Professor C. Kiparissides CERTH/CPERI Treatment of CNS Disorders Ø N2B delivery of medica*ons for CNS disorders as an alterna*ve to intravenous delivery. Ø N2B-patch: Applica*on of an in situ forming hydrogel containing drug loaded NPs to the olfactory epithelium via an endoscopic catheter. Ø Mul5ple pathways to the brain through the olfactory region Ø Very complex problem requiring contribu*ons from many disciplines
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Treatment of CNS Disorders...Treatment of CNS Disorders Ø N2B delivery of medicaons for CNS disorders as an alternave to intravenous delivery. Ø N2B-patch: Applicaon of an in situ
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ProfessorC.Kiparissides CERTH/CPERI
Treatment of CNS Disorders
Ø N2B delivery of medica*ons for CNS disorders as analterna*vetointravenousdelivery.
Ø N2B-patch:Applica*onof an in situ forming hydrogelcontainingdrugloadedNPstotheolfactoryepitheliumviaanendoscopiccatheter.
Ø Mul5plepathways to thebrain through theolfactoryregion
Ø Very complex problem requiring contribu*ons frommanydisciplines
ProfessorC.Kiparissides CERTH/CPERI
Many and Different Models!
Drug release from the hydrogel to mucosa Hydrogel swelling and shrinkage
Drug release from embedded par:cles
0.0 0.5 1.0 1.5 2.0 2.5 3.0 3.5 4.0
5.0x105
1.0x106
1.5x106
2.0x106
2.5x106
3.0x106
3.5x106
pH = 5pH = 5 .5pH = 6pH = 6 .5pH = 7
Weigh
tAve
rage
Molec
ularW
eigh
t
T ime (m in)
Simula:on of gela:on kine:cs
Key mechanisms of hydrogel film forma:on
HA droplet spreading
HA droplet spreading over the olfactory mucous surface
Mucous layer
Flux JpR(t)
Hydrogellayerz
⎟⎠
⎞⎜⎝
⎛= )t,0(
dzdC,tfJ H
m
CH(z)
( ))t,z(C),t,r(C),t(RfJ Hp =1 2
4 3
Jm(t)
Jp(t)
N2B Drug Transport Mechanism and drug release profile