Trichuriasis

TrichuriasisAbigail Nix

Tuesday, April 3rd, 2012Biology 402

UNC Chapel Hill

Trichuriasis is one of the seven most prevalent Neglected Tropical Diseases

WHO

WHO

NTDs coexist with poverty because they thrive where access to clean water and sanitation are limited and people live without

protection from disease vectors.

iconsinmedicine.wordpress.com

Trichuriasis is one of the three common diseases caused by soil-transmitted

helminths

Forgotten people, forgotten diseases

Approximately 604-795 million people in the world are infected with

whipworm

WHO 2002

Trichuriasis is caused by the parasitic nematode Trichuris trichiura

Bodyfixer.com

Trichuriasis is transmitted through the oral-fecal route

Sabin.org handwashingforlife.com

Adult whipworms live in the large intestine of humans

Unembryonated Trichuris eggs must develop in the soil for at least 2 weeks

naturalhealthtechniques.comStanford.edu

Two types of Trichuriasis infection: heavy and light

smartplanet.com

A stool sample is used to diagnose trichuriasis

Wikipedia.org

Trichuriasis is one of the neglected tropical diseases that can be controlled by mass drug administration

cdc.gov

Three first line medications for trichuriasis: mebendazole, albendazole and ivermectin

Stanford.edu

fredunpharmaceuticals.com

Indiamart.com

Benzimidazoles inhibit the polymerization of tubulin and assembly of tubulin into microtubules

Stanford.edu Cureforneedy.org

Benzimidazoles inhibit the polymerization of tubulin and assembly of tubulin into microtubules

Stanford.edu Cureforneedy.org

Ivermectin binds to and deactivates glutamate-gated chloride channels

Filariajournal.com

Prevention measures for

trichuriasis focus on basic

sanitation and educational

efforts as well as mass drug

administrationsStanford.edu

Could whipworm and other helminth infections be used as future therapeutic

treatments?

landesbioscience.com

Sumers R W et al.

Summers R W et al. Gut 2005;54:87-90

Fleming J O et al.

References"About the Neglected Tropical Disease Program." NTD Program: Neglected Tropical Diseases. USAID, 28 Mar. 2012. Web. <http://www.neglecteddiseases.gov/index.html>.

DrugBank: Open Data Drug & Drug Target Database. University of Alberta, 13 June 2005. Web. <http://www.drugbank.ca/>.

Fleming, J. O., et al. "Probiotic Helminth Administration in Relapsing-remitting Multiple Sclerosis: A Phase 1 Study." Multiple Sclerosis 17.6 (2011): 743-54. Print.

Hotez, Peter J. Forgotten People, Forgotten Diseases: The Neglected Tropical Diseases and Their Impact on Global Health and Development. Washington DC: ASM, 2008. Print.

Hotez, Peter J. "Rescuing the Bottom Billion through Control of Neglected Tropical Diseases." Lancet 373 (2009): 1570-575. Print.

Summers, R. W., et al. "Trichuris Suis Therapy in Crohn's Disease." GUT 54 (2005): 87-90. Print.

Summers, R. W. , et al. "Trichuris Suis Therapy for Active Ulcerative Colitis: A Randomized Controlled Trial." Gastroenterology 128.4 (2005): 825-32. Print.

"Trichuriasis." Centers for Disease Control. 2 Nov. 2010. Web. <http://www.cdc.gov/parasites/whipworm/>.