Bracco, F., Battaglia A., Chouza C. et al. The long-acting dopamine receptor agonist cabergoline in early Parkinson's disease: final results of a 5-year, double-blind, levodopa-controlled study. CNS Drugs 2004; 18(11): 733–746. Hoehn, M. M. and Yahr M. D. Parkinsonism: onset, progression, and mortality. Neurology 1967; 17(5): 427–442. Hoehn, M. M. and Elton R. L. Low dosages of bromocriptine added to levodopa in Parkinson's disease. Neurology 1985; 35(2): 199–206. Hoehn, M. M. The natural history of Parkinson's disease in the pre-levodopa and post-levodopa eras. Neurol Clin 1992; 10(2): 331– 339. Holloway, R. G., Shoulson I., Fahn S. et al. Pramipexole vs levodopa as initial treatment for Parkinson disease: a 4-year randomized controlled trial. Arch Neurol 2004; 61(7): 1044–1053. Oertel, W. H., Wolters E., Sampaio C. et al. Pergolide versus levodopa monotherapy in early Parkinson's disease patients: The PELMOPET study. Mov Disord 2006; 21(3): 343–353. Traditional levodopa – strengths I
Traditional levodopa – strengths I. Bracco, F., Battaglia A., Chouza C. et al. The long-acting dopamine receptor agonist cabergoline in early Parkinson's disease: final results of a 5-year, double-blind, levodopa-controlled study. CNS Drugs 2004; 18 (11): 733–746. - PowerPoint PPT Presentation
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Bracco, F., Battaglia A., Chouza C. et al. The long-acting dopamine receptor agonist cabergoline in early Parkinson's disease: final results of a 5-year, double-blind, levodopa-controlled study. CNS Drugs 2004; 18(11): 733–746.
Hoehn, M. M. and Yahr M. D. Parkinsonism: onset, progression, and mortality. Neurology 1967; 17(5): 427–442.
Hoehn, M. M. and Elton R. L. Low dosages of bromocriptine added to levodopa in Parkinson's disease. Neurology 1985; 35(2): 199–206.
Hoehn, M. M. The natural history of Parkinson's disease in the pre-levodopa and post-levodopa eras. Neurol Clin 1992; 10(2): 331–339.
Holloway, R. G., Shoulson I., Fahn S. et al. Pramipexole vs levodopa as initial treatment for Parkinson disease: a 4-year randomized controlled trial. Arch Neurol 2004; 61(7): 1044–1053.
Oertel, W. H., Wolters E., Sampaio C. et al. Pergolide versus levodopa monotherapy in early Parkinson's disease patients: The PELMOPET study. Mov Disord 2006; 21(3): 343–353.
Traditional levodopa – strengths I
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Traditional levodopa – strengths II
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Traditional levodopa – limitations of pulsatile delivery
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Sub-optimal delivery with disease progression
Optimization of levodopa delivery I
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Optimization of levodopa delivery II
Stalevo and its benefits I
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Stalevo and its benefits II
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Stalevo and its benefits III
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Stalevo and its benefits IV
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Benefits of earlier optimization of levodopa delivery
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Future directions I
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