www.comascience.org Transcranial Direct Current Stimulation (tDCS) in patients with disorders of consciousness THIBAUT Aurore PhD Candidate Coma Science Group Cyclotron Research Centre University of Liège, Belgium Annual IUAP meeting, May 22, 2014 IUAP
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Transcranial Direct Current Stimulation (tDCS) in patients ...€¦ · Could daily stimulations be helpful for patient’s recovery? Could tDCS be implemented in daily clinical practice?
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www.comascience.org
Transcranial Direct Current Stimulation (tDCS) in patients with disorders of consciousness
THIBAUT AurorePhD Candidate Coma Science GroupCyclotron Research CentreUniversity of Liège, Belgium
Annual IUAP meeting, May 22, 2014
IUAP
www.comascience.org
disorders of consciousness | behavioural evaluation | electrophysiology | neuroimaging | methods, ethics & quality of life | perspectives
Laureys, Owen and Schiff, Lancet Neurology, 2005
Disorders of consciousness
NORMAL
CONSCIOUSNESS
AR
OU
SA
L
AW
AR
EN
ES
S
Introduction | tDCS | Studies | Conclusion
www.comascience.org
disorders of consciousness | behavioural evaluation | electrophysiology | neuroimaging | methods, ethics & quality of life | perspectives
Laureys, Owen and Schiff, Lancet Neurology, 2005
Disorders of consciousness
NORMAL
CONSCIOUSNESS
AR
OU
SA
L
AW
AR
EN
ES
S
Introduction | tDCS | Studies | Conclusion
www.comascience.org
disorders of consciousness | behavioural evaluation | electrophysiology | neuroimaging | methods, ethics & quality of life | perspectives
Laureys, Owen and Schiff, Lancet Neurology, 2005
Disorders of consciousness
NORMAL
CONSCIOUSNESS
AR
OU
SA
L
AW
AR
EN
ES
SCOMA
AR
OU
SA
L
AW
AR
EN
ES
S
Introduction | tDCS | Studies | Conclusion
www.comascience.org
disorders of consciousness | behavioural evaluation | electrophysiology | neuroimaging | methods, ethics & quality of life | perspectives
Laureys, Owen and Schiff, Lancet Neurology, 2005
Disorders of consciousness
NORMAL
CONSCIOUSNESS
AR
OU
SA
L
AW
AR
EN
ES
SCOMA
AR
OU
SA
L
AW
AR
EN
ES
S
Introduction | tDCS | Studies | Conclusion
www.comascience.org
disorders of consciousness | behavioural evaluation | electrophysiology | neuroimaging | methods, ethics & quality of life | perspectives
Laureys, Owen and Schiff, Lancet Neurology, 2005
Disorders of consciousness
NORMAL
CONSCIOUSNESS
AR
OU
SA
L
AW
AR
EN
ES
SCOMA
AR
OU
SA
L
AW
AR
EN
ES
S
VEGETATIVE STATE/
UNRESPONSIVE
WAKEFULNESS
SYNDROME
AR
OU
SA
L
AW
AR
EN
ES
S
Introduction | tDCS | Studies | Conclusion
www.comascience.org
disorders of consciousness | behavioural evaluation | electrophysiology | neuroimaging | methods, ethics & quality of life | perspectives
Laureys, Owen and Schiff, Lancet Neurology, 2005
Disorders of consciousness
NORMAL
CONSCIOUSNESS
AR
OU
SA
L
AW
AR
EN
ES
SCOMA
AR
OU
SA
L
AW
AR
EN
ES
S
VEGETATIVE STATE/
UNRESPONSIVE
WAKEFULNESS
SYNDROME
AR
OU
SA
L
AW
AR
EN
ES
S
Introduction | tDCS | Studies | Conclusion
www.comascience.org
disorders of consciousness | behavioural evaluation | electrophysiology | neuroimaging | methods, ethics & quality of life | perspectives
Laureys, Owen and Schiff, Lancet Neurology, 2005
Disorders of consciousness
NORMAL
CONSCIOUSNESS
AR
OU
SA
L
AW
AR
EN
ES
SCOMA
AR
OU
SA
L
AW
AR
EN
ES
S
VEGETATIVE STATE/
UNRESPONSIVE
WAKEFULNESS
SYNDROME
AR
OU
SA
L
AW
AR
EN
ES
S
MINIMALLY
CONSCIOUS
STATE
AR
OU
SA
L
AW
AR
EN
ES
S
Introduction | tDCS | Studies | Conclusion
www.comascience.org
disorders of consciousness | behavioural evaluation | electrophysiology | neuroimaging | methods, ethics & quality of life | perspectives
Laureys, Owen and Schiff, Lancet Neurology, 2005
Disorders of consciousness
NORMAL
CONSCIOUSNESS
AR
OU
SA
L
AW
AR
EN
ES
SCOMA
AR
OU
SA
L
AW
AR
EN
ES
S
VEGETATIVE STATE/
UNRESPONSIVE
WAKEFULNESS
SYNDROME
AR
OU
SA
L
AW
AR
EN
ES
S
MINIMALLY
CONSCIOUS
STATE
AR
OU
SA
L
AW
AR
EN
ES
S
Introduction | tDCS | Studies | Conclusion
www.comascience.org
Clinical entities
Laureys, Scientific American, 2007
Introduction | tDCS | Studies | Conclusion
www.comascience.org
Clinical entities
Laureys, Scientific American, 2007
Introduction | tDCS | Studies | Conclusion
www.comascience.org
Clinical entities
Laureys, Scientific American, 2007
Introduction | tDCS | Studies | Conclusion
www.comascience.org
Clinical entities
Laureys, Scientific American, 2007
Introduction | tDCS | Studies | Conclusion
www.comascience.org
Clinical entities
Laureys, Scientific American, 2007
PermanentMinimally Conscious
State
?
Introduction | tDCS | Studies | Conclusion
www.comascience.org
Clinical entities
Laureys, Scientific American, 2007
PermanentMinimally Conscious
State
?
Introduction | tDCS | Studies | Conclusion
How to improve recovery?
www.comascience.org
Pharmacological treatments
Adapted from Demertzi et al, Expert Rev Neurotherapeutics, 2008