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October 2013 – September 2015 Ext Narumon Sa-ngaareekul Ext Piriya Pibalkul Ext Jirawut Muninnimit Tuberculosis Review in Soidao hospital
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Tuberculosis Review in Soidao hospital · 2016-10-31 · Drug induce hepatitis, ARDS, repiratory failure refer PPK 6. E1, PCP, encephalitis, TB LN 7. Unknown 2 case. Dead cases ปี

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Page 1: Tuberculosis Review in Soidao hospital · 2016-10-31 · Drug induce hepatitis, ARDS, repiratory failure refer PPK 6. E1, PCP, encephalitis, TB LN 7. Unknown 2 case. Dead cases ปี

October 2013 – September 2015

Ext Narumon Sa-ngaareekul

Ext Piriya Pibalkul

Ext Jirawut Muninnimit

Tuberculosis Review

in Soidao hospital

Page 2: Tuberculosis Review in Soidao hospital · 2016-10-31 · Drug induce hepatitis, ARDS, repiratory failure refer PPK 6. E1, PCP, encephalitis, TB LN 7. Unknown 2 case. Dead cases ปี

Overview

Introduction

Definition & Importance

Objective

Methodology

Result

Discussion

Conclusion

Page 3: Tuberculosis Review in Soidao hospital · 2016-10-31 · Drug induce hepatitis, ARDS, repiratory failure refer PPK 6. E1, PCP, encephalitis, TB LN 7. Unknown 2 case. Dead cases ปี

Tuberculosis

TB is a disease caused by a bacterium called Mycobacterium

tuberculosis. The bacteria usually attack the lungs, but TB

bacteria can attack any part of the body. If not treated

properly, TB disease can be fatal. TB disease was once the

leading cause of death in the United States. (CDC)

Page 4: Tuberculosis Review in Soidao hospital · 2016-10-31 · Drug induce hepatitis, ARDS, repiratory failure refer PPK 6. E1, PCP, encephalitis, TB LN 7. Unknown 2 case. Dead cases ปี

Mycobacterium tuberculosis

Genus Mycobacterium

Airborne-transmitted between Humans

Highly aerobic

Slow growing

Lipid rich cell wall provide resistance

Gram ghost

AFB positive bacilli

Page 5: Tuberculosis Review in Soidao hospital · 2016-10-31 · Drug induce hepatitis, ARDS, repiratory failure refer PPK 6. E1, PCP, encephalitis, TB LN 7. Unknown 2 case. Dead cases ปี

Clinical manifestation

Page 6: Tuberculosis Review in Soidao hospital · 2016-10-31 · Drug induce hepatitis, ARDS, repiratory failure refer PPK 6. E1, PCP, encephalitis, TB LN 7. Unknown 2 case. Dead cases ปี

Clinical manifestation

Page 7: Tuberculosis Review in Soidao hospital · 2016-10-31 · Drug induce hepatitis, ARDS, repiratory failure refer PPK 6. E1, PCP, encephalitis, TB LN 7. Unknown 2 case. Dead cases ปี

Diagnosis

PTB

Sputum/BAL AFB stain/Culture positive

CXR + Clinical

EPTB

Specimen AFB stain/Culture positive

Clinical + Laboratory

Pathologic Dx

Page 8: Tuberculosis Review in Soidao hospital · 2016-10-31 · Drug induce hepatitis, ARDS, repiratory failure refer PPK 6. E1, PCP, encephalitis, TB LN 7. Unknown 2 case. Dead cases ปี

Treatment

Page 9: Tuberculosis Review in Soidao hospital · 2016-10-31 · Drug induce hepatitis, ARDS, repiratory failure refer PPK 6. E1, PCP, encephalitis, TB LN 7. Unknown 2 case. Dead cases ปี

Treatment

Page 10: Tuberculosis Review in Soidao hospital · 2016-10-31 · Drug induce hepatitis, ARDS, repiratory failure refer PPK 6. E1, PCP, encephalitis, TB LN 7. Unknown 2 case. Dead cases ปี

Treatment

Page 11: Tuberculosis Review in Soidao hospital · 2016-10-31 · Drug induce hepatitis, ARDS, repiratory failure refer PPK 6. E1, PCP, encephalitis, TB LN 7. Unknown 2 case. Dead cases ปี

Drug resistance

Page 12: Tuberculosis Review in Soidao hospital · 2016-10-31 · Drug induce hepatitis, ARDS, repiratory failure refer PPK 6. E1, PCP, encephalitis, TB LN 7. Unknown 2 case. Dead cases ปี

World wide situation 2007

Page 13: Tuberculosis Review in Soidao hospital · 2016-10-31 · Drug induce hepatitis, ARDS, repiratory failure refer PPK 6. E1, PCP, encephalitis, TB LN 7. Unknown 2 case. Dead cases ปี

World wide situation 2013

Page 14: Tuberculosis Review in Soidao hospital · 2016-10-31 · Drug induce hepatitis, ARDS, repiratory failure refer PPK 6. E1, PCP, encephalitis, TB LN 7. Unknown 2 case. Dead cases ปี

World wide situation 2013

Page 15: Tuberculosis Review in Soidao hospital · 2016-10-31 · Drug induce hepatitis, ARDS, repiratory failure refer PPK 6. E1, PCP, encephalitis, TB LN 7. Unknown 2 case. Dead cases ปี

World wide situation 2014

Page 16: Tuberculosis Review in Soidao hospital · 2016-10-31 · Drug induce hepatitis, ARDS, repiratory failure refer PPK 6. E1, PCP, encephalitis, TB LN 7. Unknown 2 case. Dead cases ปี

World wide situation 2014

Page 17: Tuberculosis Review in Soidao hospital · 2016-10-31 · Drug induce hepatitis, ARDS, repiratory failure refer PPK 6. E1, PCP, encephalitis, TB LN 7. Unknown 2 case. Dead cases ปี

Global trend

Page 18: Tuberculosis Review in Soidao hospital · 2016-10-31 · Drug induce hepatitis, ARDS, repiratory failure refer PPK 6. E1, PCP, encephalitis, TB LN 7. Unknown 2 case. Dead cases ปี

TB & HIV

ในปี พ.ศ. 2549 (ค.ศ. 2006) องค์การอนามัยโลกรายงานจ านวนผู้ป่วยวัณโรคทั่วโลก 14 ล้าน 4 แสนราย

ในจ านวนนี้มีผู้ติดเชื้อเอชไอวี 709,000 ราย (4.9 %)

ประเทศไทยอยู่ในล าดับที่ 17 จาก 22 ประเทศที่องค์การอนามัยโลกจัดให้เป็นประเทศที่มีจ านวนผู้ป่วยวัณโรคมากที่สุดในโลก

Page 19: Tuberculosis Review in Soidao hospital · 2016-10-31 · Drug induce hepatitis, ARDS, repiratory failure refer PPK 6. E1, PCP, encephalitis, TB LN 7. Unknown 2 case. Dead cases ปี

TB & HIV

Page 20: Tuberculosis Review in Soidao hospital · 2016-10-31 · Drug induce hepatitis, ARDS, repiratory failure refer PPK 6. E1, PCP, encephalitis, TB LN 7. Unknown 2 case. Dead cases ปี

TB & HIV

Page 21: Tuberculosis Review in Soidao hospital · 2016-10-31 · Drug induce hepatitis, ARDS, repiratory failure refer PPK 6. E1, PCP, encephalitis, TB LN 7. Unknown 2 case. Dead cases ปี

TB & HIV

Page 22: Tuberculosis Review in Soidao hospital · 2016-10-31 · Drug induce hepatitis, ARDS, repiratory failure refer PPK 6. E1, PCP, encephalitis, TB LN 7. Unknown 2 case. Dead cases ปี

TB & HIV

Page 23: Tuberculosis Review in Soidao hospital · 2016-10-31 · Drug induce hepatitis, ARDS, repiratory failure refer PPK 6. E1, PCP, encephalitis, TB LN 7. Unknown 2 case. Dead cases ปี

Holistic care

Page 24: Tuberculosis Review in Soidao hospital · 2016-10-31 · Drug induce hepatitis, ARDS, repiratory failure refer PPK 6. E1, PCP, encephalitis, TB LN 7. Unknown 2 case. Dead cases ปี

Objective

To study the epidemiology of active TB in Soidao hospital

during October, 2013 – September, 2015 (ปีงบประมาณ 2556-2558)

To study the type, response to treatment, success rate &

complication

To study the HIV co-infection in TB patient

Page 25: Tuberculosis Review in Soidao hospital · 2016-10-31 · Drug induce hepatitis, ARDS, repiratory failure refer PPK 6. E1, PCP, encephalitis, TB LN 7. Unknown 2 case. Dead cases ปี

Methodology

Data collection: from TB clinic & Admission data in Soidao

hospital 2013-2015

Categorization and review medical record via HOSxP

Data analysis, discussion and summary

Page 26: Tuberculosis Review in Soidao hospital · 2016-10-31 · Drug induce hepatitis, ARDS, repiratory failure refer PPK 6. E1, PCP, encephalitis, TB LN 7. Unknown 2 case. Dead cases ปี

RESULTS

Page 27: Tuberculosis Review in Soidao hospital · 2016-10-31 · Drug induce hepatitis, ARDS, repiratory failure refer PPK 6. E1, PCP, encephalitis, TB LN 7. Unknown 2 case. Dead cases ปี

จ ำนวนผู้ป่วยวัณโรคในคลินิกวัณโรค รพ.

สอยดำว

ปีงบประมาณ 2556 2557 2558

5953

77

22

37

18

35

24

53

จ านวนผู้ป่วย

Page 28: Tuberculosis Review in Soidao hospital · 2016-10-31 · Drug induce hepatitis, ARDS, repiratory failure refer PPK 6. E1, PCP, encephalitis, TB LN 7. Unknown 2 case. Dead cases ปี

ปีงบประมาณ อายุเฉลี่ย น้อยที่สุด มากที่สุด2556 47.5 8 822557 45.3 18 862558 66.8 23 94

Page 29: Tuberculosis Review in Soidao hospital · 2016-10-31 · Drug induce hepatitis, ARDS, repiratory failure refer PPK 6. E1, PCP, encephalitis, TB LN 7. Unknown 2 case. Dead cases ปี

กำรกระจำยตัวของโรค แบ่งตำม

ต ำบล

ปีงบประมาณ2556 2557 2558

17

1112

13

15

18

1010

22

78

13

10

43

2

5

9

Page 30: Tuberculosis Review in Soidao hospital · 2016-10-31 · Drug induce hepatitis, ARDS, repiratory failure refer PPK 6. E1, PCP, encephalitis, TB LN 7. Unknown 2 case. Dead cases ปี

Pulmonary VS Extrapulmonary TB

ปีงบประมาณ Pulmonary TB Extrapulmonary TB Both2556 51 9 12557 40 13 02558 68 9 0

Page 31: Tuberculosis Review in Soidao hospital · 2016-10-31 · Drug induce hepatitis, ARDS, repiratory failure refer PPK 6. E1, PCP, encephalitis, TB LN 7. Unknown 2 case. Dead cases ปี

Pulmonary TB

2556 2557 2558

82%

18%

73%

27%

75%

25%

Page 32: Tuberculosis Review in Soidao hospital · 2016-10-31 · Drug induce hepatitis, ARDS, repiratory failure refer PPK 6. E1, PCP, encephalitis, TB LN 7. Unknown 2 case. Dead cases ปี

Pulmonary TB

Smear + - + - + -2556 2557 2558

42

9

29

11

51

17

Page 33: Tuberculosis Review in Soidao hospital · 2016-10-31 · Drug induce hepatitis, ARDS, repiratory failure refer PPK 6. E1, PCP, encephalitis, TB LN 7. Unknown 2 case. Dead cases ปี

Sputum AFB

2556 2557 2558

(25.8%)

(74.2%)

(27.5%)

(72.5%)

(25.4%)

(74.6%)

Page 34: Tuberculosis Review in Soidao hospital · 2016-10-31 · Drug induce hepatitis, ARDS, repiratory failure refer PPK 6. E1, PCP, encephalitis, TB LN 7. Unknown 2 case. Dead cases ปี

CXR finding

2556 2558

49%

27%

14%

10%

36%

9%

51%

4%

42%

5%

51%

2%

Page 35: Tuberculosis Review in Soidao hospital · 2016-10-31 · Drug induce hepatitis, ARDS, repiratory failure refer PPK 6. E1, PCP, encephalitis, TB LN 7. Unknown 2 case. Dead cases ปี

2556 2557 2558

20%

64%

16%

9%

71%

20%

13%

79%

8%

HIV infection in TB patients

Page 36: Tuberculosis Review in Soidao hospital · 2016-10-31 · Drug induce hepatitis, ARDS, repiratory failure refer PPK 6. E1, PCP, encephalitis, TB LN 7. Unknown 2 case. Dead cases ปี

Treatment regimen

2556

2557

2558

Page 37: Tuberculosis Review in Soidao hospital · 2016-10-31 · Drug induce hepatitis, ARDS, repiratory failure refer PPK 6. E1, PCP, encephalitis, TB LN 7. Unknown 2 case. Dead cases ปี

ผลการรักษา ปีงบประมาณ 2556

N=59

Loss follow-up

(32)

(14)

(2)

(3)

(4)(4)

Page 38: Tuberculosis Review in Soidao hospital · 2016-10-31 · Drug induce hepatitis, ARDS, repiratory failure refer PPK 6. E1, PCP, encephalitis, TB LN 7. Unknown 2 case. Dead cases ปี

ผลการรักษา ปีงบประมาณ 2557

(21)

(20)

(3)

(8)

(1)

N=53

Page 39: Tuberculosis Review in Soidao hospital · 2016-10-31 · Drug induce hepatitis, ARDS, repiratory failure refer PPK 6. E1, PCP, encephalitis, TB LN 7. Unknown 2 case. Dead cases ปี

ผลการรักษา ปีงบประมาณ 2558

N=77

(31)

(25)

(2)

(6)

(4)

(9)

Page 40: Tuberculosis Review in Soidao hospital · 2016-10-31 · Drug induce hepatitis, ARDS, repiratory failure refer PPK 6. E1, PCP, encephalitis, TB LN 7. Unknown 2 case. Dead cases ปี

(31)

(25)

(2)

(6)

(4)

(9)

2556 2557

2558

Loss follow-up

(32)

(14)

(2)

(3)

(4)(4)

(21)

(20)

(3)

(8)

(1)

Page 41: Tuberculosis Review in Soidao hospital · 2016-10-31 · Drug induce hepatitis, ARDS, repiratory failure refer PPK 6. E1, PCP, encephalitis, TB LN 7. Unknown 2 case. Dead cases ปี

Admission cases ปี 56 admit 12 case

Dx pulmonary TB smear positive 10 cases(hepatitis 1 case)

Dx Pulmonary TB smear negative 1 case

DxTB meningitis 1 case

Page 42: Tuberculosis Review in Soidao hospital · 2016-10-31 · Drug induce hepatitis, ARDS, repiratory failure refer PPK 6. E1, PCP, encephalitis, TB LN 7. Unknown 2 case. Dead cases ปี

Admission cases ปี 57 admit 17 case

Dx pulmonary smear positive TB 7 cases

Dx pulmonary TB + Hemoptysis 2 cases

Dx Bronchopneumonia ontop pulmonary TB 3 cases

Dx Pleural effusion 4 case

Dx Drug allergy 1 cases

ปี 58 admit 3 case

Dx Localized peritonistis > refer รพศ Dx Bronchopneumonia 2 cases

Page 43: Tuberculosis Review in Soidao hospital · 2016-10-31 · Drug induce hepatitis, ARDS, repiratory failure refer PPK 6. E1, PCP, encephalitis, TB LN 7. Unknown 2 case. Dead cases ปี

Case admit ทีไ่มไ่ด ้F/U TB clinic

ปี 56 : 8 case

Pulmonary TB smear positive 4 cases

TB meningitis

TB pericarditis

TB spine

TB base of skull mass with MDS

ปี 57 : 1 case

Pulmonary TB smear positive 1 case

Page 44: Tuberculosis Review in Soidao hospital · 2016-10-31 · Drug induce hepatitis, ARDS, repiratory failure refer PPK 6. E1, PCP, encephalitis, TB LN 7. Unknown 2 case. Dead cases ปี

Dead cases ปี 56 dead 5 case

1. Pulmonary TB smear positive with respiratory failure

2. E1 with disseminated TB

3. Suicide

4. TB base skull mass with MDS (no F/U TB clinic)

5. Pulmonary TB smear positive, AAA, UGIB (no F/U TB

clinic)

Page 45: Tuberculosis Review in Soidao hospital · 2016-10-31 · Drug induce hepatitis, ARDS, repiratory failure refer PPK 6. E1, PCP, encephalitis, TB LN 7. Unknown 2 case. Dead cases ปี

Dead cases ปี 57 dead 8 case

1. Pleural effusion with hemoptysis refer PPK

2. HyperK, MI (arrest at home)

3. Drug induce hepatitis with liver failure

4. Pulmonary TB with respiratory failure refer PPK

5. Drug induce hepatitis, ARDS, repiratory failure refer PPK

6. E1, PCP, encephalitis, TB LN

7. Unknown 2 case

Page 46: Tuberculosis Review in Soidao hospital · 2016-10-31 · Drug induce hepatitis, ARDS, repiratory failure refer PPK 6. E1, PCP, encephalitis, TB LN 7. Unknown 2 case. Dead cases ปี

Dead cases ปี 58 dead 6 case

1. Pneumonia on top pulmonary TB (tracheostomy)

2. Peritonitis refer PPK

3. COPD with AE on ETT refer PPK

4. COPD with AE on ETT refer PPK

5. Death at home unknown casuse

6. Severe destroy lung NR off ETT at home

Page 47: Tuberculosis Review in Soidao hospital · 2016-10-31 · Drug induce hepatitis, ARDS, repiratory failure refer PPK 6. E1, PCP, encephalitis, TB LN 7. Unknown 2 case. Dead cases ปี

Conclusion

Page 48: Tuberculosis Review in Soidao hospital · 2016-10-31 · Drug induce hepatitis, ARDS, repiratory failure refer PPK 6. E1, PCP, encephalitis, TB LN 7. Unknown 2 case. Dead cases ปี

Conclusion

Good success rate High HIV-TB co infection

Accurate complication rate can’t be stated ‘Hidden’ case issue – Cambodian & others

Previous & further data review will be helpful to summarize more accurate trend

Page 49: Tuberculosis Review in Soidao hospital · 2016-10-31 · Drug induce hepatitis, ARDS, repiratory failure refer PPK 6. E1, PCP, encephalitis, TB LN 7. Unknown 2 case. Dead cases ปี

สรุปรายงานการเฝ้าระวังโรคประจ าปี2552

Page 50: Tuberculosis Review in Soidao hospital · 2016-10-31 · Drug induce hepatitis, ARDS, repiratory failure refer PPK 6. E1, PCP, encephalitis, TB LN 7. Unknown 2 case. Dead cases ปี

สรุปรายงานการเฝ้าระวังโรคประจ าปี2552

Page 51: Tuberculosis Review in Soidao hospital · 2016-10-31 · Drug induce hepatitis, ARDS, repiratory failure refer PPK 6. E1, PCP, encephalitis, TB LN 7. Unknown 2 case. Dead cases ปี

สรุปรายงานการเฝ้าระวังโรคประจ าปี2552

Page 52: Tuberculosis Review in Soidao hospital · 2016-10-31 · Drug induce hepatitis, ARDS, repiratory failure refer PPK 6. E1, PCP, encephalitis, TB LN 7. Unknown 2 case. Dead cases ปี

ประชากรกลางปี 2557 อ าเภอสอยดาว

Page 53: Tuberculosis Review in Soidao hospital · 2016-10-31 · Drug induce hepatitis, ARDS, repiratory failure refer PPK 6. E1, PCP, encephalitis, TB LN 7. Unknown 2 case. Dead cases ปี

TB incidence (per 100,000 population)

ปี 56 : 88

ปี 57 : 79

ปี 58 : 115

Page 54: Tuberculosis Review in Soidao hospital · 2016-10-31 · Drug induce hepatitis, ARDS, repiratory failure refer PPK 6. E1, PCP, encephalitis, TB LN 7. Unknown 2 case. Dead cases ปี

Conclusion

More incidence than global

More incidence than Thailand

Less incidence than overall Chantaburi province

Page 55: Tuberculosis Review in Soidao hospital · 2016-10-31 · Drug induce hepatitis, ARDS, repiratory failure refer PPK 6. E1, PCP, encephalitis, TB LN 7. Unknown 2 case. Dead cases ปี

Suggestion

Aim for 100% HIV counseling & Screening

Record for previous HIV / new HIV

Record for Complication of treatment during F/U

Public health education for TB importance

AEC issue

Page 56: Tuberculosis Review in Soidao hospital · 2016-10-31 · Drug induce hepatitis, ARDS, repiratory failure refer PPK 6. E1, PCP, encephalitis, TB LN 7. Unknown 2 case. Dead cases ปี

For TB

Early Dx

Prompt & Adequate treatment

Scheduled follow up & protocal

Prevent transmission

Prevent drug resistance

Look for HIV

Health education

Page 57: Tuberculosis Review in Soidao hospital · 2016-10-31 · Drug induce hepatitis, ARDS, repiratory failure refer PPK 6. E1, PCP, encephalitis, TB LN 7. Unknown 2 case. Dead cases ปี

Reference

Treatment for tuberculosis guideline, 4th ed, WHO, 2010

Guidelines on the management of latent tuberculosis

infection, WHO, 2015

Management of MDR-TB: A field guide, WHO, 2009

แนวทางเวชปฏิบัติการรักษาวัณโรคในผู้ใหญ่พ.ศ. 2556 ,

ส านักวัณโรคกรมควบคุมโรค และ สมาคมอุรเวชช์แห่งประเทศไทย

Page 58: Tuberculosis Review in Soidao hospital · 2016-10-31 · Drug induce hepatitis, ARDS, repiratory failure refer PPK 6. E1, PCP, encephalitis, TB LN 7. Unknown 2 case. Dead cases ปี

WHO

Data

Page 59: Tuberculosis Review in Soidao hospital · 2016-10-31 · Drug induce hepatitis, ARDS, repiratory failure refer PPK 6. E1, PCP, encephalitis, TB LN 7. Unknown 2 case. Dead cases ปี

Suggestion

Page 60: Tuberculosis Review in Soidao hospital · 2016-10-31 · Drug induce hepatitis, ARDS, repiratory failure refer PPK 6. E1, PCP, encephalitis, TB LN 7. Unknown 2 case. Dead cases ปี

Reference

Treatment for tuberculosis guideline, 4th ed, WHO, 2010

Guidelines on the management of latent tuberculosis

infection, WHO, 2015

Management of MDR-TB: A field guide, WHO, 2009

แนวทางเวชปฏิบัติการรักษาวัณโรคในผู้ใหญ่พ.ศ. 2556 ,

ส านักวัณโรคกรมควบคุมโรค และ สมาคมอุรเวชช์แห่งประเทศไทย