ae(yh/li#e y!#% "i(!#%k!* )e#%!k(i,k!# '!/*l!')i" e(iulu) )ele*!'k!#

=! y!#% !"! "!l!) /(/( =! (e'e-u( )e#e)*el *!"! */(/#i# )e#%!ki-!(k!#

-i#"i#% 'i(e (elih!( i#"i#% 'i(e -e(e)u "e#%!# )i/'i# he!" )e)-e#(uk /''

-i"%e "!# /''-i"%e )el!kuk!# */4e '(/ke )e#%!ki-!(k!# !(i# )e#"ek!(

"e#%!# )i/'i# S!k/)e )e)e#"ek 'ehi#%%! /(/( -i'! "i%e!kk!#

13


19/20

BAB IV

PENUTUP

4& S%m3*la(.!l'iu) )eu*!k!# )i#e!l y!#% '!#%!( *e#(i#% -!%i )!#u'i! S!l!h '!(u

,u#%'i "!i k!l'iu) y!i(u i/# k!l'iu) )e)*u#y!i *e!#!# *e#(i#% *!"! k/#(!k'i

/(/( $!#% (ej!"i *!"! /(/( !#%k! y!i(u '(i)ulu' y!#% )e)iu 'e-!%i!# -e'!

k/#(!k'i /(/( */l/' !"!l!h !"!#y! *e#i#%k!(!# i/# k!l'iu) i#(!'elule

Pe#i#%k!(!# i#i "!*!( "i(i)-ulk!# *!"! je#i' /(/( */l/' y!#% -e-e"! I/#

k!l'iu) !k!# -eik!(!# "e#%!# k!l)/"uli# ke)u"i!# -e%!-u#% "e#%!# "!#

'ek!li%u' )e#%!k(i,k!# kinase rantai ringan miosin &miosin light chain kinase'

y!i(u e#Ci) ,/',/il!'i R!#(!i i#%!# "!i 'e(i!* ke*!l! )i/'i# y!#% "i'e-u( !#(!i

*e#%!(u !k!# )e#%!l!)i ,/',/il!'i 'e-!%!i e'*/# (eh!"!* )i/'i# ki#!'e

R!#(!i *e#%!(u y!#% )e#%!l!)i ,/',/il!'i ke*!l! )e)iliki ke)!)*u!# u#(uk

-eik!(!# 'e!! -eul!#% "e#%!# ,il!)e# !k(i# "!# -ekej! )el!lui 'eluuh */'e'

'iklu' E(!ik!# -ek!l! '!)! 'e*e(i y!#% (ej!"i *!"! /(/( !#%k!( 'ehi#%%!

)e#%h!'ilk!# k/#(!k'i /(/(

14


20/20

DAFTAR PUSTAKA

Al)!('ie S 2005 Pi#'i* D!'! Il)u GiCi j!k!(! : PT G!)e"i! Pu'(!k!

U(!)! H 230+28<

ei"%e M7: S)//(h )u'le ell !liu) !(i!(i/# )eh!#i')' 7 Phy'i/l

596:508

Tugas Mandiri Ilmu Faal I.doc

Documents