Trigeminal System. uoanatomy/neuroanat/ Somatic sensory: A007 Sensory cranial: F003 Sensory cranial:

Trigeminal System

https://www1.columbia.edu/sec/itc/hs/medical/neruoanatomy/neuroanat/

Somatic sensory: A007Sensory cranial: F003Sensory cranial: F004

Somatic sensory: A006Somatic sensory: AN01

Useful animations:

Readings: Principles of NS General somatic sensory organization: 447-449Brain stem/cranial nerve review: 873-880Sensory nuclei: 880-882, Fig 44-6

Nociceptors, thermoreceptors, & itch receptors

are bare nerve

endings

Merkel’s receptorMeissner’s corpuscle Pacinian

corpuscle

Bare nerveending

Mechanoreceptors are encapsulated

Dorsal horn

Anterolateral system:spino-thalspino-reticspino-mesen

Components of the trigeminal system

• Spinal nucleus– Caudal nucleus Pain/temp/itch– Interpolar nucleus Pain/reflexes, etc, ???– Oral nucleus Reflexes, etc, ???

• Main sensory nucleus Mechanosensation• Mesencephalic nucleus Jaw proprioception• Motor nucleus Jaw muscles

Mesencephalic

Main sensorySpinal trigeminal nuc: oral interpolar caudal

Trigeminalmotor

Organization of the spinal trigeminal nucleus:

caudal nucleus

Ophthalmic divisionMaxillary divisionMandibular division

7, 9, & 10

C2

12

3

C2

C2

1

2

3Caudal nucleus

Upper spinal cord

Interpolar nucleus

Spinal trigeminaltract

Caudal nucleus

Output:Marginal zone-->Thalamus, midbrainSubstantia gelatinosa-->interneurons

Input: Small-diameter fibers Marginal zone Substantia gelatinosa

Caudal nucleus

Anterolateralsystem

Spinal trigeminaltract

Main sensory

Trigeminalmotor

Anterolateral/trigeminothal

Medial/trigeminallemniscus

Trigeminallemniscus

Mediallemniscus

MesencephalicNucleus &tract

MesencephalicNucleus &tract

Somatic Sensory Thalamus

Medial dorsal

Ventral posterior (VMpo)

Ventral posterior lateral-VPL (spinal)Ventral posterior medial-VPM (trigem)

Touch Pain

Anterolateral and Trigeminal Systems

Ventral posterior-->Postcentral gyrus •localization

Anterolateral System

Ventral medial post-->Insular •behavioral & •autonomic responses •“Limbic”

Amygdala

Medial dorsal-->Cingulate gyrus •emotional (-valence…) •“Limbic”

Anterolateral and Trigeminal Systems

Pain suppression path

Periaqueductalgray matter

Raphe nuclei(5-HT)

Limbic cortex

-Caudalnucleus

Trigeminal System• Separate components for pain and touch• Brain stem nuclei:

– Caudal nucleus (pain)– Interpolar nucleus (caudal part for pain-mouth)– Oral nucleus (???)– Main sensory nucleus

• 3 Separate thalamic pain nuclei & 1 for touch:– Pain (VPM, VMpo, MD)– Touch (VPM)

• 3 Separate cortical representations:– Postcentral gyrus (localization)– Insular (important for pain)– Cingulate (emotions, esp. for pain)

• Pain suppression system– PAG-->Raphe nuclei (5-HT)-->Caudal nucleus