Trends in Solvent Management in the Pharmaceutical Industry C. Stewart Slater and Mariano J. Savelski Department of Chemical Engineering Rowan University Glassboro, NJ Session 656: Green Engineering in the Fine Chemical and Pharmaceutical Industry AIChE Annual Meeting Nashville, TN November 8-13, 2009
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Trends in Solvent Management in the Pharmaceutical Industry C. Stewart Slater and Mariano J. Savelski Department of Chemical Engineering Rowan University.
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Trends in Solvent Management in the Pharmaceutical Industry
C. Stewart Slater and Mariano J. SavelskiDepartment of Chemical Engineering
Rowan University
Glassboro, NJ
Session 656: Green Engineering in the Fine Chemical and Pharmaceutical Industry
AIChE Annual Meeting
Nashville, TN November 8-13, 2009
Solvent Issues
• Solvent use can account for up to 80-90% of total mass of an API synthesis– Majority are organic solvents
• Solvent costs over life cycle– Pay to purchase– Pay to use (energy and associated costs)– Pay to dispose of
• E-Factor 25->100 kg/kg of API*• Not optimal for a ChE!!!• Practice green chemistry & engineering
Sheldon, Chem Ind, 1 (1997) 12
Pharma Industry Profile
• US EPA Toxic Release Inventory (TRI) 2006
• 128 MM kg waste
• Top ten solvents account for 80% of waste
Lopez, Toxic Release Inventory, US EPA, 2006
Solvent Waste Management Trends
• ~70% of waste is treated or recycled*
• ~30% of waste is used for energy recovery*
• Only a small percent is directly released into the environment
• Incineration remains the disposal method of choice
• Solvent reduction– Recovery techniques– Novel approaches to separations– Telescoping– Novel reaction media (ionic liquids)– Biocatalytic routes– Solid-state chemistry
“Plant of the Future”
• The plant of the future will likely use a limited number of ‘universal’ green solvents – Properties allow for easy recovery– Used with other campaigns– Integrated solvent recovery systems