A TRF1 -LT-Cre Wildtype-LT-Cre 53BP1 + Tel Martinez_5435_Supplementary Fig 1A- 0 20 40 60 80 100 NT ATMi (KU55933) caffeine 53BP1 positive cells (%) n=2 MEF 189 cells n=2 MEF 246 cells n=2 MEF 179 cells n=2 MEF 195 cells n=2 MEF 156 cells n=2 MEF 226 cells TRF1 -LT-Cre Wildtype-LT-Cre p<0.0001 p<0.0001 p=0.1 p=0.04 p=0.07 TRF1 -LT-Cre Wildtype-LT-Cre 0 20 40 60 80 100 Cells with > 4 TIFs (%) n=2 MEF 13 cells n=2 MEF 21 cells n=2 MEF 17 cells ATMi (KU55933) NT NT caffeine n=2 MEF 15 cells p<0.0001 p<0.0001 B C
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A
TRF1-LT-CreWildtype-LT-Cre
53B
P1
+ T
el
Martinez_5435_Supplementary Fig 1A-C
0
20
40
60
80
100
NT ATMi(KU55933)
caffeine
53B
P1
po
siti
ve c
ells
(%
)
n=2 MEF189 cells
n=2 MEF246 cells
n=2 MEF179 cells
n=2 MEF195 cells
n=2 MEF156 cells
n=2 MEF226 cells
TRF1-LT-CreWildtype-LT-Cre
p<0.0001
p<0.0001
p=0.1p=0.04
p=0.07
TRF1-LT-CreWildtype-LT-Cre
0
20
40
60
80
100
Cel
ls w
ith
> 4
TIF
s (
%)
n=2 MEF13 cells
n=2 MEF21 cells
n=2 MEF17 cells
ATMi(KU55933)
NT NT caffeine
n=2 MEF15 cells
p<0.0001
p<0.0001
B
C
Martinez_5435_Supplementary Fig 2A,B
Martinez_5435_Supplementary Fig 3A-D
C
D
TIN
2T
IN2
+ T
RF
1T
RF
1
Wildtype-LT-Cre TRF1-LT-Cre
TRF2 + TRF1 TRF2 + TRF1
POT1 + TRF1POT1 + TRF1
Wildtype-LT-Cre TRF1-LT-Cre
A B
Martinez_5435_Supplementary Fig 4A-C
Martinez_5435_Supplementary Fig 5A,B
Martinez_5435_Supplementary Fig 5C-F
C D
E
F
Martinez_5435_Supplementary Fig 6A,B
Martinez_5435_Supplementary Fig 7
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