Treatment of Eye Cancer in Children With Chemosurgery Pierre Gobin (1) , David Abramson (2) , Ira Dunkel (3) 1: Interventional Neuroradiology, Weill Cornell Medical College 2: Ophthalmic Oncology, Memorial Sloan Kettering Cancer Center 3: Pediatric Oncology, Memorial Sloan Kettering Cancer Center Disclosures: none
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Treatment of Eye Cancer in Children With Chemosurgery
Treatment of Eye Cancer in Children With Chemosurgery Pierre Gobin (1) , David Abramson (2) , Ira Dunkel (3) 1: Interventional Neuroradiology, Weill Cornell Medical College 2: Ophthalmic Oncology, Memorial Sloan Kettering Cancer Center - PowerPoint PPT Presentation
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Treatment of Eye Cancer in Children
With Chemosurgery
Pierre Gobin (1), David Abramson (2) , Ira Dunkel (3)
1: Interventional Neuroradiology, Weill Cornell Medical College
2: Ophthalmic Oncology, Memorial Sloan Kettering Cancer Center
3: Pediatric Oncology, Memorial Sloan Kettering Cancer Center
Disclosures: none
Retinoblastoma- Definition:
-Cancer of the eye: precisely cancer of the retina, the light sensitive layer which enables the eye to see
- Frequency:- 7th most common pediatric cancer- 80% diagnosed < 3 year-old- 75% unilateral, 25% bilateral
- Prognosis:- 5 year-survival in the U.S: 98%
- Genetic: - 40% patients have the genetic form
Clinical signs- Presenting signs:
- leukocoria (white pupillary reflexion): 60%
- Cross-eyes: 25%
- Late diagnosis: leukocoria means the tumor is already filling the eye
- Diagnostic: ophthalmoscopy, ultrasound
Treatment for Intraocular disease
• Wide array of treatment including:– Photocoagulation and Cryotherapy – Radiation– Chemotherapy
• Problem:– Most children present with advanced disease for which local control is impossible: the only treatment is enucleation (removing the eye).
Why a new treatment for Retinoblastoma?
• Avoid removing the eye (enucleation)
• Avoid toxicity of current treatments by radiation and chemotherapy
Treatment protocol
• General anesthesia, outpatient• Puncture the artery in the groin • Placement of a catheter in the artery of the eye
• Inject chemotherapy drugs in the artery of the eye.
• Three treatments at 3 weeks interval
Patient population• 22 patients recruited since May 2006
– Age: 1 month to 10 years (median: 2 year)
– Bilateral: 11/22• Previous treatments:
– Contralateral Enucleation: 5– Others: 11
• All patients (except one) had advanced eye cancer normally treated by enucleation